| Project/Area Number |
19K15449
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 29020:Thin film/surface and interfacial physical properties-related
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
BALOIS MARIA VANESSA 国立研究開発法人理化学研究所, 光量子工学研究センター, 基礎科学特別研究員 (00775083)
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Raman spectroscopy / surface science / nanospectroscopy / optics / nanophotonics |
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| Outline of Research at the Start |
In situ observation of molecular interactions in a dynamic liquid environment will be realised using a nanospectroscopy system with subnanometer spatial resolution by combining a scanning probe microscope and open microfluidic device. The behavior of lipid bilayer nanodomains in varying environment conditions (e.g. temperature, pH) will be analysed by simultaneous acquisition of topographical and chemical information via Raman spectroscopy.
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| Outline of Final Research Achievements |
In this work, we were able to construct a nanospectroscopy system that can operate at 632.8 nm and 785 nm wavelengths and is housed in an environment control system to accommodate environment sensitive samples. The system was designed through the use of numerical simulations (FDTD and Mathematica) to obtain the optimal experimental parameters of the optics and probe (numerical aperture, laser illumination angle, tip tilt). A three-electrode electrochemical etching system was made to fabricate Au tips and a methodology was established to make these Au tips.
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| Academic Significance and Societal Importance of the Research Achievements |
It is important to develop nanospectroscopy systems that have both high spatial resolution and chemical sensitivity in order to study phenomena occurring at the nanometer scale. The development of a nanospectroscopy system in this project would help study both biological and non-biological samples.
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