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Novel wound healing method using electrolyzed water and low temperature plasma

Research Project

Project/Area Number 19K17791
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53050:Dermatology-related
Research InstitutionTohoku University

Principal Investigator

Mokudai Takayuki  東北大学, 金属材料研究所, 特任助教 (30466544)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords創傷治癒 / 大気圧プラズマ / 電解水 / 活性酸素 / プラズマ医療 / 低温プラズマ / 活性酸素種 / プラズマ
Outline of Research at the Start

傷の治癒において、生体機能が正常に機能するよう損傷個所の環境を整えることは重要となり、細菌による感染が発症すると膿瘍、蜂巣炎などの症状が発現する。創部の細菌感染は、治癒過程において影響を及ぼすとされ創傷環境の改善が望まれる。本研究は酸性電解水と低温プラズマ照射により、創面環境を整えることを目標として、創傷治癒に繋がる化学と工学技術の融合による新たな治療技術の基礎研究を行うものである。さらに、薬剤アレルギーをもつ患者に対しても本技術で処置できるようになることを将来展望としている。

Outline of Final Research Achievements

In this present study, electrolyzed water and atmospheric pressure plasma were used as new treatments for wound healing. The bactericidal effect was obtained with electrolyzed water, and the healing promoting effect was obtained by creating a rat skin defect model and treating it with plasma using a specific gas. However, there is insufficient data to establish a new model of wound healing and needs to be validated in the future.

Academic Significance and Societal Importance of the Research Achievements

創傷環境を酸性電解水で清浄化して、低温プラズマ照射により細胞の活性化を促進し正常な状態へのリカバリーを促すことで創面環境を整えることを目標としていた。さらに、本技術により薬剤アレルギーをもつ患者に対しても本技術で処置できるようになることを将来展望として考えている。以上の内容より本申請書では、創傷治癒に繋がる化学と工学技術の融合による新たな治療技術の基礎研究を行えた点に関して意義あるものだと考えられる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (5 results)

All 2021 2020

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Antibacterial properties of Cu-doped TiO2 prepared by chemical and heat treatment of Ti metal2021

    • Author(s)
      Suzuki Kanae、Yokoi Taishi、Iwatsu Misato、Furuya Maiko、Yokota Kotone、Mokudai Takayuki、Kanetaka Hiroyasu、Kawashita Masakazu
    • Journal Title

      Journal of Asian Ceramic Societies

      Volume: 9 Issue: 4 Pages: 1448-1456

    • DOI

      10.1080/21870764.2021.1979287

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoactivity of an anodized biocompatible TiNbSn alloy prepared in sodium tartrate / hydrogen peroxide aqueous solution2021

    • Author(s)
      N. Masahashi, Y Mori, H. Kurishima, H. Inoue, T. Mokudai, S. Semboshi, M. Hatakeyama, E. Itoi, S. Hanada
    • Journal Title

      Applied Surface Science

      Volume: 543 Pages: 1488291-11

    • DOI

      10.1016/j.apsusc.2020.148829

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Continuous release of O2/ONOO in plasma‐exposed HEPES‐buffered saline promotes TRP channel‐mediated uptake of a large cation2020

    • Author(s)
      Sasaki Shota、Zheng Yuexing、Mokudai Takayuki、Kanetaka Hiroyasu、Tachikawa Masanori、Kanzaki Makoto、Kaneko Toshiro
    • Journal Title

      Plasma Processes and Polymers

      Volume: 17 Issue: 10 Pages: 1900257-1900257

    • DOI

      10.1002/ppap.201900257

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 室内空間におけるpH調整電解水噴霧による殺菌効果2021

    • Author(s)
      目代貴之 岩井邦夫 白土翠 中村圭祐 菅野太郎 庭野吉己
    • Organizer
      日本防菌防黴学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Visible-light-induced photocatalytic activity of nitrogen-doped TiO2 and functionality2021

    • Author(s)
      Takayuki Mokudai, Misato Iwatsu, HiroyasuKanetaka, Masakazu Kawashita, Keiichi Sasaki
    • Organizer
      The 5th Symposium for the Core Research Clusters for Materials Science and Spintronics, and the 4th Symposium on International Joint Graduate Program in Materials Science
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2023-01-30  

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