Elucidation of the Mechanism of Heart Failure Induced by Immune Checkpoint Inhibitors

• Project/Area Number: 19K17574
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Fukushima Medical University
• Principal Investigator: Shimizu Takeshi 福島県立医科大学, 医学部, 助教 (30722524)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 腫瘍循環器 / 免疫チェックポイント阻害剤 / 免疫関連有害事象 / 心血管イベント / 心不全

Outline of Research at the Start

免疫チェックポイント阻害剤の治療が開始されたがん患者において、免疫関連有害事象irAEsとしての心血管合併症の頻度や重症度を前向きに観察・解析する。単に免疫チェックポイント阻害剤の副作用としてのirAEsではなく、心肥大、慢性心不全や心筋梗塞後といった心血管合併症を有するヒト臨床像に合わせて、マウスモデルを用いてT細胞と心臓リモデリングの観点からも検討する。

Outline of Final Research Achievements

In this study, we prospectively observed and analyzed the frequency and severity of cardiovascular complications as immune-related adverse events in cancer patients initiated on immune checkpoint inhibitor therapy to search for new biomarkers that reflect cardiomyocyte damage. The usefulness of biomarkers, including cell-free DNA, was suggested and should continue to be investigated. In addition, a mouse heart failure model was generated according to the human clinical picture with cardiovascular complications, and in mice mutant for immune-related protein A, an increase in αSMA-positive activated fibroblasts and CD68-positive macrophages were observed, suggesting an association with immune inflammatory cells, and further analysis is needed.

Academic Significance and Societal Importance of the Research Achievements

近年、がん治療において分子標的薬が広く臨床応用され予後改善に寄与する一方で、治療を受ける患者の高齢化も進み、免疫関連有害事象の報告も増加し、その病態と発生機序の解明が課題となっている。本研究により、免疫関連有害事象の詳細が明らかになるとともに、心不全における新規バイオバーカーの探索からその臨床応用の可能性が示唆された。また、特定の分子が心臓における免疫反応の増悪に関与していることが示唆され、本研究成果からがん治療における最善の医療への貢献が期待されるとともに、新たな心不全へのメカニズムの解明に発展することが期待される。

Research Products

• [Journal Article] Validation of Japanese Bleeding Risk Criteria in Patients After Percutaneous Coronary Intervention and Comparison With Contemporary Bleeding Risk Criteria (2022)
  • Author(s): Shimizu Takeshi、Sakuma Yuya、Kurosawa Yuta、Muto Yuuki、Sato Akihiko、Abe Satoshi、Misaka Tomofumi、Oikawa Masayoshi、Yoshihisa Akiomi、Yamaki Takayoshi、Nakazato Kazuhiko、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: Circulation Reports Volume: 4 Issue: 5 Pages: 230-238
  • DOI: 10.1253/circrep.CR-22-0023
  • ISSN: 2434-0790
  • Year and Date: 2022-05-10
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Value of the Pattern of Non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) Bleeding Risk Score for Long-Term Mortality After Percutaneous Coronary Intervention (2022)
  • Author(s): Akama Joh、Shimizu Takeshi、Ando Takuya、Anzai Fumiya、Muto Yuuki、Kimishima Yusuke、Kiko Takatoyo、Yoshihisa Akiomi、Yamaki Takayoshi、Kunii Hiroyuki、Nakazato Kazuhiko、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: International Heart Journal Volume: 63 Issue: 1 Pages: 15-22
  • DOI: 10.1536/ihj.21-440
  • NAID: 130008145732
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2022-01-29
  • Peer Reviewed / Open Access
• [Journal Article] A sudden rise in pacing threshold of left ventricular lead associated with myocardial ischemia (2021)
  • Author(s): Tomita Yusuke、Yamada Shinya、Kaneshiro Takashi、Hijioka Naoko、Shimizu Takeshi、Takeishi Yasuchika
  • Journal Title: Journal of Arrhythmia Volume: 37 Issue: 3 Pages: 693-695
  • DOI: 10.1002/joa3.12536
  • Peer Reviewed / Open Access
• [Journal Article] Residual Gensini Score Is Associated With Long-Term Cardiac Mortality in Patients With Heart Failure After Percutaneous Coronary Intervention (2020)
  • Author(s): Yokokawa T, Yoshihisa A, Kiko T, Shimizu T, Misaka T, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y.
  • Journal Title: Circulation Reports Volume: 2 Issue: 2 Pages: 89-94
  • DOI: 10.1253/circrep.CR-19-0121
  • NAID: 130007796308
  • ISSN: 2434-0790
  • Year and Date: 2020-02-10
  • Peer Reviewed / Open Access
• [Journal Article] Atrial fibrillation is associated with impaired exercise capacity and adverse prognosis in patients with heart failure with mid-range ejection fraction. (2020)
  • Author(s): Sato Y, Yoshihisa A, Kimishima Y, Yokokawa T, Abe S, Shimizu T, Misaka T, Yamada S, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y.
  • Journal Title: European Journal of Preventive Cardiology Volume: 27 Issue: 19 Pages: 2322-2325
  • DOI: 10.1177/2047487319894106
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of circulating cardiomyocyte-specific cell-free DNA in patients with heart failure: a proof-of-concept study. (2020)
  • Author(s): Yokokawa T, Misaka T, Kimishima Y, Shimizu T, Kaneshiro T, Takeishi Y.
  • Journal Title: Can J Cardiol Volume: - Issue: 6 Pages: 931-935
  • DOI: 10.1016/j.cjca.2019.10.016
  • Peer Reviewed
• [Journal Article] Intravascular ultrasound imaging of isolated and non aorto-ostial coronary Takayasu arteritis: a case report (2020)
  • Author(s): Shimizu T, Sato A, Sakamoto K, Seino Y, Kijima M, Matsumoto T, Takeishi Y
  • Journal Title: BMC Cardiovascular Disorders Volume: 20 Issue: 1 Pages: 260-260
  • DOI: 10.1186/s12872-020-01541-x
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impacts of nutritional status on long-term outcome in patients with acute myocardial infarction (2020)
  • Author(s): Ando Takuya、Yoshihisa Akiomi、Kimishima Yusuke、Kiko Takatoyo、Shimizu Takeshi、Yamaki Takayoshi、Kunii Hiroyuki、Nakazato Kazuhiko、Takeishi Yasuchika
  • Journal Title: European Journal of Preventive Cardiology Volume: 27 Issue: 19 Pages: 2229-2231
  • DOI: 10.1177/2047487319883723
  • Peer Reviewed
• [Journal Article] The clinical value of the PRECISE-DAPT score in predicting long-term prognosis in patients with acute myocardial infarction (2020)
  • Author(s): Ando Takuya、Nakazato Kazuhiko、Kimishima Yusuke、Kiko Takatoyo、Shimizu Takeshi、Misaka Tomofumi、Yamada Shinya、Kaneshiro Takashi、Yoshihisa Akiomi、Yamaki Takayoshi、Kunii Hiroyuki、Takeishi Yasuchika
  • Journal Title: IJC Heart & Vasculature Volume: 29 Pages: 100552-100552
  • DOI: 10.1016/j.ijcha.2020.100552
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic factors in heart failure patients with cardiac cachexia (2020)
  • Author(s): Sato Y, Yoshihisa A, Kimishima Y, Yokokawa T, Abe S, Shimizu T, Misaka T, Yamada S, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y
  • Journal Title: Journal of Geriatric Cardiology Volume: 17 Pages: 26-34
  • Peer Reviewed / Open Access
• [Journal Article] Anomalous origin of the coronary artery coursing between the great vessels presenting with a cardiovascular event (J-CONOMALY Registry) (2020)
  • Author(s): Nagashima K, Hiro T, Sato A, Aonuma K, Murohara T, Shimizu T, et al.
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 21 Pages: 222-230
  • DOI: 10.1093/ehjci/jez076
  • Peer Reviewed
• [Journal Article] Short-term outcome of percutaneous coronary intervention with directional coronary atherectomy followed by drug-coated balloon: a preliminary report. (2019)
  • Author(s): Sato A, Kijima M, Ichimura S, Yaegashi D, Anzai F, Shimizu T, Matsui Y, Kaneko H, Sakamoto K, Seino Y, Maruyama Y, Takeishi Y
  • Journal Title: Cardiovasc Intervent Ther Volume: 34 Issue: 2 Pages: 149-154
  • DOI: 10.1007/s12928-018-0537-6
  • NAID: 40021864122
  • Peer Reviewed / Open Access
• [Presentation] Validation of Japanese high bleeding risk criteria in patients undergoing percutaneous coronary intervention and comparisons with contemporary bleeding risk scores (2021)
  • Author(s): Shimizu T, Kimishima Y, Misaka T, Yoshihisa A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Organizer: American Heart Association Scientific Sessions 2021
  • Int'l Joint Research
• [Presentation] Impact of bleeding event for new cancer diagnosis in patients with coronary artery disease who underwent percutaneous coronary intervention. (2021)
  • Author(s): Sakuma Y, Shimizu T, Kurosawa Y, Ohara H, Sugawara Y, Watanabe K, Muto Y, Kimishima Y, Misaka T, Yoshihisa A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y.
  • Organizer: American Heart Association Scientific Sessions 2021
  • Int'l Joint Research
• [Presentation] Prognostic value of relative flow reserve by hybrid 13N-ammonia positron emission tomography/magnetic resonance imaging in coronary artery disease. (2021)
  • Author(s): Endo K, Kiko T, Shimizu T, Yamaki T, Kunii H, Nakazato K, Takeishi Y.
  • Organizer: American Heart Association Scientific Sessions 2021
  • Int'l Joint Research
• [Presentation] The prognostic impact of d-dimer on long-term mortality in patients with coronary artery disease after percutaneous coronary intervention (2021)
  • Author(s): Kurosawa Y, Shimizu T, Muto Y, Kimishima Y, Misaka T, Yoshihisa A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y.
  • Organizer: American Heart Association Scientific Sessions 2021
  • Int'l Joint Research
• [Presentation] 動脈の高度石灰化を伴う急性冠症候群をきたした偽性偽性副甲状腺機能低下症の一例 (2021)
  • Author(s): 遠藤圭一郎, 清水竹史, 武藤雄紀, 君島勇輔, 阿部諭史, 及川雅啓, 小林 淳, 八巻尚洋, 國井浩行, 中里和彦, 石田隆史, 竹石恭知
  • Organizer: 第69回 日本心臓病学会学術集会
• [Presentation] 冠動脈バイパス術後の右冠動脈入口部の慢性完全閉塞に対し、両方向性アプローチにより経皮的冠動脈形成術に成功した一例 (2021)
  • Author(s): 清水竹史, 遠藤圭一郎, 安藤卓也, 武藤雄紀, 佐藤彰彦, 阿部諭史, 及川雅啓, 小林 淳, 八巻尚洋, 中里和彦, 石田隆史, 竹石恭知
  • Organizer: 第50回 日本心血管インターベンション治療学会 東北地方会
• [Presentation] スコア化した日本版HBR評価基準の有用性 (2021)
  • Author(s): 佐久間裕也, 清水竹史, 黒沢雄太, 武藤雄紀, 君島勇輔, 八巻尚洋, 國井浩行, 中里和彦, 竹石恭知
  • Organizer: 第48回 日本心血管インターベンション治療学会 東北地方会
• [Presentation] Impact of body mass index on long-term bleeding events in patients who underwent percutaneous coronary intervention (2021)
  • Author(s): Ando T, Shimizu T, Kurosawa Y, Akama J, Anzai F, Muto Y, Kimishima Y, Kiko T, Yoshihisa A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Organizer: 第85回 日本循環器学会学術集会
• [Presentation] Impact of the academic research consortium high bleeding risk criteria on dual antiplatelet therapy regimen after percutaneous coronary intervention (2021)
  • Author(s): Kurosawa Y, Shimizu T, Akama J, Ando T, Anzai F, Muto Y, Kimishima Y, Kiko T, Yoshihisa A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Organizer: 第85回 日本循環器学会学術集会
• [Presentation] Prognostic value of the PARIS bleeding risk score for all-cause and cardiac mortalities after percutaneous coronary intervention (2021)
  • Author(s): Akama J, Shimizu T, Ando T, Anzai F, Muto Y, Kimishima Y, Kiko T, Yoshihisa A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Organizer: 第85回 日本循環器学会学術集会
• [Presentation] Prognostic value of the PARIS thrombotic risk score for all-cause and cardiac mortalities after percutaneous coronary intervention (2021)
  • Author(s): Akama J, Shimizu T, Ando T, Anzai F, Muto Y, Kimishima Y, Kiko T, Yoshihisa A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Organizer: 第85回 日本循環器学会学術集会
• [Presentation] The prognostic impact of D-dimer on long-term mortality in patients underwent percutaneous coronary intervention (2021)
  • Author(s): Kurosawa Y, Shimizu T, Akama J, Ando T, Anzai F, Muto Y, Kimishima Y, Kiko T, Yoshihisa A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Organizer: 第85回 日本循環器学会学術集会
• [Presentation] 狭小弁輪で左室流出路の石灰化がありデバイス選択に苦慮したTAVI の一例 (2021)
  • Author(s): 武藤雄紀, 國井浩行, 谷 哲矢, 菅原由紀子, 赤間 浄, 安齋文弥, 清水竹史, 及川雅啓, 小林 淳, 中里和彦, 石田隆史, 竹石恭知, 藤宮 剛, 高瀬信弥, 横山 斉
  • Organizer: 第49回 日本心血管インターベンション治療学会 東北地方会
• [Presentation] 高度石灰化病変に対するPCI中にガイドエクステンション断裂を来した1例 (2021)
  • Author(s): 遠藤圭一郎, 國井浩行, 佐藤勇太朗, 谷 哲矢, 武藤雄紀, 清水竹史, 及川雅啓, 八巻尚洋, 中里和彦, 石田隆史, 竹石恭知
  • Organizer: 第49回 日本心血管インターベンション治療学会 東北地方会
• [Presentation] 経皮的冠動脈形成術を施行した患者の出血イベントに対する血清アルブミン値の影響についての検討 (2021)
  • Author(s): 黒沢雄太, 清水竹史, 安藤卓也, 赤間 浄, 安齋文弥, 武藤雄紀, 君島勇輔, 喜古崇豊, 義久精臣, 八巻尚洋, 國井浩行, 中里和彦, 石田隆史, 竹石恭知
  • Organizer: 第171回 日本循環器学会東北地方会
• [Presentation] 糸球体腎炎を併発したBartnella henselae による血液培養陰性の感染性心内膜炎の一例 (2021)
  • Author(s): 武藤雄紀, 小林 淳, 清水竹史, 五十嵐崇, 及川雅啓, 義久精臣, 八巻尚洋, 國井浩行, 中里和彦, 石田隆史, 横山 斉, 竹石恭知
  • Organizer: 第171回 日本循環器学会東北地方会
• [Presentation] 心筋虚血による左室リード閾値の上昇に対して血行再建後に改善が得られたCRT-D植え込み患者の一例 (2021)
  • Author(s): 冨田湧介, 山田慎哉, 金城貴士, 室田定洋, 肱岡奈保子, 清水竹史, 竹石恭知
  • Organizer: 第171回 日本循環器学会東北地方会
• [Presentation] Validation of paris risk score to predict long-term bleeding events after percutaneous coronary intervention in Japanese population (2020)
  • Author(s): Shimizu T, Ando T, Akama J, Anzai F, Muto Y, Kimishima Y, Kiko T, Yoshihisa A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Organizer: American Heart Association Scientific Session 2020
  • Int'l Joint Research
• [Presentation] Prognostic value of the patterns of non-adherence to anti-platelet regimen in stented patients (PARIS) bleeding risk score for long term all-cause and cardiac mortalities after percutaneous coronary intervention (2020)
  • Author(s): Akama J, Shimizu T, Ando T, Anzai F, Muto Y, Kimishima Y, Kiko T, Yoshihisa A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Organizer: American Heart Association Scientific Session 2020
  • Int'l Joint Research
• [Presentation] The clinical value of serum albumin in predicting long-term bleeding events in patients who underwent percutaneous coronary intervention (2020)
  • Author(s): Ando T, Shimizu T, Akama J, Anzai F, Muto Y, Kimishima Y, Kiko T, Yoshihisa A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Organizer: American Heart Association Scientific Session 2020
  • Int'l Joint Research
• [Presentation] An increase in circulating cardiomyocyte-specific cell-free DNA in heart failure (2020)
  • Author(s): Misaka T, Yokokawa T, Kimishima Y, Shimizu T, Kaneshiro T, Takeishi Y
  • Organizer: American Heart Association Scientific Session 2020
  • Int'l Joint Research
• [Presentation] Impact of chronic total occlusion in non-culprit vessels on long-term survival of patients with acute myocardial infarction (2020)
  • Author(s): Nakazato K, Ando T, Kiko T, Shimizu T, Yamaki T, Kunii H, Yoshihisa A, Takeishi Y.
  • Organizer: ESC Congress 2020
  • Int'l Joint Research
• [Presentation] Increases in circulating cardiomyocyte-specific cell-free DNA in heart failure (2020)
  • Author(s): 三阪智史, 横川哲朗, 君島勇輔, 清水竹史, 金城貴士, 義久精臣, 竹石恭知
  • Organizer: 第24回 日本心不全学会学術集会
• [Presentation] Residual Gensini score is associated with long-term cardiac mortality in patients with heart failure after percutaneous coronary intervention (2020)
  • Author(s): 君島勇輔, 義久精臣, 横川哲朗, 喜古崇豊, 清水竹史, 三阪智史, 八巻尚洋, 國井浩行, 中里和彦, 石田隆史, 竹石恭知
  • Organizer: 第24回 日本心不全学会学術集会
• [Presentation] Atrial fibrillation is associated with impaired exercise capacity and adverse prognosis in heart failure patients with mid-range ejection fraction (2020)
  • Author(s): Sato Y, Yoshihisa A, Kimishima Y, Yokokawa T, Abe S, Shimizu T, Misaka T, Yamada S, Sato T, Kaneshiro T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y
  • Organizer: 第84回 日本循環器学会学術集会
• [Presentation] Impact of PRECISE-DAPT score on long-term prognosis in patients with acute myocardial infarction (2020)
  • Author(s): Ando T, Nakazato K, Kiko T, Shimizu T, Yoshihisa A, Yamaki T, Kunii H, Ishida T, Takeishi Y
  • Organizer: 第84回 日本循環器学会学術集会
• [Presentation] Impact of prognostic nutritional index on patients with acute myocardial infarction (2020)
  • Author(s): Ando T, Nakazato K, Kiko T, Shimizu T, Yoshihisa A, Yamaki T, Kunii H, Ishida T, Takeishi Y
  • Organizer: 第84回 日本循環器学会学術集会
• [Presentation] 経時的左室拡大を呈し開心術を行なった右冠動脈-左房瘻の1 例 (2020)
  • Author(s): 佐藤勇太朗, 及川雅啓, 五十嵐崇, 冨田湧介, 武藤雄紀, 清水竹史, 國井浩行, 中里和彦, 石田隆史, 竹石恭知
  • Organizer: 第171回 日本循環器学会東北地方会
• [Presentation] 若年発症の冠攣縮性狭心症の一例 (2020)
  • Author(s): 芳賀文香, 清水竹史, 武藤雄紀, 小林 淳, 八巻尚洋, 國井浩行, 中里和彦, 石田隆史, 竹石恭知
  • Organizer: 第170回 日本循環器学会東北地方会
• [Presentation] 心不全における心筋細胞特異的セルフリーDNA の臨床的意義 (2020)
  • Author(s): 三阪智史, 横川哲朗, 君島勇輔, 清水竹史, 金城貴士, 義久 精臣, 竹石 恭知
  • Organizer: 第6回 日本心筋症研究会
• [Presentation] Impella補助下にPCIを施行した低心機能虚血性心筋症の一例 (2020)
  • Author(s): 清水竹史, 佐藤勇太朗, 冨田湧介, 武藤雄紀, 及川雅啓, 八巻尚洋, 國井浩行, 中里和彦, 竹石恭知
  • Organizer: 第53回 Cardiovascular Intervention Conference (CIC)
• [Presentation] 大動脈四尖弁に経カテーテル大動脈弁留置術を施行した一例 (2020)
  • Author(s): 磯松大介, 及川雅啓, 國井浩行, 武藤雄紀, 菅野優紀, 清水竹史, 小林 淳, 高瀬信弥, 中里和彦, 竹石恭知
  • Organizer: 第47回 日本心血管インターベンション治療学会 東北地方会 (2020.2.1, いわき)
• [Presentation] LMT分岐部を責任病変とした若年不安定狭心症症例に対しDCA+DCBでPCIを施行した一例 (2020)
  • Author(s): 佐久間真悠, 國井浩行, 磯松大介, 和田健斗, 清水竹史, 及川雅啓, 八巻尚洋, 中里和彦, 石田隆史, 竹石恭知
  • Organizer: 第47回 日本心血管インターベンション治療学会 東北地方会 (2020.2.1, いわき)
• [Presentation] Bald aortaを伴うlarge ASDに対する経カテーテル的心房中隔欠損閉鎖術において、閉鎖栓留置によりP波が消失しjunctional rhythmとなった一例 (2020)
  • Author(s): 武藤雄紀, 國井浩行, 西浦司人, 清水竹史, 阿部諭史, 小林淳, 石田隆史, 竹石恭知
  • Organizer: 第47回 日本心血管インターベンション治療学会 東北地方会 (2020.2.1, いわき)
• [Presentation] 8ヶ月間のスタチン療法後に、DCAを施行した一例 (2020)
  • Author(s): 片平正隆, 八巻尚洋, 大河内諭, 八重樫大輝, 清水竹史, 佐藤崇匡, 國井浩行, 中里和彦, 石田隆史, 竹石恭知
  • Organizer: 第52回 Cardiovascular Intervention Conference (CIC) (2020.2.22, 郡山)
• [Presentation] Residual gensini score is associated with long term cardiac mortality in patients with ischemic heart failure (2019)
  • Author(s): Yokokawa T, Yoshihisa A, Ando T, Kiko T, Shimizu T, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2019 (2019.11.16-11.18, Philadelphia, USA)
  • Int'l Joint Research
• [Presentation] Impact of geriatric nutrition risk index on long-term prognosis in patients with acute myocardial infarction (2019)
  • Author(s): Ando T, Nakazato K, Kiko T, Shimizu T, Yoshihisa A, Yamaki T, Kunii H, Ishida T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2019 (2019.11.16-11.18, Philadelphia, USA)
  • Int'l Joint Research
• [Presentation] Impact of PRECISE-DAPT score on long-term prognosis in patients with acute myocardial infarction (2019)
  • Author(s): Ando T, Nakazato K, Kiko T, Shimizu T, Yoshihisa A, Yamaki T, Kunii H, Ishida T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2019 (2019.11.16-11.18, Philadelphia, USA)
  • Int'l Joint Research
• [Presentation] Impact of prognostic nutritional index on patients with acute myocardial infarction (2019)
  • Author(s): Ando T, Nakazato K, Kiko T, Shimizu T, Yoshihisa A, Yamaki T, Kunii H, Ishida T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2019 (2019.11.16-11.18, Philadelphia, USA)
  • Int'l Joint Research
• [Presentation] 冠動脈孤発性かつ非入口部病変を呈した高安動脈炎の血管内超音波所見 (2019)
  • Author(s): 清水竹史, 佐藤彰彦, 坂本圭司, 清野義胤, 木島幹博, 竹石恭知
  • Organizer: 第28回日本心血管インターベンション治療学会学術集会 (CVIT2019) (2019.9.19-9.21, 名古屋)
• [Presentation] 大動脈四尖弁に経カテーテル大動脈弁留置術を施行した一例 (2019)
  • Author(s): 磯松大介, 及川雅啓, 武藤雄紀, 菅野優紀, 清水竹史, 小林 淳, 國井浩行, 高瀬信弥, 中里和彦, 石田隆史, 竹石恭知
  • Organizer: 第169回 日本循環器学会東北地方会 (2019.12.7, 仙台)
• [Presentation] Two cases of coronary ostial stenosis after aortic valve replacement (2019)
  • Author(s): Ando T, Yamaki T, Kiko T, Shimizu T, Kunii H, Nakazato K, Komatsu N, Takeda H, Yokoyama H, Takeishi Y
  • Organizer: Complex Cardiovascular Therapeutics (CCT) 2019 (2019.10.24-10.26, 神戸)
  • Int'l Joint Research