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Inhibition of bacteremia in cancer patients with chemotherapy by regulating circadian rhythms

Research Project

Project/Area Number 19K17927
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 54030:Infectious disease medicine-related
Research InstitutionKagawa University

Principal Investigator

Uemura Makiko  香川大学, 医学部, 助教 (00710188)

Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords体内時計 / 概日リズム / 時計遺伝子 / 日内変動 / がん化学療法 / 菌血症 / 好中球減少 / 発熱性好中球減少症 / がん化学療法患者 / メラトニン受容体刺激
Outline of Research at the Start

多くの全身性疾患において体内時計である概日リズムの障害が関与していることが明らかになりつつある。感染症の分野においては、以前から感染症発症時刻と死亡の関連が議論されて来たが、それを臨床的に証明した報告はない。そこで申請者はがん化学療法中の患者において概日リズムの有無を確認し、障害された概日リズムを是正することで菌血症の予後が改善するかを検証する。本研究の仮説検証過程は以下の通りである。
(1) がん化学療法患者における概日リズム障害を時計遺伝子の定量により評価する。
(2) 概日リズムの是正が可能かどうか確認する。
(3) 概日リズムの是正が菌血症の発症と予後に影響するかどうか評価する。

Outline of Final Research Achievements

The hypothesis of this study was that “patients undergoing cancer chemotherapy have impaired circadian rhythms, and correcting them can suppress the onset of bacteremia and improve the prognosis.” In the first study, we comprehensively analyzed cases of bacteremia in chemotherapy patients and found a bacteriological relationship between oral commensal bacteria and bacteremia. It was found that about half (46.2%) of cases of bacteremia in patients undergoing chemotherapy were of oral bacterial origin. In addition, we developed and established a model to predict the relationship between the degree of neutropenia and subsequent fever episodes in patients with fever undergoing chemotherapy using the neutropenia index. There was no clear association between the onset time of bacteremia and the subsequent clinical course, and the association between circadian rhythms and bacteremia was not fully elucidated.

Academic Significance and Societal Importance of the Research Achievements

本研究において、概日リズムと菌血症の予後の関連は明確とはならなかったが、臨床管理上の理由を除いても、夜間の発症と日中の発症とでは菌血症の生物学的および免疫学的反応性が異なるではないかということが推察された。明確な関連性や影響する要因を抽出するにはさらなる臨床経過の観察および臨床感染症の観点から免疫学的評価およびモニタリングが必要であると考えられた。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (21 results)

All 2023 2022 2021 2020 2019

All Journal Article (21 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 8 results)

  • [Journal Article] Prognostic impact of the simple L-index and absolute lymphocyte count early after allogeneic hematopoietic stem cell transplantation2023

    • Author(s)
      Kubo Hiroyuki、Imataki Osamu、Fukumoto Tetsuya、Ishida Tomoya、Kubo Yukiko Hamasaki、Kida Jun-ichiro、Uemura Makiko、Fujita Haruyuki、Kadowaki Norimitsu
    • Journal Title

      Cytotherapy

      Volume: 25 Issue: 4 Pages: 415-422

    • DOI

      10.1016/j.jcyt.2022.11.008

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
  • [Journal Article] Potential factors for and the prognostic impact of ascites after allogeneic hematopoietic stem cell transplantation2023

    • Author(s)
      Kubo Hiroyuki、Imataki Osamu、Fukumoto Tetsuya、Kawanaka Yui、Ishida Tomoya、Kubo Yukiko Hamasaki、Kida Jun-ichiro、Uemura Makiko、Fujita Haruyuki、Kadowaki Norimitsu
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 13005-13005

    • DOI

      10.1038/s41598-023-39604-6

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Repeated spontaneous remission of acute myeloid leukemia in response to various infections: a case report2023

    • Author(s)
      Imataki Osamu、Ishida Tomoya、Kida Jun-ichiro、Uemura Makiko、Fujita Haruyuki、Kadowaki Norimitsu
    • Journal Title

      BMC Infectious Diseases

      Volume: 23 Issue: 1 Pages: 215-215

    • DOI

      10.1186/s12879-023-08108-z

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
  • [Journal Article] Potential clinical benefits of warfarin in end‐stage cancers: A retrospective analysis2023

    • Author(s)
      Imataki Osamu、Arai Takeshi、Uemura Makiko
    • Journal Title

      Health Science Reports

      Volume: 6 Issue: 1 Pages: 956-956

    • DOI

      10.1002/hsr2.956

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Metabolic Steal of the Myocardium by Primary Cardiac Lymphoma2023

    • Author(s)
      Imataki Osamu、Kubo Hiroyuki、Fujita Haruyuki、Uemura Makiko
    • Journal Title

      Case Reports in Oncology

      Volume: 16 Pages: 7-12

    • DOI

      10.1159/000527638

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Cost-Effectiveness Analysis of Transplantation-Ineligible Elderly Patients With Acute Leukemia Harboring a Molecular Target: Ph-Positive Acute Leukemia and FLT3-Mutated Acute Myeloid Leukemia2022

    • Author(s)
      Imataki Osamu、Ishida Tomoya、Kida Jun-ichiro、Uemura Makiko、Fujita Haruyuki、Kadowaki Norimitsu
    • Journal Title

      Journal of Clinical Medicine Research

      Volume: 14 Issue: 10 Pages: 432-435

    • DOI

      10.14740/jocmr4799

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Black eyes following stem cell transplantation2022

    • Author(s)
      Imataki Osamu、Ishida Tomoya、Fujita Haruyuki、Uemura Makiko
    • Journal Title

      eJHaem

      Volume: 4 Issue: 1 Pages: 286-287

    • DOI

      10.1002/jha2.584

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] c-D-index at day 11 can predict febrile neutropenia during chemotherapy in acute myeloid leukemia2022

    • Author(s)
      Kubo Hiroyuki、Imataki Osamu、Kubo Yukiko Hamasaki、Uemura Makiko
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 3 Pages: e0263623-e0263623

    • DOI

      10.1371/journal.pone.0263623

    • Related Report
      2021 Research-status Report
  • [Journal Article] Oral microorganisms and bloodstream infection in allogeneic hematopoietic stem cell transplantation2021

    • Author(s)
      Ohbayashi Yumiko、Imataki Osamu、Uemura Makiko、Takeuchi Akihiro、Aoki Saki、Tanaka Mao、Nakai Yasuhiro、Nakai Fumi、Miyake Minoru
    • Journal Title

      Clinical Oral Investigations

      Volume: 25 Issue: 7 Pages: 4359-4367

    • DOI

      10.1007/s00784-020-03749-9

    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Journal Article] Psychogenic fever due to worry about COVID‐19: A case report2021

    • Author(s)
      Imataki Osamu、Uemura Makiko
    • Journal Title

      Clinical Case Reports

      Volume: 9 Issue: 8

    • DOI

      10.1002/ccr3.4560

    • Related Report
      2021 Research-status Report
  • [Journal Article] Risk Factors for and the Prognostic Impact of Pericardial Effusion after Allogeneic Hematopoietic Stem Cell Transplantation2021

    • Author(s)
      Kubo Hiroyuki、Imataki Osamu、Fukumoto Tetsuya、Oku Maki、Ishida Tomoya、Kubo Yukiko Hamasaki、Kida Jun-ichiro、Uemura Makiko、Fujita Haruyuki、Ohno Hirofumi、Ide Makoto、Ohnishi Hiroaki、Kadowaki Norimitsu
    • Journal Title

      Transplantation and Cellular Therapy

      Volume: 27 Issue: 11 Pages: 949.e1-949.e8

    • DOI

      10.1016/j.jtct.2021.07.024

    • Related Report
      2021 Research-status Report
  • [Journal Article] Distinct Characteristics of Sweet’s Syndrome of the Scrotum Caused by All-<b><i>trans</i></b> Retinoic Acid in a Patient with Acute Promyelocytic Leukemia2021

    • Author(s)
      Imataki Osamu、Yoshida Shunsuke、Kaji Tomohiro、Kida Jun-ichiro、Kubo Hiroyuki、Uemura Makiko、Fujita Haruyuki、Kadowaki Norimitsu
    • Journal Title

      Case Reports in Oncology

      Volume: 14 Issue: 3 Pages: 1466-1474

    • DOI

      10.1159/000516798

    • Related Report
      2021 Research-status Report
  • [Journal Article] PML-RARα‐positive cells contribute to scrotal ulceration with all‐trans retinoic acid2021

    • Author(s)
      Imataki Osamu、Yoshida Shunsuke、Kaji Tomohiro、Kida Jun‐ichiro、Kubo Hiroyuki、Uemura Makiko、Fujita Haruyuki、Kadowaki Norimitsu
    • Journal Title

      International Journal of Dermatology

      Volume: 61 Issue: 3

    • DOI

      10.1111/ijd.15664

    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Journal Article] Oncolytic Virus Therapy with HSV-1 for Hematological Malignancies2021

    • Author(s)
      Ishino Ryo、Kawase Yumi、Kitawaki Toshio、Sugimoto Naoshi、Oku Maki、Uchida Shumpei、Imataki Osamu、Matsuoka Akihito、Taoka Teruhisa、Kawakami Kimihiro、van Kuppevelt Toin H.、Todo Tomoki、Takaori-Kondo Akifumi、Kadowaki Norimitsu
    • Journal Title

      Molecular Therapy

      Volume: 29 Issue: 2 Pages: 762-774

    • DOI

      10.1016/j.ymthe.2020.09.041

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Case of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia, Chronic Phase with ASXL1 Mutation2020

    • Author(s)
      Imataki Osamu、Ishida Tomoya、Kubo Hiroyuki、Uemura Makiko、Nanya Yasuhito、Kawakami Kimihiro、Ogawa Seishi、Kadowaki Norimitsu
    • Journal Title

      Case Reports in Oncology

      Volume: 13 Issue: 1 Pages: 449-455

    • DOI

      10.1159/000506452

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sea-Blue Histiocytosis of Bone Marrow in a Patient with t(8;22) Acute Myeloid Leukemia2020

    • Author(s)
      Imataki Osamu、Uemura Makiko
    • Journal Title

      Case Reports in Oncology

      Volume: 13 Issue: 2 Pages: 849-852

    • DOI

      10.1159/000508495

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Donor-derived XYY After BMT From a Healthy Volunteer2019

    • Author(s)
      Imataki Osamu、Kubo Hiroyuki、Uemura Makiko
    • Journal Title

      Transplantation

      Volume: 103 Issue: 10 Pages: e323-e324

    • DOI

      10.1097/tp.0000000000002861

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Severe rhabdomyolysis associated with severe fever with thrombocytopenia syndrome in a married couple: a case report2019

    • Author(s)
      Imataki Osamu、Uemura Makiko、Masugata Hisashi
    • Journal Title

      BMC Infectious Diseases

      Volume: 19 Issue: 1 Pages: 885-885

    • DOI

      10.1186/s12879-019-4535-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of ultrasound-guided central venous catheter insertion on the incidence of catheter-related bloodstream infections and mechanical complications2019

    • Author(s)
      Imataki Osamu、Shimatani Mami、Ohue Yukiko、Uemura Makiko
    • Journal Title

      BMC Infectious Diseases

      Volume: 19 Issue: 1 Pages: 857-857

    • DOI

      10.1186/s12879-019-4487-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MGUS bone2019

    • Author(s)
      Imataki Osamu、Uemura Makiko
    • Journal Title

      Oxford Medical Case Reports

      Volume: 2019 Issue: 8

    • DOI

      10.1093/omcr/omz082

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nonclonal chromosomal alterations and poor survival in cytopenic patients without hematological malignancies2019

    • Author(s)
      Imataki Osamu、Kubo Hiroyuki、Takeuchi Akihiro、Uemura Makiko、Kadowaki Norimitsu
    • Journal Title

      Molecular Cytogenetics

      Volume: 12 Issue: 1 Pages: 46-46

    • DOI

      10.1186/s13039-019-0458-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2019-04-18   Modified: 2025-01-30  

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