Elucidate the refractory mechanism for obese asthma and its therapeutic targets.

• Project/Area Number: 19K17632
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SUZUKI YUZO 浜松医科大学, 医学部, 助教 (00758435)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肥満喘息 / オートファジー / 気道上皮 / TSLP / IL-33 / Autophagy / 重症喘息 / IL-1

Outline of Research at the Start

肥満喘息は好中球優位の喘息と考えられてきた。しかし最近，肥満喘息の中で好酸球性優位の難治なフェノタイプが存在することが明らかになってきたが、その病態はほとんど解明されていない。申請者は，肥満オートファジー欠損マウスを用いた喘息モデルを作製したところ，驚くべきことに，TSLP (sthymic stromal lymphopoietin) 依存性の極めて高度の好酸球浸潤と気道過敏性亢進を認め，好酸球優位の肥満喘息に類似したモデルであると考えられた．この肥満喘息モデルを用いて「オートファジー低下」と「気道上皮からのTSLP産生亢進」に着目して，肥満喘息，とくに好酸球優位の肥満喘息の病態解明に挑む。

Outline of Final Research Achievements

The present study revealed the importance of autophagy in obese asthma. The obese asthma model was created by high-fat diet and HDM sensitization. House dust mite (HDM)-sensitized Atg5-/- obese mice exhibited marked eosinophilic inflammation and airway hyper-reactivity (AHR), compared to wild-type (WT) obese mice. Analyses of Atg5-/- obese mice showed increased levels of Th2 cells but not ILC2s together with elevated expression of Th2 cytokines in the lung. The genetic analyses of epithelial cells from HDM-immunized Atg5-/- obesity-induced mice showed an elevated expression of TSLP (thymic stromal lymphopoietin) and IL33. Notably, HDM-sensitized Atg5-/- mice developed TSLP- and IL33-dependent eosinophilic inflammation and AHR. Our results suggest that autophagy contributes to the exacerbation of eosinophilic inflammation in obese asthma. Modulations of autophagy may be a therapeutic target in obesity-associated asthma.

Academic Significance and Societal Importance of the Research Achievements

肥満の増加は，小児や成人に関わらず，世界的な健康課題である．肥満は喘息患者にも高頻度に見られ，重症喘息の中でも肥満喘息は最もコントロールが難しい一群である．しかし肥満喘息の難治化要因や，病態は十分に解明されていない．
本研究により，肥満にオートファジー低下が加わることが肥満喘息の病態や増悪に関わっていることが示された．そのためオートファジー制御が，今後の肥満喘息の新しい治療につながると考えられた．

Research Products

• [Journal Article] Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma (2022)
  • Author(s): Suzuki Yuzo、Aono Yuya、Akiyama Norimichi、Horiike Yasuoki、Naoi Hyogo、Horiguchi Ryo、Shibata Kiyoshi、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Autophagy Volume: － Issue: 9 Pages: 1-13
  • DOI: 10.1080/15548627.2022.2025571
  • Peer Reviewed / Open Access
• [Journal Article] Impact of antifibrotic therapy on lung cancer development in idiopathic pulmonary fibrosis (2022)
  • Author(s): Naoi Hyogo、Suzuki Yuzo、Mori Kazutaka、Aono Yuya、Kono Masato、Hasegawa Hirotsugu、Yokomura Koshi、Inoue Yusuke、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Thorax Volume: in press Issue: 7 Pages: 1-1
  • DOI: 10.1136/thoraxjnl-2021-218281
  • Peer Reviewed / Open Access
• [Journal Article] Impact of end-of-life respiratory modalities on quality of dying and death and symptom relief in patients with interstitial lung disease: a multicenter descriptive cross-sectional study (2022)
  • Author(s): Koyauchi Takafumi, Suzuki Yuzo, Sato Kazuki, Hozumi Hironao, Karayama Masato, Furuhashi Kazuki, Fujisawa Tomoyuki, Enomoto Noriyuki, Nakamura Yutaro, Inui Naoki, Yokomura Koshi, Imokawa Shiro, Nakamura Hidenori, Morita Tatsuya, Suda Takafumi
  • Journal Title: Respiratory Research Volume: in press Issue: 1 Pages: 79-79
  • DOI: 10.1186/s12931-022-02004-x
  • Peer Reviewed / Open Access
• [Journal Article] Acute exacerbation of rheumatoid arthritis-associated interstitial lung disease: mortality and its prediction model (2022)
  • Author(s): Hozumi Hironao、Kono Masato、Hasegawa Hirotsugu、Kato Shinpei、Inoue Yusuke、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Yokomura Koshi、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Respiratory Research Volume: 23 Issue: 1 Pages: 57-57
  • DOI: 10.1186/s12931-022-01978-y
  • Peer Reviewed / Open Access
• [Journal Article] Transient leukocytopenia following combination therapy for COVID-19 (2022)
  • Author(s): Tsuchiya Kazuo、Fujisawa Tomoyuki、Mochizuka Yasutaka、Takuma Sho、Oishi Kyohei、Endo Yoshinari、Tanaka Yuko、Fukada Atsuki、Watanabe Hirofumi、Katsumata Mineo、Aoshima Yoichiro、Inoue Yusuke、Suzuki Yuzo、Karayama Masato、Hozumi Hironao、Furuhashi Kazuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Respiratory Investigation Volume: 60 Issue: 1 Pages: 158-161
  • DOI: 10.1016/j.resinv.2021.09.007
  • Peer Reviewed
• [Journal Article] Combined assessment of the GAP index and body mass index at antifibrotic therapy initiation for prognosis of idiopathic pulmonary fibrosis (2021)
  • Author(s): Suzuki Yuzo、Mori Kazutaka、Aono Yuya、Kono Masato、Hasegawa Hirotsugu、Yokomura Koshi、Naoi Hyogo、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 18579-18579
  • DOI: 10.1038/s41598-021-98161-y
  • Peer Reviewed / Open Access
• [Journal Article] Switching antifibrotics in patients with idiopathic pulmonary fibrosis: a multi-center retrospective cohort study (2021)
  • Author(s): Suzuki Yuzo、Mori Kazutaka、Aono Yuya、Kono Masato、Hasegawa Hirotsugu、Yokomura Koshi、Naoi Hyogo、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Nakamura Hidenori、Suda Takafumi
  • Journal Title: BMC Pulmonary Medicine Volume: 21 Issue: 1 Pages: 221-221
  • DOI: 10.1186/s12890-021-01587-3
  • Peer Reviewed / Open Access
• [Journal Article] Association of the Geriatric Nutritional Risk Index with the survival of patients with non-small-cell lung cancer after platinum-based chemotherapy (2021)
  • Author(s): Masato Karayama, Yusuke Inoue, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda
  • Journal Title: BMC Pulm Med . Volume: 21(1) Issue: 1 Pages: 409-409
  • DOI: 10.1186/s12890-021-01782-2
  • Peer Reviewed / Open Access
• [Journal Article] Prophylactic granulocyte-colony stimulating factor in patients with lung neuroendocrine carcinoma receiving platinum agents plus etoposide. (2021)
  • Author(s): Watanabe H, Karayama M, Yasui H, Inoue Y, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Suda T.
  • Journal Title: Cancer Treat Res Commun. Volume: 29 Pages: 100493-100493
  • DOI: 10.1016/j.ctarc.2021.100493
  • Peer Reviewed / Open Access
• [Journal Article] Radiological pleuroparenchymal fibroelastosis-like lesion in idiopathic interstitial pneumonias. (2021)
  • Author(s): Fujisawa T, Horiike Y, Egashira R, Sumikawa H, Iwasawa T, Matsushita S, Sugiura H, Kataoka K, Hashisako M, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Suda T.
  • Journal Title: Respir Res. Volume: 22(1) Issue: 1 Pages: 290-290
  • DOI: 10.1186/s12931-021-01892-9
  • Peer Reviewed / Open Access
• [Journal Article] Association of the Geriatric Nutritional Risk Index With the Survival of Patients With Non?Small Cell Lung Cancer After Nivolumab Therapy (2021)
  • Author(s): Karayama Masato、Inoue Yusuke、Yoshimura Katsuhiro、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Journal of Immunotherapy Volume: 45 Issue: 2 Pages: 125-131
  • DOI: 10.1097/cji.0000000000000396
  • Peer Reviewed
• [Journal Article] Efficacy of immune checkpoint inhibitors in non-small cell lung cancer with uncommon histology: a propensity-score-matched analysis (2021)
  • Author(s): Miyashita K、Karayama M、Inoue Y、Hozumi H、Suzuki Y、Furuhashi K、Fujisawa T、Enomoto N、Nakamura Y、Kono M、Matsui T、Niwa M、Koda K、Toyoshima M、Matsushima S、Matsuura S、Asada K、Fujii M、Kusagaya H、Matsuda H、Inui N、Suda T
  • Journal Title: BMC Pulmonary Medicine Volume: 21 Issue: 1
  • DOI: 10.1186/s12890-021-01681-6
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension (2021)
  • Author(s): Enomoto Noriyuki、Suzuki Seiichiro、Hozumi Hironao、Karayama Masato、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Nakamura Yutaro、Odagiri Keiichi、Ishikawa Takamichi、Kataoka Kensuke、Kondoh Yasuhiro、Maekawa Masato、Inui Naoki、Watanabe Hiroshi、Suda Takafumi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1
  • DOI: 10.1038/s41598-021-94907-w
  • Peer Reviewed / Open Access
• [Journal Article] Comparative assessment of NOIR-SS and ddPCR for ctDNA detection of EGFR L858R mutations in advanced L858R-positive lung adenocarcinomas. (2021)
  • Author(s): Akahori D, Inoue Y, Inui N, Karayama M, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Suda T.
  • Journal Title: Sci Rep. Volume: 11(1) Issue: 1 Pages: 14999-14999
  • DOI: 10.1038/s41598-021-94592-9
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Significance of Cold-Inducible RNA-Binding Protein in Idiopathic Pulmonary Fibrosis (2021)
  • Author(s): Hozumi Hironao、Kataoka Kensuke、Kondoh Yasuhiro、Isayama Takuya、Okada Jun、Sugiura Katsunori、Mori Kazutaka、Kono Masato、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Suda Takafumi
  • Journal Title: Chest Volume: 160 Issue: 6 Pages: 2149-2157
  • DOI: 10.1016/j.chest.2021.06.067
  • Peer Reviewed
• [Journal Article] Serum S100A8 and S100A9 as prognostic biomarkers in acute exacerbation of idiopathic pulmonary fibrosis. (2021)
  • Author(s): Tanaka K, Enomoto N, Hozumi H, Isayama T, Naoi H, Aono Y, Katsumata M, Yasui H, Karayama M, Suzuki Y, Furuhashi K, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Respir Investig. Volume: 59(6) Issue: 6 Pages: 827-836
  • DOI: 10.1016/j.resinv.2021.05.008
  • Peer Reviewed
• [Journal Article] Increased serum cholesterol and long-chain fatty acid levels are associated with the efficacy of nivolumab in patients with non-small cell lung cancer (2021)
  • Author(s): Karayama M、Inui N、Inoue Y、Yoshimura K、Mori K、Hozumi H、Suzuki Y、Furuhashi K、Fujisawa T、Enomoto N、Nakamura Y、Asada K、Uto T、Fujii M、Matsui T、Matsuura S、Hashimoto D、Toyoshima M、Kusagaya H、Matsuda H、Inami N、Kaida Y、Niwa M、Ito Y、Suda T
  • Journal Title: Cancer Immunology, Immunotherapy Volume: 71 Issue: 1 Pages: 203-217
  • DOI: 10.1007/s00262-021-02979-4
  • Peer Reviewed
• [Journal Article] Prognostic and Clinical Value of Cluster Analysis in Idiopathic Pleuroparenchymal Fibroelastosis Phenotypes (2021)
  • Author(s): Nakamura Yutaro、Mori Kazutaka、Enomoto Yasunori、Kono Masato、Sumikawa Hiromitsu、Johkoh Takeshi、Colby Thomas V.、et al.
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 7 Pages: 1498-1498
  • DOI: 10.3390/jcm10071498
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic classification in acute exacerbation of idiopathic pulmonary fibrosis: a multicentre retrospective cohort study (2021)
  • Author(s): Suzuki Takahito、Hozumi Hironao、Miyashita Koichi、Kono Masato、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Hasegawa Hirotsugu、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Yokomura Koshi、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1
  • DOI: 10.1038/s41598-021-88718-2
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of peripheral blood monocyte and neutrophil counts in rheumatoid arthritis-associated interstitial lung disease (2021)
  • Author(s): Saku Aiko、Fujisawa Tomoyuki、Nishimoto Koji、Yoshimura Katsuhiro、Hozumi Hironao、Karayama Masato、Suzuki Yuzo、Furuhashi Kazuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Respiratory Medicine Volume: 182 Pages: 106420-106420
  • DOI: 10.1016/j.rmed.2021.106420
  • Peer Reviewed
• [Journal Article] Simple method for detecting idiopathic interstitial pneumonias by measuring vertical lung length on chest X-ray. (2021)
  • Author(s): Karayama M, Aoshima Y, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Suda T.
  • Journal Title: Sci Rep. Volume: 11(1) Issue: 1 Pages: 7669-7669
  • DOI: 10.1038/s41598-021-87452-z
  • Peer Reviewed / Open Access
• [Journal Article] Conventional type 2 lung dendritic cells are potent inducers of follicular helper T cells in the asthmatic lung (2021)
  • Author(s): Sakurai S, Furuhashi K, Horiguchi R, Nihashi F, Yasui H, Karayama M, Suzuki Y, Hozumi H, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T,
  • Journal Title: Allergology International Volume: - Issue: 3 Pages: 351-359
  • DOI: 10.1016/j.alit.2021.01.008
  • NAID: 130008064053
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Significance of Interstitial Lung Disease and Its Acute Exacerbation in Microscopic Polyangiitis (2021)
  • Author(s): Hozumi H, Kono M, Hasegawa H, Yasui H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Yokomura K, Nakamura H, Suda T.
  • Journal Title: Chest . Volume: S0012-3692(21) Issue: 6 Pages: 00259-2
  • DOI: 10.1016/j.chest.2021.01.083
  • Peer Reviewed
• [Journal Article] Exposure to PM2.5 is a risk factor for acute exacerbation of surgically diagnosed idiopathic pulmonary fibrosis: a case?control study (2021)
  • Author(s): Tahara Masahiro、Fujino Yoshihisa、Yamasaki Kei、Oda Keishi、Kido Takashi、Sakamoto Noriho、Kawanami Toshinori、Kataoka Kensuke、Egashira Ryoko、Hashisako Mikiko、Suzuki Yuzo、Fujisawa Tomoyuki、Mukae Hiroshi、Suda Takafumi、Yatera Kazuhiro
  • Journal Title: Respiratory Research Volume: 22 Issue: 1 Pages: 80-80
  • DOI: 10.1186/s12931-021-01671-6
  • Peer Reviewed / Open Access
• [Journal Article] Cluster analysis-based clinical phenotypes of idiopathic interstitial pneumonias: associations with acute exacerbation and overall survival (2021)
  • Author(s): Aoshima Y, Karayama M, Horiike Y, Mori K, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Suda T.
  • Journal Title: BMC Pulm Med. Volume: 21(1) Issue: 1 Pages: 63-63
  • DOI: 10.1186/s12890-021-01428-3
  • Peer Reviewed / Open Access
• [Journal Article] Predictors for bronchoalveolar lavage recovery failure in diffuse parenchymal lung disease (2021)
  • Author(s): Koda K, Hozumi H, Yasui H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Sci Rep . Volume: 11(1) Issue: 1 Pages: 1682-1682
  • DOI: 10.1038/s41598-021-81313-5
  • Peer Reviewed / Open Access
• [Journal Article] Pneumothorax in Patients with Idiopathic Pleuroparenchymal Fibroelastosis: Incidence, Clinical Features, and Risk Factors (2021)
  • Author(s): Kono Masato、Nakamura Yutaro、Enomoto Yasunori、Yasui Hideki、Hozumi Hironao、Karayama Masato、Suzuki Yuzo、Furuhashi Kazuki、Miki Yoshihiro、Hashimoto Dai、Fujisawa Tomoyuki、Enomoto Noriyuki、Inui Naoki、Suda Takafumi
  • Journal Title: Respiration Volume: 100 Issue: 1 Pages: 19-26
  • DOI: 10.1159/000511965
  • Peer Reviewed
• [Journal Article] Quality of dying and death in patients with interstitial lung disease compared with lung cancer: an observational study (2020)
  • Author(s): Koyauchi Takafumi、Suzuki Yuzo、Sato Kazuki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Yokomura Koshi、Imokawa Shiro、Nakamura Hidenori、Morita Tatsuya、Suda Takafumi
  • Journal Title: Thorax Volume: 76 Issue: 3 Pages: 248-255
  • DOI: 10.1136/thoraxjnl-2020-215917
  • Peer Reviewed / Open Access
• [Journal Article] Cause of mortality and sarcopenia in patients with idiopathic pulmonary fibrosis receiving antifibrotic therapy (2020)
  • Author(s): Suzuki Yuzo、Aono Yuya、Kono Masato、Hasegawa Hirotsugu、Yokomura Koushi、Naoi Hyogo、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Respirology Volume: 26 Issue: 2 Pages: 171-179
  • DOI: 10.1111/resp.13943
  • NAID: 120007159867
  • Peer Reviewed
• [Journal Article] Disease course and prognosis of pleuroparenchymal fibroelastosis compared with idiopathic pulmonary fibrosis (2020)
  • Author(s): Suzuki Yuzo、Fujisawa Tomoyuki、Sumikawa Hiromitsu、Tanaka Tomonori、Sugimoto Chikatoshi、Kono Masato、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Respiratory Medicine Volume: 171 Pages: 106078-106078
  • DOI: 10.1016/j.rmed.2020.106078
  • NAID: 120007165670
  • Peer Reviewed
• [Journal Article] CD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancer (2020)
  • Author(s): Yoshimura Katsuhiro、Suzuki Yuzo、Inoue Yusuke、Tsuchiya Kazuo、Karayama Masato、Iwashita Yuji、Kahyo Tomoaki、Kawase Akikazu、Tanahashi Masayuki、Ogawa Hiroshi、Inui Naoki、Funai Kazuhito、Shinmura Kazuya、Niwa Hiroshi、Sugimura Haruhiko、Suda Takafumi
  • Journal Title: OncoImmunology Volume: 9 Issue: 1 Pages: 1746554-1746554
  • DOI: 10.1080/2162402x.2020.1746554
  • Peer Reviewed / Open Access
• [Journal Article] Prednisolone and tacrolimus versus prednisolone and cyclosporin A to treat polymyositis/dermatomyositis‐associated ILD : A randomized, open‐label trial (2020)
  • Author(s): Fujisawa Tomoyuki、Hozumi Hironao、Kamiya Yosuke、Kaida Yusuke、Akamatsu Taisuke、Kusagaya Hideki、Satake Yasuomi、Mori Kazutak、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Respirology Volume: 26 Issue: 4 Pages: 370-377
  • DOI: 10.1111/resp.13978
  • Peer Reviewed
• [Journal Article] Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium. (2020)
  • Author(s): Kamiya Y, Fujisawa T, Katsumata M, Yasui H, Suzuki Y, Karayama M, Hozumi H, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Setou M, Ito M, Suzuki T, Ikegami K, Suda T.
  • Journal Title: Respir Res. Volume: 21 Issue: 1 Pages: 282-282
  • DOI: 10.1186/s12931-020-01555-1
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Programmed Death Ligand 1 (PD-L1) Gene Amplification and Response to Nivolumab Monotherapy in Non-small Cell Lung Cancer (2020)
  • Author(s): Inoue Y, Yoshimura K, Nishimoto K, Inui N, Karayama M, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Asada K, Uto T, Fujii M, Matsui T, Matsuura S, Hashimoto D, Toyoshima M, Kusagaya H, Matsuda H, Inami N, Kaida Y, Niwa M, Ito Y, Sugimura H, Suda T.
  • Journal Title: JAMA Netw Open. Volume: 3(9) Issue: 9 Pages: e2011818-e2011818
  • DOI: 10.1001/jamanetworkopen.2020.11818
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of forced vital capacity decline prior to and following antifibrotic therapy in idiopathic pulmonary fibrosis (2020)
  • Author(s): Aono Yuya、Nakamura Yutaro, et al.
  • Journal Title: Therapeutic Advances in Respiratory Disease Volume: 14
  • DOI: 10.1177/1753466620953783
  • Peer Reviewed / Open Access
• [Journal Article] Erlotinib and bevacizumab in elderly patients ?75?years old with non-small cell lung cancer harboring epidermal growth factor receptor mutations (2020)
  • Author(s): Aoshima Yoichiro、Karayama Masato、Inui Naoki、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Mikamo Masashi、Matsuura Shun、Kusagaya Hideki、Kaida Yusuke、Uto Tomohiro、Hashimoto Dai、Matsui Takashi、Asada Kazuhiro、Suda Takafumi
  • Journal Title: Investigational New Drugs Volume: 39 Issue: 1 Pages: 210-216
  • DOI: 10.1007/s10637-020-00988-1
  • NAID: 120007143503
  • Peer Reviewed / Open Access
• [Journal Article] Development of a novel T cell‐oriented vaccine using CTL/Th‐hybrid epitope long peptide and biodegradable microparticles, against an intracellular bacterium (2020)
  • Author(s): Tanaka Kazuki、Enomoto Noriyuki, et al.
  • Journal Title: Microbiology and Immunology Volume: 64 Issue: 10 Pages: 666-678
  • DOI: 10.1111/1348-0421.12836
  • Peer Reviewed
• [Journal Article] Pneumothorax in connective tissue disease-associated interstitial lung disease. (2020)
  • Author(s): Nishimoto K, Fujisawa T, Yoshimura K, Enomoto Y, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Sumikawa H, Johkoh T, Suda T.
  • Journal Title: PLoS One. Volume: 15(7) Issue: 7 Pages: e0235624-e0235624
  • DOI: 10.1371/journal.pone.0235624
  • Peer Reviewed / Open Access
• [Journal Article] Acute exacerbation of unclassifiable idiopathic interstitial pneumonia: comparison with idiopathic pulmonary fibrosis (2020)
  • Author(s): Enomoto N, Naoi H, Aono Y, Katsumata M, Horiike Y, Yasui H, Karayama M, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Ther Adv Respir Dis. Volume: 14
  • DOI: 10.1177/1753466620935774
  • Peer Reviewed / Open Access
• [Journal Article] Palliative Care for Idiopathic Pulmonary Fibrosis Patients: Pulmonary Physicians' View (2020)
  • Author(s): Akiyama N, Fujisawa T, Morita T, Mori K, Yasui H, Hozumi H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Suda T.
  • Journal Title: J Pain Symptom Manage. Volume: 60(5) Issue: 5 Pages: 933-940
  • DOI: 10.1016/j.jpainsymman.2020.06.012
  • NAID: 120007173433
  • Peer Reviewed
• [Journal Article] Comprehensive assessment of multiple tryptophan metabolites as potential biomarkers for immune checkpoint inhibitors in patients with non-small cell lung cancer (2020)
  • Author(s): Karayama M.、Masuda J.、Mori K.、Yasui H.、Hozumi H.、Suzuki Y.、Furuhashi K.、Fujisawa T.、Enomoto N.、Nakamura Y.、Inui N.、Suda T.、Maekawa M.、Sugimura H.、Takada A.
  • Journal Title: Clinical and Translational Oncology Volume: 23 Issue: 2 Pages: 418-423
  • DOI: 10.1007/s12094-020-02421-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Imaging mass spectrometry to visualise increased acetylcholine in lungs of asthma model mice (2020)
  • Author(s): Matsuda Takeshi、Suzuki Yuzo、Fujisawa Tomoyuki、Suga Yasunori、Saito Nobuyuki、Suda Takafumi、Yao Ikuko
  • Journal Title: Analytical and Bioanalytical Chemistry Volume: In press Issue: 18 Pages: 4327-4341
  • DOI: 10.1007/s00216-020-02670-0
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Immune-Related Interstitial Lung Disease in Patients With NSCLC Treated with Immune Checkpoint Inhibitors: A Multicenter Prospective Study (2020)
  • Author(s): Suzuki Y, Karayama M, Uto T, Fujii M, Matsui T, Asada K, Kusagaya H, Kato M, Matsuda H, Matsuura S, Toyoshima M, Mori K, Ito Y, Koyauchi T, Yasui H, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T.
  • Journal Title: Journal of Thoracic Oncology Volume: S1556 Issue: 8 Pages: 1317-1327
  • DOI: 10.1016/j.jtho.2020.04.002
  • Peer Reviewed
• [Journal Article] Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer. (2020)
  • Author(s): Karayama M, Yoshizawa N, Sugiyama M, Mori K, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Goshima S, Suda T, Takehara Y.
  • Journal Title: Lung Cancer Volume: 143 Pages: 47-54
  • DOI: 10.1016/j.lungcan.2020.03.013
  • NAID: 120007041512
  • Peer Reviewed
• [Journal Article] Pulse oximetric saturation to fraction of inspired oxygen (SpO2/FIO2) ratio 24 hours after high-flow nasal cannula (HFNC) initiation is a good predictor of HFNC therapy in patients with acute exacerbation of interstitial lung disease. (2020)
  • Author(s): Koyauchi T, Yasui H, Enomoto N, Hasegawa H, Hozumi H, Suzuki Y, Karayama M, Furuhashi K, Fujisawa T, Nakamura Y, Inui N, Yokomura K, Suda T.
  • Journal Title: Therapeutic Advances in Respiratory Disease Volume: 14
  • DOI: 10.1177/1753466620906327
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative computed tomography measures of skeletal muscle mass in patients with idiopathic pulmonary fibrosis according to a multidisciplinary discussion diagnosis: A retrospective nationwide study in Japan (2020)
  • Author(s): Awano Nobuyasu、Inomata Minoru、Kuse Naoyuki、Tone Mari、Yoshimura Hanako、Jo Tatsunori、Takada Kohei、Sugimoto Chikatoshi、Tanaka Tomonori、Sumikawa Hiromitsu、Suzuki Yuzo、Fujisawa Tomoyuki、Suda Takafumi、Izumo Takehiro
  • Journal Title: Respiratory Investigation Volume: 58 Issue: 2 Pages: 91-101
  • DOI: 10.1016/j.resinv.2019.11.002
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous Occurrence of Sarcoidosis and Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis in a Patient with Lung Cancer (2019)
  • Author(s): Tsuchiya Kazuo、Karayama Masato、Sato Taichi、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Sugimura Haruhiko、Yasuda Hideo、Suda Takafumi
  • Journal Title: Internal Medicine Volume: 58 Issue: 22 Pages: 3299-3304
  • DOI: 10.2169/internalmedicine.3004-19
  • NAID: 130007746063
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-11-15
  • Peer Reviewed
• [Journal Article] Synchronous Occurrence of Bazex Syndrome and Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome in a Patient with Lung Cancer (2019)
  • Author(s): Aoshima Yoichiro、Karayama Masato、Sagisaka Shinya、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Internal Medicine Volume: 58 Issue: 22 Pages: 3267-3271
  • DOI: 10.2169/internalmedicine.3032-19
  • NAID: 130007746069
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-11-15
  • Peer Reviewed
• [Journal Article] A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity (2019)
  • Author(s): Maazi Hadi、Hartiala Jaana A.、Suzuki Yuzo、Crow Amanda L.、Shafiei Jahani Pedram、Lam Jonathan、Patel Nisheel、Rigas Diamanda、Han Yi、Huang Pin、Eskin Eleazar、Lusis Aldons. J.、Gilliland Frank D.、Akbari Omid、Allayee Hooman
  • Journal Title: PLOS Genetics Volume: 15 Issue: 12 Pages: e1008528-e1008528
  • DOI: 10.1371/journal.pgen.1008528
  • Peer Reviewed / Open Access
• [Journal Article] Macrophage Mannose Receptor CD206 Predicts Prognosis in Community-acquired Pneumonia (2019)
  • Author(s): Tsuchiya K, Suzuki Y, Yoshimura K, Yasui H, Karayama M, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Yokomura K, Suda T.
  • Journal Title: Sci Rep. Volume: 9(1) Issue: 1 Pages: 55289-2
  • DOI: 10.1038/s41598-019-55289-2
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic factors for primary Sjögren's syndrome-associated interstitial lung diseases. (2019)
  • Author(s): Kamiya Y, Fujisawa T, Kono M, Nakamura H, Yokomura K, Koshimizu N, Toyoshima M, Imokawa S, Sumikawa H, Johkoh T, Yasui H, Hozumi H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Suda T.
  • Journal Title: Respiratory Medicine Volume: 159 Pages: 105811-105811
  • DOI: 10.1016/j.rmed.2019.105811
  • Peer Reviewed
• [Journal Article] Effect of PD-1 inhibitor on exhaled nitric oxide and pulmonary function in non-small cell lung cancer patients with and without COPD. (2019)
  • Author(s): Suzuki Y, Inui N, Karayama M, Imokawa S, Yamada T, Yokomura K, Asada K, Kusagaya H, Kaida Y, Matsuda H, Koshimizu N, Toyoshima M, Masuda M, Hayakawa H, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Suda T.
  • Journal Title: International Journal of Chronic Obstructive Pulmonary Disease Volume: 14 Pages: 1867-1877
  • DOI: 10.2147/copd.s214610
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of serum S100 calcium-binding protein A4 in idiopathic pulmonary fibrosis. (2019)
  • Author(s): Akiyama N, Hozumi H, Isayama T, Okada J, Sugiura K, Yasui H, Suzuki Y, Kono M, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Respirology Volume: 0 Issue: 7 Pages: 0-0
  • DOI: 10.1111/resp.13707
  • NAID: 120007097006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Once-daily fluticasone furoate/vilanterol combination versus twice-daily budesonide/formoterol combination in the treatment of controlled stable asthma: a randomized crossover trial. (2019)
  • Author(s): Furuhashi K, Fujisawa T, Hashimoto D, Kamiya Y, Yasui H, Karayama M, Suzuki Y, Hozumi H, Enomoto N, Nakamura Y, Inui N, Suda T.
  • Journal Title: Journal of Asthma and Allergy Volume: 12 Pages: 253-261
  • DOI: 10.2147/jaa.s223093
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of an early marginal decline in forced vital capacity in idiopathic pulmonary fibrosis patients treated with pirfenidone. (2019)
  • Author(s): Kono M, Nakamura Y, Enomoto N, Saito G, Koyanagi Y, Miyashita K, Tsutsumi A, Kobayashi T, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Miki Y, Hashimoto D, Fujisawa T, Inui N, Suda T, Nakamura H.
  • Journal Title: Respir Investig. Volume: 57 Issue: 6 Pages: 552-560
  • DOI: 10.1016/j.resinv.2019.07.003
  • Peer Reviewed / Open Access
• [Journal Article] Body composition changes successfully classify prognosis in patients with mycobacterium avium complex lung disease. (2019)
  • Author(s): Akahori D, Suzuki Y, Yokomura K, Shirai M, Yasui H, Hozumi H, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Hayakawa H, Suda T.
  • Journal Title: Journal of Infection Volume: 79 Issue: 4 Pages: 341-348
  • DOI: 10.1016/j.jinf.2019.07.014
  • Peer Reviewed
• [Journal Article] Analysis of serum adiponectin and leptin in patients with acute exacerbation of idiopathic pulmonary fibrosis. (2019)
  • Author(s): Enomoto N, Oyama Y, Yasui H, Karayama M, Hozumi H, Suzuki Y, Kono M, Furuhashi K, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 10484-10484
  • DOI: 10.1038/s41598-019-46990-3
  • Peer Reviewed / Open Access
• [Journal Article] Heterogeneity analysis of PD-L1 expression and copy number status in EBUS-TBNA biopsy specimens of non-small cell lung cancer: Comparative assessment of primary and metastatic sites (2019)
  • Author(s): Yoshimura Katsuhiro、Inoue Yusuke、Karayama Masato、Tsuchiya Kazuo、Mori Kazutaka、Suzuki Yuzo、Iwashita Yuji、Kahyo Tomoaki、Kawase Akikazu、Tanahashi Masayuki、Ogawa Hiroshi、Yokomura Koushi、Inui Naoki、Funai Kazuhito、Shinmura Kazuya、Niwa Hiroshi、Suda Takafumi、Sugimura Haruhiko
  • Journal Title: Lung Cancer Volume: 134 Pages: 202-209
  • DOI: 10.1016/j.lungcan.2019.06.002
  • Peer Reviewed
• [Journal Article] Clinical features of three-dimensional computed tomography-based radiologic phenotypes of chronic obstructive pulmonary disease. (2019)
  • Author(s): Karayama M, Inui N, Yasui H, Kono M, Hozumi H, Suzuki Y, Furuhashi K, Hashimoto D, Enomoto N, Fujisawa T, Nakamura Y, Watanabe H, Suda T.
  • Journal Title: International Journal of Chronic Obstructive Pulmonary Disease Volume: 14 Pages: 1333-1342
  • DOI: 10.2147/copd.s207267
  • Peer Reviewed / Open Access
• [Journal Article] Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management (2019)
  • Author(s): Suzuki Yuzo、Suda Takafumi
  • Journal Title: Allergology International Volume: 68 Issue: 4 Pages: 413-419
  • DOI: 10.1016/j.alit.2019.05.006
  • NAID: 130007733125
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Frequency and clinical relevance of anti-cyclic citrullinated peptide antibody in idiopathic interstitial pneumonias (2019)
  • Author(s): Katsumata M, Hozumi H, Yasui H, Suzuki Y, Kono M, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Respir Med Volume: 154 Pages: 102-108
  • DOI: 10.1016/j.rmed.2019.06.016
  • Peer Reviewed
• [Journal Article] Successful classification of macrophage-mannose receptor CD206 in severity of anti-MDA5 antibody positive dermatomyositis associated ILD (2019)
  • Author(s): Horiike Yasuoki, Suzuki Yuzo, Fujisawa Tomoyuki, Yasui Hideki, Karayama, Masato, Hozumi Hironao, Furuhashi Kazuki, Enomoto Noriyuki, Nakamura Yutaro, Inui Naoki, Ogawa Noriyoshi, Suda Takafumi
  • Journal Title: Rheumatology Volume: 印刷中 Issue: 12 Pages: 2143-2152
  • DOI: 10.1093/rheumatology/kez185
  • Peer Reviewed
• [Journal Article] Physiological and morphological differences of airways between COPD and asthma?COPD overlap (2019)
  • Author(s): Karayama Masato、Inui Naoki、Yasui Hideki、Kono Masato、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Hashimoto Dai、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Watanabe Hiroshi、Suda Takafumi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 7818-7818
  • DOI: 10.1038/s41598-019-44345-6
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Significance of Serum Chitotriosidase Level in Anti-MDA5 Antibody?positive Dermatomyositis-associated Interstitial Lung Disease (2019)
  • Author(s): Fujisawa Tomoyuki、Hozumi Hironao、Yasui Hideki、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: The Journal of Rheumatology Volume: 46 Issue: 8 Pages: 935-942
  • DOI: 10.3899/jrheum.180825
  • Peer Reviewed
• [Journal Article] Nationwide cloud-based integrated database of idiopathic interstitial pneumonias for multidisciplinary discussion. (2019)
  • Author(s): Fujisawa T, Mori K, Mikamo M, Ohno T, Kataoka K, Sugimoto C, Kitamura H, Enomoto N, Egashira R, Sumikawa H, Iwasawa T, Matsushita S, Sugiura H, Hashisako M, Tanaka T, Terasaki Y, Kunugi S, Kitani M, Okuda R, Horiike Y, Enomoto Y, Yasui H, Hozumi H, Suzuki Y, Nakamura Y, Fukuoka J, Johkoh T, Kondoh Y, Ogura T,,, Suda T.
  • Journal Title: Eur Respir J. Volume: 3 Issue: 5 Pages: 1802243-1802243
  • DOI: 10.1183/13993003.02243-2018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of corticosteroid and intravenous cyclophosphamide in acute exacerbation of idiopathic pulmonary fibrosis: A propensity score‐matched analysis (2019)
  • Author(s): Hozumi Hironao、Hasegawa Hirotsugu、Miyashita Koichi、Yasui Hideki、Suzuki Yuzo、Kono Masato、Karayama Masato、Furuhashi Kazuki、Hashimoto Dai、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Yokomura Koshi、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Respirology Volume: 印刷中 Issue: 8 Pages: 792-798
  • DOI: 10.1111/resp.13506
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy of Glucocorticoids and Calcineurin Inhibitors for Anti-aminoacyl-tRNA Synthetase Antibody?positive Polymyositis/dermatomyositis?associated Interstitial Lung Disease: A Propensity Score?matched Analysis (2019)
  • Author(s): Hozumi Hironao、Fujisawa Tomoyuki、Nakashima Ran、Yasui Hideki、Suzuki Yuzo、Kono Masato、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Inui Naoki、Nakamura Yutaro、Mimori Tsuneyo、Suda Takafumi
  • Journal Title: The Journal of Rheumatology Volume: 印刷中 Issue: 5 Pages: 509-517
  • DOI: 10.3899/jrheum.180778
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Methotrexate-associated Lymphoproliferative Disorder with Diffuse Ground-Glass Opacities (2019)
  • Author(s): Tsuchiya Kazuo、Suzuki Yuzo、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Baba Satoshi、Suda Takafumi
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 199 Issue: 8 Pages: 1031-1033
  • DOI: 10.1164/rccm.201806-1115im
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Impaired Autophagy Exacerbates Eosinophilic Airway Inflammation in Murine Model of Obesity Asthma (2021)
  • Author(s): Suzuki YUZO
  • Organizer: American Thoracic Society Annual Meeting 2021
  • Int'l Joint Research
• [Presentation] 肺MAC症の予後予測 (2021)
  • Author(s): 鈴木勇三
  • Organizer: 日本結核・非結核性抗酸菌症学会総会・学術講演会
• [Presentation] オートファジー低下はTSLP依存性に肥満喘息を悪化させる (2021)
  • Author(s): 鈴木勇三
  • Organizer: 日本呼吸器学会学術講演会
• [Presentation] 抗線維化薬の切り替えは有益か？ 多施設後方視研究 (2021)
  • Author(s): 鈴木勇三
  • Organizer: 日本呼吸器学会学術講演会
• [Presentation] Pleuroparenchymal Fibroelastosis (PPFE): Prognostic Concordance Of Clinical Diagnosis, Acute Exacerbation And Prognosis Comparison With IPF (2020)
  • Author(s): YUZO SUZUKI
  • Organizer: American Thoracic Society Annual Meeting 2020
  • Int'l Joint Research
• [Presentation] 肺機能低下は免疫関連肺障害の予測因子である：多施設共同前向き研究 (2020)
  • Author(s): 鈴木勇三
  • Organizer: 日本呼吸器学会学術講演会
• [Presentation] PPFE臨床診断の確からしさ、急性増悪と予後：IPFとの比較 (2020)
  • Author(s): 鈴木勇三
  • Organizer: 日本呼吸器学会学術講演会
• [Presentation] Prognostic Significance of Macrophage-Mannose Receptor, CD206, in Anti-MDA5 DM-ILD (2019)
  • Author(s): Yuzo Suzuki
  • Organizer: American Thoracic Society Annual Meeting
  • Int'l Joint Research
• [Presentation] 抗MDA5抗体陽性皮膚筋炎に合併する間質性肺炎とM2マクロファージ関連マーカーCD206の意義 (2019)
  • Author(s): 鈴木勇三
  • Organizer: 第68回日本アレルギー学会学術大会
• [Presentation] 血清CD206-マクロファージマンノース受容体-は肺結核患者の予後予測マーカーである (2019)
  • Author(s): 鈴木勇三
  • Organizer: 第94回日本結核病学会総会
• [Presentation] 筋肉量の減少や変化が間質性肺疾患の予後に与える影響 (2019)
  • Author(s): 鈴木勇三
  • Organizer: 第59回日本呼吸器学会学術講演会