A multifaceted study on heterogeneity in attention-deficit/hyperactivity disorder
| Project/Area Number |
19K17068
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Nara Medical University |
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Principal Investigator |
Nakanishi Yoko 奈良県立医科大学, 医学部, 研究員 (80458025)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 近赤外線スペクトロスコピー / 注意欠如多動症 / 虐待 / ADHD / 逆境的小児期体験 / 精神神経科学 / 注意欠如・多動症 |
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| Outline of Research at the Start |
注意欠如・多動症（Attention Deficit Hyperactivity Disorder：ADHD）が神経発達症として認識されて久しいが、近年はその異質性が注目されている。また逆境的小児期体験（Adverse Childhood Experience : ACE）と成人後の精神障害の発症との関連が示唆されている。本研究は成人期ADHDにおいてACEへの暴露の有無による表現型や神経生物学的な中間表現型への影響を多面的に検討することである。本研究によりADHDの病態理解を深めると同時に、生物学的基盤の異質性に基づく適切な診断やテーラーメードな治療方法の確立を目指す。
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| Outline of Final Research Achievements |
he presence or absence of exposure to adversarial childhood experiences in ADHD was investigated; an ACE score of 0 was considered an ACE exposure - group, and an ACE score of 1 or greater was considered an ACE exposure + group. Background information, social functioning (LSAMI), ADHD symptom severity (CAARS), cognitive function (WISC-III, CAT), brain imaging (MRI), and neurophysiological testing (ERP, NIRS) were performed on all subjects.ASD with ADHD group 31 subjects, ASD without ADHD 43 and 41 Control subjects were recruited and analyzed. No significant differences were found in the analysis of neurophysiological tests among the three groups. No relationship between NIRS values and CATS or ACE, which are indicators of abuse, was also found.
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| Academic Significance and Societal Importance of the Research Achievements |
ADHDを虐待の有無によって細分化を試みたが明らかな結果を得ることができなかった。さまざまな精神疾患では虐待の有無によってその臨床症状や生物学的指標が異なることが報告されているが、ADHDではそのような結果にはならなかった。今後はさらに症例数を増やすこと、ASDを背景としてもっている患者を対象としていたので純粋なADHD患者を対象にする必要がある。少なくとも虐待は多くの精神疾患に影響を与えうるものであり、引き続き研究を継続する必要がある。
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] Delayed Prefrontal Hemodynamic Response Associated With Suicide Risk in Autism Spectrum Disorder2020
Author(s)
Ota T, Iida J, Okazaki K, Ishida R, Takahashi M, Okamura K, Yamamuro K, Kishimoto N, Kimoto S, Yasuda Y, Hashimoto R, Makinodan M, Kishimoto T.
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Journal Title
Psychiatry Res
Volume: 289
Pages: 112971-112971
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The efficacy prediction of methylphenidate using by event-related potentials in treatment-naïve adolescent and pediatric patients with Attention-Deficit Hyperactivity Disorder.2019
Author(s)
Okazaki K, Ota T, Iida J, Mizui R, Nagahama T, Azechi T, Matsuura H, Yamamuro K, Uratani M, Kishimoto N, and Kishimoto T.
Organizer
10th Congress of The Asian Society for Child and Adolescent Psychiatry and Allied Professions
Related Report
Int'l Joint Research
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[Presentation] Association between event-related potential components and intra-individual variability in children and adolescents with attention deficit hyperactivity disorder2019
Author(s)
Morimoto T, Yamamuro K, Kishimoto N, Morito H, Ueda J, Tanaka T, Harada I, Matsuda Y, Ota T, Iida J, Kishimoto T.
Organizer
APA (American Psychiatric Association 172th Annual Meeting)
Related Report
Int'l Joint Research
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