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Elucidate the immune modulation mechanism of muscle and bone.

Research Project

Project/Area Number 19K16688
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 49070:Immunology-related
Research InstitutionKyoto University

Principal Investigator

Minagawa Atsutaka  京都大学, iPS細胞研究所, 特定研究員 (90838822)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords運動 / 免疫 / 免疫細胞療法 / 運動刺激 / 細胞免疫 / 細胞療法 / 免疫療法 / 養子免疫
Outline of Research at the Start

免疫不全マウスに、腫瘍を皮下移植しその後運動負荷群とコントロール群にわけ、腫瘍内に腫瘍抗原に特異的なTCR及びLuciferase酵素を発現させたT細胞を投与する。腫瘍進展、T細胞の動態、体重、筋肉量、骨量、体温、摂食状態等を観察し、また腫瘍内のT細胞の遺伝子変化を観察する事で、運動によるT細胞活性を変化させる因子の抽出を行っていく。それに平行し、筋肉、神経への各種刺激を行い、運動の一部を代替できる刺激方法を模索していく。運動で変化する、免疫状態変化因子を抽出し、その因子を最も変化させる運動代替刺激法を確立する事で、運動免疫効果を発揮する新規免疫行動療法を開発する。

Outline of Final Research Achievements

It has been suggested that exercise may change the immune cell dynamics in an individual's body, and it is thought that by studying the relationship between exercise and immunity, new immunotherapeutic targets can be explored. In this study, we investigated the regulatory mechanism of cell dynamics by analyzing the effect of combined exercise on the effect of immuno-cell therapy in a cancer-bearing mouse model.
We succeeded in constructing an experimental system in which tumor growth is suppressed by exercise, and it was suggested that it is more effective to exercise for a short period of time multiple times with an interval than for long-term continuous exercise. Furthermore, it was confirmed that the tumor suppressive effect can be observed depending on the tumor position even by electrical stimulation of the muscle.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果は、養子免疫療法において、運動等の外的刺激により、治療効果を改善する事が可能である事を意味しており、今後の免疫療法における新しい介入手段となる事が期待出来る。薬剤ではない、新しい手法であるため、既存の治療法との併用が容易である。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (5 results)

All 2021

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy2021

    • Author(s)
      Iriguchi Shoichi、Yasui Yutaka、Kawai Yohei、Arima Suguru、Kunitomo Mihoko、Sato Takayuki、Ueda Tatsuki、Minagawa Atsutaka、Mishima Yuta、Yanagawa Nariaki、Baba Yuji、Miyake Yasuyuki、Nakayama Kazuhide、Takiguchi Maiko、Shinohara Tokuyuki、Nakatsura Tetsuya、Yasukawa Masaki、Kassai Yoshiaki、Hayashi Akira、Kaneko Shin
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 430-430

    • DOI

      10.1038/s41467-020-20658-3

    • NAID

      120006954089

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells2021

    • Author(s)
      Bo Wang, Shoichi Iriguchi, Masazumi Waseda, Norihiro Ueda, Tatsuki Ueda, Huaigeng Xu, Atsutaka Minagawa, Akihiro Ishikawa, Hisashi Yano, Tomoko Ishi, Ryoji Ito, Motohito Goto, Riichi Takahashi, Yasushi Uemura, Akitsu Hotta and Shin Kaneko
    • Journal Title

      Nature Biomedical Engineering

      Volume: in press Issue: 5 Pages: 429-440

    • DOI

      10.1038/s41551-021-00730-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Capturing human trophoblast development with naive pluripotent stem cells in vitro2021

    • Author(s)
      S Io M Kabata Y Lemura N Morone A Minagawa B Wong I Okamoto T Nakamura Y Kojima C Iwatani H Tsuchiya B Kawswandy E KondohS Kaneko K Woltjen M Saitou T Yamanoto M Mandai Y Takashima
    • Journal Title

      Cell Stem Cell

      Volume: 21 Issue: 6 Pages: 10-10

    • DOI

      10.1016/j.stem.2021.03.013

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-derived iPS cells2021

    • Author(s)
      Ito Takeshi、Kawai Yohei、Yasui Yutaka、Iriguchi Shoichi、Minagawa Atsutaka、Ishii Tomoko、Miyoshi Hiroyuki、Taketo M. Mark、Kawada Kenji、Obama Kazutaka、Sakai Yoshiharu、Kaneko Shin
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 1-1

    • DOI

      10.1038/s42003-021-02195-x

    • NAID

      120007142149

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Presentation] iPS細胞を利用した腫瘍免疫療法2021

    • Author(s)
      南川淳隆
    • Organizer
      日本生殖免疫学会
    • Related Report
      2021 Annual Research Report
    • Invited

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Published: 2019-04-18   Modified: 2023-01-30  

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