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Investigation of the effect of diabetes mellitus on aortic wall as atherosclerosis progresses

Research Project

Project/Area Number 19K17591
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53020:Cardiology-related
Research InstitutionNagoya University

Principal Investigator

Tanaka Akihito  名古屋大学, 医学部附属病院, 助教 (70725829)

Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords糖尿病 / 大動脈 / 冠動脈疾患 / 大動脈瘤 / 石灰化 / 動脈硬化
Outline of Research at the Start

近年、糖尿病が大動脈径拡大に対して抑制的に働くというねじれの現象が観察され、糖尿病と大動脈瘤の負の相関関係が注目されている。糖尿病は、冠動脈疾患を始めとする動脈硬化性疾患の強力な危険因子であり、高血圧や脂質異常など動脈硬化のその他の危険因子を同時に有する事も多い。さらに冠動脈疾患や脳血管、末梢血管疾患の進行は大動脈瘤の有病率とも正の相関をすることがわかっている。それにもかかわらず、この負の相関関係が存在するが、その詳細なメカニズムは十分に明らかにされていない。本研究は、冠動脈疾患患者での糖尿病有無による大動脈径を比較検証することで、ねじれ現象の原因を詳細に解析し、そのメカニズムを探求する。

Outline of Final Research Achievements

We investigated the impact of DM on the progression of aortic dilatation and calcification in patients with coronary artery disease. We observed an inverse association between DM and aortic diameter at the time of PCI and no difference in the growth rate of aortic dilatation after PCI between patients with and without diabetes. While no difference in aortic calcification at the time of PCI, and the growth rate of aortic calcification after PCI was significantly larger among patients with DM. Our findings suggest that DM negatively affects aortic dilatation in the early phase of atherosclerotic progression and positively affects progression of aortic calcification in the later phases. The effect of DM on the aortic wall may be changing as atherosclerosis progresses.

Academic Significance and Societal Importance of the Research Achievements

今回の検討で、糖尿病が動脈硬化進行の初期の段階で大動脈拡張と負の関連があり、後期の段階では大動脈石灰化の進行に正の影響を及ぼしていることが示された。大動脈壁に対する糖尿病の影響は動脈硬化が進行するにつれて変化している可能性があり、これは大動脈疾患、動脈硬化性疾患の病態を捉える上で、時相が重要であることを示唆している。このことは臨床並びに今後の研究において、さらには今後の動脈硬化性疾患、大動脈疾患に対する効果的な予防を含めた内科治療戦略を構築していく上で重要な概念となると考えられる。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (10 results)

All 2023 2022 2021 2020

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Impact of Handgrip Strength on Clinical Outcomes after Percutaneous Coronary Intervention2023

    • Author(s)
      Tobe Akihiro、Tanaka Akihito、Shirai Yoshinori、Kubota Yoshiaki、Kunieda Takeshige、Sato Sara、Furusawa Kenji、Ishii Hideki、Murohara Toyoaki
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 30 Issue: 9 Pages: 1115-1122

    • DOI

      10.5551/jat.63854

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2023-09-01
    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterogeneous Carotid Plaque Predicts Cardiovascular Events after Percutaneous Coronary Intervention2023

    • Author(s)
      Tobe Akihiro、Tanaka Akihito、Furusawa Kenji、Shirai Yoshinori、Funakubo Hiroshi、Otsuka Satoshi、Kubota Yoshiaki、Kunieda Takeshige、Yoshioka Naoki、Sato Sara、Kudo Nobutaka、Ishii Hideki、Murohara Toyoaki
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 30 Issue: 9 Pages: 1187-1197

    • DOI

      10.5551/jat.63622

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2023-09-01
    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fifteen-Year Mortality and Cardiac, Thrombotic, and Bleeding Events in Survivors of ST-Elevation Myocardial Infarction2022

    • Author(s)
      Takagi K, Tanaka A, Morishima I, Morita Y, Yoshioka N, Yoshida R, Kanzaki Y, Watanabe N, Yamauchi R, Komeyama S, Sugiyama H, Shimojo K, Imaoka T, Sakamoto G, Ohi T, Goto H, Ishii H, Murohara T.
    • Journal Title

      Cardiovascular Revascularization Medicine

      Volume: 36 Pages: 43-50

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of appropriate body mass index cut-off points for long-term mortality among ST-elevation myocardial infarction survivors in Asian population using machine learning algorithm2022

    • Author(s)
      Yoshioka N, Takagi K, Tanaka A, Morita Y, Yoshida R, Nagai H, Kanzaki Y, Watanabe N, Yamauchi R, Komeyama S, Sugiyama H, Shimojo K, Imaoka T, Sakamoto G, Ohi T, Goto H, Ishii H, Morishima I, Murohara T.
    • Journal Title

      Heart and Vessels

      Volume: 37(2) Issue: 2 Pages: 219-228

    • DOI

      10.1007/s00380-021-01916-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Influence of Eicosapentaenoic Acid to Arachidonic Acid Ratio on Long-term Cardiovascular Events Following Percutaneous Coronary Intervention2021

    • Author(s)
      Niwa K, Tanaka A, Funakubo H, Otsuka S, Yoshioka N, Kudo N, Tobe A, Sakakibara K, Miki Y, Kataoka T, Furusawa K, Ishii H, Murohara T.
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 24 Pages: 3865-3871

    • DOI

      10.2169/internalmedicine.7336-21

    • NAID

      130008129468

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-12-15
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between epicardial adipose tissue volume and coronary artery spasm2021

    • Author(s)
      Kataoka T, Harada K, Tanaka A, Onishi T, Matsunaga S, Funakubo H, Harada K, Nagao T, Shinoda N, Marui N, Niwa K, Tashiro H, Hitora Y, Furusawa K, Ishii H, Amano T, Murohara T.
    • Journal Title

      International Journal of Cardiology

      Volume: 324 Pages: 8-12

    • DOI

      10.1016/j.ijcard.2020.09.074

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of Diabetes Mellitus on the Aortic Wall Changes as Atherosclerosis Progresses: Aortic Dilatation and Calcification2020

    • Author(s)
      Iwakawa Naoki、Tanaka Akihito、Ishii Hideki、Kataoka Takashi、Niwa Kiyoshi、Hitora Yusuke、 Tashiro Hiroshi、Mitsuda Takayuki、Kojima Hiroki、Hirayama Kenshi、Furusawa Kenji、Yoshida Ruka、Suzuki Susumu、Murohara Toyoaki
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 27 Issue: 6 Pages: 509-515

    • DOI

      10.5551/jat.50930

    • NAID

      130007850102

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2020-06-01
    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Clinical Impact of Handgrip Strength on Prognosis After Percutaneous Coronary Intervention2022

    • Author(s)
      Akihiro Tobe, Akihito Tanaka, Yoshinori Shirai, Yoshiaki Kubota, Takeshige Kunieda, Sara Sato, Kenji Furusawa, Hideki Ishii, Toyoaki Murohara
    • Organizer
      American Heart Associasion scientific session 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Heterogeneous Carotid Plaque is Associated with Cardiovascular Events after Percutaneous Coronary Intervention2022

    • Author(s)
      Akihiro Tobe, Akihito Tanaka, Kenji Furusawa, Yoshinori Shirai, Hiroshi Funakubo, Satoshi Otsuka, Yoshiaki Kubota, Takeshige Kunieda, Naoki Yoshioka, Sara Sato, Nobuyuki Kudo, Hideki. Ishii, Toyoaki Murohara
    • Organizer
      European Society of Cardiology 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impact of Handgrip Strength on Clinical Outcomes in Coronary Artery Disease Patients2022

    • Author(s)
      戸部彰洋 田中哲人 白井義憲 大塚智 舟久保浩 工藤信隆 久保田善秋 國枝武茂 佐藤沙良 吉岡直輝 古澤健司 石井秀樹 室原豊明
    • Organizer
      第86回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report

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Published: 2019-04-18   Modified: 2025-01-30  

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