| Project/Area Number |
19K17954
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Toda Gotaro 東京大学, 医学部附属病院, 助教 (30780332)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肥満 / 腸内細菌 / 免疫細胞 / サイトカイン / インスリン / 肥満症 / マクロファージ / 腸内細菌叢 / 糖尿病 / 食後糖代謝調節 / 免疫 |
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| Outline of Research at the Start |
食べ物を口にするという私たちが日常生活で行うことは、体内で大きな変化を引き起こす。私たちはこれらの現象の中でも、食べることにより腸の中の細菌が大幅に変化することに注目し、特に免疫がいかにその変化に反応するかということを研究してきた。本研究では食べることに対する正常の反応、また肥満・糖尿病などの異常な状態でその反応がいかに不調となるかを明らかにすることにより、新たな肥満・糖尿病の治療につなげたいと考えている。
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| Outline of Final Research Achievements |
Obesity is a major risk factor for a myriad of diseases, including metabolic disorders such as type 2 diabetes, cardiovascular disease and cancer which directly compromise the patient’s quality of life. Moreover, the pathogenesis of obesity is multifactorial, affected by lifestyle of which excess intake of food and a deficit in physical activity have been considered primary, and further driven by stress that comes from everyday life in modern society. Genetic factors also contribute to obesity. Physiologically, normal homeostasis is perturbed by these factors among which inflammation is a process that is driven by immune cells. We have shown through the present research that in the normal lean state, macrophages react to insulin and lipopolysaccharide from the intestinal microbiota and produce IL-10 through Akt-mTOR signaling, which normally suppresses gluconeogenesis after feeding.
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| Academic Significance and Societal Importance of the Research Achievements |
代表的な環境因子である食事に対する免疫細胞の正常な応答が、正常な代謝機能を維持しうることを明らかにした。免疫細胞は広範な疾患の病態形成に関わるため、その正常機能を維持することが新たな健康維持戦略になることが期待される。
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