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Circadian rhythm sleep-wake disorder in outpatients with schizophrenia and its association with psychosocial functioning

Research Project

Project/Area Number 19K17098
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Matsui Kentaro  国立研究開発法人国立精神・神経医療研究センター, 病院 臨床検査部, 医長 (30647152)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords統合失調症 / 概日リズム睡眠・覚醒障害 / 有病率 / 精神病症状 / 社会機能障害 / 概日リズム睡眠覚醒障害 / 再発 / メラトニン
Outline of Research at the Start

統合失調症および統合失調感情障害(統合失調症スペクトラム障害)では、概日リズム睡眠覚醒障害(Circadian rhythm sleep-wake disorder:CRSWD)がしばしば併存すると考えられている。しかしCRSWDの併存率や、併存による社会機能の低下との関連は明らかではなく、また併存した場合の治療法も確立されていない。本研究では統合失調症スペクトラム障害患者におけるCRSWDの有病率調査を行い、CRSWDが社会機能に与える影響について検討する。さらにCRSWDが併存していた患者を対象に、高照度光療法を用いたランダム化クロスオーバー比較試験を行い、その治療効果について検討する。

Outline of Final Research Achievements

The prevalence of circadian rhythm sleep-wake disorder (CRSWD) among patients with schizophrenia was not clear. The effect of comorbid CRSWD on such patients has also not been fully evaluated yet. Of the 105 patients with schizophrenia, 19 (18.1%) had CRSWD. There were trends toward higher Brief Psychiatric Rating Scale (BPRS) and lower Global Assessment of Functioning (GAF) scores in the CRSWD group than in the non-CRSWD group, although these did not reach statistical significance following a false discovery rate correction. Among the BPRS subitems, the anxiety scores were significantly higher in the CRSWD group than in the non-CRSWD group (p < 0.01). Comorbidities of CRSWD may affect psychopathological characteristics and psychosocial functioning.

Academic Significance and Societal Importance of the Research Achievements

本研究は維持期の統合失調症患者における概日リズム睡眠・覚醒障害(CRSWD)の有病率や、精神病症状・社会機能との関係について調べた初めての研究であり、実臨床において極めて重要な情報を提供することができたと考えている。統合失調症に併存するCRSWDにより二次的に生じた不眠症状はしばしば見過ごされている可能性があり、適切な診断および介入が、患者の社会機能の向上に寄与する可能性がある。今後の研究でCRSWDの併存が統合失調症患者の長期予後に及ぼす影響について検証されることが望ましい。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (14 results)

All 2021 2020

All Journal Article (8 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (6 results) (of which Invited: 5 results)

  • [Journal Article] Psychological burden of attention-deficit/hyperactivity disorder traits on medical workers under the COVID-19 outbreak: a cross-sectional web-based questionnaire survey2021

    • Author(s)
      Matsui Kentaro、Yoshiike Takuya、Tsuru Ayumi、Otsuki Rei、Nagao Kentaro、Ayabe Naoko、Hazumi Megumi、Utsumi Tomohiro、Yamamoto Kentaro、Fukumizu Michio、Kuriyama Kenichi
    • Journal Title

      BMJ Open

      Volume: 11 Issue: 10 Pages: e053737-e053737

    • DOI

      10.1136/bmjopen-2021-053737

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Cross-Sectional Study of Evening Hyperphagia and Nocturnal Ingestion: Core Constituents of Night Eating Syndrome with Different Background Factors2021

    • Author(s)
      Matsui Kentaro、Komada Yoko、Okajima Isa、Takaesu Yoshikazu、Kuriyama Kenichi、Inoue Yuichi
    • Journal Title

      Nutrients

      Volume: 13 Issue: 11 Pages: 4179-4179

    • DOI

      10.3390/nu13114179

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Subjective Quality and Quantity of Sleep with Quality of Life among a General Population2021

    • Author(s)
      Matsui Kentaro、Yoshiike Takuya、Nagao Kentaro、Utsumi Tomohiro、Tsuru Ayumi、Otsuki Rei、Ayabe Naoko、Hazumi Megumi、Suzuki Masahiro、Saitoh Kaori、Aritake-Okada Sayaka、Inoue Yuichi、Kuriyama Kenichi
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 23 Pages: 12835-12835

    • DOI

      10.3390/ijerph182312835

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of Circadian Rhythm Sleep-Wake Disorder in Outpatients with Schizophrenia and Its Association with Psychopathological Characteristics and Psychosocial Functioning2021

    • Author(s)
      Matsui Kentaro、Inada Ken、Kuriyama Kenichi、Yoshiike Takuya、Nagao Kentaro、Oshibuchi Hidehiro、Akaho Rie、Nishimura Katsuji
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Issue: 7 Pages: 1513-1513

    • DOI

      10.3390/jcm10071513

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The efficacy of add-on ramelteon and subsequent dose reduction of benzodiazepine derivatives/Z-drugs for the treatment of sleep-related eating disorder and night eating syndrome: a retrospective analysis of consecutive cases2021

    • Author(s)
      Matsui Kentaro、Kuriyama Kenichi、Kobayashi Mina、Inada Ken、Nishimura Katsuji、Inoue Yuichi
    • Journal Title

      Journal of Clinical Sleep Medicine

      Volume: - Issue: 7 Pages: 1475-1483

    • DOI

      10.5664/jcsm.9236

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The effect of short or long sleep duration on quality of life and depression: an internet-based survey in Japan2020

    • Author(s)
      Matsui Kentaro、Kuriyama Kenichi、Yoshiike Takuya、Nagao Kentaro、Ayabe Naoko、Komada Yoko、Okajima Isa、Ito Wakako、Ishigooka Jun、Nishimura Katsuji、Inoue Yuichi
    • Journal Title

      Sleep Medicine

      Volume: 76 Pages: 80-85

    • DOI

      10.1016/j.sleep.2020.10.012

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clozapine‐induced agranulocytosis in Japan: Changes in leukocyte/neutrophil counts before and after discontinuation of clozapine2020

    • Author(s)
      Matsui Kentaro、Ishibashi Mikiko、Kawano Masahiko、Oshibuchi Hidehiro、Ishigooka Jun、Nishimura Katsuji、Inada Ken
    • Journal Title

      Human Psychopharmacology: Clinical and Experimental

      Volume: 35 Issue: 4

    • DOI

      10.1002/hup.2739

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prevalence and Associated Factors of Nocturnal Eating Behavior and Sleep-Related Eating Disorder-Like Behavior in Japanese Young Adults: Results of an Internet Survey Using Munich Parasomnia Screening2020

    • Author(s)
      Matsui Kentaro、Komada Yoko、Nishimura Katsuji、Kuriyama Kenichi、Inoue Yuichi
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 4 Pages: 1243-1243

    • DOI

      10.3390/jcm9041243

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 認知症に併存するレム睡眠行動障害の診断と治療を考える2021

    • Author(s)
      松井健太郎
    • Organizer
      日本精神神経学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] COVID-19の流行がわが国の医療関係者の心理的健康に与える影響2021

    • Author(s)
      松井健太郎、吉池卓也、都留あゆみ、大槻怜、長尾賢太朗、綾部直子、羽澄恵、内海智博、山元健太朗、福水道郎、栗山健一
    • Organizer
      日本精神神経学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] コロナ禍における医療従事者の睡眠とメンタルヘルス2021

    • Author(s)
      松井健太郎
    • Organizer
      日本睡眠学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 統合失調症における睡眠・生体リズム変化と治療戦略2021

    • Author(s)
      松井健太郎
    • Organizer
      日本睡眠学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 抗精神病薬の多剤併用について2021

    • Author(s)
      松井健太郎
    • Organizer
      日本臨床精神神経薬理学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] パンデミックと睡眠問題2021

    • Author(s)
      松井健太郎
    • Organizer
      日本時間生物学会
    • Related Report
      2021 Annual Research Report
    • Invited

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Published: 2019-04-18   Modified: 2023-01-30  

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