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Elucidation of pathophysiology for inflammatory bowel disease from the perspective of RNA binding protein-RNA interaction

Research Project

Project/Area Number 19K17419
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionAsahikawa Medical College

Principal Investigator

Ando Katsuyoshi  旭川医科大学, 大学病院, 助教 (70548677)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords炎症性腸疾患 / RNA結合蛋白 / micro RNA / エクソソーム / RNA結合蛋白-RNA相互作用 / 腸管外合併症 / RBP・RNA相互作用
Outline of Research at the Start

本研究では、炎症性腸疾患(IBD)の腸炎発症および腸管外合併症の発生進展のメカニズムを、RNA結合蛋白(RBP)・RNA相互作用の観点から解明することを目的とする。IBD患者の腸管組織、血清・血清エクソソームにおけるRBPの発現変化および、発現変化のあったRBPに結合するmRNAやmiRNAをトランスクリプトーム解析やマイクロアレイ解析を用いて同定し、腸管炎症の程度や腸管外合併症の有無などと比較検討する。RBPのsiRNAライブラリーや、炎症を誘発した腸管上皮プライマリー細胞・腸炎モデルマウスを用いて、RBP・RNA相互作用の関与について基礎的検討を行う。

Outline of Final Research Achievements

The mechanisms underlying the development and progression of intestinal and extraintestinal inflammation in inflammatory bowel disease (IBD) were analyzed from the perspective of RNA-binding protein (RBP) and target RNA interactions. Using experimental enteritis models and patient-derived samples, we found that RBPs in intestinal tissues and in serum-derived exosomes in addition to changes in target RNAs fluctuate during exacerbation and recovery from enteritis, indicating that the RBP-RNA interaction might be involved in the pathogenesis of IBD. In addition, the exacerbation of experimental enteritis model by the administration of serum derived from IBD patients was clarified in this study. Further research should be conducted to elucidate the pathogenesis of IBD and develop new therapeutic targets in terms of exosome and RBP-RNA interactions.

Academic Significance and Societal Importance of the Research Achievements

腸管を主体とした全身の慢性炎症性疾患であり、原因不明で根治治療がない炎症性腸疾患の発生・進展のメカニズムについて、RNA結合蛋白-RNA相互作用、エクソソームといった新たな側面から解析を行った研究である。本研究の成果より、免疫担当細胞やサイトカインだけではなく、エクソソーム・RNA結合蛋白と標的RNAといった側面から炎症性腸疾患の発症・進展機構を解明し、新規のバイオマーカー・新規治療の開発に寄与する。これらの成果を発展させることで、種々の臓器や炎症性疾患におけるRNA結合蛋白-RNA相互作用やエクソソームの役割を解明していくという新たな研究領域の創生に寄与する。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (69 results)

All 2023 2022 2021 2020 2019

All Journal Article (41 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 40 results,  Open Access: 21 results) Presentation (28 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Gastro-colic Fistula-associated Hypersplenism Causes Pancytopenia in a Patient with Crohn's Disease2023

    • Author(s)
      Saito Seisuke、Ueno Nobuhiro、Kamikokura Yuki、Sugiyama Yuya、Kobayashi Yu、Murakami Yuki、Kunogi Takehito、Sasaki Takahiro、Takahashi Keitaro、Ando Katsuyoshi、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Tanino Mishie、Okumura Toshikatsu、Fujiya Mikihiro
    • Journal Title

      Internal Medicine

      Volume: 62 Issue: 1 Pages: 69-74

    • DOI

      10.2169/internalmedicine.9590-22

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2023-01-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local recurrence after successful endoscopic submucosal dissection for rectal mucinous mucosal adenocarcinoma: A case report2023

    • Author(s)
      Murakami Yuki、Tanabe Hiroki、Ono Yusuke、Sugiyama Yuya、Kobayashi Yu、Kunogi Takehito、Sasaki Takahiro、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Yuzawa Sayaka、Moriichi Kentaro、Mizukami Yusuke、Fujiya Mikihiro、Okumura Toshikatsu
    • Journal Title

      World Journal of Gastrointestinal Oncology

      Volume: 15 Issue: 1 Pages: 186-194

    • DOI

      10.4251/wjgo.v15.i1.186

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Concomitant pharmacologic medications influence the clinical outcomes of granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis: A multicenter retrospective cohort study2023

    • Author(s)
      Ueno Nobuhiro、Sugiyama Yuya、Kobayashi Yu、Murakami Yuki、Iwama Takuya、Sasaki Takahiro、Kunogi Takehito、Sakatani Aki、Takahashi Keitaro、Tanaka Kazuyuki、Serikawa Shinya、Ando Katsuyoshi、Kashima Shin、Muto Momotaro、Inaba Yuhei、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu、Fujiya Mikihiro
    • Journal Title

      Journal of Clinical Apheresis

      Volume: - Issue: 4 Pages: 406-421

    • DOI

      10.1002/jca.22040

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 炎症性腸疾患の治療 合併症の診断とマネージメント 静脈血栓塞栓症2023

    • Author(s)
      7.安藤 勝祥, 藤谷 幹浩
    • Journal Title

      日本臨床80巻3号

      Volume: 80 Pages: 499-503

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Severe immune checkpoint inhibitor-associated gastritis: A case series and literature review2022

    • Author(s)
      Sugiyama Yuya、Tanabe Hiroki、Matsuya Taisuke、Kobayashi Yu、Murakami Yuki、Sasaki Takahiro、Kunogi Takehito、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanino Mishie、Mizukami Yusuke、Fujiya Mikihiro、Okumura Toshikatsu
    • Journal Title

      Endoscopy International Open

      Volume: 10 Issue: 07 Pages: E982-E989

    • DOI

      10.1055/a-1839-4303

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nasal breathing is superior to oral breathing when performing and undergoing transnasal endoscopy: a randomized trial2022

    • Author(s)
      Takahashi Keitaro、Murakami Yuki、Sasaki Takahiro、Ueno Nobuhiro、Tachibana Shion、Ikeda Junpei、Ishigaki Kenichi、Horiuchi Masashi、Yoshida Moe、Uehara Kyoko、Kobayashi Yu、Sugiyama Yuya、Kunogi Takehito、Muto Mizue、Ando Katsuyoshi、et al.
    • Journal Title

      Endoscopy

      Volume: 55 Issue: 03 Pages: 207-216

    • DOI

      10.1055/a-1900-6004

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report2022

    • Author(s)
      Kumei Shima、Ishioh Masatomo、Murakami Yuki、Ando Katsuyoshi、Nozu Tsukasa、Okumura Toshikatsu
    • Journal Title

      Journal of Medical Case Reports

      Volume: 16 Issue: 1

    • DOI

      10.1186/s13256-022-03446-z

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic recanalization for the complete closure of long-gap esophageal atresia after reconstruction surgery2022

    • Author(s)
      Kashima Shin、Moriichi Kentaro、Kobayashi Yu、Sugiyama Yuya、Murakami Yuki、Sasaki Takahiro、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Tanabe Hiroki、Fujiya Mikihiro
    • Journal Title

      BMC Gastroenterology

      Volume: 22 Issue: 1

    • DOI

      10.1186/s12876-022-02207-y

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lower effectiveness of intravenous steroid treatment for moderate‐to‐severe ulcerative colitis in hospitalised patients with older onset: A multicentre cohort study2022

    • Author(s)
      Okabayashi Shinji、Yamazaki Hajime、Tominaga Keiichi、Miura Miki、Sagami Shintaro、Matsuoka Katsuyoshi、Yamaguchi Yoshiharu、Noake Toshihiro、Ozeki Keiji、Miyazaki Ryosuke、Kamano Toshiaki、Fukuda Tomohiro、Yoshioka Kyoko、Ando Katsuyoshi、et al.
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: - Issue: 12 Pages: 1569-1580

    • DOI

      10.1111/apt.16865

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Carbazochrome sodium sulfonate is not effective for prevention of post-gastric endoscopic submucosal dissection bleeding: A retrospective study2022

    • Author(s)
      Takahashi Keitaro、Sasaki Takahiro、Ueno Nobuhiro、Uehara Kyoko、Kobayashi Yu、Sugiyama Yuya、Murakami Yuki、Kunogi Takehito、Ando Katsuyoshi、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu、Fujiya Mikihiro
    • Journal Title

      Surgical Endoscopy

      Volume: 36 Issue: 10 Pages: 7486-7493

    • DOI

      10.1007/s00464-022-09171-4

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation Among Body Composition Parameters and Long-Term Outcomes in Crohn's Disease After Anti-TNF Therapy2022

    • Author(s)
      Ando Katsuyoshi、Uehara Kyoko、Sugiyama Yuya、Kobayashi Yu、Murakami Yuki、Sato Hiroki、Kunogi Takehito、Sasaki Takahiro、Takahashi Keitaro、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu、Fujiya Mikihiro
    • Journal Title

      Frontiers in Nutrition

      Volume: 9 Pages: 765209-765209

    • DOI

      10.3389/fnut.2022.765209

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Testis‐specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization2022

    • Author(s)
      Murakami Yuki、Konishi Hiroaki、Fujiya Mikihiro、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu
    • Journal Title

      Cancer Medicine

      Volume: - Issue: 19 Pages: 3643-3656

    • DOI

      10.1002/cam4.4738

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Optimal Dose of Tacrolimus in Combination Therapy with an Anti-TNFα Antibody in a Mouse Colitis Model2021

    • Author(s)
      Murakami Yuki、Fujiya Mikihiro、Konishi Hiroaki、Isozaki Shotaro、Sugiyama Yuya、Kobayashi Yu、Sasaki Takahiro、Kunogi Takehito、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 44 Issue: 4 Pages: 564-570

    • DOI

      10.1248/bpb.b20-00916

    • NAID

      130008014301

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2021-04-01
    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cardiac Metastasis Caused Fatal Ventricular Arrhythmia in a Patient with a Rectal Neuroendocrine Tumor2021

    • Author(s)
      Ando Katsuyoshi、Fujiya Mikihiro、Yoshida Moe、Kobayashi Yu、Sugiyama Yuya、Murakami Yuki、Iwama Takuya、Sato Hiroki、Sasaki Takahiro、Kunogi Takehito、Takahashi Keitaro、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 3 Pages: 373-378

    • DOI

      10.2169/internalmedicine.5208-20

    • NAID

      130007979706

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-02-01
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic factors to predict the survival in patients with advanced gastric cancer who receive later‐line nivolumab monotherapy?The Asahikawa Gastric Cancer Cohort Study (AGCC)2021

    • Author(s)
      Tanaka Kazuyuki、Tanabe Hiroki、Sato Hiroki、Ishikawa Chisato、Goto Mitsuru、Yanagida Naoyuki、Akabane Hiromitsu、Yokohama Shiro、Hasegawa Kimiharu、Kitano Yohei、Sugiyama Yuya、Uehara Kyoko、Kobayashi Yu、Murakami Yuki、Kunogi Takehito、Sasaki Takahiro、Takahashi Keitaro、Ando Katsuyoshi、et al.
    • Journal Title

      Cancer Medicine

      Volume: 11 Issue: 2 Pages: 406-416

    • DOI

      10.1002/cam4.4461

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Balloon endoscopy and capsule endoscopy are useful in the diagnosis of small bowel lesions in Whipple's disease2021

    • Author(s)
      Kunogi Takehito、Ando Katsuyoshi、Fujiya Mikihiro
    • Journal Title

      Digestive Endoscopy

      Volume: 34 Issue: 1 Pages: 248-248

    • DOI

      10.1111/den.14180

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of pulmonary sarcoidosis in Crohn’s disease patient under infliximab biosimilar treatment after long-term original infliximab treatment: a case report and literature review2021

    • Author(s)
      Kashima Shin、Moriichi Kentaro、Ando Katsuyoshi、Ueno Nobuhiro、Tanabe Hiroki、Yuzawa Sayaka、Fujiya Mikihiro
    • Journal Title

      BMC Gastroenterology

      Volume: 21 Issue: 1

    • DOI

      10.1186/s12876-021-01948-6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case Report: A Rare Case of Esophagogastric Junctional Squamous Cell Carcinoma After the Successful Treatment of Neuroendocrine Carcinoma: Clonal Tumor Evolution Revealed by Genetic Analysis2021

    • Author(s)
      Sato Hiroki、Ono Yusuke、Mizukami Yusuke、Okumura Toshikatsu et al
    • Journal Title

      Frontiers in Genetics

      Volume: 12 Pages: 608324-608324

    • DOI

      10.3389/fgene.2021.608324

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A nationwide survey concerning the mortality and risk of progressing severity due to arterial and venous thromboembolism in inflammatory boweldisease in Japan2021

    • Author(s)
      Katsuyoshi Ando,Kenji Watanabe, Sakiko Hiraoka, Taku Kobayashi,Masakazu Nagahori, Hiroki Ikeuchi, Shingo Kato, Motohiro Esaki, Makoto Naganuma, Satoshi Motoya,Masayuki Saruta, Hideo Suzuki, Hiroshi Nakase, Toshiaki Shimizu,Masahiro Iizuka, Mamoru Watanabe, YasuoSuzuki, and Tadakazu Hisamatsu
    • Journal Title

      J Gastroenterol .

      Volume: 56 Issue: 12 Pages: 1062-1079

    • DOI

      10.1007/s00535-021-01829-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usefulness of endoscopic band ligation with gel immersion endoscopy for colonic diverticular bleeding and hemorrhoidal bleeding2021

    • Author(s)
      Kobayashi Yu、Ando Katsuyoshi、Sasaki Takahiro、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Fujiya Mikihiro
    • Journal Title

      Endoscopy

      Volume: - Issue: 07 Pages: E384-E385

    • DOI

      10.1055/a-1550-1913

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fecal calprotectin is a useful biomarker for predicting the clinical outcome of granulocyte and monocyte adsorptive apheresis in ulcerative colitis patients: a prospective observation study2021

    • Author(s)
      Ueno Nobuhiro、Sugiyama Yuya、Kobayashi Yu、Murakami Yuki、Iwama Takuya、Sasaki Takahiro、Kunogi Takehito、Takahashi Keitaro、Tanaka Kazuyuki、Ando Katsuyoshi、Kashima Shin、Inaba Yuhei、Moriichi Kentaro、Tanabe Hiroki、Taruishi Masaki、Saitoh Yusuke、Okumura Toshikatsu、Fujiya Mikihiro
    • Journal Title

      BMC Gastroenterology

      Volume: 21 Issue: 1

    • DOI

      10.1186/s12876-021-01889-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Identification of RNA-Binding Proteins Functionally Associated with Tumor Progression in Gastrointestinal Cancer2021

    • Author(s)
      Konishi Hiroaki、Kashima Shin、Goto Takuma、Ando Katsuyoshi、Sakatani Aki、Tanaka Hiroki、Ueno Nobuhiro、Moriichi Kentaro、Okumura Toshikatsu、Fujiya Mikihiro
    • Journal Title

      Cancers

      Volume: 13 Issue: 13 Pages: 3165-3165

    • DOI

      10.3390/cancers13133165

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Probiotic Aspergillus oryzae produces anti-tumor mediator and exerts anti-tumor effects in pancreatic cancer through the p38 MAPK signaling pathway.2021

    • Author(s)
      Konishi H, Isozaki S, Kashima S, Moriichi K, Ichikawa S, Yamamoto K, Yamamura C, Ando K, Ueno N, Akutsu H, Ogawa N, Fujiya M.
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 11070-11070

    • DOI

      10.1038/s41598-021-90707-4

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Probiotic derived polyphosphate accelerates intestinal epithelia wound healing through inducing platelet-derived mediators.2021

    • Author(s)
      Isozaki S, Konishi H, Fujiya M, Tanaka H, Murakami Y, Kashima S, Ando K, Ueno N, Moriichi K, Okumura T.
    • Journal Title

      Mediators of Inflammation

      Volume: 2021:5582943 Pages: 1-14

    • DOI

      10.1155/2021/5582943

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-term Observation of Gastric Adenocarcinoma of Fundic Gland Mucosa Type before and after Helicobacter pylori Eradication: a Case Report2021

    • Author(s)
      Takahashi Keitaro、Ueno Nobuhiro、Sasaki Takahiro、Kobayashi Yu、Sugiyama Yuya、Murakami Yuki、Kunogi Takehito、Ando Katsuyoshi、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Kamikokura Yuki、Yuzawa Sayaka、Tanino Mishie、Okumura Toshikatsu、Fujiya Mikihiro
    • Journal Title

      Journal of Gastric Cancer

      Volume: 21 Issue: 1 Pages: 103-103

    • DOI

      10.5230/jgc.2021.21.e11

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetics of the oral multikinase inhibitor regorafenib and its association with real‐world treatment outcomes.2021

    • Author(s)
      Fukudo Masahide、Asai Keiko、Tani Chikayoshi、Miyamoto Masashi、Ando Katsuyoshi、Ueno Nobuhiro
    • Journal Title

      Investigational New Drugs

      Volume: - Issue: 5 Pages: 1422-1431

    • DOI

      10.1007/s10637-021-01115-4

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endoscopic recanalization with an incision using a needle knife after identifying the oral‐side lumen in complete anastomotic stenosis2021

    • Author(s)
      Murakami Yuki、Ando Katsuyoshi、Fujiya Mikihiro
    • Journal Title

      Digestive Endoscopy

      Volume: 33 Issue: 4

    • DOI

      10.1111/den.13963

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological characteristics of Epstein-Barr virus and microsatellite instability subtypes of early gastric neoplasms classified by the Japanese and the World Health Organization criteria.2021

    • Author(s)
      Tanabe Hiroki、Mizukami Yusuke、Takei Hidehiro、Tamamura Nobue、Omura Yuhi、Kobayashi Yu、Murakami Yuki、Kunogi Takehito、Sasaki Takahiro、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Yuzawa Sayaka、Hasegawa Kimiharu、Sumi Yasuo、Tanino Mishie、Fujiya Mikihiro、Okumura Toshikatsu
    • Journal Title

      The Journal of Pathology: Clinical Research

      Volume: - Issue: 4 Pages: 397-409

    • DOI

      10.1002/cjp2.209

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bacteria-derived ferrichrome inhibits tumor progression in sporadic colorectal neoplasms and colitis-associated cancer.2021

    • Author(s)
      Iwama T, Fujiya M, Konishi H, Tanaka H, Murakami Y, Kunogi T, Sasaki T, Takahashi K, Ando K, Ueno N, Kashima S, Moriichi K, Tanabe H, Okumura T.
    • Journal Title

      Cancer Cell Int

      Volume: 21 Issue: 1 Pages: 21-21

    • DOI

      10.1186/s12935-020-01723-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endoscopic finding of a lace pattern in a case of Epstein-Barr virus associated early gastric carcinoma2021

    • Author(s)
      Kobayashi Yu、Tanabe Hiroki、Ando Katsuyoshi、Fujiya Mikihiro、Okumura Toshikatsu
    • Journal Title

      Gastrointestinal Endoscopy

      Volume: 93 Issue: 3 Pages: 768-769

    • DOI

      10.1016/j.gie.2020.10.008

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Probiotic-derived ferrichrome inhibits the growth of refractory pancreatic cancer cells.2020

    • Author(s)
      Kita A, Fujiya M, Konishi H, Tanaka H, Kashima S, Iwama T, Ijiri M, Murakami Y, Takauji S, Goto T, Sakatani A, Ando K, Ueno N, Ogawa N, Okumura T.
    • Journal Title

      Int J Oncol

      Volume: 57 Issue: 3 Pages: 721-732

    • DOI

      10.3892/ijo.2020.5096

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 12020

    • Author(s)
      Takahashi Keitaro、Fujiya Mikihiro、Konishi Hiroaki、Murakami Yuki、Iwama Takuya、Sasaki Takahiro、Kunogi Takehito、Sakatani Aki、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 12 Pages: 4514-4514

    • DOI

      10.3390/ijms21124514

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic alteration of colorectal adenoma‐carcinoma sequence among gastric adenocarcinoma and dysplastic lesions in a patient with attenuated familial adenomatous polyposis2020

    • Author(s)
      Hiroki Tanabe, Kentaro Moriichi, Keitaro Takahashi, Yusuke Ono, Yu Kobayashi, Yuki Murakami, Takuya Iwama, Takehito Kunogi, Takahiro Sasaki, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Hidehiro Takei, Yusuke Mizukami, Mikihiro Fujiya, Toshikatsu Okumura
    • Journal Title

      Molecular Genetics & Genomic Medicine

      Volume: 8 Issue: 9

    • DOI

      10.1002/mgg3.1348

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serrated adenomas with a BRAF mutation in a young patient with familial adenomatous polyposis.2020

    • Author(s)
      Kentaro Moriichi, Hiroki Tanabe, Yusuke Ono, Yu Kobayashi, Yuki Murakami, Takuya Iwama, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Hidehiro Takei, Yusuke Mizukami, Mikihiro Fujiya, Toshikatsu Okumura
    • Journal Title

      International journal of colorectal disease

      Volume: 35 Issue: 10 Pages: 1967-1972

    • DOI

      10.1007/s00384-020-03657-0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A tumor-specific modulation of heterogeneous ribonucleoprotein A0 promotes excessive mitosis and growth in colorectal cancer cells.2020

    • Author(s)
      Konishi H, Fujiya M, Kashima S, Sakatani A, Dokoshi T, Ando K, Ueno N, Iwama T, Moriichi K, Tanaka H, Okumura T
    • Journal Title

      Cell Death & Disease

      Volume: 11 Issue: 4 Pages: 245-245

    • DOI

      10.1038/s41419-020-2439-7

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-Chain Polyphosphate Is a Potential Agent for Inducing Mucosal Healing of the Colon in Ulcerative Colitis.2020

    • Author(s)
      Fujiya M, Ueno N, Kashima S, Tanaka K, Sakatani A, Ando K, Moriichi K, Konishi H, Kamiyama N, Tasaki Y, Omura T, Matsubara K, Taruishi M, Okumura T.
    • Journal Title

      Clinical Pharmacology & Therapeutics

      Volume: 107 Issue: 2 Pages: 452-461

    • DOI

      10.1002/cpt.1628

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lymph Node Metastasis From Gastroesophageal Cancer Successfully Treated by Nivolumab: A Case Report of a Young Patient.2019

    • Author(s)
      Kashima S, Tanabe H, Tanino M, Kobayashi Y, Murakami Y, Iwama T, Sasaki T, Kunogi T, Takahashi K, Ando K, Ueno N, Moriichi K, Fukudo M, Tasaki Y, Hosokawa M, Mizukami Y, Fujiya M, Okumura T.
    • Journal Title

      Front Oncol.

      Volume: 9 Pages: 1375-1375

    • DOI

      10.3389/fonc.2019.01375

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gastric submucosa-invasive carcinoma associated with Epstein-Barr virus and endoscopic submucosal dissection: A case report.2019

    • Author(s)
      Kobayashi Y, Kunogi T, Tanabe H, Murakami Y, Iwama T, Sasaki T, Takahashi K, Ando K, Nomura Y, Ueno N, Kashima S, Moriichi K, Takei H, Fujiya M, Okumura T.
    • Journal Title

      World J Gastrointest Oncol.

      Volume: 11 Issue: 10 Pages: 925-932

    • DOI

      10.4251/wjgo.v11.i10.925

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autofluorescence Imaging Reflects the Nuclear Enlargement of Tumor Cells as well as the Cell Proliferation Ability and Aberrant Status of the p53, Ki-67, and p16 Genes in Colon Neoplasms2019

    • Author(s)
      Moriichi K, Fujiya M, Kobayashi Y, Murakami Y, Iwama T, Kunogi T, Sasaki T, Ijiri M, Takahashi K, Tanaka K, Sakatani A, Ando K, Nomura Y, Ueno N, Kashima S, Ikuta K, Tanabe H, Mizukami Y, Saitoh Y, Okumura T.
    • Journal Title

      Molecules

      Volume: 24 Issue: 6 Pages: 1106-1106

    • DOI

      10.3390/molecules24061106

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] hite coat status is a predictive marker for post-esophageal endoscopic submucosal dissection stricture: a retrospective study.2019

    • Author(s)
      Takahashi K, Fujiya M, Ueno N, Saito T, Sugiyama Y, Murakami Y, Iwama T, Sasaki T, Ijiri M, Tanaka K, Sakatani A, Ando K, Nomura Y, Kashima S, Goto M, Moriichi K, Okumura T.
    • Journal Title

      Esophagus.

      Volume: - Issue: 3 Pages: 258-263

    • DOI

      10.1007/s10388-019-00659-y

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of gastric carcinoma with lymphoid stroma diagnosed by an endoscopic ultrasound-guided fine-needle biopsy.2019

    • Author(s)
      Tanabe H, Ando K, Sutoh D, Ohta K, Ohdaira H, Suzuki Y, Fujiya M, Okumura T.
    • Journal Title

      J Clin Ultrasound.

      Volume: 47 Issue: 7 Pages: 419-422

    • DOI

      10.1002/jcu.22696

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Clinical outcomes and predictive factors accounting for short- to medium-term effectiveness of ustekinumab in treating ulcerative colitis: A Japan-based study.2022

    • Author(s)
      Ando K, Fujiya M, Ueno N, Motoya S, Nasuno M, Tanaka H, Ito T, Maemoto A, Sakurai K, Katsurada T, Orii F, Ashida T, Hirayama D, Nakase H.
    • Organizer
      DDW2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical effectiveness and safety of Ustekinumab for Ulcerative Colitis: Real-world data from Japan-based multicenter cohort (Phoenix cohort).2022

    • Author(s)
      Ando K, Fujiya M, Ueno N, Motoya S, Nasuno M, Tanaka H, Ito T, Maemoto A, Sakurai K, Katsurada T, Orii F, Ashida T, Hirayama D, Nakase H.
    • Organizer
      AOCC2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Concomitant medication influences the remission induction of granulomonocyte adsorptive apheresis in patients with Ulcerative colitis.2022

    • Author(s)
      Sugiyama Y, Ueno N, Kobayashi Yu, Murakami Y, Iwama T, Sasaki T, Kunogi T, Takahashi K, Tanaka K, Serikawa S, Ando K, Kashima S, Muto M, Inaba Y, Moriichi K, Tanabe H, Okumura T, Fujiya M.
    • Organizer
      AOCC2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 慢性下痢・腹痛を主訴とし診断に難渋したWhipple病の一例.2022

    • Author(s)
      1立花史音, 安藤勝祥, 久野木健仁,佐々木貴弘, 上野伸展,嘉島伸,盛一健太郎,田邊裕貴,藤谷幹浩,奥村利勝.
    • Organizer
      第24回日本神経消化器病学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Prediction of relapse and therapeutic optimization based on conventional and magnifying endoscopy in ulcerative colitis with clinical remission.2022

    • Author(s)
      安藤勝祥, 盛一健太郎, 藤谷幹浩.
    • Organizer
      第103回日本消化器内視鏡学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 炎症性腸疾患における動静脈血栓塞栓症の重症化・死亡頻度に関する全国多施設調査.2022

    • Author(s)
      安藤 勝祥, 上野 伸展, 藤谷 幹浩
    • Organizer
      第64回日本消化器病学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 潰瘍性大腸炎に対するウステキヌマブのポジショニング~Phoenix cohortのデータから~2022

    • Author(s)
      安藤勝祥、藤谷幹浩、上野伸展、本谷聡、那須野正尚、田中浩紀、伊藤貴博、前本篤男、桜井健介、桂田武彦、折居史佳、蘆田知史、平山大輔、仲瀬裕志
    • Organizer
      第13回日本炎症性腸疾患学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 炎症性腸疾患入院患者に合併する静脈血栓塞栓症発生率の推移とリスクの層別化.2022

    • Author(s)
      立花史音,安藤勝祥,杉山雄哉,小林裕,久野木健仁,佐々木貴弘,坂谷慧、高橋慶太郎,上野伸展,嘉島伸,盛一健太郎,田邊裕貴,奥村利勝,藤谷幹浩.
    • Organizer
      第13回日本炎症性腸疾患学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 無症候期クローン病の小腸病変評価おけるカプセル内視鏡と便中カルプロテクチン測定の有用性2022

    • Author(s)
      坂谷慧、上野伸展、安藤勝祥、嘉島伸、盛一健太郎、奥村利勝、藤谷幹浩
    • Organizer
      第13回日本炎症性腸疾患学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 便中カルプロテクチンは顆粒球吸着除去療法(GMA)の臨床効果予測に有用なバイオマーカーである2022

    • Author(s)
      上野 伸展, 安藤 勝祥, 田中 一之, 稲場 勇平, 藤谷 幹浩
    • Organizer
      第43回日本アフェレシス学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 骨格筋と内臓脂肪が抗TNF-α抗体投与後のクローン病に与える影響.2022

    • Author(s)
      安藤 勝祥、小林 裕、杉山 雄哉、村上 雄樹、久野木 健仁、佐々木 貴弘、高橋 慶太郎、上野 伸展、嘉島 伸、盛一 健太郎、田邊 裕貴、奥村 利勝、藤谷 幹浩.
    • Organizer
      第108回日本消化器病学会総会(一般演題)
    • Related Report
      2022 Annual Research Report
  • [Presentation] 潰瘍性大腸炎に対するウステキヌマブの実臨床での治療成績と短期有効性予測因子2021

    • Author(s)
      安藤 勝祥、藤谷 幹浩、仲瀬 裕志
    • Organizer
      JDDW2021
    • Related Report
      2021 Research-status Report
  • [Presentation] 炎症性腸疾患における動脈・静脈血栓塞栓症の重症化・死亡症例の頻度と危険因子:全国多施設調査2021

    • Author(s)
      安藤勝祥、上野伸展、藤谷幹浩、IBD血栓症調査研究グループ
    • Organizer
      第12回日本炎症性腸疾患学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 血栓症発症例や手術例からみた炎症性腸疾患入院患者のマネジメント2021

    • Author(s)
      安藤 勝祥、藤谷 幹浩、奥村 利勝
    • Organizer
      第107回日本消化器病学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 炎症性腸疾患におけるインフリキシマブバイオシミラーの使用成績2021

    • Author(s)
      村上雄紀、安藤勝祥、齊藤成亮、上原恭子、小林裕、杉山雄哉、佐々木貴弘、久野木健仁、高橋慶太郎、上野伸展、嘉島伸、盛一健太郎、田邊裕貴、藤谷幹浩、奥村利勝
    • Organizer
      第17回日本消化管学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] クローン病に対するウステキヌマブの実臨床での治療成績と有効性に関する指標2021

    • Author(s)
      安藤勝祥、齊藤成亮、上原恭子、小林裕、杉山雄哉、村上雄紀、佐々木貴弘、久野木健仁、高橋慶太郎、上野伸展、嘉島伸、盛一健太郎、田邊裕貴、藤谷幹浩、奥村利勝
    • Organizer
      第48回日本潰瘍学会
    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Presentation] 乳酸菌由来長鎖ポリリン酸は腸内細菌叢を変化させ急性膵炎を改善する2021

    • Author(s)
      小西 弘晃、高氏 修平、嘉島 伸、高橋 慶太朗、久野木 健仁、佐々木 貴弘 、村上 雄紀、杉山 雄哉、小林 裕、安藤 勝祥 、上野 伸展 、盛一 健太郎 、藤谷 幹浩
    • Organizer
      第58回日本消化器免疫学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Disease activity monitoring and therapeutic optimization using conventional and magnifying endoscopy in patients with ulcerative colitis in clinical remission2020

    • Author(s)
      Katsuyoshi Ando, Yu Kobayashi, Yuya Sugiyama, Yuuki Murakami, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Mikihiro Fujiya, Toshikatsu Okumura
    • Organizer
      The 8th Annual meeting of AOCC
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] High volumes of skeletal muscle and visceral fat mass are possible predictors of the long-term prognosis after anti-TNF therapy in biologic-naive CD patients2020

    • Author(s)
      Katsuyoshi Ando, Yu Kobayashi, Yuya Sugiyama, Yuuki Murakami, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Mikihiro Fujiya, Toshikatsu Okumura
    • Organizer
      DDW2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 筋肉量と脂肪量からみたクローン病に対する抗TNF-α抗体投与後の長期経過2020

    • Author(s)
      安藤 勝祥、小林 裕、杉山 雄哉、村上 雄紀、佐々木 貴弘、久野木 健仁、高橋 慶太郎、上野 伸展、嘉島 伸、盛一 健太郎、田邊 裕貴、藤谷 幹浩、奥村 利勝
    • Organizer
      JDDW2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 寛解期潰瘍性大腸炎患者における通常・拡大内視鏡所見を指標にした治療強化と長期予後2020

    • Author(s)
      安藤 勝祥、小林 裕、杉山 雄哉、村上 雄紀、久野木 健仁、佐々木 貴弘、高橋 慶太郎、上野 伸展、嘉島 伸、盛一 健太郎、田邊 裕貴、藤谷 幹浩、奥村 利勝
    • Organizer
      第57回日本消化器免疫学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 寛解期潰瘍性大腸炎における通常・拡大内視鏡を用いた活動性評価と再燃予測2020

    • Author(s)
      安藤 勝祥、藤谷 幹浩、奥村 利勝
    • Organizer
      第47回日本潰瘍学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 炎症性腸疾患入院患者における静脈血栓塞栓症の発症頻度 多施設前向き研究2019

    • Author(s)
      岩間 琢哉 安藤 勝祥, 稲葉 勇平, 杉山 雄哉, 村上 雄紀, 久野木 健仁, 佐々木 貴弘, 高橋 慶太郎, 上野 伸展, 嘉島 伸, 盛一 健太郎, 田邊 裕貴, 山田 聡, 仲瀬 裕志, 藤谷 幹浩, 奥村 利勝
    • Organizer
      JDDW2019
    • Related Report
      2019 Research-status Report
  • [Presentation] 腎機能障害・血小板増多症を伴い、不明熱が診断契機となったMEFV遺伝子変異合併クローン病の一例2019

    • Author(s)
      吉田 萌, 安藤 勝祥, 杉山 雄哉, 村上 雄紀, 岩間 琢哉, 久野木 健仁, 佐々木 貴弘, 高橋 慶太郎, 上野 伸展, 嘉島 伸, 盛一 健太郎, 田邊 裕貴, 藤谷 幹浩, 粂井 志麻, 奥村 利勝
    • Organizer
      第125回日本消化器病学会北海道地方会
    • Related Report
      2019 Research-status Report
  • [Presentation] 潰瘍性大腸炎における通常観察と拡大内視鏡観察による粘膜治癒の評価と再燃予測2019

    • Author(s)
      安藤 勝祥, 藤谷 幹浩, 奥村 利勝
    • Organizer
      第97回日本消化器内視鏡学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] クローン病に対する生物学的製剤投与時における骨格筋筋肉量・内臓脂肪量と臨床経過2019

    • Author(s)
      安藤 勝祥, 藤谷 幹浩, 奥村 利勝
    • Organizer
      第105回日本消化器病学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] The correlation among the skeletal muscle, visceral fat and clinical course in patients with Crohn’s disease treated with anti-TNF-α antibody2019

    • Author(s)
      Katsuyoshi Ando, Yuki Murakami, Takuya Iwama, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Mikihiro Fujiya, Toshikatsu Okumura
    • Organizer
      The 7th Annual Meeting of AOCC
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 寛解維持療法中の潰瘍性大腸炎患者における通常・拡大内視鏡観察による活動性のモニタリングと治療適正化に関する検討2019

    • Author(s)
      安藤 勝祥、杉山 雄哉、村上 雄紀、岩間 琢哉、久野木 健仁、佐々木 貴弘、高橋 慶太郎、上野 伸展、嘉島 伸、盛一 健太郎、田邊 裕貴、藤谷 幹浩、奥村 利勝
    • Organizer
      第10回日本炎症性腸疾患学会学術集会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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