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Development of organellar selective biopharmaceutical delivery platforms comprising of reactive oxygen species triggered degradable polypeptides

Research Project

Project/Area Number 19K15401
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 28030:Nanomaterials-related
Research InstitutionHiroshima University

Principal Investigator

Kawasaki Riku  広島大学, 先進理工系科学研究科(工), 助教 (40836194)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsポリペプチド / 自己組織化 / ナノ材料 / 刺激応答性ナノ材料 / タンパク質医薬品 / ゲノム編集 / オルガネラ / バイオ医薬品 / ドラッグデリバリー / ペプチド / 刺激応答性ナノ粒子 / 活性酸素種 / 分子集合体 / ナノマテリアル / 刺激応答性
Outline of Research at the Start

植物細胞を構成するミトコンドリアや葉緑体は物質生産やエネルギー生産などの役割を担っている。またミトコンドリアや葉緑体は独自の遺伝子を有しているため、核酸や機能性タンパク質の送達によるオルガネラの機能制御や機能改変が試みられてきた。しかしながら、これら2つのオルガネラへと選択的かつ効率的な核酸やタンパク質の送達は困難である。本研究では、これら2つのオルガネラ移行性ペプチドと会合性ペプチドからなる融合ペプチドが構築するナノ会合体への活性酸素種(ROS)応答性の付与による植物細胞のミトコンドリアや葉緑体への選択的かつ効率的な送達技術の開発を目的としている。

Outline of Final Research Achievements

To develop organellar selective biopharmaceutics delivery platforms, the applicant designed and synthesized several types of nanomaterials using polypeptides including nanoaggregate and polyion complex vesicle (PICsome). First, we developed reative oxygen species (ROS) triggered degradable nanoaggregate using oligoproline containing peptides. Here, ROS are generated by chloroplast via photosynthesis and mitochondria via oxidative phosphorylation in plants. Our system comprising of oligoproline containing peptides exhibited sensitivity against physiologically relevant level of ROS, which is generated by photosynthesis, suggesting current system is applicable as chloroplast selective release of cargo molecules. We next addressed genome editing based on RNP using cell penetrating peptides modified PICsome. Delivered RNP could induce genome editing against host genome in plant cells by enhancing the efficiencies of cytosolic delivery of RNP.

Academic Significance and Societal Importance of the Research Achievements

本研究により開発したオリゴプロリンペプチドからなるナノ粒子や膜透過性ペプチドを提示したポリイオンコンプレックスベシクルはその内部に低分子から核酸、タンパク質を安定に内包できる送達基盤材料としての高いポテンシャルを示した。特にオリゴプロリンペプチドからなるナノ粒子は葉緑体の光合成に応答して内包薬剤を選択的に放出できる。また膜透過性ペプチドを提示したポリイオンコンプレックスベシクルはその内部にCRISPR/Cas9 gRNA複合体を封入し、植物カルスへと導入することでゲノム編集を実現した。これらの方法は植物体の種類を選ばないオルガネラ改変技術やゲノム編集技術として学術的・社会的意義が高い。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (54 results)

All 2022 2021 2020 2019

All Journal Article (19 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 19 results,  Open Access: 7 results) Presentation (32 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Water solubilization of paclitaxel using polypeptides for cancer therapy2022

    • Author(s)
      Kawasaki Riku、Kawamura Shogo、Hino Shodai、Yamana Keita、Ikeda Atsushi
    • Journal Title

      Materials Advances

      Volume: 3 Issue: 1 Pages: 467-473

    • DOI

      10.1039/d1ma00800e

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetically Navigated Protein Transduction In Vivo using Iron Oxide‐Nanogel Chaperone Hybrid2021

    • Author(s)
      Kawasaki Riku、Sasaki Yoshihiro、Nishimura Tomoki、Katagiri Kiyofumi、Morita Kei‐ichi、Sekine Yurina、Sawada Shin‐ichi、Mukai Sada‐atsu、Akiyoshi Kazunari
    • Journal Title

      Advanced Healthcare Materials

      Volume: 1 Issue: 9 Pages: 2001988-2001988

    • DOI

      10.1002/adhm.202001988

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor-targeting hyaluronic acid/fluorescent carborane complex for boron neutron capture therapy2021

    • Author(s)
      Yamana Keita、Kawasaki Riku、Sanada Yu、Tabata Anri、Bando Kaori、Yoshikawa Kouhei、Azuma Hideki、Sakurai Yoshinori、Masunaga Shin-ichiro、Suzuki Minoru、Sugikawa Kouta、Nagasaki Takeshi、Ikeda Atsushi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 559 Pages: 210-216

    • DOI

      10.1016/j.bbrc.2021.04.037

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanoscale Polyion Complex Vesicles for Delivery of Cargo Proteins and Cas9 Ribonucleoprotein Complexes to Plant Cells2021

    • Author(s)
      Odahara Masaki、Watanabe Kenta、Kawasaki Riku、Tsuchiya Kousuke、Tateishi Ayaka、Motoda Yoko、Kigawa Takanori、Kodama Yutaka、Numata Keiji
    • Journal Title

      ACS Applied Nano Materials

      Volume: 4 Issue: 6 Pages: 5630-5635

    • DOI

      10.1021/acsanm.1c00695

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Photodynamic therapy using self-assembled nanogels comprising chlorin e6-bearing pullulan2021

    • Author(s)
      Kawasaki Riku、Ohdake Reo、Yamana Keita、Eto Takuro、Sugikawa Kouta、Ikeda Atsushi
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 9 Issue: 32 Pages: 6357-6363

    • DOI

      10.1039/d1tb00377a

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Aqueous Solutions with Information on Solids (ASIS) of a Mechanochromic Luminescent Tetraphenylethylene Derivative by Complexation with Polysaccharides2021

    • Author(s)
      Omokawa Riku、Kawasaki Riku、Sugikawa Kouta、Nishimura Tomoki、Nakaya Toshimi、Ikeda Atsushi
    • Journal Title

      ACS Applied Polymer Materials

      Volume: 3 Issue: 8 Pages: 3708-3713

    • DOI

      10.1021/acsapm.1c00646

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple Formation of Cancer Drug-Containing Self-Assembled Hydrogels with Temperature and pH-Responsive Release2021

    • Author(s)
      Lee Ji Ha、Tachibana Tomoyuki、Yamana Keita、Kawasaki Riku、Yabuki Akihiro
    • Journal Title

      Langmuir

      Volume: 37 Issue: 38 Pages: 11269-11275

    • DOI

      10.1021/acs.langmuir.1c01700

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photo-triggered cargo release from liposome chlorin e6-bearing pullulan hybrid nanoparticles via membrane permeabilization2021

    • Author(s)
      Kawasaki Riku、Ohdake Reo、Eto Takuro、Yamana Keita、Nakaya Toshimi、Ishida Takenori、Kuroda Akio、Ikeda Atsushi
    • Journal Title

      RSC Advances

      Volume: 11 Issue: 58 Pages: 36564-36568

    • DOI

      10.1039/d1ra07807k

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fullerene porphyrin hybrid nanoparticles that generate activated oxygen by photoirradiation2021

    • Author(s)
      Sugikawa Kouta、Masuda Kosuke、Kozawa Kentaro、Kawasaki Riku、Ikeda Atsushi
    • Journal Title

      RSC Advances

      Volume: 11 Issue: 3 Pages: 1564-1568

    • DOI

      10.1039/d0ra09387d

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy2021

    • Author(s)
      Kawasaki Riku、Yamana Keita、Shimada Risako、Sugikawa Kouta、Ikeda Atsushi
    • Journal Title

      ACS Omega

      Volume: 6 Issue: 4 Pages: 3209-3217

    • DOI

      10.1021/acsomega.0c05647

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aggregation-Induced Emission and Chiral Memory of Tetraphenylethylene Incorporated by Polysaccharides in Water2020

    • Author(s)
      Hino Shodai、Sugikawa Kouta、Kawasaki Riku、Funabashi Hisakage, Kuroda Akio、Ikeda Atsushi
    • Journal Title

      ChemPhotoChem

      Volume: 4 Issue: 8 Pages: 577-581

    • DOI

      10.1002/cptc.202000022

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydrogen Sulfide-Responsive Self-Assembled Nanogel2020

    • Author(s)
      Hsu Peng-Hao、Kawasaki Riku、Yamana Keita、Isozaki Hinata、Kawamura Shogo、Ikeda Atsushi、Almutairi Adah
    • Journal Title

      ACS Applied Polymer Materials

      Volume: 2 Issue: 9 Pages: 3756-3760

    • DOI

      10.1021/acsapm.0c00759

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Water Solubilization of Phthalocyanine Derivatives via Interactions of Long Alkyl Chains and Cyclodextrins: Potential Complexes for Photodynamic Therapy2020

    • Author(s)
      Goto Yuya、Hino Shodai、Sugikawa Kouta、Kawasaki Riku、Ikeda Atsushi
    • Journal Title

      Asian Journal of Organic Chemistry

      Volume: 9 Issue: 10 Pages: 1589-1596

    • DOI

      10.1002/ajoc.202000076

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of Reactive Oxygen Species-Triggered Degradable Nanoparticles Using Oligoproline-Containing Peptides2020

    • Author(s)
      Kawasaki Riku、Tsuchiya Kousuke、Kodama Yutaka、Numata Keiji
    • Journal Title

      Biomacromolecules

      Volume: 21 Issue: 10 Pages: 4116-4122

    • DOI

      10.1021/acs.biomac.0c00915

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bacterial elimination via the photodynamic activity of a fullerene/light-harvesting antenna molecule assembled system integrated into liposome membranes2020

    • Author(s)
      Kawasaki Riku、Antoku Daiki、Ohdake Reo、Sugikawa Kouta、Ikeda Atsushi
    • Journal Title

      Nanoscale Advances

      Volume: 2 Issue: 10 Pages: 4395-4399

    • DOI

      10.1039/d0na00132e

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanism toward Turn‐on of Polysaccharide‐Porphyrin Complexes for Fluorescence Probes and Photosensitizers in Photodynamic Therapy in Living Cells2020

    • Author(s)
      Hino Shodai、Funada Rikushi、Sugikawa Kouta、Kawasaki Riku、Koumoto Kazuya、Suzuki Toshio、Nagasaki Takeshi、Ikeda Atsushi
    • Journal Title

      ChemMedChem

      Volume: 16 Issue: 5 Pages: 793-803

    • DOI

      10.1002/cmdc.202000656

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nanogel hybrid assembly for exosome intracellular delivery: effects on endocytosis and fusion by exosome surface polymer engineering2020

    • Author(s)
      Sawada Shin-ichi、Sato Yuko T.、Kawasaki Riku、Yasuoka Jun-ichi、Mizuta Ryosuke、Sasaki Yoshihiro、Akiyoshi Kazunari
    • Journal Title

      Biomaterials Science

      Volume: 8 Issue: 2 Pages: 619-630

    • DOI

      10.1039/c9bm01232j

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in β-(1,3-1,6)-D-Glucan with On-Off Switch2020

    • Author(s)
      S. Hino, S. Satake, H. Shinmori, S. Kawabata, K. Koumoto, T. Suzuki, T. Nagasaki, K. Sugikawa, R. Kawasaki, A. Ikeda
    • Journal Title

      Chemistry - An Asian Journal

      Volume: 15 Issue: 3 Pages: 365-370

    • DOI

      10.1002/asia.201901582

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Magnetically Navigated Intracellular Delivery of Extracellular Vesicles Using Amphiphilic Nanogels2019

    • Author(s)
      Mizuta Ryosuke、Sasaki Yoshihiro、Kawasaki Riku、Katagiri Kiyofumi、Sawada Shin-ichi、Mukai Sada-atsu、Akiyoshi Kazunari
    • Journal Title

      Bioconjugate Chemistry

      Volume: 30 Issue: 8 Pages: 2150-2155

    • DOI

      10.1021/acs.bioconjchem.9b00369

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Fullerene nanocrystal-gold nanoparticle hybrid for theranostic agent based on photothermal therapy and photoacoustic imaging2022

    • Author(s)
      Riku Kawasaki, Kosuke Kondo, Risako Miura, Keita Yamana, Hinata Isozaki, Shogo Kawamura, Tomoki Nisihimura, Naoki Tarutani, Kiyofumi Katagiri, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi, Atsushi Ikeda
    • Organizer
      Kyoto University/ERATO International Symposium Chemistry and Plant Biology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The complex of pyrene-substituted carborane with hyaluronic acid for tumor-targeted boron neutron capture therapy2022

    • Author(s)
      Keita Yamana, Riku Kawasaki, Yu Sanada, Anri Tabata, Kaori Bando, Kouhei Yoshikawa, Hideki Azuma, Yoshinori Sakurai, Shin-ichiro Masunaga, Minoru Suzuki, Takeshi Nagasaki, Atsushi Ikeda
    • Organizer
      Kyoto University/ERATO International Symposium Chemistry and Plant Biology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Water solubilization of hydrophobic anti-cancer agent, paclitaxel, using polypeptides2022

    • Author(s)
      Shogo Kawamura, Riku Kawasaki, Shodai Hino, Keita Yamana, Atsushi Ikeda
    • Organizer
      Kyoto University/ERATO International Symposium Chemistry and Plant Biology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 多糖ーポルフィリン誘導体ナノ複合体による光線力学療法2021

    • Author(s)
      山名啓太・河﨑陸・杉川幸太・池田篤志
    • Organizer
      バイオ関連化学シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] ヒアルロン酸ー蛍光性カルボラン複合体によるBNCT2021

    • Author(s)
      河﨑陸・山名啓太・真田悠生・増永慎一郎・櫻井良憲・鈴木実・坂東香里・田畑杏里・吉川浩平・東秀紀・長崎健・杉川幸太・池田篤志
    • Organizer
      バイオ関連化学シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 光増感剤修飾多糖ナノ粒子の創製と光線力学療法への応用2021

    • Author(s)
      大嶽怜央・河﨑陸・杉川幸太・池田篤志
    • Organizer
      第14回有機π電子系シンポジウム
    • Related Report
      2020 Research-status Report
  • [Presentation] 蛍光性カルボランを用いたホウ素のバイオイメージングと中性子捕捉療法への応用2021

    • Author(s)
      山名啓太・河﨑陸・杉川幸太・池田篤志
    • Organizer
      第14回有機π電子系シンポジウム
    • Related Report
      2020 Research-status Report
  • [Presentation] シクロデキストリンとの複合化によるポルフィリンの安定性と光線力学活性の向上2021

    • Author(s)
      湯本剛大・佐竹秀平・日野彰大・杉川幸太・河﨑陸・池田篤志
    • Organizer
      第14回有機π電子系シンポジウム
    • Related Report
      2020 Research-status Report
  • [Presentation] ポルフィリン誘導体が形成する超分子ナノファイバーによるリポソームの形状制御2021

    • Author(s)
      大野雅貴・杉川幸太・河﨑陸・池田篤志
    • Organizer
      第14回有機π電子系シンポジウム
    • Related Report
      2020 Research-status Report
  • [Presentation] 超分子ナノファイバーによるリポソームゲルの機能制御2020

    • Author(s)
      杉川幸太・山田大夢・河﨑陸・池田篤志
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2020 Research-status Report
  • [Presentation] フラーレン―光アンテナ分子二元系の設計とそのバイオ機能2020

    • Author(s)
      河﨑陸・安德大輝・杉川幸太・池田篤志
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2020 Research-status Report
  • [Presentation] ホウ素中性子捕捉療法を指向したATP応答性疎水化多糖ナノ粒子の開発2020

    • Author(s)
      河﨑陸・山名啓太・杉川幸太・池田篤志
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2020 Research-status Report
  • [Presentation] ATP応答性多糖ナノ粒子の開発とホウ素中性子捕捉療法への応用2020

    • Author(s)
      山名啓太・河﨑陸・杉川幸太・池田篤志
    • Organizer
      第69回高分子学討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] リポソームに内包した光捕集分子-C60 誘導体二元系を用いる光線力学治療法への応用2020

    • Author(s)
      池田篤志・安德大輝・杉川幸太・河﨑陸
    • Organizer
      第59回フラーレン・ナノチューブ・グラフェン総合シンポジウムオンライン
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 種々の有機色素を含有したフラーレンナノ粒子の合成2020

    • Author(s)
      増田幸将・杉川幸太・河﨑陸・池田篤志
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2020 Research-status Report
  • [Presentation] 多糖によって水溶化した不斉結晶の水溶液中におけるキラル情報の維持2020

    • Author(s)
      日野彰大・杉川幸太・河﨑陸・舟橋久景・黒田章夫・池田篤志
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2020 Research-status Report
  • [Presentation] 光線力学療法を志向した光増感剤修飾多糖ナノ粒子の開発2020

    • Author(s)
      大嶽怜央・河﨑陸・杉川幸太・池田篤志
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2020 Research-status Report
  • [Presentation] ポルフィリン誘導体の多糖を用いた水曜かと光線力学活性への応用2020

    • Author(s)
      山名啓太・河﨑陸・杉川幸太・池田篤志
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2020 Research-status Report
  • [Presentation] 超分子ナノファイバーを用いたリポソーム ゲルの物性制御2020

    • Author(s)
      山田大夢・杉川幸太・河﨑陸・池田篤志
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2020 Research-status Report
  • [Presentation] ポルフィリン誘導体を用いた脂質ベシクルの形状制御2020

    • Author(s)
      大野雅貴・杉川幸太・河﨑陸・池田篤志
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2020 Research-status Report
  • [Presentation] シクロデキストリンとの錯体化によるポルフィリンの安定性と光線力学活性の向上2020

    • Author(s)
      湯本剛大・佐竹秀平・日野彰大・杉川幸太・河﨑陸・池田篤志
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2020 Research-status Report
  • [Presentation] 低侵襲ながん治療法の確立を志向したインテリジェントナノ材料の創製と機能2020

    • Author(s)
      河﨑陸
    • Organizer
      大阪市立大学大学院工学研究科 医工・生命工学教育研究センター 第10回セミナー
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Development of tumor microenvironment responsive polysaccharide nanoparticles for boron neutron capture therapy2020

    • Author(s)
      Riku Kawasaki, Keita Yamana, Kouta Sugikawa, Atsushi Ikeda
    • Organizer
      Chemistry and Plant Biology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ゲスト交換反応を利用したハイドロゲルへのフラーレンの導入2020

    • Author(s)
      杉川 幸太・井上 裕也・河﨑 陸・池田 篤志
    • Organizer
      日本化学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Turn-on型光線力学治療薬および診断薬の機能を有するポルフィリン誘導体-多糖複合体の調製2020

    • Author(s)
      日野 彰大・杉川 幸太・河﨑 陸・甲元 一也・鈴木 利雄・長崎 健・池田 篤志
    • Organizer
      日本化学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 糖からなる可溶化剤を用いたクロリン誘導体の水溶化と光線力学活性の評価2020

    • Author(s)
      山名 啓太・杉川 幸太・河﨑 陸・池田 篤志
    • Organizer
      日本化学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 活性部位-光捕集部位二元系を用いることによる光線力学活性の向上2020

    • Author(s)
      安徳 大輝・河崎 陸・杉川 幸太・池田 篤志
    • Organizer
      日本化学会
    • Related Report
      2019 Research-status Report
  • [Presentation] ポルフィリン誘導体を用いたリポソームの形状制御2020

    • Author(s)
      大野 雅貴・杉川 幸太・河崎 陸・池田 篤志
    • Organizer
      日本化学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Design of reactive oxygen species responsive peptide and evaluation of their capability of nanoparticle formulation2019

    • Author(s)
      Riku Kawasaki, Kousuke Tsuchiya, Keiji Numata
    • Organizer
      高分子学会年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Development of ROS-triggered degradable nanoparticles using oligoproline peptides as biomolecule delivery platform for plant cells2019

    • Author(s)
      Riku Kawasaki, Kousuke Tsuchiya, Keiji Numata
    • Organizer
      ACS National Meeting Fall
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 植物の微小環境に応答するペプチドナノ粒子の設計とその機能評価2019

    • Author(s)
      河﨑 陸、土屋 康祐、沼田 圭司
    • Organizer
      バイオ機能関連化学シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 活性酸素種応答性ペプチドナノ粒子の設計とバイオ機能2019

    • Author(s)
      河﨑 陸、土屋 康祐、沼田 圭司
    • Organizer
      バイオ高分子研究会
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 難水溶性物質の可溶化方法および難水溶性物質の可溶化組成物2021

    • Inventor(s)
      池田篤志・河﨑陸・日野彰大
    • Industrial Property Rights Holder
      池田篤志・河﨑陸・日野彰大
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-067318
    • Filing Date
      2021
    • Related Report
      2020 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞膜透過性ベシクル2020

    • Inventor(s)
      沼田圭司・土屋康佑・藤田聖矢・河﨑陸・渡邊健太
    • Industrial Property Rights Holder
      沼田圭司・土屋康佑・藤田聖矢・河﨑陸・渡邊健太
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Acquisition Date
      2020
    • Related Report
      2020 Research-status Report
  • [Patent(Industrial Property Rights)] 粒子を形成することが可能なペプチドを含む組成物2019

    • Inventor(s)
      沼田圭司、土屋康祐、河﨑陸
    • Industrial Property Rights Holder
      沼田圭司、土屋康祐、河﨑陸
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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