Establishment of prediction method for therapeutic efficacy in boron neutron capture therapy

• Project/Area Number: 19K17218
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: National Cancer Center Japan
• Principal Investigator: 中村 哲志 国立研究開発法人国立がん研究センター, 中央病院, 医学物理専門職 (20638374)
• Project Period (FY): 2019-04-01 – 2025-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: BNCT / 薬剤分布 / 線量分布 / 腫瘍内不均一性 / BPA / 18F-BPA / FDG / PET / 線量計算 / ホウ素中性子捕捉療法 / 放射線治療 / 18F-FDG / SUV / 治療効果 / 18F-BPA PET / 非剛体位置合わせ / モンテカルロシミュレーション / 治療計画 / 予測 / 付与線量 / 機械学習

Outline of Research at the Start

ホウ素中性子捕捉療法(BNCT)は原子炉での良好な成績が注目され、加速器を使用した病
院併設型のシステムとして導入され始めている。しかし、課題も存在し、「BNCTでの治療効果の予測が適正に出来ていない」ことが挙げられる。BNCTでは薬剤によりホウ素を腫瘍へ取り込ませるが、薬剤がアミノ酸誘導体であるため、腫瘍内のホウ素濃度が不均一さや時間変化が考えられる。そのため、線量評価には不確かさがあり、治療効果を予測するには、治療成績と人体へ付与された線量との相関関係を的確に評価する必要がある。本研究は、BNCTの治療効果の予測できるデータを集め、定量性のある治療効果予測方法の構築を行うことを目指す。

Outline of Annual Research Achievements

ホウ素中性子捕捉療法(BNCT)は原子炉での良好な成績が注目され、加速器を使用した病院併設型のシステムとして導入され始めている。しかし、他の治療法と同様に臨床選択されるには課題が存在し、その最も重要な一つとして「BNCTでの治療効果の予測が適正に出来ていない」ことが挙げられる。それゆえに、現在のBNCTはリスク臓器の耐容線量を照射することで実施されている。BNCTで主に使用されるホウ素薬剤はアミノ酸誘導体であり、代謝を利用して腫瘍へ取り込ませている。そのため、腫瘍内のホウ素濃度が不均一さやホウ素濃度がBNCT中に時間変化することなどが考えられ、1) BNCT時の腫瘍の治癒線量が不確かであり、2)実際に腫瘍へ照射される線量が不確かである。これらを解決し、治療前に治療効果を予測するには、治療成績と腫瘍及び正常組織へ付与された線量との相関関係を評価する必要がある。本研究の目的は、BNCTの治療効果の予測できるデータを集め、定量性のある治療効果予測方法の構築を行うことである。
研究実績としては、ホウ素の体内分布を18F-BPA PET画像から取得し、それをBNCTの線量分布計算に反映する方法を開発した。この研究実績について特許出願を令和5年6月26日に行った。また、後ろ向き研究として、当院で18F-BPAを実施した患者について、開発した技術と従来法による線量分布計算/評価をともに実施し、比較した。その結果、従来法の線量評価法では、過剰評価されている可能性が示唆された。この内容については、国際学会で演題が採択され、2024年度発表予定となっている。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

研究開発した成果を昨年度に特許出願し、その有用性について2024年度国際学会で発表する予定である。
また、得られた成果を英文査読付き雑誌に投稿を予定しているため。

Strategy for Future Research Activity

現在、研究開発により得られた技術を適応した場合の患者データ数は20名程度であるため、対象患者数を増やして、統計解析を十分確保できるデータ数をそろえる予定である。その結果、がん種などに依存しているかなどを詳細に検討していく。

Research Products

• [Journal Article] A preliminary study on rectal dose reduction associated with hyaluronic acid implantation in brachytherapy for prostate cancer (2024)
  • Author(s): Kashihara Tairo、Urago Yuka、Okamoto Hiroyuki、Takemori Mihiro、Nakayama Hiroki、Mikasa Shohei、Nakaichi Tetsu、Iijima Kotaro、Chiba Takahito、Kuwahara Junichi、Nakamura Satoshi、Chang Weishan、Matsui Yoshiyuki、Igaki Hiroshi
  • Journal Title: Asian Journal of Urology Volume: 11 Issue: 2 Pages: 286-293
  • DOI: 10.1016/j.ajur.2022.08.006
  • Peer Reviewed / Open Access
• [Journal Article] Sketch-based semantic retrieval of medical images (2024)
  • Author(s): Kobayashi Kazuma、Gu Lin、Hataya Ryuichiro、Mizuno Takaaki、Miyake Mototaka、Watanabe Hirokazu、Takahashi Masamichi、Takamizawa Yasuyuki、Yoshida Yukihiro、Nakamura Satoshi、Kouno Nobuji、Bolatkan Amina、Kurose Yusuke、Harada Tatsuya、Hamamoto Ryuji
  • Journal Title: Medical Image Analysis Volume: 92 Pages: 103060-103060
  • DOI: 10.1016/j.media.2023.103060
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correlation between L‐amino acid transporter 1 expression and 4‐borono‐2‐¹⁸F‐fluoro‐phenylalanine accumulation in humans (2023)
  • Author(s): Kashihara Tairo、Mori Taisuke、Nakaichi Tetsu、Nakamura Satoshi、Ito Kimiteru、Kurihara Hiroaki、Kusumoto Masahiko、Itami Jun、Yoshimoto Seiichi、Igaki Hiroshi
  • Journal Title: Cancer Medicine Volume: 12 Issue: 21 Pages: 20564-20572
  • DOI: 10.1002/cam4.6635
  • Peer Reviewed
• [Journal Article] Non-operative management involving chemoradiation therapy combined with high-dose-rate brachytherapy for T3 rectal cancer using a vaginal shielded cylindrical applicator: a technical report (2023)
  • Author(s): Murakami Naoya、Kojima Kanako、Okuma Kae、Kashihara Tairo、Nakamura Satoshi、Shimizu Wakako、Suda Ryuichiro、Igaki Hiroshi、Shikama Naoto
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 53 Issue: 11 Pages: 1082-1086
  • DOI: 10.1093/jjco/hyad099
  • Peer Reviewed / Open Access
• [Journal Article] Salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report (2023)
  • Author(s): Murakami Naoya、Nakatani Fumihiko、Takahashi Kana、Nakamura Satoshi、Igaki Hiroshi、Shikama Naoto
  • Journal Title: Journal of Radiation Research Volume: 64 Issue: 4 Pages: 746-749
  • DOI: 10.1093/jrr/rrad041
  • Peer Reviewed / Open Access
• [Journal Article] Relative biological effectiveness for epithermal neutron beam contaminated with fast neutrons in the linear accelerator-based boron neutron capture therapy system coupled to a solid-state lithium target (2023)
  • Author(s): Nakamura Satoshi、Imamichi Shoji、Shimada Kenzi、Takemori Mihiro、Kanai Yui、Iijima Kotaro、Chiba Takahito、Nakayama Hiroki、Nakaichi Tetsu、Mikasa Shohei、Urago Yuka、Kashihara Tairo、Takahashi Kana、Nishio Teiji、Okamoto Hiroyuki、Itami Jun、Ishiai Masamichi、Suzuki Minoru、Igaki Hiroshi、Masutani Mitsuko
  • Journal Title: Journal of Radiation Research Volume: 64 Issue: 4 Pages: 661-667
  • DOI: 10.1093/jrr/rrad037
  • Peer Reviewed / Open Access
• [Journal Article] Analyzing spatial distribution between 18F-fluorodeoxyglucose and 18F-boronophenylalanine positron emission tomography to investigate selection indicators for boron neutron capture therapy (2022)
  • Author(s): Nakaichi Tetsu、Nakamura Satoshi、Ito Kimiteru、Takahashi Kana、Takemori Mihiro、Kashihara Tairo、Kunito Kouji、Murakami Naoya、Iijima Kotaro、Chiba Takahito、Nakayama Hiroki、Mikasa Shohei、Nishio Teiji、Okamoto Hiroyuki、Itami Jun、Kurihara Hiroaki、Igaki Hiroshi
  • Journal Title: EJNMMI Physics Volume: 9 Issue: 1 Pages: 89-89
  • DOI: 10.1186/s40658-022-00514-7
  • Peer Reviewed / Open Access
• [Journal Article] Failure modes and effects analysis study for accelerator‐based Boron Neutron Capture Therapy (2022)
  • Author(s): Takemori Mihiro、Nakamura Satoshi、Sofue Toshimitsu、et al
  • Journal Title: Medical Physics Volume: 50 Issue: 1 Pages: 424-439
  • DOI: 10.1002/mp.16104
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of local control of primary tumour in definitive radiotherapy for scalp angiosarcomas (2022)
  • Author(s): Kashihara Tairo、Ogata Dai、Okuma Kae、Nakamura Satoshi、Nakayama Hiroki、Mori Taisuke、Takahashi Akira、Namikawa Kenjiro、Takahashi Ayaka、Takahashi Kana、Kaneda Tomoya、Inaba Koji、Murakami Naoya、Okamoto Hiroyuki、Nakayama Yuko、Yamazaki Naoya、Igaki Hiroshi
  • Journal Title: Skin Research and Technology Volume: 29 Issue: 1
  • DOI: 10.1111/srt.13243
  • Peer Reviewed / Open Access
• [Journal Article] Monte Carlo simulation of tilted contact plaque brachytherapy placement for juxtapapillary retinoblastoma (2022)
  • Author(s): Nakamura Satoshi、Murakami Naoya、Suzuki Shigenobu、Ito Kimiteru、Takemori Mihiro、Nakayama Hiroki、Kaga Keita、Chiba Takahito、Iijima Kotaro、Takahashi Kana、Goka Tomonori、Itami Jun、Okamoto Hiroyuki、Igaki Hiroshi
  • Journal Title: Radiation Oncology Volume: 17 Issue: 1 Pages: 16-16
  • DOI: 10.1186/s13014-022-01986-8
  • Peer Reviewed / Open Access
• [Journal Article] High-Dose-Rate Interstitial Brachytherapy for Deeply Situated Gynecologic Tumors Guided by Combination of Transrectal and Transabdominal Ultrasonography: A Technical Note (2022)
  • Author(s): Shimizu Yuri、Murakami Naoya、Chiba Takahito、Kaneda Tomoya、Okamoto Hiroyuki、Nakamura Satoshi、Takahashi Ayaka、Kashihara Tairo、Takahashi Kana、Inaba Koji、Okuma Kae、Nakayama Yuko、Itami Jun、Igaki Hiroshi
  • Journal Title: Frontiers in Oncology Volume: 11 Pages: 808721-808721
  • DOI: 10.3389/fonc.2021.808721
  • Peer Reviewed / Open Access
• [Journal Article] Bevacizumab increases late toxicity in re-irradiation with image-guided high-dose-rate brachytherapy for gynecologic malignancies (2022)
  • Author(s): Murakami Naoya、Okuma Kae、Okamoto Hiroyuki、Nakamura Satoshi、Kashihara Tairo、Kaneda Tomoya、Takahashi Kana、Inaba Koji、Igaki Hiroshi、Masui Koji、Yoshida Ken、Kato Tomoyasu、Itami Jun
  • Journal Title: Journal of Contemporary Brachytherapy Volume: 14 Issue: 1 Pages: 52-59
  • DOI: 10.5114/jcb.2022.113549
  • Peer Reviewed / Open Access
• [Journal Article] Scalp angiosarcoma treated with linear accelerator-based boron neutron capture therapy: A report of two patients (2022)
  • Author(s): Igaki Hiroshi、Murakami Naoya、Nakamura Satoshi、et. al.
  • Journal Title: Clinical and Translational Radiation Oncology Volume: 33 Pages: 128-133
  • DOI: 10.1016/j.ctro.2022.02.006
  • Peer Reviewed / Open Access
• [Journal Article] Technical note: Analysis of brachytherapy source movement by high-speed camera (2022)
  • Author(s): Hiroyuki Okamoto, Kotaro Iijima, Takahito Chiba, et al.,
  • Journal Title: Medical Physics Volume: 1 Issue: 7 Pages: 1-8
  • DOI: 10.1002/mp.15601
  • Peer Reviewed
• [Journal Article] Prognostic factor analysis of definitive radiotherapy using intensity-modulated radiation therapy and volumetric modulated arc therapy with boluses for scalp angiosarcomas (2022)
  • Author(s): Kashihara Tairo、Igaki Hiroshi、Ogata Dai、Nakayama Hiroki、Nakamura Satoshi、Okuma Kae、Mori Taisuke、Yamakawa Kohei、Takahashi Akira、Namikawa Kenjiro、Takahashi Ayaka、Takahashi Kana、Kaneda Tomoya、Inaba Koji、Murakami Naoya、Nakayama Yuko、Okamoto Hiroyuki、Yamazaki Naoya、Itami Jun
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 4355-4355
  • DOI: 10.1038/s41598-022-08362-2
  • Peer Reviewed
• [Journal Article] Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy (2022)
  • Author(s): Imamichi Shoji、Chen Lichao、Ito Tasuku、Tong Ying、Onodera Takae、Sasaki Yuka、Nakamura Satoshi、Mauri PierLuigi、Sanada Yu、Igaki Hiroshi、Murakami Yasufumi、Suzuki Minoru、Itami Jun、Masunaga Shinichiro、Masutani Mitsuko
  • Journal Title: Biology Volume: 11 Issue: 3 Pages: 420-420
  • DOI: 10.3390/biology11030420
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target (2021)
  • Author(s): Nakamura Satoshi、Igaki Hiroshi、Ito Masashi、Imamichi Shoji、Kashihara Tairo、Okamoto Hiroyuki、Nishioka Shie、Iijima Kotaro、Chiba Takahito、Nakayama Hiroki、Takemori Mihiro、Abe Yoshihisa、Kaneda Tomoya、Takahashi Kana、Inaba Koji、Okuma Kae、Murakami Naoya、Nakayama Yuko、Masutani Mitsuko、Nishio Teiji、Itami Jun
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 8090-8090
  • DOI: 10.1038/s41598-021-87627-8
  • Peer Reviewed / Open Access
• [Journal Article] Initial Experience of Intentional Internal High-Dose Policy Volumetric Modulated Arc Therapy of Neck Lymph Node Metastases; 2 cm in Patients With Head and Neck Squamous Cell Carcinoma (2021)
  • Author(s): Tairo Kashihara, Satoshi Nakamura, Naoya Murakami, Kimiteru Ito, Yoshifumi Matsumoto, Kenya Kobayashi, Go Omura, Taisuke Mori, Yoshitaka Honma, Yuko Kubo, Hiroyuki Okamoto, Kana Takahashi, Koji Inaba, Kae Okuma, Hiroshi Igaki, Yuko Nakayama, Ken Kato, Fumihiko Matsumoto, Seiichi Yoshimoto and Jun Itami
  • Journal Title: Frontiers in oncology Volume: 11 Pages: 651409-651409
  • DOI: 10.3389/fonc.2021.651409
  • Peer Reviewed / Open Access
• [Journal Article] Development of a real-time neutron beam detector for boron neutron capture therapy using a thin silicon sensor (2021)
  • Author(s): Takada Masashi、Nunomiya Tomoya、Masuda Akihiko、Matsumoto Tetsuro、Tanaka Hiroki、Nakamura Satoshi、Endo Satoru、Nakamura Masaru、Aoyama Kei、Ueda Osamu、Narita Masataka、Nakamura Takashi
  • Journal Title: Applied Radiation and Isotopes Volume: 176 Pages: 109856-109856
  • DOI: 10.1016/j.apradiso.2021.109856
  • Peer Reviewed
• [Journal Article] A Combination of GM-CSF and Released Factors from Gamma-Irradiated Tumor Cells Enhances the Differentiation of Macrophages from Bone Marrow Cells and Their Antigen-Presenting Function and Polarization to Type 1 (2021)
  • Author(s): Chen Lichao、Imamichi Shoji、Tong Ying、Sasaki Yuka、Onodera Takae、Nakamura Satoshi、Igaki Hiroshi、Itami Jun、Masutani Mitsuko
  • Journal Title: Medicines Volume: 8 Issue: 7 Pages: 35-35
  • DOI: 10.3390/medicines8070035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Pilot Study of Synchronization of Respiration-Induced Motions in the Duodenum and Stomach for the Primary Tumor in Radiation Therapy for Pancreatic Cancer Using 4-Dimensional Computed Tomography (2021)
  • Author(s): Umezawa Rei、Wakita Akihisa、Katsuta Yoshiyuki、Ito Yoshinori、Nakamura Satoshi、Okamoto Hiroyuki、kadoya Noriyuki、Takahashi Kana、Inaba Koji、Murakami Naoya、Igaki Hiroshi、Jingu Keiichi、Itami Jun
  • Journal Title: Advances in Radiation Oncology Volume: 6 Issue: 4 Pages: 100730-100730
  • DOI: 10.1016/j.adro.2021.100730
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of auto-segmentation accuracy of cloud-based artificial intelligence and atlas-based models (2021)
  • Author(s): Urago Yuka、Okamoto Hiroyuki、Kaneda Tomoya、Murakami Naoya、Kashihara Tairo、Takemori Mihiro、Nakayama Hiroki、Iijima Kotaro、Chiba Takahito、Kuwahara Junichi、Katsuta Shouichi、Nakamura Satoshi、Chang Weishan、Saitoh Hidetoshi、Igaki Hiroshi
  • Journal Title: Radiation Oncology Volume: 16 Issue: 1 Pages: 175-175
  • DOI: 10.1186/s13014-021-01896-1
  • Peer Reviewed / Open Access
• [Journal Article] Performance of a newly designed end-to-end phantom compatible with magnetic resonance-guided radiotherapy systems (2021)
  • Author(s): Iijima K, Okamoto H, Nishioka S, Sakasai T, Nakamura S, Chiba T, Kaga K, Takemori M, Nakayama H, Miura Y, Fujiyama D, Tsunoda Y, Igaki H, Katsuta S, Itami J.
  • Journal Title: Medical Physics Volume: 48 Issue: 11 Pages: 7541-7551
  • DOI: 10.1002/mp.15153
  • Peer Reviewed
• [Journal Article] <i>In vivo</i> dosimetry for testicular and scalp shielding in total skin electron therapy using a radiophotoluminescence glass dosimeter (2021)
  • Author(s): Okamoto Hiroyuki、Okuma Kae、Nakayama Hiroki、Nakamura Satoshi、Iijima Kotaro、Chiba Takahito、Takemori Mihiro、Fujii Kyohei、Mikasa Shohei、Nakaichi Tetsu、Aikawa Ako、Katsuta Shouichi、Igaki Hiroshi
  • Journal Title: Journal of Radiation Research Volume: 63 Issue: 1 Pages: 51-54
  • DOI: 10.1093/jrr/rrab100
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of tangential irradiation with volumetric modulated arc therapy on scalp angiosarcoma using medical linac (2021)
  • Author(s): Nakayama Hiroki、Nakamura Satoshi、Iijima Kotaro、Chiba Takahito、Takemori Mihiro、Kashihara Tairo、Okuma Kae、Igaki Hiroshi、Saitoh Hidetoshi、Chang Weishan、Okamoto Hiroyuki
  • Journal Title: Physica Medica Volume: 91 Pages: 105-116
  • DOI: 10.1016/j.ejmp.2021.10.012
  • Peer Reviewed
• [Journal Article] Dosimetric effect of the intestinal gas of online adaptive stereotactic body radiotherapy on target and critical organs without online electron density correction for pancreatic cancer (2021)
  • Author(s): Su Chen、Okamoto Hiroyuki、Nishioka Shie、Sakasai Tatsuya、Fujiyama Daisuke、Miura Yuki、Tsunoda Yuki、Kuwahara Junichi、Nakamura Satoshi、Iijima Kotaro、Chiba Takahito、Kaga Keita、Takemori Mihiro、Nakayama Hiroki、Katsuta Shouichi、Inaba Koji、Igaki Hiroshi、Nakayama Yuko、Itami Jun
  • Journal Title: The British Journal of Radiology Volume: 94 Issue: 1119 Pages: 20200239-20200239
  • DOI: 10.1259/bjr.20200239
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Configuration analysis of the injection position and shape of the gel spacer in gynecologic brachytherapy (2021)
  • Author(s): Iijima Kotaro、Murakami Naoya、Nakamura Satoshi、Nishioka Shie、Chiba Takahito、Kuwahara Junichi、Takemori Mihiro、Nakayama Hiroki、Kashihara Tairo、Okuma Kae、Takahashi Kana、Inaba Koji、Igaki Hiroshi、Okamoto Hiroyuki、Itami Jun
  • Journal Title: Brachytherapy Volume: 20 Issue: 1 Pages: 95-103
  • DOI: 10.1016/j.brachy.2020.08.021
  • Peer Reviewed
• [Journal Article] Usefulness of Simple Original Interstitial Lung Abnormality Scores for Predicting Radiation Pneumonitis Requiring Steroidal Treatment After Definitive Radiation Therapy for Patients With Locally Advanced Non-Small Cell Lung Cancer (2021)
  • Author(s): Kashihara Tairo、Nakayama Yuko、Ito Kimiteru、Kubo Yuko、Okuma Kae、Shima Satoshi、Nakamura Satoshi、Takahashi Kana、Inaba Koji、Murakami Naoya、Igaki Hiroshi、Ohe Yuichiro、Kusumoto Masahiko、Itami Jun
  • Journal Title: Advances in Radiation Oncology Volume: 6 Issue: 1 Pages: 100606-100606
  • DOI: 10.1016/j.adro.2020.10.019
  • Peer Reviewed / Open Access
• [Journal Article] A dosimetric and centeredness comparison of the conventional and novel endobronchial applicators: A preliminary study (2021)
  • Author(s): Iijima Kotaro、Murakami Naoya、Okamoto Hiroyuki、Nakamura Satoshi、Nishioka Shie、Chiba Takahito、Kuwahara Junichi、Nakayama Hiroki、Takemori Mihiro、Aikawa Ako、Yoshihiro Shibata、Kashihara Tairo、Takahashi Kana、Inaba Koji、Okuma Kae、Igaki Hiroshi、Nakayama Yuko、Itami Jun
  • Journal Title: Brachytherapy Volume: 20 Issue: 2 Pages: 467-477
  • DOI: 10.1016/j.brachy.2020.11.005
  • Peer Reviewed
• [Journal Article] Increased number of prostate cancer patients selecting high dose-rate interstitial brachytherapy during the COVID-19 pandemic (2021)
  • Author(s): Murakami Naoya、Nakamura Satoshi、Kashihara Tairo、Inaba Koji、Kaneda Tomoya、Takahashi Kana、Okuma Kae、Igaki Hiroshi、Itami Jun
  • Journal Title: Radiotherapy and Oncology Volume: 154 Pages: 274-275
  • DOI: 10.1016/j.radonc.2020.11.015
  • Peer Reviewed / Open Access
• [Journal Article] Summary of the Report of Task Group 100 of the AAPM: Application of Risk Analysis Methods to Radiation Therapy Quality Management (2020)
  • Author(s): 岡本 裕之、古谷 智久、山本 鋭二郎、飯島 康太郎、伊藤 芳紀、勝田 昭一、黒岡 将彦、川村 愼二、橘 英伸、遠山 尚紀、中村 勝、太田 誠一、峯村 俊行、中山 優子、川守田 龍、坂本 昌隆、中村 哲志、西岡 史絵、株木 重人、正井 範尚、水野 統文
  • Journal Title: Japanese Journal of Medical Physics (Igakubutsuri) Volume: 40 Issue: 1 Pages: 28-34
  • DOI: 10.11323/jjmp.40.1_28
  • NAID: 130007823200
  • ISSN: 1345-5354, 2186-9634
  • Year and Date: 2020-03-31
• [Journal Article] The use of hyperbaric oxygen to treat actinic rectal fistula after SpaceOAR use and radiotherapy for prostate cancer: a case report (2020)
  • Author(s): Kashihara Tairo, Inaba Koji, Komiyama Motokiyo, Nakayama Hiroki, Iijima Kotaro, Nishioka Shie, Okamoto Hiroyuki, Kikkawa Nao, Kubo Yuko, Shima Satoshi, Nakamura Satoshi, et al.
  • Journal Title: BMC Urology Volume: 20 Issue: 1 Pages: 196-196
  • DOI: 10.1186/s12894-020-00767-3
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of a real-time neutron detector for boron neutron capture therapy using a thin silicon diode (2020)
  • Author(s): Takada Masashi、Nunomiya Tomoya、Masuda Akihiko、Matsumoto Tetsuro、Tanaka Hiroki、Nakamura Satoshi、Endo Satoru、Nakamura Masaru、Aoyama Kei、Ueda Osamu、Narita Masataka、Nakamura Takashi
  • Journal Title: Radiation Measurements Volume: 137 Pages: 106381-106381
  • DOI: 10.1016/j.radmeas.2020.106381
  • Peer Reviewed
• [Journal Article] A case report of a patient with bulky uterine cervical neoplasm who achieved complete response with “intentional internal high-dose policy” high-dose-rate interstitial brachytherapy (2020)
  • Author(s): Kashihara Tairo、Kobayashi Kazuma、Iijima Kotaro、Murakami Naoya、Yoshida Ken、Okuma Kae、Nakamura Satoshi、Takahashi Kana、Inaba Koji、Igaki Hiroshi、Nakayama Yuko、Kato Tomoyasu、Uno Takashi、Itami Jun
  • Journal Title: Medicine Volume: 99 Issue: 27 Pages: e20860-e20860
  • DOI: 10.1097/md.0000000000020860
  • Peer Reviewed / Open Access
• [Journal Article] How Much Was the Elective Lymph Node Region Covered in Involved-Field Radiation Therapy for Locally Advanced Pancreatic Cancer? Evaluation of Overlap Between Gross Target Volume and Celiac Artery?Superior Mesenteric Artery Lymph Node Regions (2020)
  • Author(s): Umezawa Rei、Ito Yoshinori、Wakita Akihisa、Nakamura Satoshi、Okamoto Hiroyuki、Takahashi Kana、Inaba Koji、Murakami Naoya、Igaki Hiroshi、Jingu Keiichi、Itami Jun
  • Journal Title: Advances in Radiation Oncology Volume: 5 Issue: 3 Pages: 377-387
  • DOI: 10.1016/j.adro.2019.08.014
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of 18FBPA uptake with 18FDG uptake in cancer patients (2020)
  • Author(s): Igaki Hiroshi、Nakamura Satoshi、Kurihara Hiroaki、Abe Yoshihisa、Nishioka Shie、Fujii Ryo、Nakamura Masaru、Nakayama Yuko、Morita Takahiro、Okamoto Hiroyuki、Imahori Yoshio、Itami Jun
  • Journal Title: Applied Radiation and Isotopes Volume: 157 Pages: 109019-109019
  • DOI: 10.1016/j.apradiso.2019.109019
  • Peer Reviewed
• [Journal Article] Per-oral interstitial brachytherapy catheter insertion for boost in case of recurrent tonsillar carcinoma: dosimetry and clinical outcome (2020)
  • Author(s): Murakami Naoya、Yoshimoto Seiichi、Nakamura Satoshi、Uematsu Masakazu、Kashihara Tairo、Takahashi Kana、Inaba Koji、Okuma Kae、Igaki Hiroshi、Nakayama Yuko、Itami Jun
  • Journal Title: BJR|case reports Volume: 6 Issue: 1 Pages: 20190059-20190059
  • DOI: 10.1259/bjrcr.20190059
  • Peer Reviewed / Open Access
• [Journal Article] Hyaluronic acid gel injection in rectovaginal septum reduced incidence of rectal bleeding in brachytherapy for gynecological malignancies (2020)
  • Author(s): Murakami Naoya、Nakamura Satoshi、Kashihara Tairo、Kato Tomoyasu、Shibata Yoshihiro、Takahashi Kana、Inaba Koji、Okuma Kae、Igaki Hiroshi、Nakayama Yuko、Galalae Razvan、Itami Jun
  • Journal Title: Brachytherapy Volume: 19 Issue: 2 Pages: 154-161
  • DOI: 10.1016/j.brachy.2019.11.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prognostic value of the expression of epithelial cell adhesion molecules in head and neck squamous cell carcinoma treated by definitive radiotherapy (2019)
  • Author(s): Murakami Naoya、Mori Taisuke、Nakamura Satoshi、Yoshimoto Seiichi、Honma Yoshitaka、Ueno Takao、Kobayashi Kenya、Kashihara Tairo、Takahashi Kana、Inaba Koji、Okuma Kae、Igaki Hiroshi、Nakayama Yuko、Itami Jun
  • Journal Title: Journal of Radiation Research Volume: 60 Issue: 6 Pages: 803-811
  • DOI: 10.1093/jrr/rrz053
  • Peer Reviewed / Open Access
• [Journal Article] Dummy-run for standardizing plan quality of intensity-modulated radiotherapy for postoperative uterine cervical cancer: Japan Clinical Oncology Group study (JCOG1402). (2019)
  • Author(s): Okamoto H, Murakami N, Isohashi F, Kasamatsu T, Hasumi Y, Iijima K, Nishioka S, Nakamura S, Nakamura M, Nishio T, Igaki H, Nakayama Y, Itami J, Ishikura S, Nishimura Y, Toita T.
  • Journal Title: Radiat Oncol. Volume: 14 Issue: 1 Pages: 133-133
  • DOI: 10.1186/s13014-019-1340-y
  • Peer Reviewed / Open Access
• [Journal Article] Dose escalation of external beam radiotherapy for high-risk prostate cancer?Impact of multiple high-risk factor (2019)
  • Author(s): Umezawa Rei、Inaba Koji、Nakamura Satoshi、Wakita Akihisa、Okamoto Hiroyuki、Tsuchida Keisuke、Kashihara Tairo、Kobayashi Kazuma、Harada Ken、Takahashi Kana、Murakami Naoya、Ito Yoshinori、Igaki Hiroshi、Jingu Keiichi、Itami Jun
  • Journal Title: Asian Journal of Urology Volume: 6 Issue: 2 Pages: 192-199
  • DOI: 10.1016/j.ajur.2017.07.002
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target (2019)
  • Author(s): Nakamura Satoshi、Igaki Hiroshi、Ito Masashi、Okamoto Hiroyuki、Nishioka Shie、Iijima Kotaro、Nakayama Hiroki、Takemori Mihiro、Imamichi Shoji、Kashihara Tairo、Takahashi Kana、Inaba Koji、Okuma Kae、Murakami Naoya、Abe Yoshihisa、Nakayama Yuko、Masutani Mitsuko、Nishio Teiji、Itami Jun
  • Journal Title: PLOS ONE Volume: 14 Issue: 11 Pages: e0225587-e0225587
  • DOI: 10.1371/journal.pone.0225587
  • Peer Reviewed / Open Access
• [Journal Article] Inter-fractional variations in the dosimetric parameters of accelerated partial breast irradiation using a strut-adjusted volume implant (2019)
  • Author(s): Iijima Kotaro、Okamoto Hiroyuki、Takahashi Kana、Aikawa Ako、Wakita Akihisa、Nakamura Satoshi、Nishioka Shie、Harada Ken、Notake Ryoichi、Sugawara Akimoto、Yoshimura Ryoichi、Kunieda Etsuo、Itami Jun
  • Journal Title: Journal of Radiation Research Volume: 61 Issue: 1 Pages: 123-133
  • DOI: 10.1093/jrr/rrz061
  • Peer Reviewed / Open Access
• [Journal Article] Hemorrhage from ascending colon and gluteal muscle associated with sorafenib and radiotherapy: Radiation dose distribution corresponded with colonoscopy findings and computed tomography images. (2019)
  • Author(s): Kashihara T, Murakami N, Iizumi S, Sakamoto Y, Nakamura S, Iijima K, Takahashi K, Inaba K, Okuma K, Igaki H, Nakayama Y, Okusaka T, Uno T, and Itami J.
  • Journal Title: Practical Radiation Oncology Volume: In-press Issue: 4 Pages: 214-219
  • DOI: 10.1016/j.prro.2019.02.012
  • Peer Reviewed / Int'l Joint Research
• [Presentation] ホウ素中性子捕捉療法に適した提供体制と必要な人材の調査 (2023)
  • Author(s): 中村哲志、田中浩基、秋田和彦、加藤貴弘、高井良尋、二瓶圭二、大西洋、井垣浩
  • Organizer: 第19回日本中性子捕捉療法学会学術大会
• [Presentation] Lu-177-DOTA-TATE治療における核医学治療用線量評価ソフトの臨床導入 (2023)
  • Author(s): 中村 哲志, 中市 徹, 清水 雄平, 宍戸 淳, 石川 泰丈, 国遠 幸司, 中山広貴, 笠井 勇作, 柏原 大朗, 井垣 浩, 伊藤 公輝
  • Organizer: 第63回日本核医学会学術大会
• [Presentation] Accelerator-based BNCT system in National Cancer Center Hospital (2023)
  • Author(s): Satoshi Nakamura
  • Organizer: IAEA BNCT Training course
  • Int'l Joint Research / Invited
• [Presentation] 乳腺及び胸壁腫瘍に対するBNCTの適応の検討 (2022)
  • Author(s): 竹森望弘、中村哲志、中市徹、岡崎啓太、高橋真幸、黒崎弘正、首藤泰則、黒川聖悟、三笠翔平、平垣有史、中村勝、高橋加奈、井垣浩
  • Organizer: 第18回日本中性子捕捉療法学会学術大会
  • Invited
• [Presentation] Analyzing spatial distribution between 18F-FDG and 18F-BPA PET for investigating selection indicators for BNCT. (2022)
  • Author(s): Nakaichi T, Nakamura S*, Ito K, et al.
  • Organizer: 第123回日本医学物理学会学術大会
• [Presentation] 物理工学班での活動報告 (2022)
  • Author(s): 中村哲志、田中浩基、熊田博明
  • Organizer: 第18回日本中性子捕捉療法学会学術大会
  • Invited
• [Presentation] CICS-2を用いたBNCT照射場における熱中性子束測定 (2022)
  • Author(s): 岡崎啓太、高橋真幸、藤井亮、島田健司、中村哲志、竹森 望弘、黒崎弘正
  • Organizer: 日本量子医科学会第2回学術大会
• [Presentation] 106Ruアプリケータの通常逢着法が困難な網膜が細胞腫の患児に対する逢着法の開発 (2022)
  • Author(s): 中村哲志、村上直也、鈴木茂伸、伊藤公輝、竹森 望弘、高野勇貴、中市徹、三笠翔平、首藤泰則、中山広貴、千葉貴仁、飯島康太郎、高橋加奈、伍賀友紀、岡本裕之、井垣浩
  • Organizer: 日本放射線腫瘍学会第35回学術大会
• [Presentation] 装置開発や実際の現場での課題 (2022)
  • Author(s): 中村哲志
  • Organizer: 日本量子医科学会第2回学術大会
  • Invited
• [Presentation] Efforts to standardization for BNCT (2022)
  • Author(s): Satoshi Nakamura
  • Organizer: Academic information exchange for BNCT physics
  • Int'l Joint Research / Invited
• [Presentation] リチウムターゲットを用いた加速器ホウ素中性子捕捉療法システムでの中性子生成効率のモデルの構築と臨床使用時の精度についての評価 (2021)
  • Author(s): 中村哲志、井垣浩、竹森望弘、今道祥二、中山広貴、三笠翔平、中市徹、藤井恭平、千葉貴仁、飯島康太郎、柏原大朗、伍賀友紀、益谷美都子、岡本裕之、伊丹純
  • Organizer: 第17回日本中性子捕捉療法学会学術大会
• [Presentation] 固体リチウムターゲットと直線加速器を用いた加速器BNCTシステムの臨床導入まで (2021)
  • Author(s): 中村哲志
  • Organizer: 第17回日本中性子捕捉療法学会学術大会
  • Invited
• [Presentation] 膵癌に対するonline adaptive体幹部定位放射線治療 (2020)
  • Author(s): 井垣浩, 西岡史絵, 稲葉浩二, 逆井達也, 岡本裕之, 桑原潤一, 桑原潤一, 三浦悠記, 大熊加惠, 中村哲志, 飯島康太郎, 柏原大朗, 中山優子, 阿部容久, 勝田勝一, 伊丹純
  • Organizer: 日本放射線腫瘍学会高精度放射線外部照射部会学術大会
• [Presentation] EclipseのVMAT OptimizationにおけるAvoidance Structure Toolの有用性の検討 (2020)
  • Author(s): 飯島康太郎, 岡本裕之, 中村哲志, 西岡史絵, 中山広貴, 竹森望弘, 菅原章友, 国枝悦夫, 井垣浩, 中山優子, 伊丹純
  • Organizer: 日本放射線腫瘍学会高精度放射線外部照射部会学術大会
• [Presentation] FMEAによるon-line adaptive radiotherapyのリスク分析 (2020)
  • Author(s): 岡本裕之, 西岡史絵, 逆井達也, 三浦悠記, 桑原潤一, 桑原潤一, 冨士山大介, 角田裕樹, 中村哲志, 飯島康太郎, 竹森望弘, 中山広貴, 勝田昭一, 井垣浩, 中山優子, 伊丹純
  • Organizer: 日本放射線腫瘍学会高精度放射線外部照射部会学術大会
• [Presentation] MR画像誘導下online adaptive radiotherapyにおける,照射当日MRI画像取得から照射開始までの所要時間 (2020)
  • Author(s): 清水友理, 岡本裕之, CHE Su, 大熊加惠, 中村哲志, 西岡史絵, 飯島康太郎, 逆井達也, 冨士山大介, 三浦悠記, 角田裕樹, 村上直也, 中山優子, 井垣浩, 伊丹純
  • Organizer: 日本放射線腫瘍学会高精度放射線外部照射部会学術大会
• [Presentation] 病院設置型ホウ素中性子捕捉療法(BNCT)システムの臨床導入のための研究開発 (2020)
  • Author(s): 中村哲志、井垣浩、今道祥二、益谷美都子、柏原大朗、中村勝、藤井亮、今堀良夫、伊丹純
  • Organizer: 日本放射線腫瘍学会第33回学術大会
• [Presentation] Treatment facility design for an accelerator-based BNCT system in National Cancer Center Hospital (2020)
  • Author(s): Satoshi Nakamura, Hiroshi Igaki, Jun Itami, Hiroki Tanaka, Hiroaki Kumada
  • Organizer: Technical meeting on advances in boron neutron capture therapy
  • Int'l Joint Research
• [Presentation] FMEAによるon-line adaptive radiotherapyのリスク分析 (2020)
  • Author(s): 岡本裕之、西岡史絵、逆井達也、三浦悠記、桑原潤一、冨士山大介、角田 裕樹、中村哲志、飯島康太郎、竹森望弘、,中山広貴、勝田昭一、井垣浩、中山優子、伊丹純
  • Organizer: 第３３回高精度放射線外部照射部会学術大会
• [Presentation] EclipseのVMAT OptimizationにおけるAvoidance Structure Toolの有用性の検討 (2020)
  • Author(s): 飯島康太郎、岡本裕之、中村哲志、西岡史絵、中山広貴、竹森望弘、菅原章友、井垣浩、中山優子、国枝悦夫、伊丹純
  • Organizer: 第３３回高精度放射線外部照射部会学術大会、2020年2月29日、福岡
• [Presentation] Quality assurance of MRIdian of Cobalt from the standpoint of medical physics (2020)
  • Author(s): Okamoto H, Nishioka S, Kotaro Iijima K, Tatsuya Sakasai T, Fujiyama D, Tsunoda Y, Nakamura S, Kuwahara J, Nakayama H, Takemori M, Katsuta S, Igaki H, Itami J
  • Organizer: Asia ViewRay Meeting 2020
  • Int'l Joint Research
• [Presentation] Alpha線を用いた小線源治療 (2019)
  • Author(s): 中村哲志
  • Organizer: 臨床医学物理研究会 臨床医学物理セミナー
  • Invited
• [Presentation] 腟小線源治療におけるジェルスペーサーによる直腸出血の低減効果 (2019)
  • Author(s): 中村哲志,村上直也, 柏原大朗,岡本裕之, 西岡史絵, 飯島康太郎, 中山広貴, 竹森望弘, 高橋加奈, 稲葉浩二, 大熊加恵, 井垣浩, 中山優子, 伊丹純
  • Organizer: 日本放射線腫瘍学会小線源治療部会第20回学術大会
• [Presentation] 放射線治療による腎機能低下の予測モデル (2019)
  • Author(s): 岡本裕之、稲葉浩二、中村哲志、西岡史絵、飯島康太郎、桑原潤一、竹森望弘、中山広貴、勝田昭一、伊丹純、
  • Organizer: 日本放射線腫瘍学会第32回学術大会
• [Presentation] 外部放射線治療におけるCT画像 金属アーチファクト低減処理の 有効性の検証 (2019)
  • Author(s): 西岡史絵、岡本裕之、中村哲志、村上直也、大熊加恵、飯島康太郎、竹森望弘、中山広貴、柏原大朗、高橋彩加、伊丹純
  • Organizer: 日本放射線腫瘍学会第32回学術大会
• [Presentation] 小線源治療の不均質領域の線量計算 (2019)
  • Author(s): 岡本裕之,中村哲志,西岡史絵,飯島康太郎,竹森望弘,中山広貴,稲葉浩二,伊丹純
  • Organizer: 日本放射線腫瘍学会小線源治療部会第20回学術大会
• [Presentation] 婦人科小線源治療においてスペーサジェルがリスク臓器線量に与える影響 (2019)
  • Author(s): 飯島康太郎, 岡本裕之, 村上直也, 中村哲志, 西岡史絵, 竹森望弘 , 中山広貴, 柏原大朗, 相川亜子, 芝田祥宏, 国枝悦夫, 伊丹純
  • Organizer: 日本放射線腫瘍学会小線源治療部会第20回学術大会
• [Presentation] Assessment of dosimetric effects by latency of beam control in MRI-guided radiotherapy system (2019)
  • Author(s): Nakayama H, Okamoto H, Nakamura S, Nishioka S, Iijima K, Takemori M, Sakasai T, Miura Y, Itami J, Saitoh H
  • Organizer: The 117th Scientific Meeting of the JSMP
• [Presentation] Preliminary study of polymer gel dosimeter for QA in MRI-guided radiotherapy system (2019)
  • Author(s): Takemori M, Iijima K, Okamoto H, Nakamura S, Nishioka S, Nakayama H, Sakasai T, Miura Y, Saitoh H, Itami J
  • Organizer: The 117th Scientific Meeting of the JSMP
• [Book] インナービジョン 第38巻第11号(2023NOVEMBER) (2023)
  • Author(s): 中村哲志、中市徹、清水雄平、国遠幸司、伊藤公輝
  • Total Pages: 96
  • Publisher: インナービジョン
  • ISBN: 4910561358
• [Book] がん・放射線療法 改訂第８版 (2023)
  • Author(s): 大西 洋、唐澤 久美子、石川 仁、西尾 禎治
  • Total Pages: 1386
  • Publisher: Ｇａｋｋｅｎ
  • ISBN: 4055200498
• [Book] Advances in Accelerators and Medical Physics (2023)
  • Author(s): Satoshi Nakamura
  • Total Pages: 384
  • Publisher: Science direct
• [Book] スイスイわかる放射線治療物理学 (2021)
  • Author(s): 唐澤久美子、他
  • Total Pages: 208
  • Publisher: 学研メディカル秀潤社
  • ISBN: 4780909929
• [Remarks] 国立がん研究センター中央病院放射線品質管理室の研究と業績
  • URL: https://www.ncc.go.jp/jp/ncch/division/radiation_qulity_cotrol/050/index.html
• [Remarks] 国立がん研究センター中央病院放射線治療科の研究
  • URL: https://www.ncc.go.jp/jp/ncch/clinic/radiation_oncology/030/index.html
• [Remarks] 国立がん研究センター先端医療開発センターBNCT医療開発分野の業績
  • URL: https://www.ncc.go.jp/jp/epoc/division/bnct/tsukiji/publications/20170909135309.html
• [Remarks] 放射線品質管理室の研究と業績
  • URL: https://www.ncc.go.jp/jp/ncch/division/radiation_qulity_cotrol/050/index.html
• [Patent(Industrial Property Rights)] 線量評価方法および線量評価システム (2023)
  • Inventor(s): 中村哲志、中市徹、首藤泰則、竹森望弘、井垣浩
  • Industrial Property Rights Holder: 中村哲志、中市徹、首藤泰則、竹森望弘、井垣浩
  • Industrial Property Rights Type: 特許
  • Filing Date: 2023