Development of diagnostic assistance software for Parkinson's syndrome by brain network analysis using graph theory

• Project/Area Number: 19K17157
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Shigemoto Yoko 国立研究開発法人国立精神・神経医療研究センター, 病院 放射線診療部, 医師 (00815384)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: ネットワーク解析 / 健常者 / 年齢 / 性別 / パーキンソン病 / 構造ネットワーク解析 / パーキンソン症候群

Outline of Research at the Start

グラフ理論を用いた構造ネットワーク解析は、従来の萎縮を検出する方法に代わり、パーキンソン病などの変性疾患における異常を早期から検出しうる方法として期待されている。われわれは、最近登場した脳構造の局所的な類似に着目した手法を用いて、疾患毎のネットワークパターンを抽出することで、パーキンソニズムを来す変性疾患の早期診断および鑑別能向上を目指す。さらに健常者におけるネットワーク指標画像のデータベースを構築し、各患者のネットワーク指標画像を入力することによって自動的にパーキンソニズムをきたす変性疾患の鑑別や早期診断を可能とするソフトウェアを開発する。

Outline of Final Research Achievements

Structural network analysis was performed using brain MRI of 812 healthy subjects, and a database of local network index images was created. Next, patients with degenerative diseases with parkinsonism (Parkinson's disease, progressive supranuclear palsy, multiple system atrophy-parkinsonism variant) were similarly analyzed to detect disease-specific network abnormalities. As a result, the clustering coefficient, which is one of the local network indicators, coincided with the site of decline in brain function compared to the site of atrophy in gray matter, and was considered to be useful for differentiation.

Academic Significance and Societal Importance of the Research Achievements

MRIのグラフ理論を用いたネットワーク解析は、パーキンソニズムをきたす疾患の鑑別に有用であった。この手法は他の疾患にも応用可能と思われるため、さまざまな神経変性疾患の診断補助として日常診療に役立てることができうると考える。

Research Products

• [Journal Article] Age and Sex-Related Effects on Single-Subject Gray Matter Networks in Healthy Participants. (2023)
  • Author(s): Shigemoto Y, Sato N, Maikusa N, Sone D, Ota M, Kimura Y, Chiba E, Okita K, Yamao T, Nakaya M, Maki H, Arizono E, Matsuda H.
  • Journal Title: J Pers Med. Volume: 13 Issue: 3 Pages: 419-419
  • DOI: 10.3390/jpm13030419
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between the regional brain volume and glymphatic system activity in progressive supranuclear palsy. (2023)
  • Author(s): Ota M, Sato N, Takahashi Y, Shigemoto Y, Kimura Y, Nakaya M, Chiba E, Matsuda H.
  • Journal Title: Dement Geriatr Cogn Disord. Volume: - Issue: 3 Pages: 177-183
  • DOI: 10.1159/000530075
  • Peer Reviewed / Open Access
• [Journal Article] Voxel-based analysis of age and gender effects on striatal [123I] FP-CIT binding in healthy Japanese adults (2022)
  • Author(s): Shigemoto Yoko、Matsuda Hiroshi、Kimura Yukio、Chiba Emiko、Ohnishi Masahiro、Nakaya Moto、Maikusa Norihide、Ogawa Masayo、Mukai Yohei、Takahashi Yuji、Sako Kazuya、Toyama Hiroshi、Inui Yoshitaka、Taki Yasuyuki、Nagayama Hiroshi、Ono Kenjiro、Kono Atsushi、Sekiguchi Kenji、Hirano Shigeki、Sato Noriko
  • Journal Title: Annals of Nuclear Medicine Volume: 36 Issue: 5 Pages: 460-467
  • DOI: 10.1007/s12149-022-01725-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Frontal lobe-dominant cerebral blood flow reduction and atrophy can be progressive in Duchenne muscular dystrophy. (2022)
  • Author(s): Mori-Yoshimura M. Aizawa K, Shigemoto Y, Ishihara N, Minami N, Nishino I, Yoshida S, Sato N, Takahashi Y.
  • Journal Title: Neuromuscul Disord. Volume: 32 Issue: 6 Pages: 477-485
  • DOI: 10.1016/j.nmd.2022.02.008
  • Peer Reviewed
• [Journal Article] Clinical and neuroimaging findings in patients with lissencephaly/subcortical band heterotopia spectrum: a magnetic resonance conventional and diffusion tensor study. (2022)
  • Author(s): Chiba E, Kimura Y, Shimizu-Motohashi Y, Miyagawa N, Ota M, Shigemoto Y, Ohnishi M, Nakaya M, Nakagawa E, Sasaki M, Sato N.
  • Journal Title: Neuroradiology. Volume: 64 Issue: 4 Pages: 825-836
  • DOI: 10.1007/s00234-021-02836-2
  • Peer Reviewed
• [Journal Article] Potential Treat-to-Target Approach for Methamphetamine Use Disorder: A Pilot Study of Adenosine 2A Receptor Antagonist With Positron Emission Tomography. (2022)
  • Author(s): Okita K, Matsumoto T, Funada D, Murakami M, Kato K, Shigemoto Y, Sato N, Matsuda H.
  • Journal Title: Front Pharmacol. Volume: 13 Pages: 820447-820447
  • DOI: 10.3389/fphar.2022.820447
  • Peer Reviewed / Open Access
• [Journal Article] MR Imaging Detection of CNS Lesions in Tuberous Sclerosis Complex: The Usefulness of T1WI with Chemical Shift Selective Images. (2022)
  • Author(s): Fujii H, Sato N, Kimura Y, Mizutani M, Kusama M, Sumitomo N, Chiba E, Shigemoto Y, Takao M, Takayama Y, Iwasaki M, Nakagawa E, Mori H.
  • Journal Title: AJNR Am J Neuroradiol. Volume: 43 Issue: 8 Pages: 1202-1209
  • DOI: 10.3174/ajnr.a7573
  • Peer Reviewed
• [Journal Article] Upper cerebellar glucose hypermetabolism in patients with temporal lobe epilepsy and interictal psychosis (2022)
  • Author(s): Sone Daichi、Sato Noriko、Shigemoto Yoko、Kimura Yukio、Matsuda Hiroshi
  • Journal Title: Epilepsia Open Volume: 7 Issue: 4 Pages: 657-664
  • DOI: 10.1002/epi4.12645
  • Peer Reviewed / Open Access
• [Journal Article] Relationships Between the Deposition of Amyloid-β and Tau Protein and Glymphatic System Activity in Alzheimer's Disease: Diffusion Tensor Image Study. (2022)
  • Author(s): Ota M, Sato N, Nakaya M, Shigemoto Y, Kimura Y, Chiba E, Yokoi Y, Tsukamoto T, Matsuda H.
  • Journal Title: J Alzheimers Dis. Volume: 90(1) Issue: 1 Pages: 295-303
  • DOI: 10.3233/jad-220534
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Harmonized Z-Scores Calculated from a Large-Scale Normal MRI Database to Evaluate Brain Atrophy in Neurodegenerative Disorders (2022)
  • Author(s): Maikusa Norihide、Shigemoto Yoko、Chiba Emiko、Kimura Yukio、Matsuda Hiroshi、Sato Noriko
  • Journal Title: Journal of Personalized Medicine Volume: 12 Issue: 10 Pages: 1555-1555
  • DOI: 10.3390/jpm12101555
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impact of amyloid PET using 18F-florbetapir in patients with cognitive impairment and suspected Alzheimer's disease: a multicenter study. (2022)
  • Author(s): Matsuda H, Okita K, Motoi Y, Mizuno T, Ikeda M, Sanjo N, Murakami K, Kambe T, Takayama T, Yamada K, Suehiro T, Matsunaga K, Yokota T, Tateishi U, Shigemoto Y, Kimura Y, Chiba E, Kawashima T, Tomo Y, Tachimori H, Kimura Y, Sato N
  • Journal Title: Ann Nucl Med Volume: 36 Issue: 12 Pages: 1039-1049
  • DOI: 10.1007/s12149-022-01792-y
  • Peer Reviewed / Open Access
• [Journal Article] Free water derived by multi-shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease (2022)
  • Author(s): Nakaya M, Sato N, Matsuda H, Maikusa N, Shigemoto Y, Sone D, Yamao T, Ogawa M, Kimura Y, Chiba E, Ohnishi M, Kato K, Okita K, Tsukamoto T, Yokoi Y, Sakata M, Abe O.
  • Journal Title: Alzheimers Dement (N Y) Volume: 10;8(1) Issue: 1
  • DOI: 10.1002/trc2.12356
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Voxel-based correlation of 18F-THK5351 accumulation with gray matter structural networks in cognitively normal older adults (2021)
  • Author(s): Yoko Shigemoto, Daichi Sone, Norihide Maikusa, Yukio Kimura, Fumio Suzuki, Hiroyuki Fujii, Noriko Sato, Hiroshi Matsuda
  • Journal Title: eNeurologicalSci Volume: 23 Pages: 100343-100343
  • DOI: 10.1016/j.ensci.2021.100343
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Single-subject gray matter networks in temporal lobe epilepsy patients with hippocampal sclerosis (2021)
  • Author(s): Shigemoto Yoko,Maikusa Norihide, Matsuda Hiroshi et al.
  • Journal Title: Epilepsy Research Volume: 177 Pages: 106766-106766
  • DOI: 10.1016/j.eplepsyres.2021.106766
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gray matter structural networks related to 18 F-THK5351 retention in cognitively normal older adults and Alzheimer's disease patients (2021)
  • Author(s): Yoko Shigemoto, Daichi Sone, Kyoji Okita, Norihide Maikusa, Tensho Yamao, Yukio Kimura, Fumio Suzuki, Hiroyuki Fujii, Koichi Kato, Noriko Sato, Hiroshi Matsuda
  • Journal Title: eNeurologicalSci Volume: 22 Pages: 100309-100309
  • DOI: 10.1016/j.ensci.2021.100309
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Alzheimer’s diseaseに対するFree water imagingとタウ/神経炎症PETとの相関関係 (2023)
  • Author(s): 仲谷元, 佐藤典子, 松田博史, 舞草伯秀, 重本蓉子, 曽根大地, 山尾天翔, 木村有喜男, 千葉英美子, 阿部修
  • Organizer: 第52回日本神経放射線学会
• [Presentation] 筋萎縮性側索硬化症における中心前回の血流定量化（第2報） (2023)
  • Author(s): 山川 徹，齊藤 勇二，重本 蓉子，佐藤 典子，髙橋 祐二
  • Organizer: 第64回日本神経学会学術大会
• [Presentation] 筋萎縮性側索硬化症における中心前回の血流定量化 (2022)
  • Author(s): 山川 徹，齊藤 勇二，重本 蓉子，佐藤 典子，髙橋 祐二
  • Organizer: 第63回日本神経学会学術大会
• [Presentation] Alzheimer’s diseaseに対するFree water imagingとタウ/神経炎症PETとの相関関係 (2022)
  • Author(s): 仲谷元, 佐藤典子, 松田博史, 舞草伯秀, 重本蓉子, 曽根大地, 山尾天翔, 木村有喜男, 千葉英美子, 阿部修
  • Organizer: 第41回日本認知症学会学術集会
• [Presentation] MRI縦断画像解析法を用いたアルツハイマー病・軽度認知障害の脳萎縮評価 (2022)
  • Author(s): 舞草伯秀, 木村有喜男, 重本蓉子, 千葉英美子, 松田博史, 佐藤典子
  • Organizer: 第41回日本認知症学会学術集会
• [Presentation] NODDI, 構造ネットワーク, 脳年齢. (2021)
  • Author(s): 松田博史, 曽根大地, 重本蓉子, 佐藤典子.
  • Organizer: 第40 回日本認知症学会学術集会
  • Invited
• [Presentation] Voxel-based correlation of 18F-THK5351 accumulation with gray matter structural networks in cognitively normal older adults. (2021)
  • Author(s): Shigemoto Y, Sone D, Maikusa N, Kimura Y, Suzuki F, Fujii H, Sato N, Matsuda H.
  • Organizer: AAIC 2021
  • Int'l Joint Research
• [Presentation] 健常成人における123I-イオフルパン-SPECTのボクセル解 析：年齢および性別が与える影響. (2021)
  • Author(s): 重本蓉子, 佐藤典子, 木村有喜男, 千葉英美子, 大西正紘, 仲谷元, 舞草伯秀, 向井 洋平, 高橋祐二, 松田博史.
  • Organizer: 第61回日本核医学会学術総会
• [Presentation] 大規模健常データベースを用いたHarmonized Z-scoreによるAD代理マーカーの検討. (2021)
  • Author(s): 舞草伯秀, 重本蓉子, 木村有喜男, 千葉英美子, 松田博史, 佐藤典子.
  • Organizer: 第61回日本核医学会学術総会
• [Presentation] タウ蛋白蓄積とコネクティビティの関連 (2019)
  • Author(s): 重本蓉子
  • Organizer: 第38回日本認知症学会学術集会
  • Invited
• [Book] Radiology-Nuclear Medicine Diagnostic Imaging: A Correlative Approach Diseases of the Central Nervous System (Pages: 163-193) (2023)
  • Author(s): Hiroshi Matsuda, Eku Shimosegawa, Yoko Shigemoto, Noriko Sato, Hiroyuki Fujii, Fumio Suzuki, Yukio Kimura, Atsuhiko Sugiyama
  • Total Pages: 912
  • Publisher: Wiley-Blackwell
  • ISBN: 9781119603610