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Development of depth-of-interaction digital PET detector

Research Project

Project/Area Number 19K12857
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 90130:Medical systems-related
Research InstitutionNational Institutes for Quantum Science and Technology

Principal Investigator

Yoshida Eiji  国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 先進核医学基盤研究部, 主幹研究員 (50392246)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsPET / 検出器 / depth-of-interaction / time-of-flight / DOI / デジタル読み出し
Outline of Research at the Start

本研究では高精度かつ効率的に信号を取得可能な3次元デジタル PET 検出器を提案する。開発する検出器は受光素子の 1/4 サイズのシンチレータを用い、シンチレータは受光素子との接続面以外を光学的に遮蔽する。この際、2つの受光素子をまたがる1対のシンチレータの上部の一部分のみを光学接続することで受光素子の組み合わせと出力比で検出したシンチレータを一意に決定できる。本方式 によってシンチレータ数の1/4 の受光素子でデジタルPET検出器を実現でき、出力比から深さ情報も取得可能な検出器を開発する。

Outline of Final Research Achievements

To improve PET image quality, depth-of-interaction (DOI) information, which can reduce the parallax error, and time-of-flight (TOF) information, which can enhance the signal-to-noise ratio in a reconstructed image, are key technologies. However, it is difficult to realize and employ both technologies at the same time without degradation of the information obtained. We have developed the 3D digital PET detector that optically couples the four-loop structure, consisting of quadrisected fast LGSO crystals comparable in size to a photo-sensor, to four photo-sensors in close proximity arranged in a windmill shape. In this work, we developed the PET detector using the fast LGSO crystal for the TOF-DOI PET system. The developed detector with 1.45-mm fast LGSO crystals and ESR reflectors provided 10.1% energy resolution, 4.7 mm DOI resolution, and 293 ps CRT.

Academic Significance and Societal Importance of the Research Achievements

本検出器は従来困難な課題であったDOIとTOFの両立を1.45 mmという高い空間分解能のシンチレータで達成した。小動物PETにおいてはDOIが、臨床PETにおいてはTOFが重要視されるため、本検出器は様々なPET装置に適用可能である。また、従来の2次元検出器に対して、本検出器の主な変更点は反射材構造のみであり、低コストでの製品化が可能である。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (13 results)

All 2023 2022 2021 2020 2019

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Simultaneous time-skew and time-walk correction for TOF-PET detector2023

    • Author(s)
      Yoshida Eiji、Obata Fujino、Yamaya Taiga
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

      Volume: 1049 Pages: 168114-168114

    • DOI

      10.1016/j.nima.2023.168114

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Optimized crystal surface treatment for crosshair light-sharing TOF-DOI PET detector2023

    • Author(s)
      Yoshida Eiji、Kang Han Gyu、Obata Fujino、Yamaya Taiga
    • Journal Title

      IEEE Transactions on Radiation and Plasma Medical Sciences

      Volume: 7 Issue: 5 Pages: 459-464

    • DOI

      10.1109/trpms.2023.3255557

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Gapless implementation of crosshair light-sharing PET detector2022

    • Author(s)
      Yoshida Eiji、Obata Fujino、Kamada Kei、Yoshikawa Akira、Yamaya Taiga
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

      Volume: 1021 Pages: 165922-165922

    • DOI

      10.1016/j.nima.2021.165922

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of crosshair light sharing PET detector with TOF and DOI capabilities using fast LGSO scintillator2021

    • Author(s)
      Yoshida Eiji、Obata Fujino、Kamada Kei、Yoshikawa Akira、Yamaya Taiga
    • Journal Title

      Physics in Medicine and Biology

      Volume: 66 Issue: 22 Pages: 225003-225003

    • DOI

      10.1088/1361-6560/ac2f8b

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A crosshair light sharing PET detector with DOI and TOF capabilities using four-to-one coupling and single-ended readout2021

    • Author(s)
      Yoshida Eiji、Obata Fujino、Kamada Kei、Yamaya Taiga
    • Journal Title

      IEEE Transactions on Radiation and Plasma Medical Sciences

      Volume: 5 Issue: 5 Pages: 638-644

    • DOI

      10.1109/trpms.2020.3032466

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] First imaging demonstration of a crosshair light-sharing PET detector2021

    • Author(s)
      Yoshida Eiji、Akamatsu Go、Tashima Hideaki、Kamada Kei、Yoshikawa Akira、Yamaya Taiga
    • Journal Title

      Physics in Medicine & Biology

      Volume: 66 Issue: 6 Pages: 065013-065013

    • DOI

      10.1088/1361-6560/abe839

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of Single-Ended Readout DOI Detector With Quadrisected Crystals2020

    • Author(s)
      Yoshida Eiji、Obata Fujino、Kamada Kei、Yamaya Taiga
    • Journal Title

      IEEE Transactions on Radiation and Plasma Medical Sciences

      Volume: 4 Issue: 5 Pages: 563-569

    • DOI

      10.1109/trpms.2020.2990788

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] 20cmの体軸方向視野を有する小動物用高分解能ポータブルPETの開発2021

    • Author(s)
      赤松 剛, 吉田 英治, 田島 英朗, 伊藤 繁記, 岩男 悠真, 脇坂 秀克, 高橋 美和子, 山谷 泰賀
    • Organizer
      第61回日本核医学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] First bench-top breast-dedicated PET prototype with a dual round-edge detector arrangement2021

    • Author(s)
      Akamatsu Go, Yoshida Eiji, Tashima Hideaki, Ito Shigeki, Takahashi Miwako, Yamaya Taiga
    • Organizer
      2021 IEEE NSS/MIC, IEEE NPSS
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] CLS-PET: a high-resolution multi-purpose portable small-animal PET with DOI and TOF capability2021

    • Author(s)
      Akamatsu Go, Yoshida Eiji, Tashima Hideaki, Ito Shigeki, Iwao Yuma, Wakizaka Hidekatsu, Takahashi Miwako, Yamaya Taiga
    • Organizer
      2021 IEEE NSS/MIC, IEEE NPSS
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] ローカル重心演算による3次元PET検出器の開発2020

    • Author(s)
      吉田英治、鎌田圭、山谷泰賀
    • Organizer
      第67回応用物理学会春季講演会
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] シンチレータアレイ、放射線検出装置、及び陽電子放出断層撮影装置2022

    • Inventor(s)
      吉田英治, 山谷泰賀
    • Industrial Property Rights Holder
      吉田英治, 山谷泰賀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-018774
    • Filing Date
      2022
    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] 放射線位置検出器2019

    • Inventor(s)
      吉田英治、山谷泰賀
    • Industrial Property Rights Holder
      国立研究開発法人量子科学技術研究開発機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-126957
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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