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Real-time detection of acute cerebral infarction and cerebrovascular abnormalities

Research Project

Project/Area Number 19K17266
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKyoto University

Principal Investigator

Nakajima Satoshi  京都大学, 医学研究科, 特定病院助教 (80830091)

Project Period (FY) 2019-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords拡散強調画像 / 急性期脳梗塞 / 脳血管異常 / リアルタイム検出
Outline of Research at the Start

近年、深層学習の医療への応用の期待が高まっているが、深層学習の応用は診断精度の向上以外の方面にも検討する余地がある。本研究計画においては、深層学習を用いて、脳MRIにおける急性期脳梗塞所見のリアルタイム検出、脳MRIにおける脳血管異常のリアルタイム検出を可能とする基盤整備を行っていく。具体的には、撮像された画像をリアルタイムに監視し、拡散強調画像の異常高信号や、MRAにおける血管描出不良が見られた場合に、即座に警告するシステムを構築していく。リアルタイム検出のシステムを確立した上で、脳CTにおける急性期脳梗塞所見のリアルタイム検出にも取り組む。

Outline of Final Research Achievements

Diffusion-weighted imaging of brain MRI is a very useful imaging method that depicts acute cerebral infarction as high signal. In order to improve the real-time detectability, we found a new study item that we need to investigate how to reduce artifacts. Diffusion-weighted imaging with silent technology was suggested to be useful in terms of lesion detection and artifact frequency. The usefulness of diffusion-weighted images with low image distortion was also confirmed. To construct a real-time detection system for acute stroke, we created a diffusion-weighted image map of healthy subjects in standard brain space using the healthy database of our institution, and prepared an environment to statistically compare the diffusion-weighted image with that of acute stroke patients.

Academic Significance and Societal Importance of the Research Achievements

急性期脳梗塞を高信号として描出できる脳MRIの拡散強調画像を複数の種類において評価した。静音化技術の備わった拡散強調画像については、病変の検出能やアーチファクトの頻度の観点から、その有用性を明らかにした。画像の歪みの少ない拡散強調画像についても、その有用性を確認した。急性期脳梗塞所見のリアルタイム検出に向けて、将来に繋がる研究成果が得られた。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (13 results)

All 2021 2020

All Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 4 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Neuromelanin-Sensitive Magnetic Resonance Imaging Using DANTE Pulse.2021

    • Author(s)
      Oshima S, Fushimi Y, Okada T, Nakajima S, Yokota Y, Shima A, Grinstead J, Ahn S, Sawamoto N, Takahashi R, Nakamoto Y.
    • Journal Title

      Mov Disord.

      Volume: 36 Issue: 4 Pages: 874-882

    • DOI

      10.1002/mds.28417

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Two-Minute Quantitative Susceptibility Mapping From Three-Dimensional Echo-Planar Imaging: Accuracy, Reliability, and Detection Performance in Patients With Cerebral Microbleeds.2021

    • Author(s)
      Wicaksono KP, Fushimi Y, Nakajima S, Yokota Y, Oshima S, Otani S, Sakurama A, Shima A, Sawamoto N, Okada T, Nakamoto Y.
    • Journal Title

      Invest Radiol.

      Volume: 56 Issue: 2 Pages: 69-77

    • DOI

      10.1097/rli.0000000000000708

    • NAID

      120006958079

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deep Learning-based Noise Reduction for Fast Volume Diffusion Tensor Imaging: Assessing the Noise Reduction Effect and Reliability of Diffusion Metrics2021

    • Author(s)
      Sagawa Hajime、Fushimi Yasutaka、Nakajima Satoshi、Fujimoto Koji、Miyake Kanae Kawai、Numamoto Hitomi、Koizumi Koji、Nambu Masahito、Kataoka Hiroharu、Nakamoto Yuji、Saga Tsuneo
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 20 Issue: 4 Pages: 450-456

    • DOI

      10.2463/mrms.tn.2020-0061

    • NAID

      130008123654

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Signal Intensity and Volume of Pituitary and Thyroid Glands in Preterm and Term Infants2020

    • Author(s)
      Otani Sayo、Fushimi Yasutaka、Iwanaga Kogoro、Tomotaki Seiichi、Yokota Yusuke、Oshima Sonoko、Sakurama Azusa、Wicaksono Krishna Pandu、Hinoda Takuya、Sakata Akihiko、Nakajima Satoshi、Okada Tomohisa、Takita Junko、Kawai Masahiko、Togashi Kaori
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 53 Issue: 4 Pages: 1151-1161

    • DOI

      10.1002/jmri.27395

    • NAID

      120007026445

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of cerebral arteriovenous shunts: a comparison of parallel imaging time-of-flight magnetic resonance angiography (TOF-MRA) and compressed sensing TOF-MRA to digital subtraction angiography2020

    • Author(s)
      Sakata Akihiko、Fushimi Yasutaka、Okada Tomohisa、Nakajima Satoshi、Hinoda Takuya、Speier Peter、Schmidt Michaela、Forman Christoph、Yoshida Kazumichi、Kataoka Hiroharu、Miyamoto Susumu、Nakamoto Yuji
    • Journal Title

      Neuroradiology

      Volume: - Issue: 6 Pages: 879-887

    • DOI

      10.1007/s00234-020-02581-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Editorial for “Quantitative Susceptibility Mapping for Characterization of Intraplaque Hemorrhage and Calcification in Carotid Atherosclerotic Disease”2020

    • Author(s)
      Fushimi Yasutaka, Nakajima Satoshi
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: ー Issue: 2 Pages: 542-543

    • DOI

      10.1002/jmri.27089

    • NAID

      120006878495

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral Infarction With Increased Uptake on 123I-FP-CIT SPECT2020

    • Author(s)
      Nakajima Satoshi、Fushimi Yasutaka、Kawashima Hirotsugu、Murai Toshiya、Nakamoto Yuji
    • Journal Title

      Clinical Nuclear Medicine

      Volume: 46 Issue: 4 Pages: e193-e194

    • DOI

      10.1097/rlu.0000000000003366

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of image quality of pituitary dynamic contrast‐enhanced MRI using time‐resolved angiography with interleaved stochastic trajectories (TWIST) and iterative reconstruction TWIST (IT‐TWIST)2020

    • Author(s)
      Yokota Y, Fushimi Y, Okada T, Fujimoto K, Oshima S, Nakajima S, Fujii T, Tanji M, Inagaki N, Miyamoto S, Togashi K
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 51 Issue: 5 Pages: 1497-1506

    • DOI

      10.1002/jmri.26962

    • NAID

      120006840153

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acceleration of 2D-MR fingerprinting by reducing the number of echoes with increased in-plane resolution: a volunteer study2020

    • Author(s)
      Yokota Y, Okada T, Fushimi Y, Yamamoto A, Nakajima S, Fujimoto K, Oshima S, Koerzdoerfer G, Nittka M, Pfeuffer J, Togashi K
    • Journal Title

      MAGMA

      Volume: - Issue: 6 Pages: 783-791

    • DOI

      10.1007/s10334-020-00842-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Turbo gradient- and spin-echo diffusion-weighted imaging with non-Cartesian BLADE trajectory: initial clinical experience in patients with meningioma2020

    • Author(s)
      Satoshi Nakajima、Yasutaka Fushimi、Tomohisa Okada、Takuya Hinoda、Sonoko Oshima、Sayo Otani、Azusa Sakurama、Krishna Pandu Wicaksono、Hiroshi Tagawa、Yang Wang、Kun Zhou、Yuji Nakamoto
    • Organizer
      第48回日本磁気共鳴医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A case report of cerebral infarction with 123I-FP-CIT uptake2020

    • Author(s)
      Satoshi Nakajima、Yasutaka Fushimi、Tomohisa Okada、Takuya Hinoda、Sonoko Oshima、Yuji Nakamoto
    • Organizer
      第60回日本核医学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Quiet Diffusion-weighted Imaging in Pediatric Patients with Moyamoya Disease2020

    • Author(s)
      Satoshi Nakajima、Yasutaka Fushimi、Tomohisa Okada、Gosuke Okubo、Yusuke Yokota、Sonoko Oshima、Sayo Otani、Azusa Sakurama、Krishna Pandu Wicaksono、Kaori Togashi
    • Organizer
      ISMRM 28th Annual Meeting & Exhibition
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Application of Deep Learning Reconstruction to Compressed-sensing Thin-slice Fat-suppressed T2-weighted Imaging of the Orbit2020

    • Author(s)
      Satoshi Nakajima、Yasutaka Fushimi、Yusuke Yokota、Sonoko Oshima、Sayo Otani、Azusa Sakurama、Krishna Pandu Wicaksono、Yuichiro Sano、Ryo Matsuda、Masahito Nambu、Koji Fujimoto、Hitomi Numamoto、Kanae Kawai Miyake、Tsuneo Saga、Kaori Togashi
    • Organizer
      ISMRM 28th Annual Meeting & Exhibition
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2022-01-27  

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