| Project/Area Number |
19K16261
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 46010:Neuroscience-general-related
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| Research Institution | Kyushu University |
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Principal Investigator |
Leiwe Marcus 九州大学, 医学研究院, 助教 (80722008)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Neurosciece / Olfaction / Development / Neuroscience / Connectomics / Olfactory Bulb / Pruning / Odour / Dendrites / Sensory Processing |
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| Outline of Research at the Start |
Neuronal circuits are vital to interact with the world, and there are consequences if these circuits develop incorrectly. At birth, smell is one of the few senses that is functional in mice. However, at birth the circuit has not fully formed and changes continue all the way through to adulthood. Yet the functional consequences of circuit changes are not known. We want to know if these circuit changes also affect perception, and if they do identify the purpose of each circuit change, thus linking neuronal structure, neuronal function, and perception.
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| Outline of Final Research Achievements |
We were able to set up an awake imaging set up that could deliver odour to neonatal mice. We were also able to measure the breathing of thepup
during the imaging period too. What we discovered was that P2 mice were broadly more tuned than P6 mice meaning that P6 mice should be more able to discriminate between different odours. Additionally, the deltaF/F signals were much stronger at P6 when compared to those at P2. This may have meant that we were able to detect smaller events rather than a change in tuning (or that the tuning is masked by development). fter sharing my findings with a colleague we have now begun to explore the electrohpysical properties of mitral cells at this age. Without this grant such a study would not have been made.
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| Academic Significance and Societal Importance of the Research Achievements |
私たちは、生体内カルシウムイメージングで糸球体層の匂い反応を記録した最初の研究室でした。 私たちの調査結果は、僧帽細胞の匂い応答の発達に関与する未知数がたくさんあることを明らかにしました。 特に糸球体層のシナプス接触と
社会的意義
私たちは、出生時に匂いがどのように知覚されるかを調べることに興味がありました。 生後1週間で匂いの感度に大きな変化があることがわかりました。 次に、この最初の週に何が変化しているかを調べたいと思います。
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