• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The development of differential diagnosis method of depressive states by near-infrared spectroscopy using decision making paradigm

Research Project

Project/Area Number 19K17063
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionYamaguchi University

Principal Investigator

Chen Chong  山口大学, 大学院医学系研究科, 助教 (70783067)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords抑うつ状態 / 鑑別診断 / 意思決定 / 報酬 / 計算論的精神医学 / 脳画像 / うつ状態 / 情動認知 / 認知神経科学 / うつ病 / 双極性障害 / 統合失調症 / NIRS
Outline of Research at the Start

光トポグラフィー(NIRS)検査は2014年に「抑うつ状態の鑑別診断の補助」として初めて保険適用となった。語流暢性課題(VFT)を用いてNIRSで測定される脳血流変化がうつ病、双極性障害、統合失調症で異なることを鑑別に用いている。この事は精神医学におけるバイオマーカーによる補助診断を前進させたが、VFTは三疾患で共通する認知機能低下を測定するものであり、それぞれ特徴的な病態と直接関与していないため、鑑別精度が低い。本研究は、報酬に基づいた意思決定のパラダイムを用いて、三疾患それぞれの特徴的な病態を捉える課題を作成・評価することで、より感度・特異度の高いNIRS検査法を開発することを目的とする。

Outline of Final Research Achievements

Near infrared spectroscopy conducted with Verbal Fluency Test (VFT) has been employed as an auxiliary laboratory test for the differential diagnosis of depressive states in the Japanese health insurance, based on the observation that patients with major depressive disorder, bipolar disorder, and schizophrenia show different prefrontal activities during VFT. However, VFT evaluates cognitive functions, which is irrelevant to the central psychopathology of the three disorders. To increase the accuracy of the differential diagnosis of depressive states, we focused on the paradigm of reward-based decision-making, given that altered reward and motivational processing has been proposed to be the central psychopathology of the disorders. Specifically, we developed and validated a battery of experimental tasks that may be useful for the differential diagnosis of depressive states.

Academic Significance and Societal Importance of the Research Achievements

抑うつ状態を呈する精神疾患の鑑別は病初期など困難である場合が多い。双極性障害患者の60%は最初にうつ病と診断され、正確な診断に至るまで通常5-10年かかる。抗うつ薬使用が双極性障害の病状を悪化させる可能性があり、抑うつ状態の早期鑑別診断は適切な治療に極めて重要である。本研究は報酬に基づいた意思決定の実験パラダイムによる行動・脳画像研究の既報で得られた知見を活用し、現在保険診療の「抑うつ状態の鑑別診断の補助」より精度の高い鑑別診断法を開発するための実験課題を作成した。より早く正確に診断されれば、適切な治療や重症化予防が可能となり、患者にかかる身体・精神・経済的負担を最小限化することができる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (10 results)

All 2022 2021 2020

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Nonlinear Probability Weighting in Depression and Anxiety: Insights From Healthy Young Adults2022

    • Author(s)
      Hagiwara Kosuke、Mochizuki Yasuhiro、Chen Chong、Lei Huijie、Hirotsu Masako、Matsubara Toshio、Nakagawa Shin
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 810867-810867

    • DOI

      10.3389/fpsyt.2022.810867

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex difference in the weighting of expected uncertainty under chronic stress2021

    • Author(s)
      Lei Huijie、Mochizuki Yasuhiro、Chen Chong、Hagiwara Kosuke、Hirotsu Masako、Matsubara Toshio、Nakagawa Shin
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 8700-8700

    • DOI

      10.1038/s41598-021-88155-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Negative Association Between Positive Psychological Wellbeing and Loss Aversion2021

    • Author(s)
      Koan Ibuki、Nakagawa Takumi、Chen Chong、Matsubara Toshio、Lei Huijie、Hagiwara Kosuke、Hirotsu Masako、Yamagata Hirotaka、Nakagawa Shin
    • Journal Title

      Frontiers in Psychology

      Volume: 12 Pages: 641340-641340

    • DOI

      10.3389/fpsyg.2021.641340

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 情報処理理論からみたうつ病における認知障害 - Hot vs cold cognition -2020

    • Author(s)
      萩原康輔、陳冲、中川伸
    • Journal Title

      精神科

      Volume: 37

    • Related Report
      2019 Research-status Report
  • [Presentation] Assessment of risk aversion in depression and anxiety by computational modeling based on the Cumulative Prospect Theory2021

    • Author(s)
      Kosuke Hagiwara, Chong Chen, Huijie Lei, Masako Hirotsu, Toshio Matsubara, Shin Nakagawa
    • Organizer
      Society for Neuroscience
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] うつ・不安におけるリスク回避傾向の定量化:累積プロスペクト理論に基づく計算論的モデ ルベース解析を用いて2021

    • Author(s)
      萩原 康輔, 陳 冲, 雷 慧潔, 弘津 正子, 松原 敏郎, 中川 伸
    • Organizer
      第43回日本生物学的精神医学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Nonlinear probability weighting in depression: insights from healthy subjects2020

    • Author(s)
      Kosuke Hagiwara, Chong Chen, Huijie Lei, Ibuki Koan, Takumi Nakagawa, Masako Hirotsu, Hirotaka Yamagata, Toshio Matsubara, Shin Nakagawa
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 意思決定における非線形確率荷重傾向とうつ症状との関連性の検討2020

    • Author(s)
      萩原 康輔, 陳 冲, 雷 慧潔, 古庵 伊吹, 中川 拓海, 弘津 正子, 山形 弘隆, 松原 敏郎, 中川 伸
    • Organizer
      第42回日本生物学的精神医学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] うつ,不安,強化学習の関連における性差2020

    • Author(s)
      雷 慧潔, 陳 冲, 萩原 康輔, 中川 拓海, 古庵 伊吹, 弘津 正子, 山形 弘隆, 松原 敏郎, 中川 伸
    • Organizer
      第42回日本生物学的精神医学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Using Brain Activations During Cognitive and Emotional Tasks for the Differential Diagnosis of Depressive States: A Functional Near-Infrared Spectroscopy Study2020

    • Author(s)
      Toshio Matsubara, Chong Chen, Masako Hirotsu, Toshio Watanuki, Koji Matsuo, Yoshifumi Watanabe, Shin Nakagawa
    • Organizer
      75th Annual Meeting Society of Biological Psychiatry
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi