Development of Alternating Current Resistive Pulse Sensing Using Transport-Induced-Charge Theory
| Project/Area Number |
19K15600
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 34020:Analytical chemistry-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HSU Wei-Lun 東京大学, 大学院工学系研究科(工学部), 講師 (50771549)
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Nanopore sensing / Nanofluidics / Electrokinetics / Electroosmosis / Joule heating / Alternating current / Electrokinetic pumping / Nanopore / Resistive pulse sensing / Biosensing |
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| Outline of Research at the Start |
An alternating current nanofluidic pump will be developed for bionanosensing applications based on a new class of electrokinetic phenomenon that we theoretically proposed in prior research. The flow rate over an ultrathin membrane will be measured to evaluate the nanofluidic pumping efficiency.
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| Outline of Final Research Achievements |
Nanopore sensing has drawn attention in various fields, owing to its short processing time, ease of implementation, and ability to operate with limited sample volumes, paving the way toward high-precision medical diagnosis for various diseases. Albeit both direct current and alternating current systems have been used for electroosmotic pumping, direct current electroosmotic pumping suffers from notorious issues of bubble formation, electrode degradation, hydrodynamic instability, etc. originating from the redox reactions at electrodes. Thus, we develop alternative current electrokinetic pumping using transport-induced-charge (TIC) phenomena and investigate thermal effects in nanopore systems. Our results show that the rise of local temperature inside the nanopore significantly enhances TIC effects and thus has a significant influence on electroosmotic behavior. The results improve our knowledge of nonclassical electrokinetic phenomena for flow control in nanopore systems.
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| Academic Significance and Societal Importance of the Research Achievements |
The Covid-19 pandemic has urgently increased the demand for high accuracy and throughout medical diagnostic methods. Our results have demonstrated that it is promising to control the flow within nanopore systems by thermal management for alternating current pumping and resistive pulse sensing.
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Report
(3 results)
Research Products
(23 results)
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[Presentation] Two-Dimensional Nanopore DNA Sequencing by Diffusion Current Measurements2019
Author(s)
Wei-Lun Hsu, Yuji Nakagawa, Daisuke Egusa, Soumyadeep Paul, Ya-Lun Ho, Jean-Jacques Delaunay, Zhen Gu, Yi-Lun Ying, Yi-Tao Long, Eiji Abe, Yoshihiro Iwasa and Hirofumi Daiguji
Organizer
2019 Materials Research Society (MRS) Fall Meeting
Related Report
Int'l Joint Research
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[Presentation] Isothermal DNA Sensing Using Diffusion Current2019
Author(s)
Wei-Lun Hsu, Soumyadeep Paul, Zhen Gu, Ya-Lun Ho, Jean-Jacques Delaunay, Yi-Lun Ying, Yi-Tao Long and Hirofumi Daiguji
Organizer
The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)
Related Report
Int'l Joint Research
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