Stratification of East Asian H.pylori strains to construct the basis for selective H.pylori eradication therapy

• Project/Area Number: 19K16707
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Chiba University
• Principal Investigator: Fukuyo Masaki 千葉大学, 大学院医学研究院, 助教 (40639085)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ピロリ菌 / 胃癌 / DNAメチル化 / 発癌 / 制限酵素 / 層別化 / 選択的除菌 / 胃がん

Outline of Research at the Start

ピロリ菌は胃がん発がん細菌である．その発がん要因としてはIV型分泌装置を介してホスト細胞内に分泌されるCagAタンパクががんタンパクSHP2を活性化し異常増殖シグナルを生成すること等が分かっているが，非発がん型cagA株やcagA-株がいかにホスト細胞のゲノム変異・エピゲノム異常を引き起こし発がんに至るのか，世界中で研究が進むものの詳細は明らかになっていない．
そこで本研究では，ヒトゲノムデータとピロリ菌ゲノム・DNAメチル化(メチローム)データを統合する申請者のオミックス解析技術を駆使して，ピロリ菌東アジア株110株の層別化により除菌すべきピロリ菌の特徴を解明する．

Outline of Final Research Achievements

H. pylori is a gastric carcinogen. CagA protein is known as a carcinogen, however, it is not clear how non-cancer-causing cagA and cagA- H. pylori strains cause genomic mutations and epigenomic abnormalities in the host cell, leading to carcinogenesis. H. pylori infection increasing the gastric cancer risk, however it also suppressing esophagogastric junction cancer. It is necessary to classify H. pylori that should be eradicated or should not be eradicated.
In this study, in order to create a basis for the selective eradication treatment of high risk H. pylori, the characteristics of H. pylori to be eradicated by stratification of 110 East-Asian H. pylori strains were elucidated by human genome data and H. pylori genome/DNA methylation data. Restriction glycosylase in H. pylori was indicated as gastric cancer carcinogen.

Academic Significance and Societal Importance of the Research Achievements

胃がんは本邦において毎年10万人以上が羅漢し，約5万人が命を落とす主要な疾患の一つである．胃癌発症の主因はピロリ菌であるが，その発癌の仕組みはcagA等の一部の例外を除いてまだ不明である．ここに私達はピロリ菌多数株のゲノム・メチローム比較と，ヒト癌変異解析からピロリ菌の持つ塩基切り出し型制限酵素がヒト胃上皮細胞に変異を誘発し胃癌を引き起こしているという仮説を提唱した．
また，今回胃癌変異源候補として見出したHpPabIは選択的ピロリ菌除菌治療の指標となり得る．

Research Products

• [Int'l Joint Research] National Cancer Institute (NCI)/New England Biolabs (NEB)(米国)
• [Int'l Joint Research] National Cancer Institute (NCI)/New England Biolabs (NEB)(米国)
• [Journal Article] Genomic differentiation within East Asian Helicobacter pylori (2022)
  • Author(s): You Yuanhai、Thorell Kaisa、He Lihua、Yahara Koji、Yamaoka Yoshio、Cha Jeong-Heon、Murakami Kazunari、Katsura Yukako、Kobayashi Ichizo、Falush Daniel、Zhang Jianzhong、TEAMHp
  • Journal Title: Microbial Genomics Volume: 8 Issue: 2 Pages: 1-14
  • DOI: 10.1099/mgen.0.000676
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PHLDA3 Is an Important Downstream Mediator of p53 in Squamous Cell Carcinogenesis (2022)
  • Author(s): Saito Megumi、Sada Akane、Fukuyo Masaki、Aoki Kiyono、Okumura Kazuhiro、Tabata Yuko、Chen Yu、Kaneda Atsushi、Wakabayashi Yuichi、Ohki Rieko
  • Journal Title: Journal of Investigative Dermatology Volume: 142 Issue: 21 Pages: 02271-5
  • DOI: 10.1016/j.jid.2021.09.007
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory genetic variations and novel oncoprotein candidates (2021)
  • Author(s): Tuan V P、Yahara K、Dung H D Q、Binh T T、Huu T P、Tri T D、Thuan N P M、Khien V V、Trang T T H、Phuc B H、Tshibangu-Kabamba E、Matsumoto T、Akada J、Suzuki R、Okimoto T、Kodama M、Murakami K、Yano H、Fukuyo M、Takahashi N、Kato M、Nishiumi S、Azuma T、Ogura Y、Hayashi T、Toyoda A、Kobayashi I、Yamaoka Y
  • Journal Title: Microbial Genomics Volume: 7 Issue: 11 Pages: 1-17
  • DOI: 10.1099/mgen.0.000680
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of clonal immunoglobulin λ light-chain gene rearrangements in AL amyloidosis using next-generation sequencing (2021)
  • Author(s): Kimura K、Tsukamoto S、Miyazaki K、Kawajiri-Manako C、Ishii A、Rahmutulla B、Fukuyo M、Oshima-Hasegawa N、Mitsukawa S、Takeda Y、Mimura N、Takeuchi M、Ohwada C、Iseki T、Matsusaka K、Sanada M、Yokote K、Kaneda A、Ishida T、Suzuki K、Nakaseko C、Sakaida E
  • Journal Title: Experimental Hematology Volume: 101-102 Pages: 34-41
  • DOI: 10.1016/j.exphem.2021.08.001
  • Peer Reviewed / Open Access
• [Journal Article] Genetic subtype classification using a simplified algorithm and mutational characteristics of diffuse large B‐cell lymphoma in a Japanese cohort (2021)
  • Author(s): Mishina T、Oshima‐Hasegawa N、Tsukamoto S、Fukuyo M、Kageyama H、Muto T、Mimura N、Rahmutulla B、Nagai Y、Kayamori K、Hino Y、Mitsukawa S、Takeda Y、Ohwada C、Takeuchi M、Tsujimura H、Iseki T、Nakaseko C、Ikeda J、Itami M、Yokote K、Ohara O、Kaneda A、Sakaida E
  • Journal Title: British Journal of Haematology Volume: 195 Issue: 5 Pages: 731-742
  • DOI: 10.1111/bjh.17765
  • Peer Reviewed
• [Journal Article] Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein‐Barr virus‐positive gastric cancer (2021)
  • Author(s): Li Wenzhe、Okabe Atsushi、Usui Genki、Fukuyo Masaki、Matsusaka Keisuke、Rahmutulla Bahityar、Mano Yasunobu、Hoshii Takayuki、Funata Sayaka、Hiura Nobuhiro、Fukayama Masashi、Tan Patrick、Ushiku Tetsuo、Kaneda Atsushi
  • Journal Title: Cancer Science Volume: 112 Issue: 8 Pages: 3349-3362
  • DOI: 10.1111/cas.14978
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic alterations in squamous cell lung cancer associated with idiopathic pulmonary fibrosis (2021)
  • Author(s): Hata Atsushi、Nakajima Takahiro、Matsusaka Keisuke、Fukuyo Masaki、Nakayama Manabu、Morimoto Junichi、Ito Yuki、Yamamoto Takayoshi、Sakairi Yuichi、Rahmutulla Bahityar、Ota Satoshi、Wada Hironobu、Suzuki Hidemi、Iwata Takekazu、Matsubara Hisahiro、Ohara Osamu、Yoshino Ichiro、Kaneda Atsushi
  • Journal Title: International Journal of Cancer Volume: - Issue: 12 Pages: 3008-3018
  • DOI: 10.1002/ijc.33499
  • Peer Reviewed
• [Journal Article] Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer (2021)
  • Author(s): Sugiura Masahiro、Sato Hiroaki、Okabe Atsushi、Fukuyo Masaki、Mano Yasunobu、Shinohara Ken-ichi、Rahmutulla Bahityar、Higuchi Kosuke、Maimaiti Maihulan、Kanesaka Manato、Imamura Yusuke、Furihata Tomomi、Sakamoto Shinichi、Komiya Akira、Anzai Naohiko、Kanai Yoshikatsu、Luo Jun、Ichikawa Tomohiko、Kaneda Atsushi
  • Journal Title: Translational Oncology Volume: 14 Issue: 1 Pages: 100915-100915
  • DOI: 10.1016/j.tranon.2020.100915
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Networking and Specificity-Changing DNA Methyltransferases in Helicobacter pylori (2020)
  • Author(s): Yano Hirokazu、Alam Md. Zobaidul、Rimbara Emiko、Shibata Tomoko F.、Fukuyo Masaki、Furuta Yoshikazu、Nishiyama Tomoaki、Shigenobu Shuji、Hasebe Mitsuyasu、Toyoda Atsushi、Suzuki Yutaka、Sugano Sumio、Shibayama Keigo、Kobayashi Ichizo
  • Journal Title: Frontiers in Microbiology Volume: 11 Pages: 1628-1628
  • DOI: 10.3389/fmicb.2020.01628
  • Peer Reviewed / Open Access
• [Journal Article] Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma (2020)
  • Author(s): Okabe Atsushi, Huang Kie Kyon, Matsusaka Keisuke, Fukuyo Masaki, Xing Manjie, Ong Xuewen, Hoshii Takayuki, Usui Genki, Seki Motoaki, Mano Yasunobu, Rahmutulla Bahityar, Kanda Teru, Suzuki Takayoshi, Rha Sun Young, Ushiku Tetsuo, Fukayama Masashi, Tan Patrick, Kaneda Atsushi
  • Journal Title: Nature Genetics Volume: 52 Issue: 9 Pages: 919-930
  • DOI: 10.1038/s41588-020-0665-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differential gene analysis during the development of obliterative bronchiolitis in a murine orthotopic lung transplantation model: A comprehensive transcriptome-based analysis (2020)
  • Author(s): Hata A、Suzuki H、Nakajima T、Fujiwara T、Shiina Y、Kaiho T、Toyoda T、Inage T、Ito T、Sakairi Y、Tamura H、Wada H、Yamada Y、Chiyo M、Matsusaka K、Fukuyo M、Shinohara K、Itoga S、Motohashi S、Matsushita K、Kaneda A、Yoshino I
  • Journal Title: PLOS ONE Volume: 15 Issue: 5 Pages: 0232884-0232884
  • DOI: 10.1371/journal.pone.0232884
  • Peer Reviewed / Open Access
• [Journal Article] High expression of CXCL14 is a biomarker of lung adenocarcinoma with micropapillary pattern (2020)
  • Author(s): Sata Yuki, Nakajima Takahiro, Fukuyo Masaki, Matsusaka Keisuke, Hata Atsushi, Morimoto Junichi, Rahmutulla Bahityar, Ito Yuki, Suzuki Hidemi, Yoshino Ichiro, Kaneda Atsushi
  • Journal Title: Cancer Science Volume: 111 Issue: 7 Pages: 2588-2597
  • DOI: 10.1111/cas.14456
  • Peer Reviewed / Open Access
• [Journal Article] Higher methylation subtype of malignant melanoma and its correlation with thicker progression and worse prognosis (2020)
  • Author(s): Yamamoto Yosuke、Matsusaka Keisuke、Fukuyo Masaki、Rahmutulla Bahityar、Matsue Hiroyuki、Kaneda Atsushi
  • Journal Title: Cancer Medicine Volume: 9 Issue: 19 Pages: 7194-7204
  • DOI: 10.1002/cam4.3127
  • Peer Reviewed / Open Access
• [Journal Article] Epstein‐Barr virus positive gastric cancer involves enhancer activation through ATF3 (2020)
  • Author(s): Asakawa Yuta、Okabe Atsushi、Fukuyo Masaki、Li Wenzhe、Ikeda Eriko、Mano Yasunobu、Funata Sayaka、Namba Hiroe、Fujii Takahiro、Kita Kazuko、Matsusaka Keisuke、Kaneda Atsushi
  • Journal Title: Cancer Science Volume: 00 Issue: 5 Pages: 1-11
  • DOI: 10.1111/cas.14370
  • Peer Reviewed / Open Access
• [Journal Article] Establishment of epigenetic markers to predict irradiation efficacy against oropharyngeal cancer. (2020)
  • Author(s): Kurokawa T, Nakagawa T, Matsusaka K, Fukuyo M, Mima M, Misawa K, Rahmutulla B, Ikeda JI, Hanazawa T, Okamoto Y, Kaneda A
  • Journal Title: Cancer Sci. Volume: 111 Issue: 4 Pages: 1407-1416
  • DOI: 10.1111/cas.14338
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stratification of HPV-associated and HPV-negative oropharyngeal squamous cell carcinomas based on DNA methylation epigenotypes. (2020)
  • Author(s): Nakagawa T, Matsusaka K, Misawa K, Ota S, Fukuyo M, Rahmutulla B, Kunii N, Sakurai D, Hanazawa T, Matsubara H, Okamoto Y, Kaneda A
  • Journal Title: Int J Cancer. Volume: 146 Issue: 9 Pages: 2460-2474
  • DOI: 10.1002/ijc.32890
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A low DNA methylation epigenotype in lung squamous cell carcinoma and its association with idiopathic pulmonary fibrosis and poorer prognosis. (2020)
  • Author(s): Hata A, Nakajima T, Matsusaka K, Fukuyo M, Morimoto J, Yamamoto T, Sakairi Y, Rahmutulla B, Ota S, Wada H, Suzuki H, Matsubara H, Yoshino I, Kaneda A.
  • Journal Title: Int J Cancer Volume: 146 Issue: 2 Pages: 388-399
  • DOI: 10.1002/ijc.32532
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of Clonal Immunoglobulin λ Light-Chain Gene Rearrangements in AL Amyloidosis Using Next Generation Sequencing (2019)
  • Author(s): Kimura K.、Tsukamoto S.、Miyazaki K.i、Kawajiri-Manako C.、Rahmutulla B.、Fukuyo M.、Oshima-Hasegawa N.、Mitsukawa S.、Takeda Y.、Mimura N.、Takeuchi M.、Ohwada C.、Iseki T.、Matsusaka K.、Yokote K.、Kaneda A.、Ishida T.、Suzuki K.、Nakaseko C.、Sakaida E.
  • Journal Title: Blood Volume: 134 Issue: Supplement_1 Pages: 1748-1748
  • DOI: 10.1182/blood-2019-125028
  • Peer Reviewed
• [Presentation] Activation of EHF and Wnt signaling via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer. (2021)
  • Author(s): Atsushi Kaneda, Wenzhe Li, Atsushi Okabe, Genki Usui, Masaki Fukuyo, Keisuke Matsusaka, Bahityar Rahmutulla Nawai, Yasunobu Mano, Sayaka Funata, Takayuki Hoshii, Tetsuo Ushiku, Patrick Tan, Masashi Fukayama
  • Organizer: 第32回日本消化器癌発生学会
• [Presentation] Molecular mechanism of carcinogenesis induced by HPV insertion in head and neck squamous cell carcinoma. (2021)
  • Author(s): Masato Mima, Atsushi Okabe, Takuya Nakagawa, Tomoya Kurokawa, Satoru Kondo, Harue Mizokami, Masaki Fukuyo, Bahityar R. Nawai, Takayuki Hoshii, Kiyoshi Misawa, Atsushi Kaneda
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] H3K4 methyltransferase SETD1A regulates the mitochondrial respiration in acute myeloid leukemia. (2021)
  • Author(s): Takayuki Hoshii, Sota Kikuchi, Rahmutulla Bahityar, Masaki Fukuyo, Tomoaki Tanaka, Atsushi Kaneda
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Analyses of primary gastric cancer risk in a cohort of 4,257 asymptomatic subjects and accumulated DNA methylation. (2021)
  • Author(s): Genki Usui, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla Nawai, Eiji Sakai, Tetsuo Ushiku, Atsushi Kaneda
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 無症候検診コホートを対象とした胃発癌リスク因子の探索と胃粘膜に蓄積したDNAメチル化の解析 (2021)
  • Author(s): Genki Usui, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla Nawai, Eiji Sakai, Toshiaki Gunji, Nobuyuki Matsuhashi, Teppei Morikawa, Tetsuo Ushiku, Atsushi Kaneda
  • Organizer: 第32回日本消化器癌発生学会
• [Presentation] Tissue-wide analysis of chromatin structural aberrations induced by oncovirus infection. (2021)
  • Author(s): Atsushi Okabe, Takahiro Fujii, Harue Mizokami, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Heterochromatin disruption and chromatin structural rewiring induced by Epstein-Barr virus infection in gastric adenocarcinoma. (2021)
  • Author(s): Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Takayuki Hoshii, Bahityar Rahmutulla, Genki Usui, Teru Kanda, Tetsuo Ushiku, Masashi Fukayama, Patrick Tan, Atsushi Kaneda
  • Organizer: 19thInternational Symposium on Epstein-Barr Virus and associated diseases.
• [Presentation] Epigenome micro-evolution associated with DNA methyltransferases’ specificity changes in H. pylori. (2021)
  • Author(s): ○Masaki Fukuyo, Hideo Yonezawa, Mutsuko Konno, Tomoko Shibata, Shuji Shigenobu, Bahityar Rahmutulla, Ikuo Uchiyama, Atsushi Kaneda, Ichizo Kobayashi
  • Organizer: 第94回日本細菌学会総会
• [Presentation] ネットワークを作り配列特異性を変換するピロリ菌のDNAメチル化酵素群 (2020)
  • Author(s): 矢野大和，アラムモハメッド，林原絵美子，柴田朋子，福世真樹，古田芳一，西山智明，重信秀治，長谷部光泰，豊田敦，鈴木穣，菅野純夫，柴山恵吾，○小林一三
  • Organizer: 第43回日本分子生物学会年会
• [Presentation] DNAメチル化酵素配列特異性変換を伴うピロリ菌エピゲノム・ミクロ進化 (2020)
  • Author(s): ○福世真樹， 米澤英雄，矢野大和，桂有加子，矢原耕史，今野武津子，柴田朋子，重信秀治，BAHITYAR Rahmutulla，内山郁夫，長谷川嘉則，小原收，金田篤志，小林一三
  • Organizer: 第43回日本分子生物学会年会
• [Presentation] Epstein-Barrウイルス感染によるエンハンサー異常活性化の誘導因子の探索 (2020)
  • Author(s): ○李 文哲, 岡部 篤史, 臼井 源紀, 福世 真樹, 松坂 恵介, Rahmutulla Bahityar, 星居 孝之, 金田 篤志
  • Organizer: 第79回日本癌学会総会
• [Presentation] 4260名の無症候検診コホートの解析による胃発癌リスク因子の探索と胃粘膜に蓄積したDNAメチル化の解析 (2020)
  • Author(s): ○臼井 源紀, 松坂 恵介, 福世 真樹, Rahmutulla Bahityar, 酒井 英嗣, 牛久 哲男, 金田 篤志
  • Organizer: 第79回日本癌学会総会
• [Presentation] 癌ウイルス感染がもたらすクロマチン構造異常による癌遺伝子の活性化 (2020)
  • Author(s): ○岡部 篤史, Huang Kie Kyon, 松坂 恵介, 福世 真樹, Rahmutulla Bahityar, Tan Patrick, 金田 篤志
  • Organizer: 第79回日本癌学会総会
• [Presentation] エピゲノム技術を利用した中咽頭癌に対する放射線治療効果予測マーカーの樹立 (2020)
  • Author(s): ○黒川 友哉, 中川 拓也, 松坂 恵介, 福世 真樹, 美馬 勝人, 三澤 清, 花澤 豊行, 金田 篤志
  • Organizer: 第121回日本耳鼻咽喉科学会学術講演会
• [Presentation] ヒストンメチル化酵素SETD1Aによるミトコンドリア関連遺伝子の発現制御と急性骨髄性白血病における役割の解明 (2020)
  • Author(s): ○菊地創太, 星居孝之, 金坂学斗, RAHMUTULLA Bahityar, 福世真樹, 田中知明, 金田篤志
  • Organizer: 第79回日本癌学会総会
• [Presentation] HPV関連頭頸部扁平上皮癌のクロマチン3次元構造解析 (2020)
  • Author(s): ○美馬勝人, 美馬勝人, 岡部篤史, 中川拓也, 中川拓也, 中川拓也, 黒川友哉, 黒川友哉, 近藤悟, 福世真樹, バハテヤリ ラヒムトラ, 星居孝之, 三澤清, 峯田周幸, 金田篤志
  • Organizer: 第79回日本癌学会総会
• [Presentation] 前立腺癌における去勢抵抗性獲得後の低酸素応答の変化 (2020)
  • Author(s): ○金坂学斗, 佐藤広明, 佐藤広明, 杉浦正洋, 杉浦正洋, 星居孝之, 岡部篤史, 福世真樹, 坂本信一, 小宮顕, 市川智彦, 金田篤志
  • Organizer: 第79回日本癌学会総会
• [Presentation] ヒキガエル有毒分泌物の構成化合物シノブファギンはエピゲノム修飾を変えることで白血病細胞株に対して抗腫瘍効果を発揮する (2020)
  • Author(s): ○平崎能郎, 岡部篤史, 福世真樹, 星居孝之, 関元昭, 金田篤志
  • Organizer: 第79回日本癌学会総会
• [Presentation] 前立腺腫瘍におけるオープンクロマチンとスーパーエンハンサーのランドスケープ解明 (2020)
  • Author(s): ○佐藤広明, 佐藤広明, 金坂学斗, 杉浦正洋, 杉浦正洋, 福世真樹, 岡部篤史, 星居孝之, 坂本信一, 小宮顕, 市川智彦, 金田篤志
  • Organizer: 第79回日本癌学会総会
• [Presentation] GH産生下垂体腫瘍におけるSDHxの体細胞copy数減少症例は治療抵抗性を示す (2020)
  • Author(s): ○大和梓, 永野秀和, 山形一行, 橋本直子, 高躍, 高躍, 岩立康男, 福世真樹, 金田篤志, 井下尚子, 福原紀章, 西岡宏, 山田正三, 田中知明
  • Organizer: 第93回日本内分泌学会学術総会
• [Presentation] 胃粘膜におけるDNA異常メチル化の蓄積と胃癌発症リスク因子の探索 (2020)
  • Author(s): ○臼井源紀, 松坂恵介, 福世真樹, 篠崎智大, 酒井英嗣, 郡司俊秋, 松橋信行, 森川鉄平, 牛久哲男, 金田篤志
  • Organizer: 第109回日本病理学会総会
• [Presentation] ピロリ菌における DNA メチル化酵素の配列特異性変換に伴う エピゲノム・ミクロ進化 (2020)
  • Author(s): 福世 真樹、米澤 英雄、矢野 大和、桂 有加子、矢原 耕史、 今野 武津子、柴田 朋子、重信 秀治、バハテヤリ ラムヒトラ、 長谷川 嘉則、内山 郁夫、小原 收、金田 篤志、小林 一三
  • Organizer: 第14回日本ゲノム微生物学会年会
• [Presentation] Heterochromatin reprogramming due to Epstein-Barr virus infection activate neighboring oncogenes through aberrant enhancer activation (2019)
  • Author(s): Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] EBV infection induces domain structural changes which lead to oncogenic activation (2019)
  • Author(s): Atsushi Okabe, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Chromatin structural aberrations induced by Epstein-Barr virus infection in gastric epithelial cells (2019)
  • Author(s): Atsushi Okabe, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan Atsushi Kaneda
  • Organizer: The 6th Cancer Epigenomics Symposium
• [Presentation] Chromatin structural aberrations induced by Epstein-Barr virus infection in gastric epithelial cells (2019)
  • Author(s): Atsushi Okabe, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan Atsushi Kaneda
  • Organizer: 1st Chiba University-University of Toronto Workshop
  • Int'l Joint Research
• [Presentation] Heterochromatin reprogramming induced by Epstein-Barr virus infection induces oncogenic activation through aberrant enhancer activatio (2019)
  • Author(s): Atsushi Okabe, Keisuke Matsusaka, Masaki Fukuyo, Hiroe Namba, Sayaka Funata, Atsushi Kaneda
  • Organizer: 第13回日本エピジェネティクス研究会年会
• [Presentation] Alteration of histone modification and chromatin structure in HPV related head and neck squamous cell carcinoma (2019)
  • Author(s): Masato Mima, Atsushi Okabe, Takuya Nakagawa, Tomoya Kurokawa, Masaki Fukuyo, Rahmutulla Bahityar, Keisuke Matsusaka, Kiyoshi Misawa1, Hiroyuki Mineta, Atsushi Kaneda
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] HPV関連頭頸部扁平上皮癌のヒストン修飾・クロマチン構造解析 (2019)
  • Author(s): 美馬勝人、岡部篤史、中川拓也、黒川友哉、近藤悟、福世真樹、Bahityar Rahmutulla、松坂恵介、三澤清、峯田周幸、金田篤志
  • Organizer: 第30回日本消化器癌発生学会総会
• [Presentation] 背景胃粘膜におけるDNA異常メチル化の蓄積と胃癌発症リスク因子の探索 (2019)
  • Author(s): 臼井源紀、松坂恵介、福世真樹、篠崎智大、郡司俊秋、松橋信行、森川鉄平、牛久哲男、金田篤志
  • Organizer: 第30回日本消化器癌発生学会総会
• [Presentation] Epstein-Barrウイルス感染によるエンハンサー異常活性化の誘導因子の探索 (2019)
  • Author(s): 李文哲, 岡部 篤史,松坂 恵介, Bahityar Rahmutulla, 福世 真樹, 金田 篤志
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] 共培養システムを用いたJAG1-Notchシグナルの活性化が及ぼす老化誘導機構の解析 (2019)
  • Author(s): 眞野恭伸, 福世 真樹, 岡部 篤史, 松坂 恵介, 山中 遼太, 油谷 浩幸, 金田 篤志
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] 新規化学合成化合物によるp53依存的抗がん作用 (2019)
  • Author(s): 池田 英里子, 喜多 和子, 井上 貴登, 松田 和暁, 竹野 有加里, 宮崎 柊子, 新宅 敬彦, 依田 夏美, 丸山 陽佳, Bahityar Rahmutulla, 福世 真樹, 篠原 憲一, 松坂 恵介, 根本 哲宏, 金田 篤志
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] H. pylori epigenome micro‐evolution associated with DNA methyltransferases’ sequence‐specificity changes (2019)
  • Author(s): M. Fukuyo, H. Yano, H. Yonezawa, N. Takahashi, K. Yahara, M. Konno, T. F. Shibata, S. Shigenobu, B. Rahmutulla, I. Uchiyama, Y. Hasegawa, O. Ohara, A. Kaneda, I. Kobayashi
  • Organizer: EHMSG - XXXIInd International Workshop on Helicobacter & Microbiota in Inflammation & Cancer
  • Int'l Joint Research