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The development of novel augmentation therapy in neurocognitive disorders- a blinded randomized controlled trial of tDCS

Research Project

Project/Area Number 19K17123
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Inagawa Takuma  国立研究開発法人国立精神・神経医療研究センター, 病院 精神診療部, 医師 (90773606)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsbrain stimulation / 経頭蓋直流電気刺激 / tDCS / 認知症 / 軽度認知障害 / 無作為化比較試験 / 認知機能 / Core-tDCS
Outline of Research at the Start

神経認知障害の認知機能に対する新たな介入手法の開発は、社会的にも緊急課題である。経頭蓋直流電気刺激は、神経認知障害の認知機能に対し、認知機能トレーニングの効果を増強する可能性が示唆され、効果検証には症例数設計・評価尺度や刺激手法の適正化が必要なことを明らかとした。本研究は、認知機能への経頭蓋直流電気刺激の増強効果を無作為化試験にて標準化されたバッテリーを用いて明らかにすることを目的とする。

Outline of Final Research Achievements

Active tDCS plus cognitive training groups showed no statistically significant effects on cognitive function (ADAS-Cog total score, RBANS total score, MMSE total score), depressive symptoms (GDS), and SF-36 total score changes from baseline immediately after stimulation and one month after stimulation compared with sham tDCS plus cognitive training. Although the sample size was small, no effect of tDCS on cognitive function was observed in dementia and mild cognitive impairment was observed

Academic Significance and Societal Importance of the Research Achievements

本研究は、軽度認知症および軽度認知障害の認知機能に対するtDCSの増強療法としての効果を検証する試験である。過去には、中等度、重度のアルツハイマー型認知症に対するtDCSの効果に乏しいことは報告されているが、軽度認知障害や、軽度のアルツハイマー型認知症においては、相反する結果が出ており、かつ、増強療法、複数セッションのtDCSの方が、効果を最大化できる可能性が言われていた。そのため、質の担保された研究デザインで、手法を改良して効果を検証する学術的意義は高いと考える。本研究では、症例数こそ少なかったが、tDCSの増強療法としての効果は限定的であることが示唆された。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (29 results)

All 2022 2021 2020 2019

All Journal Article (14 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 14 results,  Open Access: 10 results) Presentation (7 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results) Book (8 results)

  • [Journal Article] Attention?deficit/hyperactivity disorder symptoms, perceived stress, and suicidal ideation during the COVID-19 pandemic2022

    • Author(s)
      Stickley Andrew、Shirama Aya、Inagawa Takuma、Ruchkin Vladislav、Koposov Roman、Isaksson Johan、Inoue Yosuke、Sumiyoshi Tomiki
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13

    • DOI

      10.3389/fpsyt.2022.1008290

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between autistic traits and binge drinking: Findings from Japan2022

    • Author(s)
      Stickley Andrew、Shirama Aya、Kamio Yoko、Takahashi Hidetoshi、Inagawa Takuma、Saito Aya、Sumiyoshi Tomiki
    • Journal Title

      Social Psychiatry and Psychiatric Epidemiology

      Volume: 58 Issue: 2 Pages: 217-226

    • DOI

      10.1007/s00127-022-02299-7

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binge drinking in Japan during the COVID-19 pandemic: Prevalence, correlates and association with preventive behaviors2022

    • Author(s)
      Stickley Andrew、Shirama Aya、Inagawa Takuma、Sumiyoshi Tomiki
    • Journal Title

      Drug and Alcohol Dependence

      Volume: 234 Pages: 109415-109415

    • DOI

      10.1016/j.drugalcdep.2022.109415

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial Direct Current Stimulation on the Left Superior Temporal Sulcus Improves Social Cognition in Schizophrenia: An Open-Label Study2022

    • Author(s)
      Yamada Yuji、Sueyoshi Kazuki、Yokoi Yuma、Inagawa Takuma、Hirabayashi Naotsugu、Oi Hideki、Shirama Aya、Sumiyoshi Tomiki
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 1-10

    • DOI

      10.3389/fpsyt.2022.862814

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Binge drinking in Japan during the COVID-19 pandemic: Prevalence, correlates and association with preventive behaviors2022

    • Author(s)
      Andrew Stickley, Shirama Aya, Inagawa Takuma, Sumiyoshi Tomiki
    • Journal Title

      Drug Alcohol Dependence

      Volume: 21 Pages: 1-1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spinocerebellar ataxia type 6 presenting with hallucination2021

    • Author(s)
      Iwata Ryo、Inagawa Takuma、Noda Takamasa、Takahashi Yuji、Kito Shinsuke
    • Journal Title

      Psychogeriatrics

      Volume: 1 Issue: 3 Pages: 173-173

    • DOI

      10.1111/psyg.12669

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Emotion Recognition Deficits in Psychiatric Disorders as a Target of Non-invasive Neuromodulation: A Systematic Review2021

    • Author(s)
      Yamada Yuji、Inagawa Takuma、Hirabayashi Naotsugu、Sumiyoshi Tomiki
    • Journal Title

      Clinical EEG and Neuroscience

      Volume: Online ahead of print. Issue: 6 Pages: 1-1

    • DOI

      10.1177/1550059421991688

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and Safety of Multi-Session Transcranial Direct Current Stimulation on Social Cognition in Schizophrenia: A Study Protocol for an Open-Label, Single-Arm Trial2021

    • Author(s)
      Yamada Yuji、Inagawa Takuma、Yokoi Yuma、Shirama Aya、Sueyoshi Kazuki、Wada Ayumu、Hirabayashi Naotsugu、Oi Hideki、Sumiyoshi Tomiki
    • Journal Title

      Journal of Personalized Medicine

      Volume: 11 Issue: 4 Pages: 317-317

    • DOI

      10.3390/jpm11040317

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Facilitative Effects of Transcranial Direct Current Stimulation on Semantic Memory Examined by Text-Mining Analysis in Patients With Schizophrenia2021

    • Author(s)
      Sumiyoshi Chika、Narita Zui、Inagawa Takuma、Yamada Yuji、Sueyoshi Kazuki、Hasegawa Yumi、Shirama Aya、Hashimoto Ryota、Sumiyoshi Tomiki
    • Journal Title

      Frontiers in Neurology

      Volume: 12 Pages: 1-9

    • DOI

      10.3389/fneur.2021.583027

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of multi-session prefrontal transcranial direct current stimulation on cognition in schizophrenia: A systematic review and meta-analysis2020

    • Author(s)
      Narita Zui、Stickley Andrew、DeVylder Jordan、Yokoi Yuma、Inagawa Takuma、Yamada Yuji、Maruo Kazushi、Koyanagi Ai、Oh Hans、Sawa Akira、Sumiyoshi Tomiki
    • Journal Title

      Schizophrenia Research

      Volume: 216 Pages: 367-373

    • DOI

      10.1016/j.schres.2019.11.011

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Time estimation in a case of Tourette’s syndrome; Effect of antipsychotic medications2020

    • Author(s)
      T, Inagawa., N, Ueda., K, Nakagome., T, Sumiyoshi
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 00 Issue: 2 Pages: 1-3

    • DOI

      10.1002/npr2.12101

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antenatal psychological intervention for universal prevention of antenatal and postnatal depression: A systematic review and meta-analysis2020

    • Author(s)
      Yasuma Naonori、Narita Zui、Sasaki Natsu、Obikane Erika、Sekiya Junpei、Inagawa Takuma、Nakajima Aiichiro、Yamada Yuji、Yamazaki Ryuichi、Matsunaga Asami、Saito Tomomi、Watanabe Kazuhiro、Imamura Kotaro、Kawakami Norito、Nishi Daisuke
    • Journal Title

      Journal of Affective Disorders

      Volume: 273 Pages: 231-239

    • DOI

      10.1016/j.jad.2020.04.063

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Safety and Feasibility of Transcranial Direct Current Stimulation for Cognitive Rehabilitation in Patients With Mild or Major Neurocognitive Disorders: A Randomized Sham-Controlled Pilot Study.2019

    • Author(s)
      Takuma Inagawa, Yuma Yokoi, Zui Narita, Kazushi Maruo, Mitsutoshi Okazaki, Kazuyuki Nakagome
    • Journal Title

      Frontiers in human neuroscience

      Volume: 13 Pages: 273-273

    • DOI

      10.3389/fnhum.2019.00273

    • NAID

      120007127792

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Social Cognition Deficits as a Target of Early Intervention for Psychoses: A Systematic Review2019

    • Author(s)
      Yamada Yuji、Inagawa Takuma、Sueyoshi Kazuki、Sugawara Norio、Ueda Natsuki、Omachi Yoshie、Hirabayashi Naotsugu、Matsumoto Madoka、Sumiyoshi Tomiki
    • Journal Title

      Frontiers in Psychiatry

      Volume: 10

    • DOI

      10.3389/fpsyt.2019.00333

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 精神疾患を有するCOVID-19患者へのステロイドパルス療法の検討2021

    • Author(s)
      鵜沼 敦, 齊藤 勇二, 榎田 嵩子, 稲川 拓磨, 佐竹 直子, 野田 隆政, 有賀 元
    • Organizer
      国立病院総合医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 新型コロナウイルス感染症の急性期診療における「脳とこころ」と「からだ」の診療連携の重要性2021

    • Author(s)
      齊藤 勇二, 鵜沼 敦, 榎田 嵩子, 稲川 拓磨, 宇佐美 貴士, 佐竹 直子, 野田 隆政, 有賀 元
    • Organizer
      神経感染症学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Transcranial direct current stimulation in patients with dementia and mild cognitive impairment. Current knowledge and future perspectives.2021

    • Author(s)
      Yuma Yokoi, Takuma Inagawa, Yuji Yamada, Tomiki Sumiyosh
    • Organizer
      20th WPA (World Psychiatric Association) World Congress of Psychiatry
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Transcranial direct current stimulation to improve functional outcomes in schizophrenia2021

    • Author(s)
      Tomiki Sumiyoshi, Yuji Yamada, Takuma Inagawa, Aya Shirama, Kazuki Sueyoshi, Yumi Hasegawa, Ayumu Wada, Zui Narita, Yuma Yokoi
    • Organizer
      20th WPA (World Psychiatric Association) World Congress of Psychiatry
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Transcranial direct current stimulation to enhance specific domains of cognitive function in schizophrenia2021

    • Author(s)
      Yuji Yamada, Takuma Inagawa, Kazuki Sueyoshi, Ayumu Wada, Aya Shirama, Tomiki Sumiyoshi
    • Organizer
      20th WPA (World Psychiatric Association) World Congress of Psychiatry
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 国立精神・神経医療研究センターにおける経頭蓋直流電気刺激研究の進捗と展望2020

    • Author(s)
      山田悠至, 稲川拓磨, 成田瑞, 横井優磨, 住吉太幹
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 統合失調症の社会認知機能障害に対する経頭蓋直流電気刺激(tDCS)の効果と展望2020

    • Author(s)
      山田悠至, 稲川拓磨, 末吉一貴, 和田歩, 長谷川由美, 白間綾, 住吉太幹
    • Organizer
      第50回 日本臨床神経生理学会 学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Book] 臨床研究法なんて怖くない! 第9回 臨床研究法の改正に向けた見直しのポイント2022

    • Author(s)
      稲川拓磨、小居秀紀
    • Total Pages
      3
    • Publisher
      先端医学社
    • Related Report
      2022 Annual Research Report
  • [Book] 臨床研究法なんて怖くない! 第8回 疾病等報告・不具合報告2022

    • Author(s)
      稲川拓磨、小居秀紀
    • Total Pages
      3
    • Publisher
      先端医学社
    • Related Report
      2022 Annual Research Report
  • [Book] 臨床研究法なんて怖くない! 第7回 特定臨床研究の中止・終了手続き2022

    • Author(s)
      稲川拓磨、小居秀紀
    • Total Pages
      3
    • Publisher
      先端医学社
    • Related Report
      2022 Annual Research Report
  • [Book] 臨床研究法なんて怖くない!(第5回) 臨床研究法における説明・同意における留意点2021

    • Author(s)
      稲川 拓磨, 飯塚 維千子, 小居 秀紀
    • Publisher
      先端医学社
    • ISBN
      9784865505290
    • Related Report
      2021 Research-status Report
  • [Book] 臨床研究法なんて怖くない!(第4回) 臨床研究法における利益相反管理 手続きを円滑に進めるための基礎知識2021

    • Author(s)
      稲川 拓磨, 玉浦 明美, 小居 秀紀
    • Publisher
      先端医学社
    • ISBN
      9784865505221
    • Related Report
      2021 Research-status Report
  • [Book] 臨床研究法なんて怖くない!第3回 モニタリングと監査 どのように研究データの質を保つか2021

    • Author(s)
      稲川 拓磨, 小居 秀紀
    • Publisher
      先端医学社
    • ISBN
      9784865505122
    • Related Report
      2021 Research-status Report
  • [Book] 臨床研究法なんて怖くない! 第一回 臨床研究法とその強み2020

    • Author(s)
      稲川拓磨
    • Total Pages
      2
    • Publisher
      先端医学者
    • Related Report
      2020 Research-status Report
  • [Book] 認知症に対するtDCSの有用性(特集 ニューロモデュレーション治療の可能性)2019

    • Author(s)
      稲川拓磨、成田瑞、横井優磨
    • Total Pages
      7
    • Publisher
      科学評論社
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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