• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of D-type cyclin gene abnormalities and development of novel therapeutic strategies in pediatric acute myeloid leukemia

Research Project

Project/Area Number 19K16832
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 50020:Tumor diagnostics and therapeutics-related
Research InstitutionKyoto University

Principal Investigator

Matsuo Hidemasa  京都大学, 医学研究科, 助教 (80769737)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Discontinued (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords白血病 / AML / 遺伝子異常 / t(8;21) / CCND2 / CDK4/6 / オートファジー / 急性骨髄性白血病 / アポトーシス / 次世代シークエンス / 遺伝子変異 / CCND
Outline of Research at the Start

本研究の目的は、D型サイクリン遺伝子異常を有する小児の急性骨髄性白血病(AML)症例の割合・臨床的特徴や予後を明確にすること、AML細胞におけるD型サイクリン遺伝子異常の果たす役割およびCDK4/6阻害剤の有効性を明らかにすることである。将来的にAML患者の新規治療戦略につながるだけでなく、D型サイクリン遺伝子異常が白血病の遺伝子検査パネルに組み込まれることで治療効果予測にも寄与する可能性がある。

Outline of Final Research Achievements

In this study, genomic analysis of t(8;21) acute myeloid leukemia (AML) patient samples revealed frequent mutations and overexpression of CCND2 gene. Furthermore, we demonstrated that simultaneous inhibition of CDK4/6 and autophagy exerts synergistic anti-tumor effects in vitro/in vivo in t(8;21) AML cell lines and clinical samples.

Academic Significance and Societal Importance of the Research Achievements

本研究ではt(8;21)という染色体上を持つ急性骨髄性白血病(AML)の患者から収集したサンプルを用いて遺伝子異常を調べることで、CCND2という遺伝子に変異や高発現が高頻度にみられることを明らかにした。これはAMLを引き起こすメカニズムの解明につながる成果ある。またCDK4/6とオートファジーを同時に阻害することが、t(8;21)AML細胞に対し有効である可能性を見出した。これはすぐに臨床応用される成果ではないが、将来的にAMLの個別化医療に結び付く可能性のある知見である。

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (55 results)

All 2021 2020 2019

All Journal Article (16 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 12 results,  Open Access: 9 results) Presentation (39 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] Efficacy of a combination therapy targeting CDK4/6 and autophagy in a mouse xenograft model of t(8;21) acute myeloid leukemia2021

    • Author(s)
      Matsuo Hidemasa、Nakatani Kana、Harata Yutarou、Higashitani Moe、Ito Yuri、Inagami Aina、Noura Mina、Nakahata Tatsutoshi、Adachi Souichi
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 27 Pages: 101099-101099

    • DOI

      10.1016/j.bbrep.2021.101099

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RUNX1 transactivates BCR‐ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia2021

    • Author(s)
      Masuda Tatsuya、Maeda Shintaro、Shimada Sae、Sakuramoto Naoya、Morita Ken、Koyama Asami、Suzuki Kensho、Mitsuda Yoshihide、Matsuo Hidemasa、...、Kamikubo Yasuhiko
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 2 Pages: 529-539

    • DOI

      10.1111/cas.15239

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Albendazole induces the terminal differentiation of acute myeloid leukaemia cells to monocytes by stimulating the Kruppel‐like factor 4‐dihydropyrimidinase‐like 2A (KLF4‐DPYSL2A) axis2021

    • Author(s)
      Noura Mina、Morita Ken、Kiyose Hiroki、Okuno Yukiko、Matsuo Hidemasa、Koyama Asami、Nishinaka‐Arai Yoko、Kamikubo Yasuhiko、Adachi Souichi
    • Journal Title

      British Journal of Haematology

      Volume: 194 Issue: 3 Pages: 598-603

    • DOI

      10.1111/bjh.17557

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Droplet digital polymerase chain reaction assay for the detection of the minor clone of KIT D816V in paediatric acute myeloid leukaemia especially showing RUNX1-RUNX1T1 transcripts.2021

    • Author(s)
      Sasaki K, Tsujimoto S, Miyake M, Uchiyama Y, Ikeda J, Yoshitomi M, Shimosato Y, Tokumasu M, Matsuo H, Yoshida K, Ohki K, Kaburagi T, Yamato G, Hara Y, Takeuchi M, Kinoshita A, Tomizawa D, Taga T, Adachi S, Tawa A, Horibe K, Hayashi Y, Matsumoto N, Ito S, Shiba N.
    • Journal Title

      British Journal of Haematology

      Volume: 194(2) Issue: 2 Pages: 414-422

    • DOI

      10.1111/bjh.17569

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia.2021

    • Author(s)
      Kaburagi T, Yamato G, Shiba N, Yoshida K, Hara Y, Tabuchi K, Shiraishi Y,Ohki K, Sotomatsu M, Arakawa H, Matsuo H, Shimada A, Taki T, Kiyokawa N, Tomizawa D, Horibe K, Miyano S, Taga T, Adachi S, Ogawa S, Hayashi Y.
    • Journal Title

      Haematologica

      Volume: - Issue: 3 Pages: 583-592

    • DOI

      10.3324/haematol.2020.269431

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibition of CDK4/6 and autophagy synergistically induces apoptosis in t(8;21) acute myeloid leukemia cells2020

    • Author(s)
      Nakatani Kana、Matsuo Hidemasa、Harata Yutarou、Higashitani Moe、Koyama Asami、Noura Mina、Nishinaka-Arai Yoko、Kamikubo Yasuhiko、Adachi Souichi
    • Journal Title

      International Journal of Hematology

      Volume: 113 Issue: 2 Pages: 243-253

    • DOI

      10.1007/s12185-020-03015-4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blast cells in acute megakaryoblastic leukaemia with Down syndrome are characterized by low CLEC12A expression2020

    • Author(s)
      Matsuo Hidemasa、Wakita Tomohiro、Hiramatsu Hidefumi、Ohmori Katsuyuki、Kodama Kumi、Nakatani Kana、Kamikubo Yasuhiko、Iwamoto Shotaro、Kondo Tadakazu、Takaori‐Kondo Akifumi、Takita Junko、Tomizawa Daisuke、Taga Takashi、Adachi Souichi
    • Journal Title

      British Journal of Haematology

      Volume: 192 Issue: 1

    • DOI

      10.1111/bjh.17122

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fusion partner?specific mutation profiles and KRAS mutations as adverse prognostic factors in MLL-rearranged AML2020

    • Author(s)
      Matsuo Hidemasa、Yoshida Kenichi、Nakatani Kana、... 、Haferlach Claudia、Ogawa Seishi、Adachi Souichi
    • Journal Title

      Blood Advances

      Volume: 4 Issue: 19 Pages: 4623-4631

    • DOI

      10.1182/bloodadvances.2020002457

    • NAID

      120006890711

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pivotal role of DPYSL2A in KLF4-mediated monocytic differentiation of acute myeloid leukemia cells2020

    • Author(s)
      Noura Mina、Morita Ken、Kiyose Hiroki、Matsuo Hidemasa、Nishinaka-Arai Yoko、Kurokawa Mineo、 Kamikubo Yasuhiko、Adachi Souichi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1-1

    • DOI

      10.1038/s41598-020-76951-0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TXNIP induces growth arrest and enhances ABT263-induced apoptosis in mixed-lineage leukemia-rearranged acute myeloid leukemia cells.2020

    • Author(s)
      Mina Noura, Hidemasa Matsuo, Asami Koyama, Souichi Adachi, Hiroshi Masutani.
    • Journal Title

      FEBS openbio

      Volume: 10 Issue: 8 Pages: 1532-1541

    • DOI

      10.1002/2211-5463.12908

    • NAID

      120006879474

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 臨床検査技師のための研究入門 原著論文の基本的な書きかた2020

    • Author(s)
      松尾 英将
    • Journal Title

      検査と技術(医学書院)

      Volume: 48(9) Pages: 980-984

    • Related Report
      2020 Research-status Report
  • [Journal Article] 臨床検査技師のための研究入門 論文を投稿しよう!2020

    • Author(s)
      松尾 英将
    • Journal Title

      検査と技術(医学書院)

      Volume: 48(9) Pages: 1014-1016

    • Related Report
      2020 Research-status Report
  • [Journal Article] AML治療におけるCDK4/6阻害薬の作用機序と有効性2020

    • Author(s)
      松尾 英将
    • Journal Title

      血液内科 (科学評論社)

      Volume: 80(1) Pages: 28-33

    • Related Report
      2020 Research-status Report
  • [Journal Article] AML治療におけるCDK4/6阻害薬の作用機序と有効性2020

    • Author(s)
      松尾英将
    • Journal Title

      血液内科

      Volume: 80 Pages: 28-33

    • Related Report
      2019 Research-status Report
  • [Journal Article] Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia2019

    • Author(s)
      Shiba N, Yoshida K, Hara Y, Yamato G, Shiraishi Y, Matsuo H, Okuno Y, Chiba K, Tanaka H, Kaburagi T, Takeuchi M, Ohki K, Sanada M, Okubo J, Tomizawa D, Taki T, Shimada A, Sotomatsu M, Horibe K, Taga T, Adachi S, Tawa A, Miyano S, Ogawa S, Hayashi Y
    • Journal Title

      Blood Adv

      Volume: 3 Issue: 20 Pages: 3157-3169

    • DOI

      10.1182/bloodadvances.2019000404

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] EVI1 triggers metabolic reprogramming associated with leukemogenesis and increases sensitivity to L-asparaginase2019

    • Author(s)
      Saito Yusuke、Sawa Daisuke、Kinoshita Mariko、Yamada Ai、Kamimura Sachiyo、Suekane Akira、Ogoh Honami、Matsuo Hidemasa、Adachi Souichi、Taga Takashi、Tomizawa Daisuke、Osato Motomi、Soga Tomoyoshi、Morishita Kazuhiro、Moritake Hiroshi
    • Journal Title

      Haematologica

      Volume: Epub Issue: 8 Pages: 2118-2129

    • DOI

      10.3324/haematol.2019.225953

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] In vivo efficacy of CDK4/6 and autophagy inhibition on t(8;21) acute myeloid leukemia2021

    • Author(s)
      Yutarou Harata, Hidemasa Matsuo, Moe Higashitani, Kana Nakatani, Yuri Ito, Yasuhiko Kamikubo, Souichi Adachi
    • Organizer
      第83回日本血液学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Clonal architecture and its prognostic significance in KMT2A-rearranged acute myeloid leukemia2021

    • Author(s)
      Hidemasa Matsuo, Kenichi Yoshida, Yasuhito Nannya, ..., Souichi Adachi
    • Organizer
      第83回日本血液学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] The importance of RUNX-NFAT axis as a novel therapeutic target for AML and GVHD2021

    • Author(s)
      Tatsuya Masuda, Hirohito Kubota, Kana Furuichi, Naoya Sakuramoto, Asuka Hada, Ayaka Horiuchi, Asami Sasaki, Kanako Takeda, Mizuho Takeda, Hidemasa Matsuo, Masahiro Hirata, Yoichi Imai, Tatsutoshi Nakahata, Junko Takita, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo
    • Organizer
      第83回日本血液学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Clonal evolution pattern and prognostic significance of clonal architecture in KMT2A-rearranged acute myeloid leukemia2021

    • Author(s)
      Hidemasa Matsuo, Kenichi Yoshida, Yasuhito Nannya, ..., Souichi Adachi
    • Organizer
      63rd ASH Annual Meeting & Exposition
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a novel single cell sequencing method from blood smears and pathological specimens2021

    • Author(s)
      Moe Higashitani, Hidemasa Matsuo, Yutarou Harata, Yuri Ito, Aina Inagami, Nana Ito, Norimitsu Uza, Masahiro Shiokawa, Masashi Kanai, Manabu Muto, Souichi Adachi
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] MLL再構成急性骨髄性白血病におけるクローン進化機構の解析2021

    • Author(s)
      伊東優里、松尾英将、吉田健一、南谷泰仁、原田優太郎、東谷萌絵、稲上愛菜、伊藤菜々、白石友一、宮野悟、富澤大輔、多賀崇、小川誠 司、足立壯一
    • Organizer
      第68回日本臨床検査医学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Albendazole Mediates Monocytic Differentiation of Acute Myeloid Leukemia Cells by Stimulating the KLF4-DPYSL2A Axis2021

    • Author(s)
      Mina Noura, Ken Morita, Hiroki Kiyose, Yukiko Okuno, Hidemasa Matsuo, Asami Koyama, Yoko Nishinaka-Arai, Yasuhiko Kamikubo, Souichi Adachi
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新型コロナ禍の血液学実習における細胞鑑別e-learningソフト(Web PRO)の使用経験2021

    • Author(s)
      松尾 英将、中西 加代子、西山 有紀子、足立 壯一
    • Organizer
      第15回日本臨床検査学教育学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Autophagy Inhibition Enhances CDK4/6 Inhibitor-Induced Apoptosis in t(8;21) Acute Myeloid Leukemia Cells.2020

    • Author(s)
      Kana Nakatani, Hidemasa Matsuo, Yutarou Harata, Moe Higashitani, Asami Koyama, Mina Noura, Yoko Nishinaka-Arai, Yasuhiko Kamikubo, Souichi Adachi
    • Organizer
      62nd ASH Annual Meeting & Exposition
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] KRAS mutations Frequently Coexist with High-Risk MLL Fusions and Are Independent Adverse Prognostic Factors in MLL-Rearranged Acute Myeloid Leukemia.2020

    • Author(s)
      Hidemasa Matsuo, Kenichi Yoshida, Kana Nakatani, ... , Claudia Haferlach, Seishi Ogawa, Souichi Adachi
    • Organizer
      62nd ASH Annual Meeting & Exposition
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] RUNX-NFAT Axis As a Novel Therapeutic Target for AML and T Cell Immunity.2020

    • Author(s)
      Tatsuya Masuda, Hirohito Kubota, Naoya Sakuramoto, Asuka Hada, Ayaka Horiuchi, Asami Sasaki, Kanako Takeda, Mizuho Takeda, Hidemasa Matsuo, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo
    • Organizer
      62nd ASH Annual Meeting & Exposition
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血液塗抹標本と病理標本を用いた新規シングルセルシークエンス技術の確立2020

    • Author(s)
      東谷萌絵, 松尾英将, 原田優太郎, 中谷香菜, 伊東優里, 平田勝啓, 片岡竜貴, 上久保靖彦, 足立壯一
    • Organizer
      第52回日本医療検査科学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Thioredoxin interacting protein induces growth arrest and autophagy in mixed-lineage leukemia-rearranged acute myeloid leukemia cells.2020

    • Author(s)
      Mina Noura, Hidemasa Matsuo, Asami Koyama, Souichi Adachi, Hiroshi Masutani
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Examination of the importance of RUNX category in EGFR wild-type non-small cell lung cancer.2020

    • Author(s)
      Atsushi Kobayakawa, Kanako Takeda, Tatsuya Masuda, Yohei Yanagida, Natsuno Obi, Naoya Sakuramoto, Asuka Hada, Ayaka Horiuchi, Mizuho Takeda, Asami Sasaki, Hidemasa Matsuo, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Novel therapeutic strategy for Kras mutated colorectal cancer and PDAC.2020

    • Author(s)
      Natsuno Obi, Mizuho Takeda, Tatsuya Masuda, Yohei Yanagida, Atsushi Kobayakawa, Naoya Sakuramoto, Asuka Hada, Ayaka Horiuchi, Asami Sasaki, Kanako Takeda, Hidemasa Matsuo, Souichi Adachi, Yasuhiko Kamikubo
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] RUNX-NFAT axis as a novel therapeutic target for AML and T cell immunity.2020

    • Author(s)
      Tatsuya Masuda, Hirohito Kubota, Naoya Sakuramoto, Asuka Hada, Ayaka Horiuchi, Asami Sasaki, Kanako Takeda, Mizuho Takeda, Hidemasa Matsuo, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Multiple regulation of FGFR signaling through CROX (Cluster regulation of RUNX) in DNPC.2020

    • Author(s)
      Yohei Yanagida, Asami Sasaki, Tatsuya Masuda, Natsuno Obi, Atsushi Kobayakawa, Naoya Sakuramoto, Asuka Hada, Ayaka Horiuchi, Mizuho Takeda, Kanako Takeda, Hidemasa Matsuo, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Identification of KRAS mutations as novel adverse prognostic factors in MLL-rearranged AML.2020

    • Author(s)
      Hidemasa Matsuo, Kenichi Yoshida, Kana Nakatani, ... , Satoru Miyano, Seishi Ogawa, Souichi Adachi
    • Organizer
      第82回日本血液学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Philadelphia染色体陽性ALL:CROX(Cluster Regulation of RUNX)法によるBCR-ABL転写制御戦略2020

    • Author(s)
      増田達哉, 窪田博仁, 立田俊也, 松尾英将, 杉山弘, 足立壯一, 上久保靖彦
    • Organizer
      第39回京都がん研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] ドットダイセクションを用いた血液塗抹標本からのシングルセルシークエンス法の確立2020

    • Author(s)
      原田優太郎, 松尾英将, 東谷萌絵, 中谷香菜, 上久保靖彦, 足立壯一
    • Organizer
      第21回日本検査血液学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Coexistence and prognostic significance of EVI1 expression and driver mutations in KMT2A-rearranged acute myeloid leukemia.2019

    • Author(s)
      Hidemasa Matsuo,Kenichi Yoshida,Kana Nakatani,Yasuhiko Kamikubo,Daisuke Tomizawa,Takashi Taga,Nobutaka Kiyokawa,Seishi Ogawa,Manja Meggendorfer,Claudia Haferlach,Souichi Adachi
    • Organizer
      61st ASH Annual Meeting & Exposition
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Recurrent gene mutations in pediatric AML patients by targeted sequencing ―the JCCG study, JPLSG AML-05―.2019

    • Author(s)
      Taeko Kaburagi,Genki Yamato,Norio Shiba,Kenichi Yoshida,Yusuke Hara,Yuichi Shiraishi,Kentaro Ohki,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Tomohiko Taki,Nobutaka Kiyokawa,Daisuke Tomizawa,Keizo Horibe,Satoru Miyano,Takashi Taga,Souichi Adachi,Seishi Ogawa,Yasuhide Hayashi
    • Organizer
      61st ASH Annual Meeting & Exposition
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical Features of Pediatric Acute Myeloid Leukemia with TP53 and CDKN2A/2B Copy Number Alterations.2019

    • Author(s)
      Yusuke Hara,Tomohiko Taki,Genki Yamato,Kenichi Yoshida,Yusuke Shiozawa,Norio Shiba,Taeko Kaburagi,Yuichi Shiraishi,Kentaro Ohki,Machiko Kawamura,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,...,Souichi Adachi,Yasuhide Hayashi
    • Organizer
      61st ASH Annual Meeting & Exposition
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical significances of patients with KMT2C and PHF6 mutations in pediatric acute myeloid leukemia.2019

    • Author(s)
      Taeko Kaburagi,Genki Yamato,Norio Shiba,Kenichi Yoshida,Yusuke Hara,Yuichi Shiraishi,Kentaro Ohki,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Tomohiko Taki,Nobutaka Kiyokawa,Daisuke Tomizawa,Keizo Horibe,Satoru Miyano,Souichi Adachi,Takashi Taga,Seishi Ogawa,Yasuhide Hayashi
    • Organizer
      第61回日本小児血液・がん学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Clinical and molecular characterization of pediatric acute myeloid leukemia with TP53 alterations.2019

    • Author(s)
      Yusuke Hara,Tomohiko Taki,Genki Yamato,Kenichi Yoshida,Norio Shiba,Taeko Kaburagi,Yuichi Shiraishi,Kentaro Ohki,Machiko Kawamura,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Nobutaka Kiyokawa,Daisuke Tomizawa,Takashi Taga,Keizo Horibe,Satoru Miyano,Seishi Ogawa,Souichi Adachi,Yasuhide Hayashi
    • Organizer
      第61回日本小児血液・がん学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] CDK4/6 and autophagy inhibitors synergistically induce apoptosis in t(8;21) AML cells.2019

    • Author(s)
      Kana Nakatani,Hidemasa Matsuo,Yuki Morimoto,Yasuhiko Kamikubo,Souichi Adachi
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Recurrent gene mutations in pediatric AML by targeted sequencing using a 343-gene custom panel.2019

    • Author(s)
      Taeko Kaburagi,Genki Yamato,Norio Shiba,Kenichi Yoshida,Yusuke Hara,Yuichi Shiraishi,Kentaro Ohki,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Tomohiko Taki,Nobutaka Kiyokawa,Daisuke Tomizawa,Keizo Horibe,Satoru Miyano,Souichi Adachi,Takashi Taga,Seishi Ogawa,Yasuhide Hayashi
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 小児MLL再構成急性骨髄性白血病(AML)の網羅的遺伝子解析による新規予後因子同定2019

    • Author(s)
      松尾英将,吉田健一,中谷香菜,上久保靖彦,小川誠司,足立壯一
    • Organizer
      第38回京都がん研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Pivotal role of DPYSL2A in KLF4-mediated monocytic differentiation of acute myeloid leukemia cells.2019

    • Author(s)
      能浦三奈,森田剣,清瀬大樹,立田俊也,松尾英将,上久保靖彦,足立壯一
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] KIT regulator "RUNX1" as a novel therapeutic target in human mast-cell diseases.2019

    • Author(s)
      増田達哉,片岡竜貴,立田俊也,松尾英将,杉山弘,足立壯一,上久保靖彦
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Targeting RUNX1-TRIM24/BCL11A axis through CROX (Cluster Regulation of RUNX) as a therapeutic strategy for neuroblastoma.2019

    • Author(s)
      小林紫乃,佐々木亜沙美,沖中えり佳,武田佳那子,武田瑞穂,松尾英将,野口勇貴,杉山弘,足立壯一,上久保靖彦
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] The combinatorial Histone Acetyltransferases (HATs) inhibition as a novel therapeutic strategy for KRAS enhanced cancers.2019

    • Author(s)
      沖中えり佳,小林紫乃,武田瑞穂,佐々木亜沙美,武田佳那子,松尾英将,足立壯一,上久保靖彦
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] The importance of pan-RUNX and CROX (Cluster Regulation of RUNX) therapeutic approach for gastrointestinal cancers.2019

    • Author(s)
      武田瑞穂,沖中えり佳,小林紫乃,割石菜月,佐々木亜沙美,武田佳那子,松尾英将,杉山弘,足立壯一,上久保靖彦
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Apoptotic cell death induced by p300/CBPSurvivin regulation in triple negative breast cancer.2019

    • Author(s)
      割石菜月,田中直,川口展子,沖中えり佳,小林紫乃,佐々木亜沙美,武田瑞穂,武田佳那子,松尾英将,足立壯一,上久保靖彦
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Induction of cell death in Malignant rhabdoid tumor (MRT) cells through regulating RUNX-Survivin Axis.2019

    • Author(s)
      三上真充,沖中えり佳,大封智雄,金谷卓弥,小林紫乃,服部悦子,松井恭澄,松尾英将,杉山弘,足立壯一,上久保靖彦
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Identification of RUNX1-NFATc2 axis as a novel target for overcoming drug-resistant APL.2019

    • Author(s)
      立田俊也,古市華菜,増田達哉,窪田博仁,岩井篤,三上真充,服部悦子,松尾英将,杉山弘,足立壯一,上久保靖彦
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Induction of autophagy by CDK4/6 inhibition in t(8;21) acute myeloid leukemia cells.2019

    • Author(s)
      中谷香菜,松尾英将,上久保靖彦,足立壯一
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 「疑似髄液」による細胞数算定検査の学内実習の試み2019

    • Author(s)
      徳野治,松尾英将,上久保靖彦,藤井康友,足立壯一,杉本直三
    • Organizer
      第14回日本臨床検査学教育学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ddPCRを用いた小児APLの微小残存病変の解析:AML-P17付随研究2019

    • Author(s)
      松尾英将,湯坐有希,高橋浩之,富澤大輔,多賀崇,足立壯一
    • Organizer
      2019年度第1回JCCG血液腫瘍分科会(JPLSG)全体会議・合同班会議
    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi