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Development of Bone Subtraction Iodine Imaging Using High-Resolution CT and Deep Learning Image Reconstruction

Research Project

Project/Area Number 19K17252
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionNational Cancer Center Japan

Principal Investigator

HIYAMA Takashi  国立研究開発法人国立がん研究センター, 東病院, 医長 (40807278)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords高精細CT / 深層学習 / サブトラクション / 頭頸部がん / BSI画像
Outline of Research at the Start

CTはコントラスト分解能が低いため,骨髄浸潤や硬膜浸潤の評価は困難である.本研究ではこの問題を解決するため,造影前後のCT画像を差分することで得られる,骨差分ヨード(bone subtraction iodine: BSI)画像を高空間分解能を有する高精細CTと最新の深層学習画像再構成法を用いて改良する.BSI画像を頭頸部がんに応用し,骨髄浸潤や硬膜浸潤などを評価できるか検証していく.

Outline of Final Research Achievements

In this study, bone subtraction iodine imaging allowed us to visualize contrast enhancement within bone, which is difficult with conventional CT, and more accurately assess the extent of tumor invasion. In addition, in areas where metallic artifacts overlap, we were able to more accurately delineate the extent of tumor spread by improving the contrast between the tumor and surrounding tissues and subtracting the artifact itself. This technique is expected to provide a more accurate assessment of tumor extension.

Academic Significance and Societal Importance of the Research Achievements

CTは簡便,短時間で全身を撮影でき,がん診療において不可欠な検査である.しかし,CTではコントラスト分解能が低いため,骨浸潤や硬膜浸潤の評価は困難で,MRIに頼らざるを得なかった.本研究では造影前後のCT画像をサブトラクションして,造影剤(ヨード)が入った部位のみを描出する骨差分ヨード画像を作成した.これにより骨浸潤の範囲が描出できるようになった.本研究により,CTでのがんのステージグがより正確になり,適切な治療を選択できることが期待できる.

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (22 results)

All 2023 2022 2021 2020 2019

All Journal Article (10 results) (of which Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 7 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Imaging Approach for Cervical Lymph Node Metastases from Unknown Primary Tumor2023

    • Author(s)
      Masuoka Sota、Hiyama Takashi、Kuno Hirofumi、Sekiya Kotaro、Sakashita Shingo、Kobayashi Tatsushi
    • Journal Title

      RadioGraphics

      Volume: 43 Issue: 3

    • DOI

      10.1148/rg.220071

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] エキスパートによる RSNA2022ベストリポート 領域別技術と臨床の最新動向:頭頸部(頭頸部腫瘍)2023

    • Author(s)
      檜山 貴志
    • Journal Title

      INNERVISION

      Volume: 38 Pages: 47-47

    • Related Report
      2022 Annual Research Report
  • [Journal Article] 頭頸部癌におけるCTー質の高い読影につなげる画像収集ー2022

    • Author(s)
      檜山 貴志
    • Journal Title

      臨床画像

      Volume: 38 Pages: 396-407

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Subtraction iodine imaging with area detector CT to improve tumor delineation and measurability of tumor size and depth of invasion in tongue squamous cell carcinoma2021

    • Author(s)
      Hiyama Takashi、Kuno Hirofumi、Sekiya Kotaro、Tsushima So、Oda Shioto、Kobayashi Tatsushi
    • Journal Title

      Japanese Journal of Radiology

      Volume: 40 Issue: 2 Pages: 167-176

    • DOI

      10.1007/s11604-021-01196-4

    • NAID

      210000187215

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of Epstein?Barr virus-positive mucocutaneous ulcer of the hypopharynx: a mimicker of hypopharyngeal squamous cell carcinoma2021

    • Author(s)
      Masuoka Sota、Hiyama Takashi、Kuno Hirofumi、Morishita Yohei、Sakashita Shingo、Kobayashi Tatsushi
    • Journal Title

      International Cancer Conference Journal

      Volume: 11 Issue: 1 Pages: 71-74

    • DOI

      10.1007/s13691-021-00523-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imaging of Malignant Minor Salivary Gland Tumors of the Head and Neck2021

    • Author(s)
      Hiyama Takashi、Kuno Hirofumi、Sekiya Kotaro、Oda Shioto、Kobayashi Tatsushi
    • Journal Title

      RadioGraphics

      Volume: 41 Issue: 1 Pages: 175-191

    • DOI

      10.1148/rg.2021200062

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 舌癌の術前画像診断2020

    • Author(s)
      久野 博文, 檜山 貴志, 小林 達伺
    • Journal Title

      頭頸部癌

      Volume: 45 Pages: 392-396

    • NAID

      130007851668

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extra-nodal extension in head and neck cancer: how radiologists can help staging and treatment planning2020

    • Author(s)
      Hiyama Takashi、Kuno Hirofumi、Nagaki Takahiko、Sekiya Kotaro、Oda Shioto、Fujii Satoshi、Hayashi Ryuichi、Kobayashi Tatsushi
    • Journal Title

      Japanese Journal of Radiology

      Volume: 38 Issue: 6 Pages: 489-506

    • DOI

      10.1007/s11604-020-00929-1

    • NAID

      50014524558

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] エキスパートによる RSNA2019ベストリポート 領域別最新動向:CT&MRIの技術と臨床を中心に頭頸部2020

    • Author(s)
      檜山 貴志
    • Journal Title

      INNERVISION

      Volume: 35 Pages: 5-6

    • Related Report
      2019 Research-status Report
  • [Journal Article] 320列面検出器CTを用いた骨差分ヨード画像の開 発と上咽頭癌頭蓋底浸潤の評価2019

    • Author(s)
      檜山 貴志
    • Journal Title

      University of Tsukuba Repository

      Volume: -

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Post-treatment head and neck cancer imaging: Anatomical considerations based on cancer subsites2022

    • Author(s)
      Takashi Hiyama, Yusuke Miyasaka, Hirofumi Kuno, Kotaro Sekiya, Shingo Sakashita, Tatsushi Kobayashi
    • Organizer
      Radiological Society of North America
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Advanced Imaging of Head and Neck Infection2022

    • Author(s)
      Akira Baba, Ryo Kurokawa, Mariko Kurokawa, Scott Reifeiss, Bruno A. Policeni, Yoshiaki Ota, Hiroaki Fujioka, Koichi Masuda, Takashi Hiyama, Hirofumi Kuno, John Kim, Toshio Moritani, Hiroya Ojiri, Ashok Srinivasan
    • Organizer
      Radiological Society of North America
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 医療AIにおける画像診断の有用性. 経時的骨差分画像による骨転移検出:がん専門病院での使用経験2022

    • Author(s)
      檜山 貴志
    • Organizer
      日本医学放射線学会臨床秋季大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 頭頸部癌におけるCT 質の高い読影につなげる画像収集と読影のポイント2021

    • Author(s)
      檜山 貴志
    • Organizer
      第34回頭頸部放射線研究会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Where is the primary tumor? Imaging approach for cervical lymph node metastases from an unknown primary tumor.2021

    • Author(s)
      Sota Masuoka MD, Takashi Hiyama MD, PhD, Hirofumi Kuno MD, PhD, Kotaro Sekiya DDS, PhD, Shingo Sakashita MD, PhD, Tatsushi Kobayashi MD
    • Organizer
      Radiological Society of North America
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Imaging of Cervical Esophageal Carcinoma: Anatomy, TNM staging, and Pre- and Post-treatment Evaluation.2021

    • Author(s)
      Shioto Oda, Takashi Hiyama, Hirofumi Kuno, Hisashi Fujiwara, Kobayashi Tatsushi, Shingo Sakashita
    • Organizer
      European congress of radiology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Subtraction Iodine Imaging Using Area Detector CT for Improving Tumor Delineation and Measurability of Size and Depth of Invasion in Tongue Squamous Cell Carcinoma2020

    • Author(s)
      Takashi Hiyama, Shioto Oda, Hirofumi Kuno, Tatsushi Kobayashi
    • Organizer
      Radiological Society of North America
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diagnostic approach from associated extraorbital head and neck findings in patients with orbital pathology2020

    • Author(s)
      Masafumi Sakai, Takashi Hiyama, Hirofumi Kuno, Toshitaka Ishiguro, Tsukasa Saida, Tomohiko Masumoto
    • Organizer
      Radiological Society of North America
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 各領域研究の進歩1:頭頸部2020

    • Author(s)
      檜山貴志
    • Organizer
      Advanced Medical Imaging 研究会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Imaging of minor salivary gland carcinomas: “Not minor” malignant tumors throughout the head and neck region2019

    • Author(s)
      Takashi Hiyama, Hirofumi Kuno, Kotaro Sekiya, Shioto Oda, Tatsushi Kobayashi
    • Organizer
      108th Radiological Society of North America
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 頭頸部癌の病期分類 画像診断のポイント:口腔・咽喉頭2019

    • Author(s)
      檜山貴志
    • Organizer
      頭頸部放射線研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Book] Chapter 4. Diagnostic Imaging of Oral Cavity Cancer. In Diagnostic Imaging in Head and Neck Cancer. 2020; 51-73.2020

    • Author(s)
      Takashi Hiyama
    • Total Pages
      221
    • Publisher
      Springer
    • ISBN
      9789811531880
    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

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