| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
In the course of elucidating the molecular mechanisms underlying circadian pruritic behavior for chronopharmacology, we found that the N-type glycosylation of Gpr176, an orphan GPCR that sets the pace of the circadian clock, plays an important role in the regulation of its protein expression level (Wang and Nakagawa et al, Sci Rep, 2020), developed a system that enables us to observe a number of circadian rhythms in physiology simultaneously (Shimatani et al, PLoS ONE, 2021), and found that in meibomian gland dysfunction, in which local changes in peripheral organs are associated with the development of its pathogenesis like itch, an age-related decrease in NAD+ leads to a decrease in local steroid synthesis, which result in an exacerbation of the disease (Sasaki, Hamada, and Yarimizu et al, Nat Aging, 2022).
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