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nvestigation of novel diagnostic criteria for schizophrenia using next-generation diffusion MRI and machine learning

Research Project

Project/Area Number 19K17061
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionKyoto University

Principal Investigator

Son Shuraku  京都大学, 医学研究科, 研究員 (60771524)

Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords統合失調症 / カルボニルストレス / MRI
Outline of Research at the Start

一部の治療抵抗性/重症統合失調症患者において、ペントシジンが増加しピリドキサールが低下する、所謂「カルボニルストレス」が病態に関与するという日本独自の新しい知見が報告されている。本研究では、統合失調症と診断される患者のうちカルボニルストレス亢進が関連する一群を、次世代拡散MRI解析および機械学習を用いて同定し、カルボニルストレスと脳構造的・機能的結合性の異常、精神症状との関連を明らかにすることを目的とする。具体的には、 a) カルボニルストレス関連マーカーの血中濃度測定を行い、b) 次世代拡散MRI、心理検査との関連を調査し、c) 機械学習を用いてカルボニルストレス亢進群の分離を試みる。

Outline of Final Research Achievements

We investigated the association between carbonyl stress markers and brain structural imaging markers in schizophrenia. As a result, it was found that enhanced carbonyl stress in the schizophrenia group was associated with decreased white matter integrity. These findings were accepted for publication in the journal Schizophrenia Research. Also, insights were gained into the association between increased carbonyl stress and decreased white matter integrity in the schizophrenia group, with a decrease in neuronal density being implicated. This research outcome was accepted for publication in Scientific Reports.
Additionally, we analyzed the relationship between plasma homocysteine levels and the microstructural features of cerebral white matter. It was found that plasma homocysteine levels are associated with microstructural abnormalities in cerebral white matter in schizophrenia patients. This research result has been accepted for publication in the journal Schizophrenia.

Academic Significance and Societal Importance of the Research Achievements

今回、我々は統合失調症におけるカルボニルストレスの亢進、およびホモシステインの亢進が大脳白質構造の異常と関連することを報告した。本研究でその神経学的微細構造変化を明らかにすることにより、これらの代謝異常が統合失調症群における脳構造変化に関連した新たな交絡因子と考えられる可能性が示された。また、治療抵抗性統合失調症及び精神病発症危険状態に対し、カルボニルストレス軽減目的としてビタミンB6を補充することや、ホモシスチン軽減目的でベタインを投与することなど、新規治療・介入法の開発につながることが予想され、統合失調症研究・臨床治療現場に対する学術的意義、社会的意義は大きいと考えられる。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (14 results)

All 2024 2023 2022 2020 2019

All Journal Article (10 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 9 results,  Open Access: 9 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Association of homocysteine with white matter dysconnectivity in schizophrenia2024

    • Author(s)
      Tabata Koichi、Son Shuraku、Miyata Jun、Toriumi Kazuya、Miyashita Mitsuhiro、Suzuki Kazuhiro、Itokawa Masanari、Takahashi Hidehiko、Murai Toshiya、Arai Makoto
    • Journal Title

      Schizophrenia

      Volume: 10 Issue: 1 Pages: 39-39

    • DOI

      10.1038/s41537-024-00458-0

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between enhanced carbonyl stress and decreased apparent axonal density in schizophrenia by multimodal white matter imaging2023

    • Author(s)
      Son Shuraku、Arai Makoto、Toriumi Kazuya、Andica Christina、Matsuyoshi Daisuke、Kamagata Koji、Aoki Shigeki、Kawashima Takahiko、Kochiyama Takanori、Okada Tomohisa、Fushimi Yasutaka、Nakamoto Yuji、Kobayashi Yuko、Murai Toshiya、Itokawa Masanari、Miyata Jun
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 12220-12220

    • DOI

      10.1038/s41598-023-39379-w

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disorganization of semantic brain networks in schizophrenia revealed by fMRI.2023

    • Author(s)
      Matsumoto Y, Nishida S, Hayashi R, Son S, Murakami A, Yoshikawa N, Ito H, Oishi N, Masuda N, Murai T, Friston K, Nishimoto S, *Takahashi H.
    • Journal Title

      Schizophrenia Bulletin.

      Volume: 49 Issue: 2 Pages: 498-506

    • DOI

      10.1093/schbul/sbac157

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular diagnosis of 405 individuals with autism spectrum disorder2023

    • Author(s)
      Miyake Noriko、Tsurusaki Yoshinori、Fukai Ryoko、Kushima Itaru...Takata Atsushi、Mizuguchi Takeshi、Ozaki Norio、Matsumoto Naomichi
    • Journal Title

      European Journal of Human Genetics

      Volume: 27-Mar Issue: 12 Pages: 1-8

    • DOI

      10.1038/s41431-023-01335-7

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cross-disorder analysis of genetic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder2022

    • Author(s)
      Kushima Itaru、Nakatochi Masahiro、Aleksic Branko、Okada Takashi、(中略)、Ozaki Norio
    • Journal Title

      Biological Psychiatry

      Volume: - Issue: 5 Pages: 362-374

    • DOI

      10.1016/j.biopsych.2022.04.003

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cortical changes in patients with schizophrenia across two ethnic backgrounds2022

    • Author(s)
      Langenbach Benedikt P.、Kohl Waldemar、Murai Toshiya、Suslow Thomas、Ohrmann Patricia、Bauer Jochen、Matsukawa Noriko、Son Shuraku、Pedersen Anya、Lichtenstein Theresa、Miyata Jun、Koelkebeck Katja
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 10810-10810

    • DOI

      10.1038/s41598-022-14914-3

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced Carbonyl Stress and Disrupted White Matter Integrity in Schizophrenia.2020

    • Author(s)
      Son S, Arai M, Toriumi K, Mizuta H, Miyata J, Hayashi T, Aso T, Itokawa M, Murai T.
    • Journal Title

      Schizophr Res

      Volume: 223 Pages: 242-248

    • DOI

      10.1016/j.schres.2020.08.007

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-PDHA1 antibody is detected in a subset of patients with schizophrenia2020

    • Author(s)
      Yukako Nakagami, Genichi Sugihara, Nakashima N, Hazama M, Son S, Ma S, Riki Matsumoto, Murai T, Akio Ikeda, Murakami K
    • Journal Title

      Scientific Reports

      Volume: - Issue: 1 Pages: 7906-7906

    • DOI

      10.1038/s41598-020-63776-0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced intra- and inter-individual diversity of semantic representations in the brains of schizophrenia patients2020

    • Author(s)
      Satoshi Nishida, Yukiko Matsumoto, Naganobu Yoshikawa, Shuraku Son, Akio Murakami, Ryusuke Hayashi, Shinji Nishimoto, Hidehiko Takahashi
    • Journal Title

      bioRxiv 2020

      Volume: 2020 Pages: 1-41

    • DOI

      10.1101/2020.06.03.132928

    • Related Report
      2020 Research-status Report
    • Open Access
  • [Journal Article] Gray matter volume reductions in patients with schizophrenia: A replication study across two cultural backgrounds2019

    • Author(s)
      Koelkebeck Katja、Dannlowski Udo、Ohrmann Patricia、Suslow Thomas、Murai Toshiya、Bauer Jochen、Pedersen Anya、Matsukawa Noriko、Son Shuraku、Haidl Theresa、Miyata Jun
    • Journal Title

      Psychiatry Research: Neuroimaging

      Volume: 292 Pages: 32-40

    • DOI

      10.1016/j.pscychresns.2019.08.008

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] シンポジウム34 脳を見る:統合失調症研究の新展開2023

    • Author(s)
      入谷 修司、孫 樹洛、水谷 隆太、石田 裕昭、村井 俊哉、尾崎 紀夫、糸川 昌成
    • Organizer
      第119回日本精神神経学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 統合失調症におけるカルボニルストレスの亢進と白質構造変化について2020

    • Author(s)
      孫樹洛
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会(NPBPPP2020合同年会)
    • Related Report
      2020 Research-status Report
  • [Presentation] Creativity and Positive Symptoms Revisited:Structural Connectivity Analysis with Diffusion Tensor Imaging2019

    • Author(s)
      Shuraku Son
    • Organizer
      World Congress of Societies of Biological Psychiatry 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Association between Creativity and Positive Symptoms Revealed by Structural Connectivity Analysis2019

    • Author(s)
      Shuraku Son
    • Organizer
      第41回日本生物学的精神医学会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2025-01-30  

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