Elucidation of the mechanisms by which plasmacytoid dendritic cells activation is regulated in skin diseases
Project/Area Number |
19K17818
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 53050:Dermatology-related
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Research Institution | Juntendo University |
Principal Investigator |
Kaitani Ayako 順天堂大学, 大学院医学研究科, 特任助教 (50833604)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 免疫受容体 / プラズマサイトイド樹状細胞 / 皮膚炎症 / ペア型免疫受容体 / 皮膚疾患 / ペア型受容体 / 自己DNA |
Outline of Research at the Start |
SLEや乾癬などの皮膚疾患の病態形成には、自己DNAと自己抗体や抗菌ペプチドの複合体を取り込みI型インターフェロンを大量に産生するプラズマサイトイド樹状細胞(pDC)の関与が指摘されているが、その制御メカニ ズムの解明は不十分である。 本研究は、pDCに発現するペア型受容体LMIR3とLMIR8に着目して皮膚疾患モデルを解析し、自己DNAによるpDCの活性化及び関連する皮膚疾患の病態の制御メカニズムを解明することを目指す。
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Outline of Final Research Achievements |
Loss of an activating receptor leukocyte mono-immunoglobulin-like receptor 8 (LMIR8), specifically expressed in plasmacytoid dendritic cells, failed to influence their activation by Toll-like receptor 7 (TLR7) or TLR9 ligand. In addition, loss of LMIR8 did not significantly influence skin inflammation in TLR7 ligand-applied mice. To examine whether the lipids such as ceramides and phosphatidylserine act as LMIR8 ligands, we performed the binding and reporter assays using an extracellular domain of LMIR8; however, we were not able to identify LMIR8 ligands during the research period.
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Academic Significance and Societal Importance of the Research Achievements |
本研究により、プラズマサイトイド樹状細胞特異的に発現する受容体LMIR8が既知の刺激によるプラズマサイトイド樹状細胞の活性化や皮膚炎症を制御しないことが判明した。本研究成果は、プラズマサイトイド樹状細胞の活性化制御による(炎症性疾患に対する)治療法開発の基礎となり、学術的意義及び社会的意義があると考えられる。
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Report
(5 results)
Research Products
(56 results)
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[Journal Article] Mucosal Mast Cell-Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling.2022
Author(s)
Nakano N, Saida K, Hara M, Izawa K, Ando T, Kaitani A, Kasakura K, Yashiro T, Nishiyama C, Ogawa H, Kitaura J, Okumura K.
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Journal Title
J Immunol.
Volume: -
Issue: 12
Pages: 3098-3106
DOI
Related Report
Peer Reviewed
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[Journal Article] Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice2021
Author(s)
Fukase S, Ando T, Matsuzawa M, Kimura M, Sone Y, Izawa K, Kaitani A, Kamei A, Kojima M, Nakano N, Maeda K, Shimizu T, Ogawa H, Okumura K, Nishiyama N, Murakami A, Ebihara N, Kitaura J.
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Journal Title
Ocul Surf.
Volume: 22
Pages: 153-162
DOI
Related Report
Peer Reviewed
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[Journal Article] Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy.2021
Author(s)
Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H
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Journal Title
Mucosal Immunol
Volume: 14
Issue: 3
Pages: 640-651
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] CD300f is a potential therapeutic target for the treatment of food allergy2019
Author(s)
Uchida Shino、Izawa Kumi、Ando Tomoaki、Yamada Hiromichi、Uchida Koichiro、Negishi Naoko、Kaitani Ayako、Maehara Akie、Nagamine Masakazu、Kamei Anna、Takamori Ayako、Maeda Keiko、Nakano Nobuhiro、Shimizu Toshiaki、Ogawa Hideoki、Okumura Ko、Nagahara Akihito、Watanabe Sumio、Kitaura Jiro
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Journal Title
Allergy
Volume: 75
Issue: 2
Pages: 471-474
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Intranasal administration of ceramide liposomes inhibits ragweed pollen-induced allergic rhinitis by targeting CD300f2022
Author(s)
Ayako Kaitani, Takuma Ide, Kumi Izawa, Tomoaki Ando, Akie Maehara, Risa Yamamoto, Yasuharu Kume, Hexing Wang, Koji Tokushige, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura
Organizer
第51回日本免疫学会学術集会
Related Report
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[Presentation] A point mutation within the function-to-find domain (FIIND) of human NLRP1 causes an autoinflammatory disease involving liver fibrosis and dyskeratosis.2021
Author(s)
Akie Maehara, Taiki Ando, Kumi Izawa, Tomoaki Ando, Ayako Kaitani, Anna Kamei, Hexing Wang, Koji Tokushige, Nobuhiro Nakano, Naoto Tamura, Ko Okumura, Jiro Kitaura.
Organizer
第50回日本免疫学会学術集会
Related Report
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[Presentation] Staphylococcus aureus d-toxin in skin promotes the development of food allergy following epicutaneous sensitization.2021
Author(s)
Anna Kamei, Hiromichi Yamada, Kumi Izawa, Tomoaki Ando, Ayako Kaitani, Akie Maehara, Hexing Wang, Koji Tokushige, Shino Uchida, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura.
Organizer
第50回日本免疫学会学術集会
Related Report
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[Presentation] CD300f suppresses IgE- and mast cell-dependent allergic rhinitis.2021
Author(s)
Ayako Kaitani, Takuma Ide, Kumi Izawa, Anna Kamei, Tomoaki Ando, Akie Maehara, Hexing Wang, Koji Tokushige, Maeda Keiko, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura
Organizer
第50回日本免疫学会学術集会
Related Report
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[Presentation] Physiological expression of St6galnac1 protects mice from allergic conjunctivitis.2021
Author(s)
Tomoaki Ando, Moe Matsuzawa, Saaya Fukase, Meiko Kimura, Kumi Izawa, Ayako Kaitani, Nobuhiro Nakano, Keiko Maeda, Ko Okumura, Akira Murakami, Nobuyuki Ebihara, Jiro Kitaura.
Organizer
第50回日本免疫学会学術集会
Related Report
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[Presentation] Pollen shells and soluble components play non-redundant roles in the development of allergic conjunctivitis2021
Author(s)
Saaya Fukase, Tomoaki Ando, Moe Matsuzawa, Meiko Kimura, Kumi Izawa, Ayako Kaitani, Anna Kamei, Goukyo Ou, Nobuhiro Nakano, Ko Okumura, Akira Murakami, Nobuyuki Ebihara, Jiro Kitaura.
Organizer
第70回日本アレルギー学会学術大会
Related Report
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[Presentation] :結膜におけるシアル化酵素の生理的発現がアレルギー性結膜炎の発症を抑制する2021
Author(s)
松澤萌, 安藤智暁, 深瀬紗綾, 木村芽以子, 伊沢久未, 貝谷綾子, 中野信浩, 前田啓子, 奥村康, 村上晶, 北浦次郎, 海老原伸行
Organizer
第125回日本眼科学会総会
Related Report
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[Presentation] マウス花粉性結膜炎モデルの発症における花粉の粒子性と抽出成分の重要性2021
Author(s)
深瀬紗綾, 安藤智暁, 松澤萌, 木村芽以子, 伊沢久未, 貝谷綾子, 亀井杏菜, 王合興,中野信浩, 奥村康, 村上晶, 北浦次郎, 海老原伸行
Organizer
第125回日本眼科学会総会
Related Report
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[Presentation] Differential lipid recognition by mouse vs human CD300f, inhibiting IgE-mediated anaphylaxis, depends on a single amino acid substitution2020
Author(s)
Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Akie Maehara, Moe Matsuzawa, Taiki Ando, Takuma Ide, Yoko Okamoto, Saaya Fukase, Mayuki Kojima, Anna Kamei, Meiko Kimura, Hexing Wang, Ko Okumura, Jiro Kitaura
Organizer
日本研究皮膚科学会 第45回年次学術大会・総会
Related Report
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[Presentation] Differential lipid recognition by mouse versus human CD300f, inhibiting IgE- and mast cell-dependent anaphylaxis, depends on a single amino acid substitution in its immunoglobulin-like domain2020
Author(s)
Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Akie Maehara, Enzhi Yin, Moe Matsuzawa, Taiki Ando, Takuma Ide, Yoko Okamoto, Saaya Fukase, Mayuki Kojima, Anna Kamei, Hexing Wang, Ko Okumura, Jiro Kitaura
Organizer
JSA/WAO Joint Congress 2020 (Web)
Related Report
Int'l Joint Research
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[Presentation] Establishment of sustained unresponsiveness to food allergens by oral immunotherapy is prevented by inhibition of Notch signaling.2020
Author(s)
Nobuhiro Nakano, Toshiyuki Yoneyama, Mutsuko Hara, Hiromichi Yamada, Kumi Izawa, Koichiro Uchida, Ayako Kaitani, Tomoaki Ando, Jiro Kitaura, Yoshikazu Ohtsuka, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura
Organizer
JSA/WAO Joint Congress 2020 (Web)
Related Report
Int'l Joint Research
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[Presentation] Differential lipid recognition by mouse versus human CD300f, inhibiting IgE-mediated mast cell activation, depends on a single amino acid substitution in its immunoglobulin-like domain2019
Author(s)
Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Akie Maehara, Enzhi Yin, Moe Matsuzawa, Saaya Fukase, Hexing Wang, Keiko Maeda, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura
Organizer
第48回日本免疫学会学術集会
Related Report
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[Presentation] Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation2019
Author(s)
Yoko Okamoto, Ayako Takamori, Kumi Izawa, Tomoaki Ando, Ayako Kaitani, Akie Maehara, Enzhi Yin, Hiromichi Yamada, Hexing Wang, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura
Organizer
第48回日本免疫学会学術集会
Related Report
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[Presentation] An inhibitory receptor CD300f inhibits the pathogenesis of OVA-induced food allergy in mice2019
Author(s)
Anna Kamei, Shino Uchida, Hiromichi Yamada, Kumi Izawa, Tomoaki Ando, Naoko Negishi, Akie Maehara, Ayako Kaitani, Yoko Okamoto, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura
Organizer
第48回日本免疫学会学術集会
Related Report
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[Presentation] Exaggerated inflammasome activation by a novel NLRP1 mutant derived from a rare disease with severe liver fibrosis2019
Author(s)
Taiki Ando, Akie Maehara, Tomoaki Ando, Kumi Izawa, Ayako Kaitani, Enzhi Yin, Takuma Ide, Keiko Maeda, Nobuhiro Nakano, Naoto Tamura, Ko Okumura, Jiro Kitaura
Organizer
第48回日本免疫学会学術集会
Related Report
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[Presentation] Mast cell- and IgE-dependent anaphylaxis is regulated by the interaction between inhibitory LMIR3/activating LMIR7 and specific lipids2019
Author(s)
Kumi Izawa, Ayako Kaitani, Tomoaki Ando, Akie Maehara, Takuma Ide, Moe Matsuzawa, Saaya Fukase, Anna Kamei, Taiki Ando, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura
Organizer
第48回日本免疫学会学術集会
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[Presentation] 経皮感作による食物アレルギーの病態メカニズム2019
Author(s)
山田啓迪, 米山俊之, 貝谷綾子, 内田志野, 伊沢久未, 安藤智暁, 北浦次郎, 大塚宜一, 奥村康, 清水俊明, 清水俊明
Organizer
第43回日本小児皮膚科学会学術大会
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