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Neural basis of direct and indirect pathways in the basal ganglia involved in the control of motor expression and goal-directed behavior.

Research Project

Project/Area Number 19K16300
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionKyoto University (2020-2021)
Tamagawa University (2019)

Principal Investigator

Satoshi Nonomura  京都大学, 霊長類研究所, 特定助教 (10737125)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords目標指向行動 / 線条体 / 直接路 / 間接路 / 背外側 / 背内側 / 報酬 / 運動 / 光遺伝学 / 背外側線条体 / 背内側線条体 / 運動発現 / 大脳基底核 / 電気生理学
Outline of Research at the Start

大脳基底核・線条体は、背外側(DMS)、背内側(DLS)、腹側(VS)の小区分ごとに機能が異なる可能性が示唆されているが、その神経基盤の全貌は明らかにされていない。本研究は、運動発現の制御と目標指向行動に関わる大脳基底核の直接路と間接路の神経基盤を、線条体内の小区分ごとに明らかにすることを目的としている。光遺伝学的手法と電気生理学的手法を組み合わせ、目標指向行動中のラットの直接路と間接路の神経活動を線条体の広範な領域で記録することで、この目的に迫る。また、小区分ごとの活動特性が確認できた場合には、関連領域の活動を光遺伝学的に操作することによって、因果性の検証をする。

Outline of Final Research Achievements

The direct and indirect pathways of the striatum are believed to be important for goal-directed action selection. However, the specific functions of these pathways remain unclear. The striatum can also be divided into three subdivisions: dorsomedial, dorsolateral, and ventral. In this study, we used optogenetic techniques to identify the neural activity of direct and indirect pathways in each striatal sub-division and to examine pathway-specific neural activity to determine the activity characteristics of these cells in motor expression and goal-directed behavior. The results showed that direct and indirect pathways, which were previously thought to work antagonistically, are synchronously active during the onset of movement.

Academic Significance and Societal Importance of the Research Achievements

目標指向的な行動選択に関わる脳機能が破綻すると、異常な固執行動や、不秩序な行動選択といった不適応行動(maladaptive behavior)が生じ、経済的、社会的及び精神的な支障をきたす。近年、神経難病で最も多いとされるパーキンソン病(PD)において、その治療薬によって行動選択が障害されることがわかってきている。
本研究成果は、こうしたPDなどの大脳基底核疾患の認知機能障害の理解や、その治療への応用が期待される。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (6 results)

All 2021 2020 2019

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] A spike analysis method for characterizing neurons based on phase locking and scaling to the interval between two behavioral events2020

    • Author(s)
      Kawabata Masanori、Soma Shogo、Saiki-Ishikawa Akiko、Nonomura Satoshi、Yoshida Junichi、R?os Alain、Sakai Yutaka、Isomura Yoshikazu
    • Journal Title

      Journal of Neurophysiology

      Volume: 124 Issue: 6 Pages: 1923-1941

    • DOI

      10.1152/jn.00200.2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 行動選択の改善に関わる大脳基底核の神経基盤(成功は直接路,失敗は間接路)2020

    • Author(s)
      野々村 聡
    • Journal Title

      Clinical Neuroscience

      Volume: 38 Pages: 922-923

    • Related Report
      2020 Research-status Report
  • [Journal Article] Neuronal Representation of Object Choice in the Striatum of the Monkey.2019

    • Author(s)
      Satoshi Nonomura, Kazuyuki Samejima
    • Journal Title

      frontiers in Neuroscience

      Volume: 13 Pages: 1283-1283

    • DOI

      10.3389/fnins.2019.01283

    • NAID

      40022526579

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Predictive coding for action selection by indirect pathway neurons in the rat dorsolateral striatum2021

    • Author(s)
      Nonomura S, Rios A , Kato S, Sakai Y, Nambu A , Takada M, Kobayashi K, Isomura Y, Kimura M
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
  • [Presentation] 目標志向行動に関わる行動特異的な線条体直接路と間接路の神経活動2021

    • Author(s)
      野々村 聡
    • Organizer
      第98回日本生理学会大会合同大会 国際シンポジウム 新たな大脳基底核像を求めて
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Differential activity of indirect pathway neurons in the dorsolateral and dorsomedial striatum for action selection2019

    • Author(s)
      Satoshi Nonomura, Shigeki Kato, Yutaka Sakai, Atsushi Nambu, Kazuto Kobayashi, Yoshikazu Isomura and Minoru Kimura
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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