Development and clinical application of multi-pool analysis using high-resolution 3D CEST imaging

• Project/Area Number: 19K17145
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyushu University
• Principal Investigator: Wada Tatsuhiro 九州大学, 大学病院, 診療放射線技師 (60444832)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 磁気共鳴医学 / 放射線医学 / 磁気共鳴画像

Outline of Research at the Start

本研究では、MR分子イメージングであるchemical exchange saturation transfer（CEST）法に圧縮センシングを応用し、高分解能3D CESTイメージングを開発を目指す。さらに、CESTイメージングのmulti-pool解析を構築することで、脳腫瘍のisocitrate dehydrogenase（IDH）変異やO6-methylguanine-DNA-methltransferase（MGMT）メチル化などの分子、遺伝子レベルの情報を反映した画像評価法の確立を目指す。

Outline of Final Research Achievements

The purpose of this study was to establish an accelerated 3D CEST imaging method combined with compressed sensing and sensitivity encoding (CS-SENSE), and to apply it clinically to patients with brain tumors.
The 3D CEST imaging combined with CS-SENSE was able to obtain image quality comparable to that of conventional 2D CEST imaging in a self-made phantom and in patients with brain tumors. It also proved to be equivalent to conventional 2D CEST imaging in the grading of glioma malignancy. Furthermore, by applying multi-pool analysis, 3D APT imaging, NOE imaging, and MTR imaging could be obtained.

Academic Significance and Societal Importance of the Research Achievements

神経膠腫において最も悪性の膠芽腫は全般的に不良である。その原因として、悪性度の高い部分を取り残してしまうことがあげられる。従来の2D CESTイメージングは１断面のみの画像取得という問題があった．
本研究で開発した3D CESTイメージングは，腫瘍全体を含めることが可能である．また，神経膠腫のCESTイメージングの信号強度は，撮像断面により変化することが本研究にて明らかになった．3D CESTイメージングを用いることで，神経膠腫の悪性度診断の精度向上が期待される．

Research Products

• [Journal Article] Grading of gliomas using 3D CEST imaging with compressed sensing and sensitivity encoding (2023)
  • Author(s): Tatsuhiro Wada, Osamu Togao, Chiaki Tokunaga, Masahiro Oga, Kazufumi Kikuchi, Koji Yamashita, Hidetaka Yamamoto, Masami Yoneyama, Koji Kobayashi, Toyoyuki Kato, Kousei Ishigami, Hidetake Yabuuchi
  • Journal Title: European Journal of Radiology Volume: 158 Pages: 110654-110654
  • DOI: 10.1016/j.ejrad.2022.110654
  • Peer Reviewed / Open Access
• [Journal Article] Three-dimensional chemical exchange saturation transfer imaging using compressed SENSE for full z-spectrum acquisition. (2022)
  • Author(s): Tatsuhiro Wada, Chiaki Tokunaga, Osamu Togao, Akio Hiwatashi, Kazufumi Kikuchi, Masami Yoneyama， Koji Kobayashi, Toyoyuki Kato, Koji Yoshimoto, Kousei Ishigami, Hidetake Yabuuchi
  • Journal Title: Magnetic Resonance Imaging Volume: 92 Pages: 58-66
  • DOI: 10.1016/j.mri.2022.05.014
  • Peer Reviewed / Open Access
• [Journal Article] Optimization of the refocusing flip angle in the characterization of cerebrospinal fluid dynamics using multi-spin echo acquisition cine imaging (MUSACI) (2021)
  • Author(s): Tatsuhiro Wada, Chiaki Tokunaga, Osamu Togao, Masami Yoneyama, Ryohei Funatsu, Yasuo Yamashita, Kouji Kobayashi, Toyoyuki Kato
  • Journal Title: Magnetic Resonance Imaging Volume: 76 Pages: 87-95
  • DOI: 10.1016/j.mri.2020.11.013
  • Peer Reviewed
• [Presentation] Three-dimensional CEST imaging with CS-SENSE for full z-spectrum acquisition in brain tumor patients: comparison with two-dimensional CEST imaging (2022)
  • Author(s): Tatsuhiro Wada, Chiaki Tokunaga, Osamu Togao, Masahiro Oga, Kouji Kobayashi, Toyoyuki Kato, Masami Yoneyama, Hidetake Yabuuchi
  • Organizer: 第50回日本磁気共鳴医学会大会
• [Presentation] 自作ファントムを用いたz-spectrum取得のための圧縮センシング併用高速3D CEST imagingの基礎的検討 (2021)
  • Author(s): 和田 達弘，德永 千晶，栂尾 理，米山 正巳，舩津 亮平，大賀 正浩，小林 幸次，藪内 英剛
  • Organizer: 第49回日本磁気共鳴医学会大会
• [Presentation] The effect of the refocusing flip angle on CSF dynamics imaging using multi-spin echo acquisition cine imaging (MUSACI) (2020)
  • Author(s): Tatsuhiro Wada, Chiaki Tokunaga, Osamu Togao, Masami Yoneyama, Yasuo Yamashita, Kouji Kobayashi, Toyoyuki Kato
  • Organizer: 2020 ISMRM & SMRT Virtual Conference & Exhibition
  • Int'l Joint Research
• [Presentation] Accelerated 3D chemical exchange saturation transfer imaging using compressed SENSE for full Z-spectrum acquisition (2020)
  • Author(s): Tatsuhiro Wada, Chiaki Tokunaga, Osamu Togao, Masami Yoneyama, Yasuo Yamashita, Kouji Kobayashi, Toyoyuki Kato, Hidetake Yabuuchi
  • Organizer: 2020 ISMRM & SMRT Virtual Conference & Exhibition
  • Int'l Joint Research