Association of sarcopenia and respiratory function, physical activity in elderly orthopedic outpatients

• Project/Area Number: 19K16245
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 45060:Applied anthropology-related
• Research Institution: Tokyo Professional University of Health Sciences (2020-2022); Nagasaki University (2019)
• Principal Investigator: Tomita Yoshihito 東京保健医療専門職大学, リハビリテーション学部, 講師 (40779584)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: サルコペニア / 呼吸機能 / 運動器疾患 / 痛み / 整形外科疾患 / 高齢者 / フレイル / 介護予防 / 転倒 / 身体活動

Outline of Research at the Start

サルコペニアは、加齢に伴う骨格筋量減少に加え、筋力低下または運動機能低下を特徴とする病態と定義される。運動器疾患を有する者は痛みをきっかけに不活動になり、サルコペニア、身体不活動、呼吸機能低下との悪循環を呈する。これは二足歩行をするヒトにとっては致命的であり、高齢者の社会環境、住環境への適応という観点からも積極的に解決すべき課題である。そこで、痛みを主訴とする運動器疾患を有する高齢者においてサルコペニアの有病状況を調査し、従来のサルコペニアの要因に加え疼痛と呼吸機能も含めた多面的に検討することで、痛み、呼吸機能、身体活動との関連を明らかにする。

Outline of Final Research Achievements

The relationship between sarcopenia and respiratory function has not been investigated in elderly Japanese orthopedic outpatients. This study aimed to assess the relationship between sarcopenia and respiratory function in elderly orthopedic outpatients in Japan. Elderly outpatients (n = 102; aged 65 years) with orthopedic diseases were enrolled in the study. The respiratory function (e.g., percent vital capacity [VC] and percent forced expiratory volume in 1 second) was also measured.
The overall prevalence of sarcopenia was 25.5% (30.0% and 24.4% in men and women, respectively). The study demonstrated that low respiratory function, which was represented by decreased percent VC, was associated with sarcopenia in outpatients visiting an orthopedic department. Sarcopenia was significantly associated with a lower percentage of VC in orthopedic outpatients after adjustment for sex, comorbidity, and smoking. Further studies are needed to determine the causality.

Academic Significance and Societal Importance of the Research Achievements

運動器疾患を有する高齢者においてサルコペニアは、性別、合併症、喫煙歴で調整後も呼吸機能と関連していた。サルコペニアを有する高齢者においては、骨格筋量だけでなく呼吸機能が低下している可能性を考慮する必要があることが分かった。
初診時や術前において規則的に測定される呼吸機能検査は、サルコペニアを予想する指標としても有用かもしれない。
本研究成果から、介護予防の観点からフレイル・サルコペニア予防が進められている中で、健診会場等での呼吸機能検査を一般化することで一歩進んだ介護予防が展開できる社会的意義を提供するものである。

Research Products

• [Journal Article] Association between sarcopenia and respiratory function in elderly orthopedic outpatients. (2022)
  • Author(s): Tomita Y, Mizukami S, Nishimura T, Arima K, Abe Y, Kanagae M, Aoyagi K.
  • Journal Title: Medicine (Baltimore) Volume: 101(29) Issue: 29 Pages: e29365-e29365
  • DOI: 10.1097/md.0000000000029365
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between fat mass by bioelectrical impedance analysis and bone mass by quantitative ultrasound in relation to grip strength and serum 25-hydroxyvitamin D in postmenopausal Japanese women: the Unzen study (2022)
  • Author(s): Mizukami Satoshi、Arima Kazuhiko、Abe Yasuyo、Tomita Yoshihito、Nakashima Hiroki、Honda Yuzo、Uchiyama Michiko、Ookawachi Tetsuji、Goto Hisashi、Hasegawa Maiko、Sou Youko、Kanagae Mitsuo、Osaki Makoto、Aoyagi Kiyoshi
  • Journal Title: Journal of Physiological Anthropology Volume: 41 Issue: 1 Pages: 7-7
  • DOI: 10.1186/s40101-022-00281-5
  • Peer Reviewed / Open Access
• [Journal Article] Association between Mothers’ Attachment Styles and Parenting Stress among Japanese Mothers with Toddlers (2022)
  • Author(s): Kit Ayano、Arima Kazuhiko、Abe Yasuyo、Mizukami Satoshi、Tomita Yoshihito、Hasegawa Maiko、Sou Yoko、Nishimura Takayuki、Ohnishi Mayumi、Aoyagi Kiyoshi
  • Journal Title: Psychiatry International Volume: 3 Issue: 2 Pages: 122-130
  • DOI: 10.3390/psychiatryint3020010
  • Peer Reviewed / Open Access
• [Journal Article] Association between serum 25-hydroxyvitamin D and physical performance measures in middle-aged and old Japanese men and women: The Unzen study. (2021)
  • Author(s): Uchiyama M, Mizukami S, Arima K, Nishimura T, Tomita Y, Abe Y, Tanaka N, Honda Y, Goto H, Hasegawa M, Sou Y, Tsujimoto R, Kanagae M, Osaki M, Aoyagi K.
  • Journal Title: PLoS One Volume: 16(12) Issue: 12 Pages: e0261639-e0261639
  • DOI: 10.1371/journal.pone.0261639
  • Peer Reviewed / Open Access
• [Journal Article] Factors associated with the development of oral allergy syndrome: A retrospective questionnaire survey of Japanese university students (2021)
  • Author(s): Matsumoto Mai、Takenaka Motoi、Aoyagi Kiyoshi、Tomita Yoshihito、Arima Kazuhiko、Yamauchi-Takihara Keiko、Murota Hiroyuki
  • Journal Title: Allergology International Volume: 70 Issue: 4 Pages: 458-462
  • DOI: 10.1016/j.alit.2021.02.003
  • NAID: 130008103672
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Association between vitamin D and bone mineral density in Japanese adults: the Unzen study (2021)
  • Author(s): Honda Yuzo、Arima Kazuhiko、Nishimura Takayuki、Tomita Yoshihito、Mizukami Satoshi、Abe Yasuyo、Tanaka Natsumi、Kojima Michiko、Jeng Tsung-Ping、Goto Hisashi、Hasegawa Maiko、Sou Youko、Tsujimoto Ritsu、Kanagae Mitsuo、Osaki Makoto、Aoyagi Kiyoshi
  • Journal Title: Archives of Osteoporosis Volume: 16 Issue: 1 Pages: 127-127
  • DOI: 10.1007/s11657-021-00984-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 運動器疾患を有する高齢者における重度サルコペニアと社会的役割障害の関連 (2021)
  • Author(s): 富田義人、有馬和彦，西村貴孝，水上諭，金ヶ江光生，安部恵代，青柳潔
  • Organizer: 第8回日本サルコペニア・フレイル学会大会
• [Presentation] 運動器疾患を有する高齢者のサルコペニアと呼吸機能との関連 (2020)
  • Author(s): 富田義人
  • Organizer: 第81回日本生理人類学会
• [Remarks] 【研究発表】理学療法学科の富田義人講師による「サルコペニアと呼吸機能に関する研究論文」
  • URL: https://www.tpu.ac.jp/news/4665/