• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Chiral sensing using helical polymer based on helicity memory

Research Project

Project/Area Number 19K15621
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 35010:Polymer chemistry-related
Research InstitutionKanazawa University

Principal Investigator

Hirose Daisuke  金沢大学, 物質化学系, 助教 (60806686)

Project Period (FY) 2019-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsポリアセチレン / らせん誘起 / 記憶 / 不斉増幅 / ビフェニル
Outline of Research at the Start

分子キラリティの識別は、光学異性体が異なる薬効を示す医薬・農薬分野において不可欠な分析技術である。本研究では、CD情報をラセン構造に記憶可能なラセン高分子CDプローブが示す、効率的な相互作用が期待できるが通常のCD測定が困難な超濃厚状態の誘起CDを、希釈した後に間接的に観測可能な特性を基に、高感度センシングおよび高難度キラル化合物のセンシングに関する研究を行う。

Outline of Final Research Achievements

Chiral sensing is an indispensable technology in pharmaceuticals and agrochemicals that act on living organisms, furthermore, a tool for clarifying the origin of chirality. In this study, by using a poly(phenylacetylene) derivative that exhibits helicity memory properties as a circular dichroism (CD) probe, we succeeded in observing chiral vapors that are difficult to evaluate accurately using conventional methods, and chiral compounds with tiny amounts or extremely low optical purity.

Academic Significance and Societal Importance of the Research Achievements

アミノ酸には鏡像関係にあるL体とD体が存在するにも関わらず、天然に存在するアミノ酸の殆どがL体で構成されている現象をホモキラリティーといいます。それに基づき生体は医薬品等の鏡像異性体間で異なる応答性を示すため、その正確な評価法の開発は重要です。さらに、なぜホモキラリティーを形成したかを解き明かすために鏡像対称性が破れる原因となる微小のキラリティの検出手法も等しく重要です。今回、キラル情報を記憶可能ならせん状高分子を用いて、従来正確な評価が困難であったキラル蒸気の固体状態での正確な評価や、従来法では検出困難な低光学純度サンプルの検出に成功しました。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (4 results)

All 2020 2019

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results)

  • [Journal Article] Synthesis of a poly(diphenylacetylene) bearing optically active anilide pendants and its application to a chiral stationary phase for high-performance liquid chromatography2020

    • Author(s)
      Nozaki Mai、Hirose Daisuke、Maeda Katsuhiro
    • Journal Title

      Journal of Chromatography A

      Volume: 1622 Pages: 461173-461173

    • DOI

      10.1016/j.chroma.2020.461173

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helix-Sense-Selective Synthesis of Right- and Left-Handed Helical Luminescent Poly(diphenylacetylene)s with Memory of the Macromolecular Helicity and Their Helical Structures2020

    • Author(s)
      Maeda Katsuhiro、Nozaki Mai、Hashimoto Kengo、Shimomura Kouhei、Hirose Daisuke、Nishimura Tatsuya、Watanabe Go、Yashima Eiji
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 16 Pages: 7668-7682

    • DOI

      10.1021/jacs.0c02542

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Three-State Switchable Chiral Stationary Phase Based on Helicity Control of an Optically Active Poly(phenylacetylene) Derivative by Using Metal Cations in the Solid State2019

    • Author(s)
      Hirose Daisuke、Isobe Asahi、Quinoa Emilio、Freire Felix、Maeda Katsuhiro
    • Journal Title

      Journal of the American Chemical Society

      Volume: 141 Issue: 21 Pages: 8592-8598

    • DOI

      10.1021/jacs.9b03177

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Macromolecular helicity control of poly(phenyl isocyanate)s with a single stimuli-responsive chiral switch2019

    • Author(s)
      Fukuda Mayu、Rodr?guez Rafael、Fern?ndez Zulema、Nishimura Tatsuya、Hirose Daisuke、Watanabe Go、Qui?o? Emilio、Freire F?lix、Maeda Katsuhiro
    • Journal Title

      Chemical Communications

      Volume: 55 Issue: 55 Pages: 7906-7909

    • DOI

      10.1039/c9cc03555a

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research

URL: 

Published: 2019-04-18   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi