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Construction of cooking method to improve content of collagen peptide in blood after ingestion of cooked meat

Research Project

Project/Area Number 19K14009
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 08030:Family and consumer sciences, and culture and living-related
Research InstitutionNara Women's University

Principal Investigator

Asai T. Tomoko  奈良女子大学, 生活環境科学系, 助教 (50832036)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords調理操作 / コラーゲンペプチド / コラーゲン加水分解物 / プロリルヒドロキシプロリン / ヒドロキシプロリルグリシン / ウナギ / 加熱調理 / Hyp / ゼラチン / 調理加工 / 調理肉 / コラーゲン
Outline of Research at the Start

コラーゲン酵素分解物の摂取は関節痛や褥瘡の治癒促進をもたらし,その要因はコラーゲン酵素分解物摂取後血中に生理作用をもつコラーゲンペプチドが増加するためであると明らかになった。コラーゲンは日常摂取する調理肉にも含まれているが,調理肉の摂取では一部のコラーゲンは消化・吸収されずに体外へと排泄されてしまう。申請者は,人工消化した調理肉中の可溶性コラーゲン量から調理肉摂取後の血中に増加するコラーゲンペプチド量の推定が可能であることを初めて見出した。そこで本研究では【調理肉摂取後の血中コラーゲンペプチド量の向上のために,人工消化後調理肉中可溶性コラーゲン量を増やす調理方法の確立】を行う。

Outline of Final Research Achievements

Contents and structures of collagen-derived peptides in human blood after ingestion of collagen with different molecular weights and structures (collagen hydrolysate, grilled and steamed Japanese eel: collagen content,13 g) were differed.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、これまで調理肉中のコラーゲン(あるいはゼラチン)を摂取してもアミノ酸として分解されてしまうため生理作用はない、とされてきた定説を改めて覆す結果である。調理操作によっても生体へと吸収されるコラーゲン由来ペプチドの構造やその量が異なることが明らかとなったことから、コラーゲン加水分解物のみならず肉や魚などの調理肉摂取が健康寿命の延伸に寄与する可能性が示された。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (14 results)

All 2022 2021 2020 2019

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (9 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results)

  • [Journal Article] Collagen-Derived Di-Peptide, Prolylhydroxyproline (Pro-Hyp): A New Low Molecular Weight Growth-Initiating Factor for Specific Fibroblasts Associated With Wound Healing2020

    • Author(s)
      Sato Kenji、Asai Tomoko T.、Jimi Shiro
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 8 Pages: 548975-548975

    • DOI

      10.3389/fcell.2020.548975

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] コラーゲンの豊富な調理肉摂取後のヒト血中コラーゲン由来ペプチド2020

    • Author(s)
      淺井智子
    • Journal Title

      食品加工技術

      Volume: 40 Pages: 54-62

    • NAID

      40022432519

    • Related Report
      2020 Research-status Report
  • [Journal Article] 腸から皮膚2020

    • Author(s)
      佐藤健司、淺井智子
    • Journal Title

      美容皮膚医学『BEAUTY』

      Volume: 3 Pages: 20-27

    • Related Report
      2020 Research-status Report
  • [Journal Article] Mouse skin fibroblasts with mesenchymal stem cell marker p75 neurotrophin receptor proliferate in response to prolyl-hydroxyproline2020

    • Author(s)
      Asai Tomoko T.、Yoshikawa Kazunobu、Sawada Kazuhiro、Fukamizu Kazuna、Koyama Yoh-ichi、Shigemura Yasutaka、Jimi Shiro、Sato Kenji
    • Journal Title

      Journal of Functional Foods

      Volume: 66 Pages: 103792-103792

    • DOI

      10.1016/j.jff.2020.103792

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Food-Derived Collagen Peptides, Prolyl-Hydroxyproline (Pro-Hyp), and Hydroxyprolyl-Glycine (Hyp-Gly) Enhance Growth of Primary Cultured Mouse Skin Fibroblast Using Fetal Bovine Serum Free from Hydroxyprolyl Peptide2019

    • Author(s)
      Asai Tomoko T.、Oikawa Fumi、Yoshikawa Kazunobu、Inoue Naoki、Sato Kenji
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 1 Pages: 229-229

    • DOI

      10.3390/ijms21010229

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Collagen-derived peptides in human blood after ingestion of collagen hydrolysate and gelatin2022

    • Author(s)
      Tomoko T. Asai
    • Organizer
      Virtual Symposium on Asian Foods and Traditional Drugs: Young Asian Researchers Association
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 調理魚肉に含まれる消化酵素可溶性コラーゲン量と摂取後ヒト血中コラーゲンペプチド量に調理加工方法が及ぼす影響2021

    • Author(s)
      関野朱夏, 淺井智子, 萬成 誉世, 松田覚, 高村 仁知, 佐藤 健司
    • Organizer
      第26回日本フードファクター学会学術集会 2021年11月19日
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effect of cooking treatment on the amount of pepsin/pancreatin-soluble collagen in meat2020

    • Author(s)
      Tomoko T. Asai, Kyoka Sugiyama, Kumiko Saito, Takayo Mannari, Hitoshi Takamura, Kenji Sato
    • Organizer
      19th World Congress on Nutrition and Food Chemistry 2020年9月
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mami Yamada, Tomoko T. Asai, Takayo Mannari, Hitoshi Takamura, Kenji Sato2020

    • Author(s)
      Effect of high temperature treatment on amino acid residues in soy protein isolate
    • Organizer
      19th World Congress on Nutrition and Food Chemistry 2020年9月
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] The p75NTR-positive fibroblasts from mouse skin respond to Pro-Hyp, collagen-derived peptide2019

    • Author(s)
      淺井 智子
    • Organizer
      The 7th International Conference of Food Factors
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 食品由来コラーゲンペプチドPro-Hyp は体性幹細胞マーカーp75NTR発現細胞の成長を促進する2019

    • Author(s)
      淺井智子,吉川和伸,澤田和浩,自見至郎,佐藤健司
    • Organizer
      第51回日本結合組織学会学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Pro-Hyp, food-derived collagen peptide in blood, enhances growth of fibroblasts expressing p75NTR, somatic stem cell marker2019

    • Author(s)
      ASAI T. Tomoko, Kazunobu Yosikawa, Kazuhiro Sawada, Shiro Jimi, Kenji Sato
    • Organizer
      2nd International Symposium on Bioactive Peptides
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pro-Hyp is specifically incorporated in fibroblast expressing p75NTR2019

    • Author(s)
      Kazuhiro Sawada, Kazunobu Yosikawa, Tomoko Asai, Kenji Sato
    • Organizer
      The 7th International Conference of Food Factors (ICoFF2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Generation of Pro-Hyp and p75NTR- positive cell in cultured skin2019

    • Author(s)
      Xin Wei, Shiro Jimi, Kazunobu Yosikawa, Tomoko Asai, Kenji Sato
    • Organizer
      The 7th International Conference of Food Factors (ICoFF2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2023-01-30  

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