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Microscopic structure and macroscopic flow properties of soft-particle dispersion observed under microfluidic platforms

Research Project

Project/Area Number 19K14675
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
Research InstitutionChiba University

Principal Investigator

Ito Hiroaki  千葉大学, 大学院理学研究院, 助教 (10783186)

Project Period (FY) 2019-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsマイクロ流路 / 油中水滴 / 流体相互作用 / マイクロ流体 / パターン形成 / 非平衡
Outline of Research at the Start

柔らかい粒子の懸濁液(たくさんの粒子が分散した溶液)がどのように流れるのかを知ることは、医療や産業の進展につながる基礎科学の目標の一つです。例えば、マヨネーズや接着剤、血液などは柔らかい粒子の懸濁液の例であり、そのサラサラ・ドロドロ(粘性)が決まるメカニズムをより深く理解することで、より"よい"性質の懸濁液を得られるでしょう。この研究では、マイクロスケールの流れの実験を通してその詳しいメカニズムを探ります。

Outline of Final Research Achievements

In this study, we tried to understand the spatio-temporal flow structure of surfactant-stabilized aqueous microdroplets dispersed in an organic phase by experimental methods with microfluidic techniques. Through the analyses of the spatio-temporal flow structure observed by light microscopy, density-dependent qualitative transition of the collective flow behavior was confirmed. Using the mechanism with this microfluidic droplet generator, we also tried to control the anisotropic gelation of the microdroplet when the polymer aqueous solution is fused with ions in another aqueous solution. We found that the microdroplets with an anisotropic shape are generated depending on the droplet size through the gelation at the front of the flowing microdroplet under the flow in a microchannel.

Academic Significance and Societal Importance of the Research Achievements

ミクロな粒子の懸濁液の流動現象は自然界から産業界にわたる様々な局面に現れる。本研究では、マイクロ流体デバイスを活用した実験により、粒子形状の効果や個々の粒子スケールのミクロなふるまいと懸濁液スケールのマクロなふるまいの関係を探り、その特徴の一端を明らかにした。これらの結果は、混相流の特異なふるまいの理解や制御を行う際の指針となる可能性が期待される。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (21 results)

All 2021 2020 2019 Other

All Journal Article (11 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (7 results) (of which Int'l Joint Research: 1 results) Remarks (3 results)

  • [Journal Article] Bifurcation analysis of a density oscillator using two-dimensional hydrodynamic simulation2020

    • Author(s)
      Nana Takeda, Naoko Kurata, Hiroaki Ito, Hiroyuki Kitahata
    • Journal Title

      Physical Review E

      Volume: 101 Issue: 4 Pages: 042216-042216

    • DOI

      10.1103/physreve.101.042216

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemically Artificial Rovers Based on Self-Propelled Droplets in Micrometer-scale Environment2020

    • Author(s)
      Toyota Taro、Sugiyama Hironori、Hiroi Soichiro、Ito Hiroaki、Kitahata Hiroyuki
    • Journal Title

      Current Opinion in Colloid & Interface Science

      Volume: accepted Pages: 60-68

    • DOI

      10.1016/j.cocis.2020.04.003

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 深層学習を利用した赤血球細胞集団の流れ解析2020

    • Author(s)
      伊藤弘明
    • Journal Title

      Colloid & Interface Communication

      Volume: 45 Pages: 5-6

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Local bifurcation structure of a bouncing ball system with a piecewise polynomial function for table displacement2020

    • Author(s)
      Yudai Okishio, Hiroaki Ito, Hiroyuki Kitahata
    • Journal Title

      Chaos

      Volume: 30 Issue: 8 Pages: 083128-083128

    • DOI

      10.1063/5.0013908

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous deformation and fission of oil droplets on an aqueous surfactant solution2020

    • Author(s)
      Masahide Okada, Yutaka Sumino, Hiroaki Ito, Hiroyuki Kitahata
    • Journal Title

      Physical Review E

      Volume: 102 Issue: 4 Pages: 042603-042603

    • DOI

      10.1103/physreve.102.042603

    • NAID

      130008153211

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rotational manipulation of a microscopic object inside a microfluidic channel2020

    • Author(s)
      Harada Hiroyuki、Kaneko Makoto、Ito Hiroaki
    • Journal Title

      Biomicrofluidics

      Volume: 14 Issue: 5 Pages: 1-16

    • DOI

      10.1063/5.0013309

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Experimental study on the bifurcation of a density oscillator depending on density difference2020

    • Author(s)
      Hiroaki Ito, Taisuke Itasaka, Nana Takeda, Hiroyuki Kitahata
    • Journal Title

      EPL (Europhysics Letters)

      Volume: 129 Issue: 1 Pages: 18001-18001

    • DOI

      10.1209/0295-5075/129/18001

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fabrication of implantable human arterial graft by periodic hydrostatic pressure2020

    • Author(s)
      Junichi Saito, Utako Yokoyama, Toshio Takayama, Hiroaki Ito, Tomomi Tadokoro, Yoshinobu Sugo, Kentaro Kurasawa, Miyuki Ogawa, Etsuko Miyagi, Hideki Taniguchi, Makoto Kaneko, Yoshihiro Ishikawa
    • Journal Title

      Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

      Volume: - Pages: 289-291

    • DOI

      10.1007/978-981-15-1185-1_46

    • ISBN
      9789811511844, 9789811511851
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bifurcation analysis of a density oscillator using two-dimensional hydrodynamic simulation2020

    • Author(s)
      Nana Takeda, Naoko Kurata, Hiroaki Ito, Hiroyuki Kitahata
    • Journal Title

      arXiv

      Volume: -

    • Related Report
      2019 Research-status Report
    • Open Access
  • [Journal Article] Spontaneous deformation and fission of oil droplets on an aqueous surfactant solution2020

    • Author(s)
      Masahide Okada, Yutaka Sumino, Hiroaki Ito, Hiroyuki Kitahata
    • Journal Title

      arXiv

      Volume: -

    • NAID

      130008153211

    • Related Report
      2019 Research-status Report
    • Open Access
  • [Journal Article] On-chip cell manipulation and applications to deformability measurements2020

    • Author(s)
      Ito Hiroaki, Kaneko Makoto
    • Journal Title

      ROBOMECH Journal

      Volume: 7 Issue: 1 Pages: 1-11

    • DOI

      10.1186/s40648-020-0154-x

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 直流電場に駆動される荷電脂質ベシクルの相分離ドメイン2021

    • Author(s)
      伊藤弘明, 下川直史, 樋口祐次
    • Organizer
      日本物理学会第76回年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マイクロ流路を流れる液滴表面の異方的ゲル化のダイナミクス2021

    • Author(s)
      李東奎, 伊藤弘明, 北畑裕之
    • Organizer
      日本物理学会第76回年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 密度差振動子の分岐構造:実験によるアプローチ2020

    • Author(s)
      伊藤弘明、板坂、竹田なな、北畑裕之
    • Organizer
      日本物理学会第75回年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] On-chip deformability measurement of eukaryotic cells: Comparison to anucleate cells2019

    • Author(s)
      Hiroaki Ito, Kohei Fujimoto, Makoto Kaneko
    • Organizer
      The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 赤血球の多体2次元流れにおける密度依存的な構造2019

    • Author(s)
      伊藤弘明
    • Organizer
      第13回自己組織化討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] 細胞密度に依存する多体二次元流れ2019

    • Author(s)
      伊藤弘明、赤井孝行、金子真、北畑裕之
    • Organizer
      日本物理学会2019年秋季大会
    • Related Report
      2019 Research-status Report
  • [Presentation] マイクロ流路で観察する二次元の細胞集団流れ2019

    • Author(s)
      伊藤弘明、赤井孝行、金子真、北畑裕之
    • Organizer
      非線形反応と協同現象研究会
    • Related Report
      2019 Research-status Report
  • [Remarks] Hiroaki Ito

    • URL

      http://nonlinear.s.chiba-u.jp/~ito/

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
  • [Remarks] ResearchGate

    • URL

      https://www.researchgate.net/profile/Hiroaki-Ito-6

    • Related Report
      2020 Annual Research Report
  • [Remarks] ResearchGate

    • URL

      https://www.researchgate.net/profile/Hiroaki_Ito3

    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2022-01-27  

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