Quantitative evaluation of biological effects of plasma-derived electric fields and elucidation of their mechanisms
| Project/Area Number |
19K14700
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 14030:Applied plasma science-related
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| Research Institution | Kyushu University |
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Principal Investigator |
Okumura Takamasa 九州大学, システム情報科学研究院, 助教 (60801149)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | プラズマ / 動物細胞 / 植物細胞 / 生体応答 / 化学種 / バイオ応用 / 活性種 / 電界 / タンパク質 / 生体 / 細胞 / バイオ医療応用 |
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| Outline of Research at the Start |
本研究は、放電プラズマを用いた細胞応答誘導技術のうち、電気刺激の一種である電界がもつ生物学的効果を調べ、その機構を解明するものです。これにより新技術であるプラズマ医療応用の実用化がさらに進み、SDGsや生涯現役社会実現に向けた次世代がん治療、移植用臓器や輸血用血液の寿命延長など、革新的医療技術の社会実装を後押しできると考えています。本研究ではその他に、化学種と呼ばれる短寿命の高エネルギー物質の生成とその輸送に関わる物理特性が把握できることから、水処理などの地球環境保全に寄与する異なる研究領域への学術貢献も期待されます。
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| Outline of Final Research Achievements |
The purpose of this study is to quantitatively evaluate and elucidate the mechanism of biological response induction technology using plasma. So far, in-situ measurements of conformational changes have shown reversible changes in the secondary and tertiary structure of proteins due to electric fields. Plasma also irreversibly fragmentate the primary structure. The optimal conditions for response induction were identified through phenotypic analysis and omics analysis of the biological response to plasma irradiation. Furthermore, a method for directly measuring a very small amount of plasma-induced active species, which has not been reported in the world, directly from the plasma-irradiated living body was created. This research is expected as a food production increase method that supports the realization of SDGs, requiring no additional agricultural land, water, nor fertilizer, and to contribute to different academic fields such as molecular biology transmitted by plasma science.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、プラズマ照射によって生体応答を誘導し、その機序解明を目的とした取り組みで、実施期間に多くの研究成果が世界へ発信された。本研究は、プラズマバイオ応用分野の理解の深化、また異分野への貢献といった学術的意義に加え、社会に対しては持続可能社会の構築に欠かせない革新的再生医療、創薬技術、食糧増産技術として還元可能であることから、社会的意義も大きい。
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Report
(4 results)
Research Products
(49 results)
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[Presentation] レタス種子表面状態に対する種子内水分およびプラズマ照射の影響2021
Author(s)
阿南輝樹, 田中颯, 山下大輔, 奥村賢直, Pankaj Attri, 鎌滝晋礼, 板垣奈穂, 古閑一憲, 白谷正治, 石橋勇志, 藤本祉史, 熊内雅人, 松井英享
Organizer
令和３年度日本表面真空学会九州支部学術講演会
Related Report
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[Presentation] Molecular analysis of plasma-induced germination improvement of rice seeds with high-temperature stress damage2021
Author(s)
K. Koga,Y. Ishibashi, C. Suriyasak, T. Okumura, H. Tanaka, P. Attri, K. Matsuo,D. Yamashita, N. Itagaki, K. Kamataki, M. Shiratani
Organizer
AVS 67th International Symposium & Exhibition
Related Report
Invited
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[Presentation] Effect of intraseed moisture and plasma irradiation on lettuce seed surface2021
Author(s)
T. Okumura, T. Anan, H. Tanaka, D. Yamashita, P. Attri, K. Kamataki, N. Itagaki, K. Koga, M. Shiratani, Y. Ishibashi, Y. Fujimoto, M. Kumauchi, H. Matsui
Organizer
Materials Research Meeting 2021 (MRM2021）
Related Report
Invited
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[Presentation] Growth of Rice Cultivated in Field from Plasma-irradiated Seeds and Its Health Assessment for rats2020
Author(s)
T. Okumura, H. Tanaka, R. Arita, D. Yamashita, K. Matsuo, P. Attri, K. Kamataki, N. Itagaki, K. Koga, M. Shiratani, A. Tanaka
Organizer
2020 The Materials Research Society of Japan
Related Report
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[Presentation] 高温障害を持つイネ種子の発芽特性へ及ぼす 誘電体バリア放電プラズマ照射の影響2020
Author(s)
奥村賢直，石橋勇志, Chetphilin Suriyasak, 田中颯, 佐藤僚哉, 有田涼，廣松真弥, 古閑一憲, Pankaj Attri, 松尾かよ, 山下大輔, 板垣奈穂, 鎌滝晋礼, 白谷正治
Organizer
第81回応用物理学会秋季学術講演会
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