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Exploratory study of biomarkers for the development of lifestyle-related diseases by steroid metabolomics analysis

Research Project

Project/Area Number 19K17956
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionKanazawa University

Principal Investigator

Karashima Shigehiro  金沢大学, GS教育系, 助教 (30801584)

Project Period (FY) 2019-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsステロイド / 生活習慣病 / メタボロミクス
Outline of Research at the Start

志賀町研究で保存されている一般住民の検体を用い、約20種のステロイドホルモンを網羅的に測定し、高血圧、糖尿病、脂質異常症といった生活習慣病の発症に関与する疾患特異的バイオマーカーステロイドの探索を行う。バイオマーカーステロイドの合成酵素や酵素阻害の機序は新たな創薬のターゲットとなる。未病段階で高リスク対象を発見し治療や指導介入を行う先制医療モデルを形成するための疫学研究である。

Outline of Final Research Achievements

Hypertension causes stroke, heart disease, and kidney disease. Hypertension is classified into two groups: salt-sensitive hypertension, in which blood pressure improves with salt reduction, and salt-resistant hypertension, in which blood pressure does not. We compared the composition of the gut microbiota and the prevalence of hypertension in 242 general residents, and found that the prevalence of hypertension in the group of patients with gut microbiota low in Bifidobacterium was similar to that in the group with high salt intake, even with low salt intake. In particular, there was a strong tendency to be associated with B. bifidum and B. breve, and steroid metabolomics analysis suggested involvement with some mineralocorticoids. To further elucidate the mechanism of salt-sensitive hypertension, we plan to conduct additional metagenomic analysis and transplantation experiments into animal models.

Academic Significance and Societal Importance of the Research Achievements

腸内細菌叢―代謝ネットワークを介した食塩感受性高血圧の発症機序の解明後、食塩感受性高血圧の診断バイオマーカーとしての腸内細菌叢の構成比や細菌叢由来代謝物の有用性を臨床的示し食塩感受性の個体差を考慮した精密医療へつなげることが次の展開と考えている。心血管イベントの発症しやすい食塩感受性高血圧の早期診断やプロバイオティクス、プレバイオティクスによる治療介入を行うことで、日本の国民病ともいうべき高血圧の新しい診療アプローチに繋がり、最終的には、心血管イベントを抑制し現代人の健康寿命の延伸に貢献する可能性がある。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (3 results)

All 2021 2020 2019

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Impact of Gut Microbiome on Hypertensive Patients With Low-Salt Intake: Shika Study Results2020

    • Author(s)
      Nagase Satoshi、Karashima Shigehiro、Tsujiguchi Hiromasa、Tsuboi Hirohito、Miyagi Sakae、Kometani Mitsuhiro、Aono Daisuke、Higashitani Takuya、Demura Masashi、Sakakibara Hiroyuki、Yoshida Akihiro、Hara Akinori、Nakamura Hiroyuki、Takeda Yoshiyu、Nambo Hidetaka、Yoneda Takashi、Okamoto Shigefumi
    • Journal Title

      Frontiers in Medicine

      Volume: 7 Pages: 475-475

    • DOI

      10.3389/fmed.2020.00475

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 腸内細菌叢の構成と塩分摂取量が高血圧有病率に及ぼす影響2021

    • Author(s)
      唐島成宙、武田仁勇
    • Organizer
      第140回日本循環器学会北陸地方会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 一般住民における腸内細菌叢の構成と塩分摂取量が高血圧有病率に及ぼす影響2019

    • Author(s)
      唐島成宙、米谷充弘、武田仁勇、米田隆
    • Organizer
      第8回臨床高血圧フォーラム
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2022-01-27  

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