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Exploration of tDCS-based ADHD treatment

Research Project

Project/Area Number 19K17016
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52020:Neurology-related
Research InstitutionJichi Medical University

Principal Investigator

Monden Yukifumi  自治医科大学, 医学部, 准教授 (80382951)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords光トポグラフィー / fNIRS / ADHD / 抗精神病薬 / 神経発達症 / 脳機能イメージング / トラウマ治療 / PCIT / ASD / 薬効応答 / tDCS
Outline of Research at the Start

小児神経発達症の代表疾患である注意欠如多動症(ADHD)の既存治療に難治な症例の症状を改善させる全く新しい治療法の開発を目的とする。そのために、磁気刺激を用いた介入治療を行う。脳機能のリアルタイムに観察できるfNIRS(光トポグラフィー)を用いてtDCS刺激中に変化する脳機能を可視化する。正常な脳機能変化が生ずるために必要なtDCS刺激をfNIRS計測を行いながら検証する。

Outline of Final Research Achievements

The initial background of the research was to investigate the specific brain impairments related to ADHD and verify the effectiveness of external magnetic stimulation in improving ADHD symptoms. However, it became evident at the beginning of the study that patients with ADHD combined with ASD (Autism Spectrum Disorder) had different brain impairments compared to cases of ADHD alone. This prompted further exploration and comparison of the brain functioning between both conditions. ASD is known to coexist in 30-60% of individuals with ADHD, but the impact of ASD on the pathophysiology of ADHD remains unclear. In this study, using AI, we focused on brain activation and cognitive task performance to accurately identify each condition with a high probability. In the future, we plan to intervene with magnetic stimulation therapy for specific lesions associated with both disorders

Academic Significance and Societal Importance of the Research Achievements

本研究では認知課題成績と脳機能変化を数値化してAIアプローチを活用しADHDの病態解明に挑んだ。同様に機械学習アプローチを活用した神経疾患の分類に焦点を当てたfNIRS研究は数件しかない。例えば、アルツハイマー病1)、外傷性脳損傷2)、うつ病3)等である。薬物治療前後の反応性に着目して病態検証し、さらに AIに基づく分類をした報告はまれである。本結果は、2022年日本ADHD学会において最優秀口演賞を頂いた。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (33 results)

All 2023 2022 2021 2020 2019 Other

All Journal Article (17 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 17 results,  Open Access: 14 results) Presentation (12 results) (of which Invited: 5 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] A TUBB4A Met363Thr variant in pediatric hypomyelination without atrophy of the basal ganglia2022

    • Author(s)
      Hashiguchi Marina、Monden Yukifumi、Nozaki Yasuyuki、Watanabe Kazuki、Nakashima Mitsuko、Saitsu Hirotomo、Yamagata Takanori、Osaka Hitoshi
    • Journal Title

      Human Genome Variation

      Volume: 9 Issue: 1 Pages: 19-19

    • DOI

      10.1038/s41439-022-00198-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic factors, psychomotor development and life of trisomy 13?patients2022

    • Author(s)
      Yamagishi Hirokazu、Osaka Hitoshi、Monden Yukifumi、Kono Yumi
    • Journal Title

      Pediatrics International

      Volume: 64 Issue: 1

    • DOI

      10.1111/ped.15369

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Establishing norms on the Japanese version of the Eyberg Child Behavior Inventory2022

    • Author(s)
      Ito Fumie、Matano Miyuki、Kato Ikuko、Monden Yukifumi、Sunohara Yuki、Kawasaki Masako、Kimura Hitoe、Furuichi Shima、Bussing Regina、Oe Yuka、Morita Nobuaki、Kim Yoshiharu、Brestan‐Knight Elizabeth、Eyberg Sheila、Kamo Toshiko
    • Journal Title

      Pediatrics International

      Volume: 64 Issue: 1

    • DOI

      10.1111/ped.14910

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Developmental changes of the neural mechanisms underlying level 2 visual perspective‐taking: A functional near‐infrared spectroscopy study2022

    • Author(s)
      Hirai Masahiro、Sakurada Takeshi、Ikeda Takahiro、Monden Yukifumi、Shimoizumi Hideo、Yamagata Takanori
    • Journal Title

      Developmental Psychobiology

      Volume: 64 Issue: 1 Pages: 1-20

    • DOI

      10.1002/dev.22229

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential of internet‐delivered PCIT for ASD in the COVID‐19 era: A pilot study2021

    • Author(s)
      Matano Miyuki、Monden Yukifumi、Kurane Koyuru、Kawasaki Masako、Kamo Toshiko
    • Journal Title

      Pediatrics International

      Volume: 64 Issue: 1 Pages: 1-20

    • DOI

      10.1111/ped.14699

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Greater reliance on proprioceptive information during a reaching task with perspective manipulation among children with autism spectrum disorders2021

    • Author(s)
      Hirai Masahiro、Sakurada Takeshi、Izawa Jun、Ikeda Takahiro、Monden Yukifumi、Shimoizumi Hideo、Yamagata Takanori
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 15974-15974

    • DOI

      10.1038/s41598-021-95349-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualizing Neuropharmacological Effects of Guanfacine Extended Release in Attention Deficit Hyperactivity Disorder Using Functional Near-Infrared Spectroscopy2021

    • Author(s)
      Takahiro Ikeda, Akari Inoue, Daisuke Tanaka, Tamao Hashimoto, Stephanie Sutoko, Tatsuya Tokuda, Yasushi Kyutoku, Atsushi Maki,Takanori Yamagata, Ippeita Dan, Yukifumi Monden
    • Journal Title

      Frontiers in Neuroergonomics

      Volume: 20 Pages: 1-21

    • DOI

      10.3389/fnrgo.2021.657657

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Japanese Version of the Eyberg Child Behavior Inventory: Translation and Validation2021

    • Author(s)
      Kamo Toshiko、Ito Fumie、Monden Yukifumi、Bussing Regina、Niwa Madoka、Kawasaki Masako、Matano Miyuki、Ujiie Yuri、Higaki Yuko、Oe Yuka、Morita Nobuaki、Kim Yoshiharu、Knight Elizabeth Brestan、Eyberg Sheila
    • Journal Title

      Japanese Psychological Research

      Volume: 1 Issue: 2 Pages: 1-20

    • DOI

      10.1111/jpr.12365

    • NAID

      210000183426

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Japanese version of the Eyberg Child Behavior Inventory: Translation and Validation.2021

    • Author(s)
      Kamo T, Ito F, Monden Y, Bussing R, Niwa M, Kawasaki M, Matano M, Ujiie Y, Higaki Y, Oe Y, Morita N, Kim Y, Elizabeth Knight B E, Eyberg S
    • Journal Title

      Japanese Psychological Research

      Volume: Accepted

    • NAID

      210000183426

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Potential of Internet-delivered PCIT for ASD in the COVID-19 era: A pilot study.2021

    • Author(s)
      Matano M, Monden Y※, Kurane K, KawasakiM, Kamo T.
    • Journal Title

      Pediatric International

      Volume: Accepted

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Atypical dynamic-connectivity recruitment in attention-deficit/hyperactivity disorder children: An insight into task-based dynamic connectivity through an fNIRS study Journal2020

    • Author(s)
      Sutoko S, Monden Y, Tokuda T, Ikeda T, Nagashima M, Funane T, Atsumori H, Kiguchi M, Maki A, Yamagata T, Dan I
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 31 Pages: 1-15

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does Culture Shape Face Perception in Autism? Cross-cultural Evidence of the Own-Race Advantage From the UK and Japan2020

    • Author(s)
      Hanley, M., Riby, DM., Derges, MJ, Douligeri, A., Philyaw, Z., Ikeda, T., Monden, Y., Shimoizumi, H., Yamagata, T., Hirai, M.
    • Journal Title

      Developmental Science

      Volume: 25 Issue: 5 Pages: 1-20

    • DOI

      10.1111/desc.12942

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Atypical Dynamic-Connectivity Recruitment in Attention-Deficit/Hyperactivity Disorder Children: An Insight Into Task-Based Dynamic Connectivity Through an fNIRS Study2020

    • Author(s)
      Sutoko Stephanie、Monden Yukifumi、Tokuda Tatsuya、Ikeda Takahiro、Nagashima Masako、Funane Tsukasa、Atsumori Hirokazu、Kiguchi Masashi、Maki Atsushi、Yamagata Takanori、Dan Ippeita
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 14 Pages: 10-15

    • DOI

      10.3389/fnhum.2020.00003

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does culture shape face perception in autism? Cross‐cultural evidence of the own‐race advantage from the UK and Japan2020

    • Author(s)
      Hanley, M., Riby, DM.*., Derges, M-J., Douligeri, A., Philyaw, Z., Ikeda, T., Monden, Y., Shimoizumi, H., Yamagata, T.,Hirai, M
    • Journal Title

      Developmental Science

      Volume: 5 Pages: 10-15

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum and cerebrospinal fluid cytokines in children with acute encephalopathy2020

    • Author(s)
      Kawahara Yuta、Morimoto Akira、Oh Yukiko、Furukawa Rieko、Wakabayashi Kei、Monden Yukifumi、Osaka Hitoshi、Yamagata Takanori
    • Journal Title

      Brain and Development

      Volume: 42 Issue: 2 Pages: 185-191

    • DOI

      10.1016/j.braindev.2019.11.002

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct methylphenidate-evoked response measured using functional near-infrared spectroscopy during Go/No-Go Task as a supporting differential diagnostic tool between attention-deficit/hyperactivity disorder and autism spectrum disorder comorbid children.2019

    • Author(s)
      Sutoko S, Monden Y, Tokuda T, Ikeda T, Nagashima M, Kiguchi M, Maki A, Yamagata T, Dan I
    • Journal Title

      Front Hum Neurosci.

      Volume: 13-7 Pages: 1-13

    • DOI

      10.3389/fnhum.2019.00007

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exploring attentive task-based connectivity for screening attention deficit/hyperactivity disorder children: a functional near-infrared spectroscopy study2019

    • Author(s)
      Sutoko Stephanie、Monden Yukifumi、Tokuda Tatsuya、Ikeda Takahiro、Nagashima Masako、Funane Tsukasa、Sato Hiroki、Kiguchi Masashi、Maki Atsushi、Yamagata Takanori、Dan Ippeita
    • Journal Title

      Neurophotonics

      Volume: 6 Issue: 04 Pages: 1-1

    • DOI

      10.1117/1.nph.6.4.045013

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ADHDの脳機能研究 up to date2023

    • Author(s)
      門田 行史
    • Organizer
      日本ADHD学会 第14回総会特別講演
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] ADHD児におけるメチルフェニデート服用終了後の脳活動について探索的研究2023

    • Author(s)
      林 念念, 田中 日花里, 大島 沙織, 倉根 超, 檀 一平太, 門田 行史
    • Organizer
      日本ADHD学会 第14回総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 光トポグラフィー検査を用いたAD/HDに対するグアンファシン(GXR)の脳機能学的薬理作用の可視化2021

    • Author(s)
      池田尚広、門田行史、井上あかり、Stephanie Sutoko、徳田竜也、橋本珠緒、田中大輔、牧敦、山形崇倫、檀一平太
    • Organizer
      第63回日本小児神経学会学術集会 優秀口演賞
    • Related Report
      2021 Research-status Report
  • [Presentation] Potential of practical Internet-delivered Parent-child Interaction Therapy in the COVID-19 era2021

    • Author(s)
      俣野美雪、倉根超、山形崇倫、門田行史
    • Organizer
      第63回日本小児神経学会 優秀English session賞
    • Related Report
      2021 Research-status Report
  • [Presentation] 機械学習を用いたASD併存/非併存のADHD児の判別2021

    • Author(s)
      檀一平太、池田尚広、川田雅子、門田行史
    • Organizer
      優秀発表賞 日本ADHD学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 光トポグラフィー検査を用いた AD/HDに対するグアンファシン(GXR)の脳機能学的薬理作用の可視化2021

    • Author(s)
      池田尚広, 門田行史, 井上あかり, Stephanie Sutoko, 徳田竜也, 橋本珠緒, 田中大輔, 牧敦 , 山形崇倫 , 檀一平太
    • Organizer
      第63回日本小児神経学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] With コロナ時代の挑戦 -親子相互交流療法(PCIT)の実践-2020

    • Author(s)
      門田行史(座長・企画者)
    • Organizer
      日本赤ちゃん学会第20回学術学会 ラウンドテーブル3
    • Related Report
      2020 Research-status Report
  • [Presentation] 「脳科学に学ぶ発達障がい」~子どもの成長を見つめて~2020

    • Author(s)
      門田行史
    • Organizer
      栃木県下野市 保健福祉センターきらら館こばと園主催 発達障がい講演会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 発達障がい×脳機能2020

    • Author(s)
      門田行史
    • Organizer
      宇都宮市子ども発達センター主催「発達障がい×脳機能」
    • Related Report
      2020 Research-status Report
  • [Presentation] NIRSを用いた小児発達障がい研究-疾病理解や治療効果判定ツールの確率を目指して2019

    • Author(s)
      門田行史
    • Organizer
      第49回日本臨床神経生理学会学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 光トポグラフィーを用いた治療前後の脳機能変化からみる病態可視化・疾病理解2019

    • Author(s)
      門田行史
    • Organizer
      日本心理学会第83回大会 日立製作所シンポジウム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 発達障害の診療と対応~かかりつけ医に期待する家族支援と地域連携~2019

    • Author(s)
      門田行史
    • Organizer
      令和元年栃木県かかりつけ医等発達障害対応向上研修
    • Related Report
      2019 Research-status Report
    • Invited
  • [Book] 第17版 今日の小児科治療指針2020

    • Author(s)
      門田行史(分担執筆)
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2020 Research-status Report
  • [Remarks] 門田研究室 Mon-lab

    • URL

      http://mon-lab.weblike.jp/

    • Related Report
      2020 Research-status Report
  • [Remarks] 門田研究室

    • URL

      http://ped-brain-lab.xii.jp/wp/

    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 脳機能指標演算装置および脳機能指標演算方法2019

    • Inventor(s)
      佐藤大樹, 牧敦, 門田行史, など
    • Industrial Property Rights Holder
      佐藤大樹, 牧敦, 門田行史, など
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2020
    • Related Report
      2020 Research-status Report
    • Overseas

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Published: 2019-04-18   Modified: 2024-01-30  

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