| Project/Area Number |
19K17150
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | MRI / Na MRI / てんかん / FCD / CEST / synthetic MRI / Focal Cortical Dysplasia / Synthetic MRI / quantitative MRI / Multi-parametric MRI / 脳 / Deep Learning |
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| Outline of Research at the Start |
てんかん焦点の同定は手術結果の向上に重要であるが、MRIなどの非侵襲的な方法では30%の患者で同定できず、頭蓋骨に穴をあける侵襲的な脳波検査が実施されることが多 い。そこで本研究では、Multi-Parametric定量MRI手法を開発し、脳統計画像解析やDeep Learning等の手法を用いて従来法MRIにて同定困難なてんかん焦点を検出する低侵襲で客観的な手法を確立することを目的とする。
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| Outline of Final Research Achievements |
Epileptic focus identification is crucial for improving surgical outcomes. Non-invasive methods like MRI fail to identify foci in 20-30% of patients, leading to invasive brain wave tests. Sodium (23Na) MRI shows promise in detecting foci due to epilepsy's excessive neuronal excitations. This study aimed to develop a minimally invasive and objective method using Multi-Parametric Quantitative MRI with Na MRI to detect challenging epileptic foci. Promising results, including simultaneous imaging with double half-echo and H MRI, and analysis of focal cortical dysplasia (FCD), were obtained. Implementation of faster double half-echo imaging for Na MRI and successful simultaneous Na and H MRI acquisition were achieved. This study lays the groundwork for clinical adoption of Na MRI and provides insights for improving FCD detection using MRI.
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| Academic Significance and Societal Importance of the Research Achievements |
Na MRIの撮像時間短縮を目的としたdouble half-echo撮像の実装やNaとH MRIの同時撮像を達成した。Na MRIは通常のH MRIと別のコイルで別途撮像することが必要であり、それが臨床導入を妨げていた。本研究により、Na MRIの臨床普及を進める素地が整えることができたと考えられる。また、FCDのMRIによる病態解明を行ったことで、今後MRIによるFCDの検出力を向上させる検討の素地を整えることができたと考えられる。
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