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Voxel-based QSM analysis as an imaging biomarker for mild cognitive impairment in Parkinson disease

Research Project

Project/Area Number 19K17148
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionNagoya City University

Principal Investigator

Uchida Yuto  名古屋市立大学, 医薬学総合研究院(医学), 研究員 (20834261)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Discontinued (Fiscal Year 2022)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsパーキンソン病 / 認知症 / 脳画像解析 / MRI / 定量的磁化率画像 / 認知機能障害 / QSM / 画像バイオマーカー
Outline of Research at the Start

パーキンソン病に伴う認知機能障害を早期に診断する画像法は確立されていない。私たちは、α-シヌクレインが鉄を介して凝集する分子機序に着目し、定量的磁化率画像(QSM) が早期診断に応用できないかと考えた。さらに、全脳の鉄沈着の分布を網羅的に画像統計解析するため、ボクセルベースQSM解析を新たに開発した。本研究では、この手法を用いて、QSMが本症の早期診断に役立つ画像バイオマーカーになることを目指す。

Outline of Final Research Achievements

Quantitative susceptibility mapping (QSM) has been developed as a non-invasive magnetic resonance technique to quantify local tissue susceptibility with high spatial resolution, which is sensitive to the presence of iron. In our research, the association of cerebral susceptibility values with cognitive impairments in Parkinson’s disease was investigated using various QSM techniques. We first developed the voxel based QSM analysis. Second, we focus on a large variety of QSM applications, ranging from common applications, such as cerebral iron deposition, to more recent applications, such as the assessment of impaired myelination, quantification of venous oxygen saturation, and measurement of blood-brain barrier function in clinical settings. Finally, we developed the machine learning model trained with QSM, which could successfully detect mild cognitive impairment in Parkinson’s disease.

Academic Significance and Societal Importance of the Research Achievements

パーキンソン病に伴う認知機能障害の画像学的早期診断法の開発と臨床応用という二つの目標達成に向けて,研究成果を国際論文として複数報告した本研究の学術的・社会的意義は大きい.一方,パーキンソン病に伴う認知機能障害の責任病巣・表現型は多様性を示すことから,集団を対象とした探索的解析では診断困難な例が一定数存在することが明らかとなった.今後は,個体脳ごとに異なる磁化率分布や時空間進展パターンを抽出し,高精度な早期診断モデルと個別化医療への展開を進める.具体的には,これまでに開発した画像を学習データとした機械学習を活用することで,パーキンソン病に伴う認知機能障害の早期発見モデルの構築を目指す.

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (17 results)

All 2022 2021 2020 2019

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Machine learning trained with quantitative susceptibility mapping to detect mild cognitive impairment in Parkinson's disease2022

    • Author(s)
      Shibata Haruto、Uchida Yuto、Inui Shohei、Kan Hirohito、Sakurai Keita、Oishi Naoya、Ueki Yoshino、Oishi Kenichi、Matsukawa Noriyuki
    • Journal Title

      Parkinsonism and Related Disorders

      Volume: 94 Pages: 104-110

    • DOI

      10.1016/j.parkreldis.2021.12.004

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] R2* relaxometry analysis for mapping of white matter alteration in Parkinson’s disease with mild cognitive impairment2022

    • Author(s)
      Kan Hirohito、Uchida Yuto、Ueki Yoshino、Arai Nobuyuki、Tsubokura Satoshi、Kunitomo Hiroshi、Kasai Harumasa、Aoyama Kiminori、Matsukawa Noriyuki、Shibamoto Yuta
    • Journal Title

      NeuroImage: Clinical

      Volume: 33 Pages: 102938-102938

    • DOI

      10.1016/j.nicl.2022.102938

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicoradiological Features in Progressive Supranuclear Palsy Comorbid with Argyrophilic Grains2022

    • Author(s)
      Sakurai Keita、Kaneda Daita、Morimoto Satoru、Uchida Yuto、Inui Shohei、Kimura Yasuyuki、Kato Takashi、Ito Kengo、Hashizume Yoshio
    • Journal Title

      Movement Disorders Clinical Practice

      Volume: 9 Issue: 4 Pages: 484-488

    • DOI

      10.1002/mdc3.13455

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] APOE e4 dose associates with increased brain iron and β-amyloid via blood-brain barrier dysfunction2022

    • Author(s)
      Yuto Uchida, Hirohito Kan, Keita Sakurai, Yoshihiko Horimoto, Emi Hayashi, Akihiko Iida, Nobuyuki Okamura, Kenichi Oishi, Noriyuki Matsukawa
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: - Issue: 7 Pages: 772-778

    • DOI

      10.1136/jnnp-2021-328519

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Penumbra Detection With Oxygen Extraction Fraction Using Magnetic Susceptibility in Patients With Acute Ischemic Stroke2022

    • Author(s)
      Uchida Yuto、Kan Hirohito、Inoue Hiroyasu、Oomura Masahiro、Shibata Haruto、Kano Yuya、Kuno Tomoyuki、Usami Toshihiko、Takada Koji、Yamada Kentaro、Kudo Kohsuke、Matsukawa Noriyuki
    • Journal Title

      Frontiers in Neurology

      Volume: 13 Pages: 752450-752450

    • DOI

      10.3389/fneur.2022.752450

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetic Susceptibility Associates with Dopaminergic Deficits and Cognition in Parkinson's Disease.2020

    • Author(s)
      Uchida Y, Kan H, Sakurai K, Inui S, Kobayashi S, Akagawa Y, Shibuya K, Ueki Y, Matsukawa N.
    • Journal Title

      Mov Disord

      Volume: in press Issue: 8 Pages: 1396-1405

    • DOI

      10.1002/mds.28077

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous voxel‐based magnetic susceptibility and morphometry analysis using magnetization‐prepared spoiled turbo multiple gradient echo2020

    • Author(s)
      Kan Hirohito、Uchida Yuto、Arai Nobuyuki、Ueki Yoshino、Aoki Toshitaka、Kasai Harumasa、Kunitomo Hiroshi、Hirose Yasujiro、Matsukawa Noriyuki、Shibamoto Yuta
    • Journal Title

      NMR in Biomedicine

      Volume: in press Issue: 5

    • DOI

      10.1002/nbm.4272

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Iron leakage owing to blood?brain barrier disruption in small vessel disease CADASIL2020

    • Author(s)
      Uchida Yuto、Kan Hirohito、Sakurai Keita、Arai Nobuyuki、Inui Shohei、Kobayashi Susumu、Kato Daisuke、Ueki Yoshino、Matsukawa Noriyuki
    • Journal Title

      Neurology

      Volume: 95 Issue: 9

    • DOI

      10.1212/wnl.0000000000010148

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decreasing iron susceptibility with temperature in quantitative susceptibility mapping: A phantom study2020

    • Author(s)
      Kan Hirohito、Uchida Yuto、Arai Nobuyuki、Takizawa Masahiro、Miyati Tosiaki、Kunitomo Hiroshi、Kasai Harumasa、Shibamoto Yuta
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 73 Pages: 55-61

    • DOI

      10.1016/j.mri.2020.08.012

    • Related Report
      2020 Research-status Report
  • [Journal Article] Voxel-based quantitative susceptibility mapping in Parkinson's disease with mild cognitive impairment2019

    • Author(s)
      Uchida Y, Kan H, Sakurai K, Arai N, Kato D, Kawashima S, Ueki Y, Matsukawa N.
    • Journal Title

      Mov Disord

      Volume: 34(8) Issue: 8 Pages: 1164-1173

    • DOI

      10.1002/mds.27717

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improvement of Signal Inhomogeneity Induced by Radio-frequency Transmit-related Phase Error for Single-step Quantitative Susceptibility Mapping Reconstruction2019

    • Author(s)
      Kan Hirohito、Arai Nobuyuki、Takizawa Masahiro、Kasai Harumasa、Kunitomo Hiroshi、Hirose Yasujiro、Shibamoto Yuta
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 18 Issue: 4 Pages: 276-285

    • DOI

      10.2463/mrms.tn.2018-0066

    • NAID

      130007728808

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Differential effect of APOE genotype on blood-brain barrier permeability2021

    • Author(s)
      打田佑人
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] A new link between striatal magnetic susceptibility and dopamine transporter imaging abnormality2021

    • Author(s)
      打田佑人
    • Organizer
      第14回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2021 Annual Research Report
  • [Presentation] Iron leakage owing to blood-brain barrier disruption in small vessel disease CADASIL2020

    • Author(s)
      打田佑人
    • Organizer
      第61回日本神経学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Clinical management for an acute phase of autoimmune epilepsy2020

    • Author(s)
      打田佑人
    • Organizer
      第61回日本神経学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Voxel-based QSM analysis as an imaging biomarker for mild cognitive impairment in Parkinson disease2019

    • Author(s)
      Yuto Uchida
    • Organizer
      第60回日本神経学会学術大会 (優秀演題口演賞)
    • Related Report
      2019 Research-status Report
  • [Presentation] Simultaneous Voxel-based Magnetic Susceptibility and Morphometry analysis in Patients with Alzheimer’s Disease2019

    • Author(s)
      Hirohito Kan, Yuto Uchida, et al.
    • Organizer
      International Society of Magnetic Resonance in Medicine 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2024-01-30  

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