Elucidation of pathophysiology for inflammatory bowel disease from the perspective of RNA binding protein-RNA interaction

• Project/Area Number: 19K17419
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Asahikawa Medical College
• Principal Investigator: Ando Katsuyoshi 旭川医科大学, 大学病院, 助教 (70548677)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 炎症性腸疾患 / RNA結合蛋白 / micro RNA / エクソソーム / RNA結合蛋白-RNA相互作用 / 腸管外合併症 / RBP・RNA相互作用

Outline of Research at the Start

本研究では、炎症性腸疾患(IBD)の腸炎発症および腸管外合併症の発生進展のメカニズムを、RNA結合蛋白(RBP)・RNA相互作用の観点から解明することを目的とする。IBD患者の腸管組織、血清・血清エクソソームにおけるRBPの発現変化および、発現変化のあったRBPに結合するmRNAやmiRNAをトランスクリプトーム解析やマイクロアレイ解析を用いて同定し、腸管炎症の程度や腸管外合併症の有無などと比較検討する。RBPのsiRNAライブラリーや、炎症を誘発した腸管上皮プライマリー細胞・腸炎モデルマウスを用いて、RBP・RNA相互作用の関与について基礎的検討を行う。

Outline of Final Research Achievements

The mechanisms underlying the development and progression of intestinal and extraintestinal inflammation in inflammatory bowel disease (IBD) were analyzed from the perspective of RNA-binding protein (RBP) and target RNA interactions. Using experimental enteritis models and patient-derived samples, we found that RBPs in intestinal tissues and in serum-derived exosomes in addition to changes in target RNAs fluctuate during exacerbation and recovery from enteritis, indicating that the RBP-RNA interaction might be involved in the pathogenesis of IBD. In addition, the exacerbation of experimental enteritis model by the administration of serum derived from IBD patients was clarified in this study. Further research should be conducted to elucidate the pathogenesis of IBD and develop new therapeutic targets in terms of exosome and RBP-RNA interactions.

Academic Significance and Societal Importance of the Research Achievements

腸管を主体とした全身の慢性炎症性疾患であり、原因不明で根治治療がない炎症性腸疾患の発生・進展のメカニズムについて、RNA結合蛋白-RNA相互作用、エクソソームといった新たな側面から解析を行った研究である。本研究の成果より、免疫担当細胞やサイトカインだけではなく、エクソソーム・RNA結合蛋白と標的RNAといった側面から炎症性腸疾患の発症・進展機構を解明し、新規のバイオマーカー・新規治療の開発に寄与する。これらの成果を発展させることで、種々の臓器や炎症性疾患におけるRNA結合蛋白-RNA相互作用やエクソソームの役割を解明していくという新たな研究領域の創生に寄与する。

Research Products

• [Journal Article] Gastro-colic Fistula-associated Hypersplenism Causes Pancytopenia in a Patient with Crohn's Disease (2023)
  • Author(s): Saito Seisuke、Ueno Nobuhiro、Kamikokura Yuki、Sugiyama Yuya、Kobayashi Yu、Murakami Yuki、Kunogi Takehito、Sasaki Takahiro、Takahashi Keitaro、Ando Katsuyoshi、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Tanino Mishie、Okumura Toshikatsu、Fujiya Mikihiro
  • Journal Title: Internal Medicine Volume: 62 Issue: 1 Pages: 69-74
  • DOI: 10.2169/internalmedicine.9590-22
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2023-01-01
  • Peer Reviewed
• [Journal Article] Local recurrence after successful endoscopic submucosal dissection for rectal mucinous mucosal adenocarcinoma: A case report (2023)
  • Author(s): Murakami Yuki、Tanabe Hiroki、Ono Yusuke、Sugiyama Yuya、Kobayashi Yu、Kunogi Takehito、Sasaki Takahiro、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Yuzawa Sayaka、Moriichi Kentaro、Mizukami Yusuke、Fujiya Mikihiro、Okumura Toshikatsu
  • Journal Title: World Journal of Gastrointestinal Oncology Volume: 15 Issue: 1 Pages: 186-194
  • DOI: 10.4251/wjgo.v15.i1.186
  • Peer Reviewed
• [Journal Article] Concomitant pharmacologic medications influence the clinical outcomes of granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis: A multicenter retrospective cohort study (2023)
  • Author(s): Ueno Nobuhiro、Sugiyama Yuya、Kobayashi Yu、Murakami Yuki、Iwama Takuya、Sasaki Takahiro、Kunogi Takehito、Sakatani Aki、Takahashi Keitaro、Tanaka Kazuyuki、Serikawa Shinya、Ando Katsuyoshi、Kashima Shin、Muto Momotaro、Inaba Yuhei、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu、Fujiya Mikihiro
  • Journal Title: Journal of Clinical Apheresis Volume: - Issue: 4 Pages: 406-421
  • DOI: 10.1002/jca.22040
  • Peer Reviewed
• [Journal Article] 炎症性腸疾患の治療 合併症の診断とマネージメント 静脈血栓塞栓症 (2023)
  • Author(s): 7.安藤 勝祥, 藤谷 幹浩
  • Journal Title: 日本臨床80巻3号 Volume: 80 Pages: 499-503
• [Journal Article] Severe immune checkpoint inhibitor-associated gastritis: A case series and literature review (2022)
  • Author(s): Sugiyama Yuya、Tanabe Hiroki、Matsuya Taisuke、Kobayashi Yu、Murakami Yuki、Sasaki Takahiro、Kunogi Takehito、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanino Mishie、Mizukami Yusuke、Fujiya Mikihiro、Okumura Toshikatsu
  • Journal Title: Endoscopy International Open Volume: 10 Issue: 07 Pages: E982-E989
  • DOI: 10.1055/a-1839-4303
  • Peer Reviewed
• [Journal Article] Nasal breathing is superior to oral breathing when performing and undergoing transnasal endoscopy: a randomized trial (2022)
  • Author(s): Takahashi Keitaro、Murakami Yuki、Sasaki Takahiro、Ueno Nobuhiro、Tachibana Shion、Ikeda Junpei、Ishigaki Kenichi、Horiuchi Masashi、Yoshida Moe、Uehara Kyoko、Kobayashi Yu、Sugiyama Yuya、Kunogi Takehito、Muto Mizue、Ando Katsuyoshi、et al.
  • Journal Title: Endoscopy Volume: 55 Issue: 03 Pages: 207-216
  • DOI: 10.1055/a-1900-6004
  • Peer Reviewed
• [Journal Article] A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report (2022)
  • Author(s): Kumei Shima、Ishioh Masatomo、Murakami Yuki、Ando Katsuyoshi、Nozu Tsukasa、Okumura Toshikatsu
  • Journal Title: Journal of Medical Case Reports Volume: 16 Issue: 1
  • DOI: 10.1186/s13256-022-03446-z
  • Peer Reviewed
• [Journal Article] Endoscopic recanalization for the complete closure of long-gap esophageal atresia after reconstruction surgery (2022)
  • Author(s): Kashima Shin、Moriichi Kentaro、Kobayashi Yu、Sugiyama Yuya、Murakami Yuki、Sasaki Takahiro、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Tanabe Hiroki、Fujiya Mikihiro
  • Journal Title: BMC Gastroenterology Volume: 22 Issue: 1
  • DOI: 10.1186/s12876-022-02207-y
  • Peer Reviewed
• [Journal Article] Lower effectiveness of intravenous steroid treatment for moderate‐to‐severe ulcerative colitis in hospitalised patients with older onset: A multicentre cohort study (2022)
  • Author(s): Okabayashi Shinji、Yamazaki Hajime、Tominaga Keiichi、Miura Miki、Sagami Shintaro、Matsuoka Katsuyoshi、Yamaguchi Yoshiharu、Noake Toshihiro、Ozeki Keiji、Miyazaki Ryosuke、Kamano Toshiaki、Fukuda Tomohiro、Yoshioka Kyoko、Ando Katsuyoshi、et al.
  • Journal Title: Alimentary Pharmacology & Therapeutics Volume: - Issue: 12 Pages: 1569-1580
  • DOI: 10.1111/apt.16865
  • Peer Reviewed
• [Journal Article] Carbazochrome sodium sulfonate is not effective for prevention of post-gastric endoscopic submucosal dissection bleeding: A retrospective study (2022)
  • Author(s): Takahashi Keitaro、Sasaki Takahiro、Ueno Nobuhiro、Uehara Kyoko、Kobayashi Yu、Sugiyama Yuya、Murakami Yuki、Kunogi Takehito、Ando Katsuyoshi、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu、Fujiya Mikihiro
  • Journal Title: Surgical Endoscopy Volume: 36 Issue: 10 Pages: 7486-7493
  • DOI: 10.1007/s00464-022-09171-4
  • Peer Reviewed
• [Journal Article] Correlation Among Body Composition Parameters and Long-Term Outcomes in Crohn's Disease After Anti-TNF Therapy (2022)
  • Author(s): Ando Katsuyoshi、Uehara Kyoko、Sugiyama Yuya、Kobayashi Yu、Murakami Yuki、Sato Hiroki、Kunogi Takehito、Sasaki Takahiro、Takahashi Keitaro、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu、Fujiya Mikihiro
  • Journal Title: Frontiers in Nutrition Volume: 9 Pages: 765209-765209
  • DOI: 10.3389/fnut.2022.765209
  • Peer Reviewed / Open Access
• [Journal Article] Testis‐specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization (2022)
  • Author(s): Murakami Yuki、Konishi Hiroaki、Fujiya Mikihiro、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu
  • Journal Title: Cancer Medicine Volume: - Issue: 19 Pages: 3643-3656
  • DOI: 10.1002/cam4.4738
  • Peer Reviewed / Open Access
• [Journal Article] The Optimal Dose of Tacrolimus in Combination Therapy with an Anti-TNFα Antibody in a Mouse Colitis Model (2021)
  • Author(s): Murakami Yuki、Fujiya Mikihiro、Konishi Hiroaki、Isozaki Shotaro、Sugiyama Yuya、Kobayashi Yu、Sasaki Takahiro、Kunogi Takehito、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 44 Issue: 4 Pages: 564-570
  • DOI: 10.1248/bpb.b20-00916
  • NAID: 130008014301
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2021-04-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cardiac Metastasis Caused Fatal Ventricular Arrhythmia in a Patient with a Rectal Neuroendocrine Tumor (2021)
  • Author(s): Ando Katsuyoshi、Fujiya Mikihiro、Yoshida Moe、Kobayashi Yu、Sugiyama Yuya、Murakami Yuki、Iwama Takuya、Sato Hiroki、Sasaki Takahiro、Kunogi Takehito、Takahashi Keitaro、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu
  • Journal Title: Internal Medicine Volume: 60 Issue: 3 Pages: 373-378
  • DOI: 10.2169/internalmedicine.5208-20
  • NAID: 130007979706
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2021-02-01
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic factors to predict the survival in patients with advanced gastric cancer who receive later‐line nivolumab monotherapy?The Asahikawa Gastric Cancer Cohort Study (AGCC) (2021)
  • Author(s): Tanaka Kazuyuki、Tanabe Hiroki、Sato Hiroki、Ishikawa Chisato、Goto Mitsuru、Yanagida Naoyuki、Akabane Hiromitsu、Yokohama Shiro、Hasegawa Kimiharu、Kitano Yohei、Sugiyama Yuya、Uehara Kyoko、Kobayashi Yu、Murakami Yuki、Kunogi Takehito、Sasaki Takahiro、Takahashi Keitaro、Ando Katsuyoshi、et al.
  • Journal Title: Cancer Medicine Volume: 11 Issue: 2 Pages: 406-416
  • DOI: 10.1002/cam4.4461
  • Peer Reviewed / Open Access
• [Journal Article] Balloon endoscopy and capsule endoscopy are useful in the diagnosis of small bowel lesions in Whipple's disease (2021)
  • Author(s): Kunogi Takehito、Ando Katsuyoshi、Fujiya Mikihiro
  • Journal Title: Digestive Endoscopy Volume: 34 Issue: 1 Pages: 248-248
  • DOI: 10.1111/den.14180
  • Peer Reviewed
• [Journal Article] Development of pulmonary sarcoidosis in Crohn’s disease patient under infliximab biosimilar treatment after long-term original infliximab treatment: a case report and literature review (2021)
  • Author(s): Kashima Shin、Moriichi Kentaro、Ando Katsuyoshi、Ueno Nobuhiro、Tanabe Hiroki、Yuzawa Sayaka、Fujiya Mikihiro
  • Journal Title: BMC Gastroenterology Volume: 21 Issue: 1
  • DOI: 10.1186/s12876-021-01948-6
  • Peer Reviewed / Open Access
• [Journal Article] Case Report: A Rare Case of Esophagogastric Junctional Squamous Cell Carcinoma After the Successful Treatment of Neuroendocrine Carcinoma: Clonal Tumor Evolution Revealed by Genetic Analysis (2021)
  • Author(s): Sato Hiroki、Ono Yusuke、Mizukami Yusuke、Okumura Toshikatsu et al
  • Journal Title: Frontiers in Genetics Volume: 12 Pages: 608324-608324
  • DOI: 10.3389/fgene.2021.608324
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A nationwide survey concerning the mortality and risk of progressing severity due to arterial and venous thromboembolism in inflammatory boweldisease in Japan (2021)
  • Author(s): Katsuyoshi Ando,Kenji Watanabe, Sakiko Hiraoka, Taku Kobayashi,Masakazu Nagahori, Hiroki Ikeuchi, Shingo Kato, Motohiro Esaki, Makoto Naganuma, Satoshi Motoya,Masayuki Saruta, Hideo Suzuki, Hiroshi Nakase, Toshiaki Shimizu,Masahiro Iizuka, Mamoru Watanabe, YasuoSuzuki, and Tadakazu Hisamatsu
  • Journal Title: J Gastroenterol . Volume: 56 Issue: 12 Pages: 1062-1079
  • DOI: 10.1007/s00535-021-01829-5
  • Peer Reviewed
• [Journal Article] Usefulness of endoscopic band ligation with gel immersion endoscopy for colonic diverticular bleeding and hemorrhoidal bleeding (2021)
  • Author(s): Kobayashi Yu、Ando Katsuyoshi、Sasaki Takahiro、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Fujiya Mikihiro
  • Journal Title: Endoscopy Volume: - Issue: 07 Pages: E384-E385
  • DOI: 10.1055/a-1550-1913
  • Peer Reviewed
• [Journal Article] Fecal calprotectin is a useful biomarker for predicting the clinical outcome of granulocyte and monocyte adsorptive apheresis in ulcerative colitis patients: a prospective observation study (2021)
  • Author(s): Ueno Nobuhiro、Sugiyama Yuya、Kobayashi Yu、Murakami Yuki、Iwama Takuya、Sasaki Takahiro、Kunogi Takehito、Takahashi Keitaro、Tanaka Kazuyuki、Ando Katsuyoshi、Kashima Shin、Inaba Yuhei、Moriichi Kentaro、Tanabe Hiroki、Taruishi Masaki、Saitoh Yusuke、Okumura Toshikatsu、Fujiya Mikihiro
  • Journal Title: BMC Gastroenterology Volume: 21 Issue: 1
  • DOI: 10.1186/s12876-021-01889-0
  • Peer Reviewed / Open Access
• [Journal Article] The Identification of RNA-Binding Proteins Functionally Associated with Tumor Progression in Gastrointestinal Cancer (2021)
  • Author(s): Konishi Hiroaki、Kashima Shin、Goto Takuma、Ando Katsuyoshi、Sakatani Aki、Tanaka Hiroki、Ueno Nobuhiro、Moriichi Kentaro、Okumura Toshikatsu、Fujiya Mikihiro
  • Journal Title: Cancers Volume: 13 Issue: 13 Pages: 3165-3165
  • DOI: 10.3390/cancers13133165
  • Peer Reviewed / Open Access
• [Journal Article] Probiotic Aspergillus oryzae produces anti-tumor mediator and exerts anti-tumor effects in pancreatic cancer through the p38 MAPK signaling pathway. (2021)
  • Author(s): Konishi H, Isozaki S, Kashima S, Moriichi K, Ichikawa S, Yamamoto K, Yamamura C, Ando K, Ueno N, Akutsu H, Ogawa N, Fujiya M.
  • Journal Title: Sci Rep Volume: 11 Issue: 1 Pages: 11070-11070
  • DOI: 10.1038/s41598-021-90707-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Probiotic derived polyphosphate accelerates intestinal epithelia wound healing through inducing platelet-derived mediators. (2021)
  • Author(s): Isozaki S, Konishi H, Fujiya M, Tanaka H, Murakami Y, Kashima S, Ando K, Ueno N, Moriichi K, Okumura T.
  • Journal Title: Mediators of Inflammation Volume: 2021:5582943 Pages: 1-14
  • DOI: 10.1155/2021/5582943
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-term Observation of Gastric Adenocarcinoma of Fundic Gland Mucosa Type before and after Helicobacter pylori Eradication: a Case Report (2021)
  • Author(s): Takahashi Keitaro、Ueno Nobuhiro、Sasaki Takahiro、Kobayashi Yu、Sugiyama Yuya、Murakami Yuki、Kunogi Takehito、Ando Katsuyoshi、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Kamikokura Yuki、Yuzawa Sayaka、Tanino Mishie、Okumura Toshikatsu、Fujiya Mikihiro
  • Journal Title: Journal of Gastric Cancer Volume: 21 Issue: 1 Pages: 103-103
  • DOI: 10.5230/jgc.2021.21.e11
  • Peer Reviewed
• [Journal Article] Pharmacokinetics of the oral multikinase inhibitor regorafenib and its association with real‐world treatment outcomes. (2021)
  • Author(s): Fukudo Masahide、Asai Keiko、Tani Chikayoshi、Miyamoto Masashi、Ando Katsuyoshi、Ueno Nobuhiro
  • Journal Title: Investigational New Drugs Volume: - Issue: 5 Pages: 1422-1431
  • DOI: 10.1007/s10637-021-01115-4
  • Peer Reviewed / Open Access
• [Journal Article] Endoscopic recanalization with an incision using a needle knife after identifying the oral‐side lumen in complete anastomotic stenosis (2021)
  • Author(s): Murakami Yuki、Ando Katsuyoshi、Fujiya Mikihiro
  • Journal Title: Digestive Endoscopy Volume: 33 Issue: 4
  • DOI: 10.1111/den.13963
  • Peer Reviewed
• [Journal Article] Clinicopathological characteristics of Epstein-Barr virus and microsatellite instability subtypes of early gastric neoplasms classified by the Japanese and the World Health Organization criteria. (2021)
  • Author(s): Tanabe Hiroki、Mizukami Yusuke、Takei Hidehiro、Tamamura Nobue、Omura Yuhi、Kobayashi Yu、Murakami Yuki、Kunogi Takehito、Sasaki Takahiro、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Yuzawa Sayaka、Hasegawa Kimiharu、Sumi Yasuo、Tanino Mishie、Fujiya Mikihiro、Okumura Toshikatsu
  • Journal Title: The Journal of Pathology: Clinical Research Volume: - Issue: 4 Pages: 397-409
  • DOI: 10.1002/cjp2.209
  • Peer Reviewed / Open Access
• [Journal Article] Bacteria-derived ferrichrome inhibits tumor progression in sporadic colorectal neoplasms and colitis-associated cancer. (2021)
  • Author(s): Iwama T, Fujiya M, Konishi H, Tanaka H, Murakami Y, Kunogi T, Sasaki T, Takahashi K, Ando K, Ueno N, Kashima S, Moriichi K, Tanabe H, Okumura T.
  • Journal Title: Cancer Cell Int Volume: 21 Issue: 1 Pages: 21-21
  • DOI: 10.1186/s12935-020-01723-9
  • Peer Reviewed / Open Access
• [Journal Article] Endoscopic finding of a lace pattern in a case of Epstein-Barr virus associated early gastric carcinoma (2021)
  • Author(s): Kobayashi Yu、Tanabe Hiroki、Ando Katsuyoshi、Fujiya Mikihiro、Okumura Toshikatsu
  • Journal Title: Gastrointestinal Endoscopy Volume: 93 Issue: 3 Pages: 768-769
  • DOI: 10.1016/j.gie.2020.10.008
  • Peer Reviewed
• [Journal Article] Probiotic-derived ferrichrome inhibits the growth of refractory pancreatic cancer cells. (2020)
  • Author(s): Kita A, Fujiya M, Konishi H, Tanaka H, Kashima S, Iwama T, Ijiri M, Murakami Y, Takauji S, Goto T, Sakatani A, Ando K, Ueno N, Ogawa N, Okumura T.
  • Journal Title: Int J Oncol Volume: 57 Issue: 3 Pages: 721-732
  • DOI: 10.3892/ijo.2020.5096
  • Peer Reviewed / Open Access
• [Journal Article] Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1 (2020)
  • Author(s): Takahashi Keitaro、Fujiya Mikihiro、Konishi Hiroaki、Murakami Yuki、Iwama Takuya、Sasaki Takahiro、Kunogi Takehito、Sakatani Aki、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 12 Pages: 4514-4514
  • DOI: 10.3390/ijms21124514
  • Peer Reviewed / Open Access
• [Journal Article] Genetic alteration of colorectal adenoma‐carcinoma sequence among gastric adenocarcinoma and dysplastic lesions in a patient with attenuated familial adenomatous polyposis (2020)
  • Author(s): Hiroki Tanabe, Kentaro Moriichi, Keitaro Takahashi, Yusuke Ono, Yu Kobayashi, Yuki Murakami, Takuya Iwama, Takehito Kunogi, Takahiro Sasaki, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Hidehiro Takei, Yusuke Mizukami, Mikihiro Fujiya, Toshikatsu Okumura
  • Journal Title: Molecular Genetics & Genomic Medicine Volume: 8 Issue: 9
  • DOI: 10.1002/mgg3.1348
  • Peer Reviewed / Open Access
• [Journal Article] Serrated adenomas with a BRAF mutation in a young patient with familial adenomatous polyposis. (2020)
  • Author(s): Kentaro Moriichi, Hiroki Tanabe, Yusuke Ono, Yu Kobayashi, Yuki Murakami, Takuya Iwama, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Hidehiro Takei, Yusuke Mizukami, Mikihiro Fujiya, Toshikatsu Okumura
  • Journal Title: International journal of colorectal disease Volume: 35 Issue: 10 Pages: 1967-1972
  • DOI: 10.1007/s00384-020-03657-0
  • Peer Reviewed
• [Journal Article] A tumor-specific modulation of heterogeneous ribonucleoprotein A0 promotes excessive mitosis and growth in colorectal cancer cells. (2020)
  • Author(s): Konishi H, Fujiya M, Kashima S, Sakatani A, Dokoshi T, Ando K, Ueno N, Iwama T, Moriichi K, Tanaka H, Okumura T
  • Journal Title: Cell Death & Disease Volume: 11 Issue: 4 Pages: 245-245
  • DOI: 10.1038/s41419-020-2439-7
  • Peer Reviewed / Open Access
• [Journal Article] Long-Chain Polyphosphate Is a Potential Agent for Inducing Mucosal Healing of the Colon in Ulcerative Colitis. (2020)
  • Author(s): Fujiya M, Ueno N, Kashima S, Tanaka K, Sakatani A, Ando K, Moriichi K, Konishi H, Kamiyama N, Tasaki Y, Omura T, Matsubara K, Taruishi M, Okumura T.
  • Journal Title: Clinical Pharmacology & Therapeutics Volume: 107 Issue: 2 Pages: 452-461
  • DOI: 10.1002/cpt.1628
  • Peer Reviewed
• [Journal Article] Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient. (2019)
  • Author(s): Kashima S, Tanabe H, Tanino M, Kobayashi Y, Murakami Y, Iwama T, Sasaki T, Kunogi T, Takahashi K, Ando K, Ueno N, Moriichi K, Fukudo M, Tasaki Y, Hosokawa M, Mizukami Y, Fujiya M, Okumura T.
  • Journal Title: Front Oncol. Volume: 9 Pages: 1375-1375
  • DOI: 10.3389/fonc.2019.01375
  • Peer Reviewed / Open Access
• [Journal Article] Gastric submucosa-invasive carcinoma associated with Epstein-Barr virus and endoscopic submucosal dissection: A case report. (2019)
  • Author(s): Kobayashi Y, Kunogi T, Tanabe H, Murakami Y, Iwama T, Sasaki T, Takahashi K, Ando K, Nomura Y, Ueno N, Kashima S, Moriichi K, Takei H, Fujiya M, Okumura T.
  • Journal Title: World J Gastrointest Oncol. Volume: 11 Issue: 10 Pages: 925-932
  • DOI: 10.4251/wjgo.v11.i10.925
  • Peer Reviewed
• [Journal Article] Autofluorescence Imaging Reflects the Nuclear Enlargement of Tumor Cells as well as the Cell Proliferation Ability and Aberrant Status of the p53, Ki-67, and p16 Genes in Colon Neoplasms (2019)
  • Author(s): Moriichi K, Fujiya M, Kobayashi Y, Murakami Y, Iwama T, Kunogi T, Sasaki T, Ijiri M, Takahashi K, Tanaka K, Sakatani A, Ando K, Nomura Y, Ueno N, Kashima S, Ikuta K, Tanabe H, Mizukami Y, Saitoh Y, Okumura T.
  • Journal Title: Molecules Volume: 24 Issue: 6 Pages: 1106-1106
  • DOI: 10.3390/molecules24061106
  • Peer Reviewed / Open Access
• [Journal Article] hite coat status is a predictive marker for post-esophageal endoscopic submucosal dissection stricture: a retrospective study. (2019)
  • Author(s): Takahashi K, Fujiya M, Ueno N, Saito T, Sugiyama Y, Murakami Y, Iwama T, Sasaki T, Ijiri M, Tanaka K, Sakatani A, Ando K, Nomura Y, Kashima S, Goto M, Moriichi K, Okumura T.
  • Journal Title: Esophagus. Volume: - Issue: 3 Pages: 258-263
  • DOI: 10.1007/s10388-019-00659-y
  • Peer Reviewed
• [Journal Article] A case of gastric carcinoma with lymphoid stroma diagnosed by an endoscopic ultrasound-guided fine-needle biopsy. (2019)
  • Author(s): Tanabe H, Ando K, Sutoh D, Ohta K, Ohdaira H, Suzuki Y, Fujiya M, Okumura T.
  • Journal Title: J Clin Ultrasound. Volume: 47 Issue: 7 Pages: 419-422
  • DOI: 10.1002/jcu.22696
  • Peer Reviewed
• [Presentation] Clinical outcomes and predictive factors accounting for short- to medium-term effectiveness of ustekinumab in treating ulcerative colitis: A Japan-based study. (2022)
  • Author(s): Ando K, Fujiya M, Ueno N, Motoya S, Nasuno M, Tanaka H, Ito T, Maemoto A, Sakurai K, Katsurada T, Orii F, Ashida T, Hirayama D, Nakase H.
  • Organizer: DDW2022
  • Int'l Joint Research
• [Presentation] Clinical effectiveness and safety of Ustekinumab for Ulcerative Colitis: Real-world data from Japan-based multicenter cohort (Phoenix cohort). (2022)
  • Author(s): Ando K, Fujiya M, Ueno N, Motoya S, Nasuno M, Tanaka H, Ito T, Maemoto A, Sakurai K, Katsurada T, Orii F, Ashida T, Hirayama D, Nakase H.
  • Organizer: AOCC2022
  • Int'l Joint Research
• [Presentation] Concomitant medication influences the remission induction of granulomonocyte adsorptive apheresis in patients with Ulcerative colitis. (2022)
  • Author(s): Sugiyama Y, Ueno N, Kobayashi Yu, Murakami Y, Iwama T, Sasaki T, Kunogi T, Takahashi K, Tanaka K, Serikawa S, Ando K, Kashima S, Muto M, Inaba Y, Moriichi K, Tanabe H, Okumura T, Fujiya M.
  • Organizer: AOCC2022
  • Int'l Joint Research
• [Presentation] 慢性下痢・腹痛を主訴とし診断に難渋したWhipple病の一例. (2022)
  • Author(s): 1立花史音, 安藤勝祥, 久野木健仁，佐々木貴弘, 上野伸展，嘉島伸，盛一健太郎，田邊裕貴，藤谷幹浩，奥村利勝.
  • Organizer: 第24回日本神経消化器病学会
• [Presentation] Prediction of relapse and therapeutic optimization based on conventional and magnifying endoscopy in ulcerative colitis with clinical remission. (2022)
  • Author(s): 安藤勝祥, 盛一健太郎, 藤谷幹浩.
  • Organizer: 第103回日本消化器内視鏡学会総会
• [Presentation] 炎症性腸疾患における動静脈血栓塞栓症の重症化・死亡頻度に関する全国多施設調査. (2022)
  • Author(s): 安藤 勝祥, 上野 伸展, 藤谷 幹浩
  • Organizer: 第64回日本消化器病学会大会
• [Presentation] 潰瘍性大腸炎に対するウステキヌマブのポジショニング～Phoenix cohortのデータから～ (2022)
  • Author(s): 安藤勝祥、藤谷幹浩、上野伸展、本谷聡、那須野正尚、田中浩紀、伊藤貴博、前本篤男、桜井健介、桂田武彦、折居史佳、蘆田知史、平山大輔、仲瀬裕志
  • Organizer: 第13回日本炎症性腸疾患学会学術集会
• [Presentation] 炎症性腸疾患入院患者に合併する静脈血栓塞栓症発生率の推移とリスクの層別化. (2022)
  • Author(s): 立花史音，安藤勝祥，杉山雄哉，小林裕，久野木健仁，佐々木貴弘，坂谷慧、高橋慶太郎，上野伸展，嘉島伸，盛一健太郎，田邊裕貴，奥村利勝，藤谷幹浩.
  • Organizer: 第13回日本炎症性腸疾患学会学術集会
• [Presentation] 無症候期クローン病の小腸病変評価おけるカプセル内視鏡と便中カルプロテクチン測定の有用性 (2022)
  • Author(s): 坂谷慧、上野伸展、安藤勝祥、嘉島伸、盛一健太郎、奥村利勝、藤谷幹浩
  • Organizer: 第13回日本炎症性腸疾患学会学術集会
• [Presentation] 便中カルプロテクチンは顆粒球吸着除去療法(GMA)の臨床効果予測に有用なバイオマーカーである (2022)
  • Author(s): 上野 伸展, 安藤 勝祥, 田中 一之, 稲場 勇平, 藤谷 幹浩
  • Organizer: 第43回日本アフェレシス学会学術大会
• [Presentation] 骨格筋と内臓脂肪が抗TNF-α抗体投与後のクローン病に与える影響. (2022)
  • Author(s): 安藤 勝祥、小林 裕、杉山 雄哉、村上 雄樹、久野木 健仁、佐々木 貴弘、高橋 慶太郎、上野 伸展、嘉島 伸、盛一 健太郎、田邊 裕貴、奥村 利勝、藤谷 幹浩.
  • Organizer: 第108回日本消化器病学会総会（一般演題）
• [Presentation] 潰瘍性大腸炎に対するウステキヌマブの実臨床での治療成績と短期有効性予測因子 (2021)
  • Author(s): 安藤 勝祥、藤谷 幹浩、仲瀬 裕志
  • Organizer: JDDW2021
• [Presentation] 炎症性腸疾患における動脈・静脈血栓塞栓症の重症化・死亡症例の頻度と危険因子：全国多施設調査 (2021)
  • Author(s): 安藤勝祥、上野伸展、藤谷幹浩、IBD血栓症調査研究グループ
  • Organizer: 第12回日本炎症性腸疾患学会学術集会
• [Presentation] 血栓症発症例や手術例からみた炎症性腸疾患入院患者のマネジメント (2021)
  • Author(s): 安藤 勝祥、藤谷 幹浩、奥村 利勝
  • Organizer: 第107回日本消化器病学会総会
• [Presentation] 炎症性腸疾患におけるインフリキシマブバイオシミラーの使用成績 (2021)
  • Author(s): 村上雄紀、安藤勝祥、齊藤成亮、上原恭子、小林裕、杉山雄哉、佐々木貴弘、久野木健仁、高橋慶太郎、上野伸展、嘉島伸、盛一健太郎、田邊裕貴、藤谷幹浩、奥村利勝
  • Organizer: 第17回日本消化管学会学術集会
• [Presentation] クローン病に対するウステキヌマブの実臨床での治療成績と有効性に関する指標 (2021)
  • Author(s): 安藤勝祥、齊藤成亮、上原恭子、小林裕、杉山雄哉、村上雄紀、佐々木貴弘、久野木健仁、高橋慶太郎、上野伸展、嘉島伸、盛一健太郎、田邊裕貴、藤谷幹浩、奥村利勝
  • Organizer: 第48回日本潰瘍学会
• [Presentation] 乳酸菌由来長鎖ポリリン酸は腸内細菌叢を変化させ急性膵炎を改善する (2021)
  • Author(s): 小西 弘晃、高氏 修平、嘉島 伸、高橋 慶太朗、久野木 健仁、佐々木 貴弘 、村上 雄紀、杉山 雄哉、小林 裕、安藤 勝祥 、上野 伸展 、盛一 健太郎 、藤谷 幹浩
  • Organizer: 第58回日本消化器免疫学会総会
• [Presentation] Disease activity monitoring and therapeutic optimization using conventional and magnifying endoscopy in patients with ulcerative colitis in clinical remission (2020)
  • Author(s): Katsuyoshi Ando, Yu Kobayashi, Yuya Sugiyama, Yuuki Murakami, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Mikihiro Fujiya, Toshikatsu Okumura
  • Organizer: The 8th Annual meeting of AOCC
  • Int'l Joint Research
• [Presentation] High volumes of skeletal muscle and visceral fat mass are possible predictors of the long-term prognosis after anti-TNF therapy in biologic-naive CD patients (2020)
  • Author(s): Katsuyoshi Ando, Yu Kobayashi, Yuya Sugiyama, Yuuki Murakami, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Mikihiro Fujiya, Toshikatsu Okumura
  • Organizer: DDW2020
  • Int'l Joint Research
• [Presentation] 筋肉量と脂肪量からみたクローン病に対する抗TNF-α抗体投与後の長期経過 (2020)
  • Author(s): 安藤 勝祥、小林 裕、杉山 雄哉、村上 雄紀、佐々木 貴弘、久野木 健仁、高橋 慶太郎、上野 伸展、嘉島 伸、盛一 健太郎、田邊 裕貴、藤谷 幹浩、奥村 利勝
  • Organizer: JDDW2020
• [Presentation] 寛解期潰瘍性大腸炎患者における通常・拡大内視鏡所見を指標にした治療強化と長期予後 (2020)
  • Author(s): 安藤 勝祥、小林 裕、杉山 雄哉、村上 雄紀、久野木 健仁、佐々木 貴弘、高橋 慶太郎、上野 伸展、嘉島 伸、盛一 健太郎、田邊 裕貴、藤谷 幹浩、奥村 利勝
  • Organizer: 第57回日本消化器免疫学会
• [Presentation] 寛解期潰瘍性大腸炎における通常・拡大内視鏡を用いた活動性評価と再燃予測 (2020)
  • Author(s): 安藤 勝祥、藤谷 幹浩、奥村 利勝
  • Organizer: 第47回日本潰瘍学会総会
• [Presentation] 炎症性腸疾患入院患者における静脈血栓塞栓症の発症頻度 多施設前向き研究 (2019)
  • Author(s): 岩間 琢哉 安藤 勝祥, 稲葉 勇平, 杉山 雄哉, 村上 雄紀, 久野木 健仁, 佐々木 貴弘, 高橋 慶太郎, 上野 伸展, 嘉島 伸, 盛一 健太郎, 田邊 裕貴, 山田 聡, 仲瀬 裕志, 藤谷 幹浩, 奥村 利勝
  • Organizer: JDDW2019
• [Presentation] 腎機能障害・血小板増多症を伴い、不明熱が診断契機となったMEFV遺伝子変異合併クローン病の一例 (2019)
  • Author(s): 吉田 萌, 安藤 勝祥, 杉山 雄哉, 村上 雄紀, 岩間 琢哉, 久野木 健仁, 佐々木 貴弘, 高橋 慶太郎, 上野 伸展, 嘉島 伸, 盛一 健太郎, 田邊 裕貴, 藤谷 幹浩, 粂井 志麻, 奥村 利勝
  • Organizer: 第125回日本消化器病学会北海道地方会
• [Presentation] 潰瘍性大腸炎における通常観察と拡大内視鏡観察による粘膜治癒の評価と再燃予測 (2019)
  • Author(s): 安藤 勝祥, 藤谷 幹浩, 奥村 利勝
  • Organizer: 第97回日本消化器内視鏡学会総会
• [Presentation] クローン病に対する生物学的製剤投与時における骨格筋筋肉量・内臓脂肪量と臨床経過 (2019)
  • Author(s): 安藤 勝祥, 藤谷 幹浩, 奥村 利勝
  • Organizer: 第105回日本消化器病学会総会
• [Presentation] The correlation among the skeletal muscle, visceral fat and clinical course in patients with Crohn’s disease treated with anti-TNF-α antibody (2019)
  • Author(s): Katsuyoshi Ando, Yuki Murakami, Takuya Iwama, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Mikihiro Fujiya, Toshikatsu Okumura
  • Organizer: The 7th Annual Meeting of AOCC
  • Int'l Joint Research
• [Presentation] 寛解維持療法中の潰瘍性大腸炎患者における通常・拡大内視鏡観察による活動性のモニタリングと治療適正化に関する検討 (2019)
  • Author(s): 安藤 勝祥、杉山 雄哉、村上 雄紀、岩間 琢哉、久野木 健仁、佐々木 貴弘、高橋 慶太郎、上野 伸展、嘉島 伸、盛一 健太郎、田邊 裕貴、藤谷 幹浩、奥村 利勝
  • Organizer: 第10回日本炎症性腸疾患学会学術集会