New diagnostic method for Parkinson's disease by multimodal imaging

• Project/Area Number: 19K17244
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Juntendo University
• Principal Investigator: Kamagata Koji 順天堂大学, 医学部, 准教授 (60568153)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: パーキンソン病 / マルチモーダルMRI / 拡散MRI / 神経突起イメージング / 自由水イメージング / ミエリンイメージング / 神経メラニンMRI / 深層学習 / Fixel based analysis / パーキンソニズム / 進行性核上性麻痺 / 大脳皮質基底核症候群 / 疾患進行モデリング / 多系統萎縮症 / Double diffusion encode / MRI / マルチモーダルイメージング

Outline of Research at the Start

本研究では次世代定量MRI技術やドパミントランスポーターイメージングを組み合わせたマルチモーダル解析により、パーキンソン病（PD）脳の微細病理変化に対して多面的なアプローチを行い、PD病態の神経基盤を解明し、客観的PD診断評価法を開発を目指す。

Outline of Final Research Achievements

The purpose of this research project was to develop an early diagnosis method for Parkinson's disease (PD) and to elucidate the neural basis of PD pathology through comprehensive evaluation using multimodal MRI analysis. We reported new findings on PD pathology, including neurodegeneration and neuroinflammation in PD and Parkinsonism, which could not be evaluated or detected by conventional MRI techniques, using multimodal MRI analysis that combines advanced diffusion MRI techniques including neurite orientation dispersion and density imaging (NODDI) and free-water imaging (FWI), myelin imaging, and neuromelanin-sensitive MRI. In addition, we have developed MRI scanning techniques and analysis pipelines necessary for these multimodal MRI analyses.

Academic Significance and Societal Importance of the Research Achievements

PDはアルツハイマー病に次ぎ、2番目に頻度の高い神経変性疾患であるが、臨床診断の誤診率の高さや、現時点で根治が不可能な点などが臨床的に重要な課題となっている。本課題において報告した、従来のMRIでは評価不可能であった新たなPD病態や、MRI解析技術の開発は、PDの早期診断を可能とするイメージングバイオマーカーの確立につながるものであり、早期診断により適切な対症療法でのPD患者の日常生活動作の改善や、疾患進行を遅らせることも目的とした神経保護治療の開発や、iPS細胞を用いた再生医療研究の推進にも繋がる。

Research Products

• [Int'l Joint Research] University College of London(英国)
• [Int'l Joint Research] Univeristy College of London(英国)
• [Int'l Joint Research] University of Melbourne(オーストラリア)
• [Int'l Joint Research] University college of London(英国)
• [Int'l Joint Research] University of Melbourne(オーストラリア)
• [Int'l Joint Research] University Paris Descartes(フランス)
• [Journal Article] MR Fingerprinting for Liver Tissue Characterization: A Histopathologic Correlation Study. (2023)
  • Author(s): Fujita S, Sano K, Cruz G, Fukumura Y, Kawasaki H, Fukunaga I, Morita Y, Yoneyama M, Kamagata K, Abe O, Ikejima K, Botnar RM, Prieto C, Aoki S.
  • Journal Title: Radiology Volume: 306 Issue: 1 Pages: 150-159
  • DOI: 10.1148/radiol.220736
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuroimaging findings related to glymphatic system alterations in older adults with metabolic syndrome (2023)
  • Author(s): Andica Christina、Kamagata Koji、Takabayashi Kaito、Kikuta Junko、Kaga Hideyoshi、Someya Yuki、Tamura Yoshifumi、Kawamori Ryuzo、Watada Hirotaka、Taoka Toshiaki、Naganawa Shinji、Aoki Shigeki
  • Journal Title: Neurobiology of Disease Volume: 177 Pages: 105990-105990
  • DOI: 10.1016/j.nbd.2023.105990
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glymphatic system impairment in nonathlete older male adults who played contact sports in their youth associated with cognitive decline: A diffusion tensor image analysis along the perivascular space study (2023)
  • Author(s): Morita Yuichi、Kamagata Koji、Andica Christina、Takabayashi Kaito、Kikuta Junko、Fujita Shohei、Samoyeau Thomas、Uchida Wataru、Saito Yuya、Tabata Hiroki、Naito Hitoshi、Someya Yuki、Kaga Hideyoshi、Tamura Yoshifumi、Miyata Mari、Akashi Toshiaki、Wada Akihiko、Taoka Toshiaki、Naganawa Shinji、et al.
  • Journal Title: Frontiers in Neurology Volume: 14 Pages: 1100736-1100736
  • DOI: 10.3389/fneur.2023.1100736
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multiparametric MRI (2023)
  • Author(s): Hagiwara Akifumi、Fujita Shohei、Kurokawa Ryo、Andica Christina、Kamagata Koji、Aoki Shigeki
  • Journal Title: Investigative Radiology Volume: Publish Ahead of Print Pages: 1-13
  • DOI: 10.1097/rli.0000000000000962
  • Peer Reviewed / Open Access
• [Journal Article] Automated three-dimensional major white matter bundle segmentation using diffusion magnetic resonance imaging (2023)
  • Author(s): Andica Christina、Kamagata Koji、Aoki Shigeki
  • Journal Title: Anatomical Science International Volume: - Issue: 3 Pages: 318-336
  • DOI: 10.1007/s12565-023-00715-9
  • Peer Reviewed / Open Access
• [Journal Article] Multisite harmonization of diffusion tensor image analysis along the perivascular space using the COMBined Association Test (2023)
  • Author(s): Saito Yuya、Kamagata Koji、Andica Christina、Taoka Toshiaki、Tuerxun Rukeye、Uchida Wataru、Takabayashi Kaito、Owaki Mana、Yoshida Seina、Yamazaki Keigo、Naganawa Shinji、Aoki Shigeki
  • Journal Title: Japanese Journal of Radiology Volume: - Issue: 10 Pages: 1072-1083
  • DOI: 10.1007/s11604-023-01432-z
  • Peer Reviewed / Open Access
• [Journal Article] Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index calculated by manual and automated methods (2023)
  • Author(s): Saito Yuya、Kamagata Koji、Uchida Wataru、Takabayashi Kaito、Aoki Shigeki
  • Journal Title: Japanese Journal of Radiology Volume: - Issue: 9 Pages: 1033-1034
  • DOI: 10.1007/s11604-023-01429-8
  • Peer Reviewed / Open Access
• [Journal Article] White matter fiber-specific degeneration in older adults with metabolic syndrome (2022)
  • Author(s): Andica Christina、Kamagata Koji、Uchida Wataru、Takabayashi Kaito、Shimoji Keigo、Kaga Hideyoshi、Someya Yuki、Tamura Yoshifumi、Kawamori Ryuzo、Watada Hirotaka、Hori Masaaki、Aoki Shigeki
  • Journal Title: Molecular Metabolism Volume: 62 Pages: 101527-101527
  • DOI: 10.1016/j.molmet.2022.101527
  • Peer Reviewed / Open Access
• [Journal Article] Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease (2022)
  • Author(s): Kamagata Koji、Andica Christina、Takabayashi Kaito、Saito Yuya、Taoka Toshiaki、Nozaki Hayato、Kikuta Junko、Fujita Shohei、Hagiwara Akifumi、Kamiya Kouhei、Wada Akihiko、Akashi Toshiaki、Sano Katsuhiro、Nishizawa Mitsuo、Hori Masaaki、Naganawa Shinji、Aoki Shigeki、for the Alzheimer's Disease Neuroimaging Initiative
  • Journal Title: Neurology Volume: 99 Issue: 24
  • DOI: 10.1212/wnl.0000000000201300
  • Peer Reviewed / Open Access
• [Journal Article] White matter microstructures in Parkinson's disease with and without impulse control behaviors (2022)
  • Author(s): Takeshige‐Amano Haruka、Hatano Taku、Kamagata Koji、Andica Christina、Uchida Wataru、Abe Masahiro、Ogawa Takashi、Shimo Yasushi、Oyama Genko、Umemura Atsushi、Ito Masanobu、Hori Masaaki、Aoki Shigeki、Hattori Nobutaka
  • Journal Title: Annals of Clinical and Translational Neurology Volume: 9 Issue: 3 Pages: 253-263
  • DOI: 10.1002/acn3.51504
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Temporal Progression Patterns of Brain Atrophy in Corticobasal Syndrome and Progressive Supranuclear Palsy Revealed by Subtype and Stage Inference (SuStaIn) (2022)
  • Author(s): Saito Yuya、Kamagata Koji、Wijeratne Peter A.、Andica Christina、Uchida Wataru、Takabayashi Kaito、Fujita Shohei、Akashi Toshiaki、Wada Akihiko、Shimoji Keigo、Hori Masaaki、Masutani Yoshitaka、Alexander Daniel C.、Aoki Shigeki
  • Journal Title: Frontiers in Neurology Volume: 13 Pages: 814768-814768
  • DOI: 10.3389/fneur.2022.814768
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rigid real-time prospective motion-corrected three-dimensional multiparametric mapping of the human brain (2022)
  • Author(s): Fujita Shohei、Hagiwara Akifumi、Takei Naoyuki、Fukunaga Issei、Hagiwara Yasuhiro、Ogawa Takashi、Hatano Taku、Rettmann Dan、Banerjee Suchandrima、Hwang Ken-Pin、Amemiya Shiori、Kamagata Koji、Hattori Nobutaka、Abe Osamu、Aoki Shigeki
  • Journal Title: NeuroImage Volume: 255 Pages: 119176-119176
  • DOI: 10.1016/j.neuroimage.2022.119176
  • Peer Reviewed / Open Access
• [Journal Article] White matter alterations in Parkinson's disease with levodopa-induced dyskinesia (2021)
  • Author(s): Ogawa Takashi、Hatano Taku、Kamagata Koji、Andica Christina、Takeshige-Amano Haruka、Uchida Wataru、Saito Yuya、Shimo Yasushi、Oyama Genko、Umemura Atsushi、Iwamuro Hirokazu、Ito Masanobu、Hori Masaaki、Aoki Shigeki、Hattori Nobutaka
  • Journal Title: Parkinsonism & Related Disorders Volume: 90 Pages: 8-14
  • DOI: 10.1016/j.parkreldis.2021.07.021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] White matter and nigral alterations in multiple system atrophy-parkinsonian type (2021)
  • Author(s): Ogawa Takashi、Hatano Taku、Kamagata Koji、Andica Christina、Takeshige-Amano Haruka、Uchida Wataru、Kamiyama Daiki、Shimo Yasushi、Oyama Genko、Umemura Atsushi、Iwamuro Hirokazu、Ito Masanobu、Hori Masaaki、Aoki Shigeki、Hattori Nobutaka
  • Journal Title: npj Parkinson's Disease Volume: 7 Issue: 1 Pages: 1-12
  • DOI: 10.1038/s41531-021-00236-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fiber-specific white matter alterations in early-stage tremor dominant Parkinson’s disease (2021)
  • Author(s): Andica C, Kamagata K, Saito Y, Uchida U, Fujita S, Hagiwara A, Akashi T, Wada A, Ogawa T, Hatano T, Hattori N, Aoki S.
  • Journal Title: NPJ Parkinsons Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases (2021)
  • Author(s): Kamagata K, Andica C, Kato A, Saito Y, Uchida W, Hatano T, Lukies M, Ogawa T, Takeshige-Amano H, Akashi T, Hagiwara A, Fujita S, Aoki S.
  • Journal Title: Int. J. Mol. Sci. Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] Parkinson’s disease: deep learning with a parameter-weighted structural connectome matrix for diagnosis and neural circuit disorder investigation (2021)
  • Author(s): Yasaka Koichiro、Kamagata Koji、Ogawa Takashi、Hatano Taku、Takeshige-Amano Haruka、Ogaki Kotaro、Andica Christina、Akai Hiroyuki、Kunimatsu Akira、Uchida Wataru、Hattori Nobutaka、Aoki Shigeki、Abe Osamu
  • Journal Title: Neuroradiology Volume: Online ahead of print. Issue: 9 Pages: 1451-1462
  • DOI: 10.1007/s00234-021-02648-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease (2021)
  • Author(s): Koinuma Takahiro、Hatano Taku、Kamagata Koji、Andica Christina、Mori Akio、Ogawa Takashi、Takeshige-Amano Haruka、Uchida Wataru、Saiki Shinji、Okuzumi Ayami、Ueno Shin-Ichi、Oji Yutaka、Saito Yuya、Hori Masaaki、Aoki Shigeki、Hattori Nobutaka
  • Journal Title: Journal of Parkinson's Disease Volume: - Issue: 3 Pages: 1-15
  • DOI: 10.3233/jpd-202495
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Brain White-Matter Degeneration Due to Aging and Parkinson Disease as Revealed by Double Diffusion Encoding (2020)
  • Author(s): Kamiya Kouhei、Kamagata Koji、Ogaki Kotaro、Hatano Taku、Ogawa Takashi、Takeshige-Amano Haruka、Murata Syo、Andica Christina、Murata Katsutoshi、Feiweier Thorsten、Hori Masaaki、Hattori Nobutaka、Aoki Shigeki
  • Journal Title: Frontiers in Neuroscience Volume: 14 Pages: 584-510
  • DOI: 10.3389/fnins.2020.584510
  • Peer Reviewed / Open Access
• [Journal Article] Neurocognitive and psychiatric disorders‐related axonal degeneration in Parkinson's disease (2020)
  • Author(s): Andica Christina、Kamagata Koji、Hatano Taku、Saito Yuya、Uchida Wataru、Ogawa Takashi、Takeshige‐Amano Haruka、Hagiwara Akifumi、Murata Syo、Oyama Genko、Shimo Yashushi、Umemura Atsushi、Akashi Toshiaki、Wada Akihiko、Kumamaru Kanako K.、Hori Masaaki、Hattori Nobutaka、Aoki Shigeki
  • Journal Title: Journal of Neuroscience Research Volume: 98 Issue: 5 Pages: 936-949
  • DOI: 10.1002/jnr.24584
  • Peer Reviewed / Open Access
• [Journal Article] Scan-rescan and inter-vendor reproducibility of neurite orientation dispersion and density imaging metrics (2020)
  • Author(s): Andica C, Kamagata K, Hayashi T, Hagiwara A, Uchida W, Saito Y, Kamiya K, Fujita S, Akashi T, Wada A, Abe M, Kusahara H, Hori M, Aoki S.
  • Journal Title: Neuroradiology Volume: 62 Issue: 4 Pages: 483-494
  • DOI: 10.1007/s00234-019-02350-6
  • Peer Reviewed / Open Access
• [Journal Article] Free-Water Imaging in White and Gray Matter in Parkinson’s Disease (2019)
  • Author(s): Andica、Kamagata、Hatano、Saito、Uchida、Ogawa、Takeshige-Amano、Zalesky、Wada、Suzuki、Hagiwara、Irie、Hori、Kumamaru、Oyama、Shimo、Umemura、Pantelis、Hattori、Aoki
  • Journal Title: Cells Volume: 8 Issue: 8 Pages: 839-839
  • DOI: 10.3390/cells8080839
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MR biomarkers of degenerative brain disorders derived from diffusion imaging (2019)
  • Author(s): Andica Christina、Kamagata Koji、Hatano Taku、Saito Yuya、Ogaki Kotaro、Hattori Nobutaka、Aoki Shigeki
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: ー Issue: 6 Pages: 1620-1636
  • DOI: 10.1002/jmri.27019
  • Peer Reviewed / Open Access
• [Journal Article] Free-Water Imaging in White and Gray Matter in Parkinson's Disease. (2019)
  • Author(s): Andica C, Kamagata K, Hatano T, Saito A, Uchida W, Ogawa T, Takeshige-Amano H, Zalesky A, Wada A, Suzuki M, Hagiwara A, Irie R, Hori M, Kumamaru KK, Oyama G, Shimo Y, Umemura A, Pantelis C, Hattori N, Aoki S.
  • Journal Title: Cells Volume: 8(8) Issue: 12 Pages: 839-839
  • DOI: 10.1007/s00234-019-02279-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 拡散MRI：脳微細構造解析及び脳コネクトーム解析 (2022)
  • Author(s): 鎌形康司
  • Organizer: 2022年度生理学研究所研究会 多次元脳形態研究会
  • Invited
• [Presentation] Noninvasive magnetic resonance imaging measures of glymphatic system activity (2022)
  • Author(s): 鎌形康司
  • Organizer: 第40回日本神経治療学会学術集会
  • Invited
• [Presentation] Non-invasive MRI measurements of glymphatic system activity associated with CSF Aβ levels and FDG PET uptake in Alzheimer’s disease. ISMRM 30th annual meeting and exhibition (2022)
  • Author(s): Kamagata K, Andica C, Takabayashi K, Saito Y, Taoka T, Nozaki H, Kikuta J, Fujita S, Kamiya K, Wada A, Akashi T, Hori M, Naganawa S, Aoki S.
  • Organizer: ISMRM 30th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] Fixel-Based Analysis of White Matter Degeneration in Patients with Progressive Supranuclear Palsy and Corticobasal Syndrome. ISMRM 30th annual meeting and exhibition (2022)
  • Author(s): Uchida W, Kamagata K, Andica C, Saito Y, Takabayashi K, Hagiwara A, Fujita S, Akashi T, Wada A, Hori M, Aoki S
  • Organizer: ISMRM 30th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] Harmonization of multi-site DTI and NODDI data using the combined association test (2022)
  • Author(s): Saito Y, Kamagata K, Andica C, Uchida W, Nozaki H, Owaki M, Hagiwara A, Fujita S, Akashi T, Wada A, Hori M, Aoki S
  • Organizer: ISMRM 30th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] A structural connectivity approach to identify human paraventricular thalamic nucleus (2022)
  • Author(s): Kamagata K, Uchida W, Andica C, Nagai Y, Nishioka M, Owaki M, Saito Y, Takabayashi K, Hagiwara A, Wada A, Akashi T, Aoki S, Kato T
  • Organizer: 第50回日本磁気共鳴医学会大会
• [Presentation] Fiber-specific white matter changes in early-stage Parkinson's disease-linked glucocerebrosidase gene mutations (2022)
  • Author(s): Andica C, Kamagata K, Uchida W, Saito Y, Takabayashi K, Owaki M, Hagiwara A, Aoki S
  • Organizer: 第50回日本磁気共鳴医学会大会
• [Presentation] Impact of DTI metrics harmonization on multicenter Alzheimer's disease study (2022)
  • Author(s): Saito Y, Kamagata K, Andica C, Uchida W, Takabayashi K, Yoshida S, Owaki M, Hagiwara A, Fujita S, Wada A, Akashi T, Irie R, Shimoji K, Hori M, Aoki S
  • Organizer: 第50回日本磁気共鳴医学会大会
• [Presentation] Harmonization of multicenter DTI and NODDI data using ComBat and TSGLM (2022)
  • Author(s): Saito Y, Kamagata K, Andica C, Maikusa N, Uchida W, Takabayashi K, Yoshida S, Owaki M, Hagiwara A, Fujita S, Akashi T, Wada A, Irie R, Shimoji K, Hori M, Kamiya K, Koike S, Hayashi T, Aoki S
  • Organizer: 第50回日本磁気共鳴医学会大会
• [Presentation] Free-water Imaging in the white matter under Selegiline Treatment in Parkinson’s Disease (2022)
  • Author(s): Takeshige H, Hatano T, Kamagata K, Andica C, Ogawa T, Shindo A, Ucihda W, Shimo Y, Oyama G, Umemura A, Ito M, Hori M, Aoki S, Hattori N
  • Organizer: 第63回日本神経学会学術大会
• [Presentation] Striatal degeneration and Cerebellar fiber alterations of Parkinson’s disease (2022)
  • Author(s): Shindo A, Ogawa T, Hatano T, Shinichi U, Sako W, Kamagata K, Andica C, Takeshige H, Uchida W, Oyama G, Umemura A, Iwamuro H, Ito M, Nakanishi A, Murakami K, Aoki S, Hattori N
  • Organizer: 第63回日本神経学会学術大会
• [Presentation] White matter differences between MSA-P and MSA-C using fixel-based analysis (2022)
  • Author(s): Ogawa T, Hatano T, Kamagata K, Uchida W, Andica A, Takeshige H, Shindo A, Sako W, Shimo Y, Oyama G, Umemura A, Iwamuro H, Aoki S, Hattori N
  • Organizer: 第63回日本神経学会学術大会
• [Presentation] Relationship between subjective evaluation of Parkinson's disease and brain finestructure (2022)
  • Author(s): Kujirai H, Ogawa T, Shindo A, Takeshige H, Hatano T, Uchida W, Kamagata K, Aoki S, Hattori N
  • Organizer: 第63回日本神経学会学術大会
• [Presentation] MIBG cardiac scintigraphy may detect Frontal dysfunction in Parkinson's disease (2022)
  • Author(s): Okada H, Hatano T, Kamagata K, Takeshige H, Shindo A, Uchida W, Aoki S, Hattori N
  • Organizer: 第63回日本神経学会学術大会
• [Presentation] 神経MRI解析技術の最近のトピックス (2021)
  • Author(s): 鎌形康司
  • Organizer: 脳とこころの研究センターシンポジウム・指定講演
  • Invited
• [Presentation] Diffusion MRI: from microstructure to macroscale connectomics (2021)
  • Author(s): 鎌形康司
  • Organizer: 第５回ヒト脳イメージング研究会・教育講演
  • Invited
• [Presentation] Advanced MRI in Parkinson's disease（シンポジウム） (2021)
  • Author(s): 鎌形康司
  • Organizer: 第7回DCC検討会・指名講演
  • Invited
• [Presentation] Microstructural Gray Matter Abnormalities in Progressive Supranuclear Palsy and Corticobasal Syndrome: Evaluation by Free-water Imaging. (2021)
  • Author(s): Koji Kamagata, Christina Andica, Kaito Takabayashi, Yuya Saito, Wataru Uchida, Shohei Fujita, Toshiaki Akashi, Akihiko Wada, Kouhei Kamiya, Masaaki Hori, and Shigeki Aoki
  • Organizer: ISMRM 29th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] Association between magnetic resonance imaging measures of glymphatic system activity in healthy elderly individuals. (2021)
  • Author(s): Koji Kamagata, Toshiaki Taoka, Yuya Saito, Jyunko Kikuta, Hideyoshi Kaga, Yuki Someya, Christina Andica, Toshiaki Akashi, Akihiko Wada, Yoshifumi Tamura, Ryuzo Kawamori, Hirotaka Watada, Shinji Naganawa, Shigeki Aoki.
  • Organizer: 第49回日本磁気共鳴医学会大会
• [Presentation] Temporal progression patterns of white-matter degeneration in CBS and PSP identified with Subtype & Stage Inference (SuStaIn) (2021)
  • Author(s): Yuya Saito, Peter A. Wijeratne, Koji Kamagata, Christina Andica, Wataru Uchida, Toshiaki Akashi, Akihiko Wada, Masaaki Hori, and Shigeki Aoki
  • Organizer: ISMRM 29th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] Brain white and gray matter alterations in early-stage Parkinson’s disease with GBA1 gene mutations evaluated using free water imaging. (2021)
  • Author(s): Christina Andica, Koji Kamagata, Masahiro Abe, Wataru Uchida, Yuya Saito, Hayato Nozaki, Kaito Takabayashi, Masaaki Hori, and Shigeki Aoki.
  • Organizer: ISMRM 29th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] Harmonization of multicenter DTI and NODDI data using combined association test (ComBat) (2021)
  • Author(s): 15.Yuya Saito, Koji Kamagata, Christina Andica, Wataru Uchida, Toshiaki Akashi, Akihiko Wada, Masaaki Hori, Shigeki Aoki
  • Organizer: 第49回日本磁気共鳴医学会大会
• [Presentation] Single-shell 3-Tissue-CSDを用いたパーキンソン病における神経構造的接続性の評価. (2021)
  • Author(s): 大脇 万奈、鎌形 康司、白川 崇子、Christina Andica、内田 航、高林 海斗、斎藤 勇哉、青木 茂樹
  • Organizer: 第５回ヒト脳イメージング研究会
• [Presentation] 先端的MRIを用いたパーキンソン病の病態解明（シンポジウム） (2020)
  • Author(s): 鎌形康司
  • Organizer: AD研究会 画像診断サブコミッティ
  • Invited
• [Presentation] 神経メラニンイメージング（ランチョンセミナー） (2020)
  • Author(s): 鎌形康司
  • Organizer: 第40回神経放射線ワークショップ
  • Invited
• [Presentation] Advanced MRI in Parkinson's disease（シンポジウム） (2020)
  • Author(s): 鎌形康司
  • Organizer: 第38回日本神経治療学会学術集会
  • Invited
• [Presentation] 拡散MRIによるコネクトーム解析（シンポジウム） (2020)
  • Author(s): 鎌形康司
  • Organizer: 第24回MR実践・先端講座
  • Invited
• [Presentation] Temporal progression patterns of brain atrophy in CBS and PSP determined using Subtype and Stage Inference. (2020)
  • Author(s): Yuya Saito, Koji Kamagata, Christina Andica, Wataru Uchida, Akifumi Hagiwara, Toshiaki Akashi, Akihiko Wada, Masaaki Hori, Shigeki Aoki
  • Organizer: ISMRM 28th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] White Matter Plasticity in Newly Diagnosed Parkinson’s Disease With/Without Mild Cognitive Impairment (2020)
  • Author(s): Christina Andica, Koji Kamagata, Yuya Saito, Wataru Uchida, Akifumi Hagiwara, Shohei Fujita, Syo Murata, Masaaki Hori, and Shigeki Aoki
  • Organizer: ISMRM 28th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] 進行性核上性麻痺における free-water imaging による白質評価 (2020)
  • Author(s): 加藤 亜結美、鎌形 康司、Andica Christina、斎藤 勇哉、萩原 彰文、明石 敏昭、和田 昭彦、堀 正明、藤井 進也、青木 茂樹.
  • Organizer: 第49回神経放射線学会
• [Presentation] Corticospinal Tracts Neuroplasticity in Drug-Naive Newly Diagnosed Parkinson's Disease: A Fixel-Based Analysis. (2020)
  • Author(s): Christina Andica, Koji Kamagata, Yuya Saito, Wataru Uchida, Shigeki Aoki.
  • Organizer: 第48回日本磁気共鳴医学会大会
• [Presentation] SuStaIn を用いた大脳皮質基底核症候群および進行性核上性麻痺における脳萎縮の時間的進行パターンの推定 (2020)
  • Author(s): 斎藤勇哉, 鎌形康司, アンディカ・クリスティナ, 内田航, 村田渉, 萩原彰文, 明石敏昭, 和田昭彦, 堀正明, 青木茂樹.
  • Organizer: 第22回日本ヒト脳機能マッピング学会
• [Presentation] Diffusion MRI-Based Connectomics Study in Neurodegenerative Diseases (Educational lecture) (2019)
  • Author(s): Koji Kamagata
  • Organizer: ISMRM 27th annual meeting and exhibition
  • Int'l Joint Research / Invited
• [Presentation] Linked alterations in microstructural morphology of white matter in patients with Parkinson’s disease: A multimodal magnetic resonance imaging study (2019)
  • Author(s): Koji Kamagata Kouhei Kamiya, Yuya Saito, Taku Hatano, Christina Andica, Tomoko Maekawa, Shohei Fujita, Asami Saito, Takashi Ogawa, Genko Oyama, Haruka Takeshige-Amano, Yasushi Shimo, Akifumi Hagiwara, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki
  • Organizer: ISMRM 27th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] Free-Water Imaging Improves the Evaluation of White and Gray-Matter in Early Parkinson’s Disease (2019)
  • Author(s): Christina Andica, Koji Kamagata, Taku Hatano, Yuki Takenaka, Asami Saito, Mana Kuramochi, Wataru Uchida, Akifumi Hagiwara, Takashi Ogawa, Haruka Takeshige-Amano, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki
  • Organizer: ISMRM 27th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] 早期パーキンソン病における白質と灰白質のfree water imaging (2019)
  • Author(s): クリスティナ・アンディカ, 鎌形 康司, 波田野 琢, 小川 崇, 竹重 遥香, 大山 彦光, 下 泰司, 梅村 淳, 堀 正明, 青木 茂樹, 服部 信孝
  • Organizer: 第13回パーキンソン病・運動障害疾患コングレス
• [Presentation] パーキンソン病患者における衝動制御障害と白質微小構造の検討 (2019)
  • Author(s): 竹重 遥香, 波田野 琢, 鎌形 康司, Andica Christina, 小川 崇, 下 泰司, 大山 彦光, 梅村 淳, 伊藤 賢伸, 堀 正明, 青木 茂樹, 服部 信孝
  • Organizer: 第13回パーキンソン病・運動障害疾患コングレス
• [Presentation] LIDがあるパーキンソン病患者では白質構造が保たれる (2019)
  • Author(s): 小川 崇, 波田野 琢, 竹重 遥香, Andica Christina, 齊藤 麻美, 鎌形 康司, 濃沼 崇博, 中村 亮太, 岩室 宏一, 大山 彦光, 下 泰司, 梅村 淳, 伊藤 賢伸, 青木 茂樹, 服部 信孝
  • Organizer: 第13回パーキンソン病・運動障害疾患コングレス
• [Presentation] 拡散テンソル画像を用いたPARK2の白質変化について (2019)
  • Author(s): 濃沼 崇博, 波田野 琢, 鎌形 康司, 奥住 文美, 森 聡生, 王子 悠, 堀 正明, 青木 茂樹, 服部 信孝
  • Organizer: 第13回パーキンソン病・運動障害疾患コングレス
• [Presentation] PARK2の白質障害は酸化ストレスマーカーと関連する (2019)
  • Author(s): 波田野 琢, 鎌形 康司, 濃沼 崇博, 森 聡生, 王子 悠, 奥住 文美, 堀 正明, 青木 茂樹, 服部 信孝
  • Organizer: 第13回パーキンソン病・運動障害疾患コングレス
• [Presentation] Uncovering the heterogeneity and temporal complexity of Progressive supranuclear palsy and Parkinson's disease with Subtype and Stage Inference (2019)
  • Author(s): Koji Kamagata, Taku Hatano, Christina Andica, Wataru Uchida, Yuya Saito, Mana Kuramochi, Takashi Ogawa, Haruka Takeshige, Akifumi Hagiwara, Toshiaki Akashi, Akihiko Wada, Genko Oyama, Yasushi Shimo, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] Intra- and Inter-scanner Variability of Neurite Orientation Dispersion and Density Imaging in the White and Gray Matter of Healthy Subjects at 3T MRI (2019)
  • Author(s): Christina Andica, Koji Kamagata, Wataru Uchida, Kouhei Kamiya, Akifumi Hagiwara, Mana Kuramochi, Shohei Fujita, Toshiaki Akashi, Akihiko Wada, Masahiro Abe, Hiroshi Kusahara, Masaaki Hori, Shigeki Aoki
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] Fibre-specific white matter reductions in Parkinson's disease (2019)
  • Author(s): Ayumi Kato, Koji Kamagata, Taku Hatano, Christina Andica, Wataru Uchida, Yuya Saito, Takashi Ogawa, Haruka Takeshige, Akifumi Hagiwara, Toshiaki Akashi, Akihiko Wada, Genko Oyama, Yasushi Shimo, Masaaki Hori, Nobutaka Hattori, Shinya Fujii, Shigeki Aoki
  • Organizer: 第47回日本磁気共鳴医学会大会