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Association of sarcopenia and respiratory function, physical activity in elderly orthopedic outpatients

Research Project

Project/Area Number 19K16245
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 45060:Applied anthropology-related
Research InstitutionTokyo Professional University of Health Sciences (2020-2022)
Nagasaki University (2019)

Principal Investigator

Tomita Yoshihito  東京保健医療専門職大学, リハビリテーション学部, 講師 (40779584)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsサルコペニア / 呼吸機能 / 運動器疾患 / 痛み / 整形外科疾患 / 高齢者 / フレイル / 介護予防 / 転倒 / 身体活動
Outline of Research at the Start

サルコペニアは、加齢に伴う骨格筋量減少に加え、筋力低下または運動機能低下を特徴とする病態と定義される。運動器疾患を有する者は痛みをきっかけに不活動になり、サルコペニア、身体不活動、呼吸機能低下との悪循環を呈する。これは二足歩行をするヒトにとっては致命的であり、高齢者の社会環境、住環境への適応という観点からも積極的に解決すべき課題である。そこで、痛みを主訴とする運動器疾患を有する高齢者においてサルコペニアの有病状況を調査し、従来のサルコペニアの要因に加え疼痛と呼吸機能も含めた多面的に検討することで、痛み、呼吸機能、身体活動との関連を明らかにする。

Outline of Final Research Achievements

The relationship between sarcopenia and respiratory function has not been investigated in elderly Japanese orthopedic outpatients. This study aimed to assess the relationship between sarcopenia and respiratory function in elderly orthopedic outpatients in Japan. Elderly outpatients (n = 102; aged 65 years) with orthopedic diseases were enrolled in the study. The respiratory function (e.g., percent vital capacity [VC] and percent forced expiratory volume in 1 second) was also measured.
The overall prevalence of sarcopenia was 25.5% (30.0% and 24.4% in men and women, respectively). The study demonstrated that low respiratory function, which was represented by decreased percent VC, was associated with sarcopenia in outpatients visiting an orthopedic department. Sarcopenia was significantly associated with a lower percentage of VC in orthopedic outpatients after adjustment for sex, comorbidity, and smoking. Further studies are needed to determine the causality.

Academic Significance and Societal Importance of the Research Achievements

運動器疾患を有する高齢者においてサルコペニアは、性別、合併症、喫煙歴で調整後も呼吸機能と関連していた。サルコペニアを有する高齢者においては、骨格筋量だけでなく呼吸機能が低下している可能性を考慮する必要があることが分かった。
初診時や術前において規則的に測定される呼吸機能検査は、サルコペニアを予想する指標としても有用かもしれない。
本研究成果から、介護予防の観点からフレイル・サルコペニア予防が進められている中で、健診会場等での呼吸機能検査を一般化することで一歩進んだ介護予防が展開できる社会的意義を提供するものである。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (9 results)

All 2022 2021 2020 Other

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Association between sarcopenia and respiratory function in elderly orthopedic outpatients.2022

    • Author(s)
      Tomita Y, Mizukami S, Nishimura T, Arima K, Abe Y, Kanagae M, Aoyagi K.
    • Journal Title

      Medicine (Baltimore)

      Volume: 101(29) Issue: 29 Pages: e29365-e29365

    • DOI

      10.1097/md.0000000000029365

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between fat mass by bioelectrical impedance analysis and bone mass by quantitative ultrasound in relation to grip strength and serum 25-hydroxyvitamin D in postmenopausal Japanese women: the Unzen study2022

    • Author(s)
      Mizukami Satoshi、Arima Kazuhiko、Abe Yasuyo、Tomita Yoshihito、Nakashima Hiroki、Honda Yuzo、Uchiyama Michiko、Ookawachi Tetsuji、Goto Hisashi、Hasegawa Maiko、Sou Youko、Kanagae Mitsuo、Osaki Makoto、Aoyagi Kiyoshi
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 41 Issue: 1 Pages: 7-7

    • DOI

      10.1186/s40101-022-00281-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Mothers’ Attachment Styles and Parenting Stress among Japanese Mothers with Toddlers2022

    • Author(s)
      Kit Ayano、Arima Kazuhiko、Abe Yasuyo、Mizukami Satoshi、Tomita Yoshihito、Hasegawa Maiko、Sou Yoko、Nishimura Takayuki、Ohnishi Mayumi、Aoyagi Kiyoshi
    • Journal Title

      Psychiatry International

      Volume: 3 Issue: 2 Pages: 122-130

    • DOI

      10.3390/psychiatryint3020010

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between serum 25-hydroxyvitamin D and physical performance measures in middle-aged and old Japanese men and women: The Unzen study.2021

    • Author(s)
      Uchiyama M, Mizukami S, Arima K, Nishimura T, Tomita Y, Abe Y, Tanaka N, Honda Y, Goto H, Hasegawa M, Sou Y, Tsujimoto R, Kanagae M, Osaki M, Aoyagi K.
    • Journal Title

      PLoS One

      Volume: 16(12) Issue: 12 Pages: e0261639-e0261639

    • DOI

      10.1371/journal.pone.0261639

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors associated with the development of oral allergy syndrome: A retrospective questionnaire survey of Japanese university students2021

    • Author(s)
      Matsumoto Mai、Takenaka Motoi、Aoyagi Kiyoshi、Tomita Yoshihito、Arima Kazuhiko、Yamauchi-Takihara Keiko、Murota Hiroyuki
    • Journal Title

      Allergology International

      Volume: 70 Issue: 4 Pages: 458-462

    • DOI

      10.1016/j.alit.2021.02.003

    • NAID

      130008103672

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between vitamin D and bone mineral density in Japanese adults: the Unzen study2021

    • Author(s)
      Honda Yuzo、Arima Kazuhiko、Nishimura Takayuki、Tomita Yoshihito、Mizukami Satoshi、Abe Yasuyo、Tanaka Natsumi、Kojima Michiko、Jeng Tsung-Ping、Goto Hisashi、Hasegawa Maiko、Sou Youko、Tsujimoto Ritsu、Kanagae Mitsuo、Osaki Makoto、Aoyagi Kiyoshi
    • Journal Title

      Archives of Osteoporosis

      Volume: 16 Issue: 1 Pages: 127-127

    • DOI

      10.1007/s11657-021-00984-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 運動器疾患を有する高齢者における重度サルコペニアと社会的役割障害の関連2021

    • Author(s)
      富田義人、有馬和彦,西村貴孝,水上諭,金ヶ江光生,安部恵代,青柳潔
    • Organizer
      第8回日本サルコペニア・フレイル学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 運動器疾患を有する高齢者のサルコペニアと呼吸機能との関連2020

    • Author(s)
      富田義人
    • Organizer
      第81回日本生理人類学会
    • Related Report
      2020 Research-status Report
  • [Remarks] 【研究発表】理学療法学科の富田義人講師による「サルコペニアと呼吸機能に関する研究論文」

    • URL

      https://www.tpu.ac.jp/news/4665/

    • Related Report
      2022 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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