Development of diagnostic software using perfusion imaging for post-stroke epilepsy
Project/Area Number |
19K16888
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 51010:Basic brain sciences-related
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
Fukuma Kazuki 国立研究開発法人国立循環器病研究センター, 病院, 医師 (20820674)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 脳卒中 / てんかん / SPECT / 脳卒中後てんかん / 灌流画像 / 脳波 |
Outline of Research at the Start |
先行研究で構築した脳卒中後てんかんレジストリのデータを解析し、①脳波判読アシスト機能のある灌流画像診断ソフト、②人工知能(AI)を用いて脳卒中病巣・脳波・灌流画像の情報から脳卒中後てんかんの診断・重症度・再発リスクを自動解析する診断・予後評価ソフトを開発し、てんかん診療に携わる医師が,専門性によらず、広く臨床現場で活用でき、治療に直結する診療支援ツールの構築を目指す。
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Outline of Final Research Achievements |
We have developed an imaging diagnostic method for detecting hyperperfusion using postictal single-photon emission computed tomography in patients with poststroke epilepsy. We also investigated clinical features of nonmotor onset seizures in poststroke epilepsy. The nonmotor onset seizure type accounted for 43% of PSE cases, and 67% of patients had no subsequent convulsions. Poststroke hemiparesis, frontal lobe, and putaminal stroke lesions were negative indicators of non-MOS. Postictal single-photon emission computed tomography revealed hyperperfusion in the temporal lobe more frequently in the non-motor onset seizure group than in the motor onset seizure group.
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Academic Significance and Societal Importance of the Research Achievements |
脳卒中後てんかんにおいて、発作後遷延性過灌流がみられることを初めて明らかにし、その画像診断法を開発した。脳卒中後てんかんは、けいれんやてんかん性脳波異常波を認めない場合には、診断が困難となる。非運動起始発作を呈する患者において、発作後過灌流が高率に検出されることが明らかとなり、補助診断としての灌流画像の有用性が期待される。
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Report
(5 results)
Research Products
(28 results)
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[Journal Article] Association of Cortical Superficial Siderosis with Post-Stroke Epilepsy2022
Author(s)
Tomotaka Tanaka, Kazuki Fukuma, Soichiro Abe, Soichiro Matsubara, Shuhei Ikeda, Naruhiko Kamogawa, Hiroyuki Ishiyama, Satoshi Hosoki, Katsuya Kobayashi, Akihiro Shimiotake, Yuriko Nakaoku, Soshiro Ogata, Kunihiro Nishimura, Masatoshi Koga, Kazunori Toyoda, Riki Matsumoto, Ryosuke Takahashi, Akio Ikeda, Masafumi Ihara
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Journal Title
Annals of Neurology
Volume: Online ahead of print
Issue: 2
Pages: 357-370
DOI
Related Report
Peer Reviewed
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[Journal Article] Developing an Asymmetry Method for Detecting Postictal Hyperperfusion in Poststroke Epilepsy2022
Author(s)
Kazuki Fukuma, Tomotaka Tanaka, Shigetoshi Takaya, Maya Tojima, Katsuya Kobayashi, Akihiro Shimotake, Yoshiaki Morita, Kunihiro Nishimura, Masatoshi Koga, Kazunori Toyoda, Riki Matsumoto, Ryosuke Takahashi, Akio Ikeda, Masafumi Ihara
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Journal Title
Frontiers of neurology
Volume: eCollection
Pages: 877386-877386
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical and imaging features of nonmotor onset seizure in poststroke epilepsy2022
Author(s)
Kazuki Fukuma, Shunhei Ikeda, Tomotaka Tanaka, Naruhiko Kamogawa, Hiroyuki Ishiyama, Soichiro Abe, Maya Tojima, Katsuya Kobayashi, Akihiro Shimotake, Yuriko Nakaoku, Kunihiro Nishimura, Masatoshi Koga, Kazunori Toyoda, Riki Matsumoto, Akio Ikeda, Masafumi Ihara
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Journal Title
Epilepsia
Volume: 63
Issue: 8
Pages: 2068-2080
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical and imaging features of nonmotor onset seizure in poststroke epilepsy.2022
Author(s)
Fukuma K (corresponding author), Ikeda S, Tanaka T, Kamogawa N, Ishiyama H, Abe S, Tojima M, Kobayashi K, Shimotake A, Nakaoku Y, Nishimura K, Koga M, Toyoda K, Matsumoto R, Ikeda A, Ihara M.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Developing an asymmetry method for detecting postictal hyperperfusion in poststroke epilepsy.2022
Author(s)
Fukuma K (corresponding author), Tanaka T, Takaya S, Tojima M, Kobayashi K, Shimotake A, Morita Y, Nishimura K, Koga M, Toyoda K, Matsumoto R, Takahashi R, Ikeda A, Ihara M.
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Journal Title
Frontiers in Neurology
Volume: -
Related Report
Peer Reviewed / Open Access
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[Presentation] 非運動起始発作を呈する脳卒中後てんかん患者の臨床的および画像的特徴2022
Author(s)
福間一樹, 池田宗平, 田中智貴, 鴨川徳彦, 石山浩之, 阿部宗一郎, 戸島摩耶, 小林勝哉, 下竹昭寛, 西村邦宏, 古賀政利, 豊田一則, 松本理器, 池田昭夫, 猪原匡史
Organizer
第55回日本てんかん学会学術集会
Related Report
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[Presentation] 周期性放電を認めた脳卒中後てんかんの臨床転帰に関連する脳波の特異的特徴2020
Author(s)
戸島麻耶, 福間一樹, 田中智貴, 梶川駿介, 鴨川徳彦, 池田宗平, 小林勝哉, 下竹昭寛, 宇佐美清英, 松橋眞生, 高橋良輔, 池田昭夫, 猪原匡史
Organizer
第61回日本神経学会学術大会
Related Report
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[Presentation] PROgnosisof POstStroke Epilepsy (PROPOSE) study -baseline data2019
Author(s)
Fukuma K, Tanaka T, Nishimura K, Motoyama R, Matsubara S, Mizobuchi M, Yoshimura H, Matsuki T, Manabe Y, Suzuki J, Ikeda A, Koga M, Toyoda K, Ihara M,and PROPOSE Study Investigators
Organizer
33rd International Epilepsy Congress
Related Report
Int'l Joint Research
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