| Project/Area Number |
19K17263
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | University of Toyama |
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Principal Investigator |
ジャベド パラス 富山大学, 附属病院, 研究員 (00838980)
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Project Status |
Discontinued (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | Reactive Oxygen Species / GSH / Gold Nanoparticles / Cold Atmospheric Plasma / Apoptosis / Gold nanoparticles / Radiation / 放射線 |
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| Outline of Research at the Start |
Therapy resistance and non-selectively are the major drawbacks associated with conventional anti-cancer therapies like radiation, etc. Gold nanoparticles(Au-NPs) effects can vary depending on the size and the applied physical stress. Therefore, we aim to create a targeted cancer cell death enhancement method, by utilizing the interaction between various sizes of Au-NPs and radiation/other physical stresses. The aim is also to develop selective cancer targeting method with less side effects on normal cells using optimized size or dose of Au-NPs for therapeutic application.
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| Outline of Annual Research Achievements |
The main objective of this study is to identify the role of various sizes of Au-NPs with physical modalities, as Au-NPs are considered fully multifunctional, so preferred over other metal nanoparticles. In this study, only small size Au-NPs can enhance He-CAP induced apoptosis due to the decrease of intracellular GSH levels that leads to excessive generation of intracellular ROS. ROS mediated damage to intracellular components initiate the apoptotic cell death either by intrinsic or extrinsic apoptotic pathways. These findings highlight the importance of determining the Au-NPs size dependent effects with CAP on various cancer cells. The complex phenomena and contradictory reports on Au-NPs size make it essential to develop an optimized design of Au-NPs for future CAP therapy. The results have been published in a form of original article in the Journal Cell Death and Discovery.
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