• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of diabetes treatment method aiming at beta cell protection

Research Project

Project/Area Number 19K17960
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionMie University

Principal Investigator

Yasuma Taro  三重大学, 医学系研究科, 助教 (80773887)

Project Period (FY) 2019-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsβ細胞 / 糖尿病 / トロンボモジュリン / アポトーシス / 膵β細胞 / 膵Β細胞
Outline of Research at the Start

これまでの研究によりトロンボモジュリンは抗凝固作用と共に抗炎症作用、抗アポトーシス作用を有していることが示されており、膵β細胞保護効果を介して糖尿病の進展を抑制する可能性がある。しかし糖尿病治療薬としての効果は未だに検討されていない。
本研究ではSTZ誘発糖尿病モデルマウスを用いたin vivo実験および膵β細胞株を用いたin vitro実験により、トロンボモジュリンのβ細胞のアポトーシス抑制効果・耐糖能に及ぼす影響を検討し、そのメカニズムについても解析する。

Outline of Final Research Achievements

Pancreatic β-cell dysfunction is involved in the progression of diabetes. Thrombomodulin is a glycoprotein on the surface of endothelial cells which has inhibitory effect on cell apoptosis. We evaluated the effect of thrombomodulin on β-cell apoptosis and glucose tolerance in diabetic mice. Thrombomodulin attenuated hyperglycemia, ameliorated insulin secretion, and reduced β cell apoptosis. These results indicate that thrombomodulin has antidiabetic effect by suppressing β-cell apoptosis.

Academic Significance and Societal Importance of the Research Achievements

糖尿病人口は世界中で爆発的に増え続け、糖尿病有病者数は世界で4億人以上といわれており、医療経済的にも問題となっている。糖尿病の主な型のうち、1型糖尿病は自己免疫的要因により膵β細胞が選択的に破壊され発症する。2型糖尿病は生活習慣などの環境因子と遺伝因子が関与し、インスリン抵抗性とインスリン分泌不全により発症する。いずれの型の糖尿病においても、β細胞のアポトーシスは糖尿病の病態進展の主要な機序であると考えられているが、それを抑制する有用な治療法は確立されていない。本研究成果はトロンボモジュリンのβ細胞保護および抗糖尿病効果を示すものであり、糖尿病の進展抑制につながる有意義な研究である。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (18 results)

All 2021 2020 2019

All Journal Article (9 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 9 results,  Open Access: 7 results) Presentation (9 results)

  • [Journal Article] Sudden Death Associated with Severe Hypoglycemia in a Diabetic Patient During Sensor-Augmented Pump Therapy with the Predictive Low Glucose Management System2021

    • Author(s)
      Nishihama Kota、Eguchi Kazuhito、Maki Kanako、Okano Yuko、Tanaka Soichiro、Inoue Chisa、Uchida Akihiro、Uemura Mei、Suzuki Toshinari、Yasuma Taro、D'Alessandro-Gabazza Corina N.、Gabazza Esteban C.、Yano Yutaka
    • Journal Title

      American Journal of Case Reports

      Volume: 22

    • DOI

      10.12659/ajcr.928090

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Missed diagnosis and delayed treatment of acromegaly in a patient with severe diabetes: A case report2020

    • Author(s)
      Nishihama Kota、Yano Yutaka、Yasuma Taro、Gabazza Esteban
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 20 Issue: 6 Pages: 1-1

    • DOI

      10.3892/etm.2020.9394

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thrombomodulin ameliorates transforming growth factor-β1-mediated chronic kidney disease via the G-protein coupled receptor 15/Akt signal pathway2020

    • Author(s)
      Takeshita Atsuro、Yasuma Taro、Nishihama Kota、D’Alessandro-Gabazza Corina N.、Toda Masaaki、Totoki Toshiaki、Okano Yuko、Uchida Akihiro、Inoue Ryo、Qin Liqiang、Wang Shujie、D’Alessandro Valeria Fridman、Kobayashi Tetsu、Takei Yoshiyuki、Mizoguchi Akira、Yano Yutaka、Gabazza Esteban C.
    • Journal Title

      Kidney International

      Volume: 98 Issue: 5 Pages: 1179-1192

    • DOI

      10.1016/j.kint.2020.05.041

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis2020

    • Author(s)
      D’Alessandro-Gabazza Corina N、Kobayashi Tetsu、Yasuma Taro、Toda Masaaki、Fujimoto Hajime、Hataji Osamu、Takeshita Atsuro、Nishihama Kota、Okano Tomohito、Okano Yuko、Nishii Yoichi、Tomaru Atsushi、Fujiwara Kentaro、D’Alessandro Valeria Fridman、Yano Yutaka、Cann Isaac、Gabazza Esteban C
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 1539-1539

    • DOI

      10.1038/s41467-020-15344-3

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Plant growth regulators and Axl and immune checkpoint inhibitors from the edible mushroom Leucopaxillus giganteus2020

    • Author(s)
      Malya Irine Yunhafita、Wu Jing、Harada Etsuko、Toda Masaaki、D’Alessandro-Gabazza Corina N、Yasuma Taro、Gabazza Esteban C、Choi Jae-Hoon、Hirai Hirofumi、Kawagishi Hirokazu
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: - Issue: 7 Pages: 1-7

    • DOI

      10.1080/09168451.2020.1743170

    • NAID

      120006825989

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Too Premature to Deny the Potential of Thrombomodulin-alfa in Idiopathic Pulmonary Fibrosis2020

    • Author(s)
      Kobayashi Tetsu、Hataji Osamu、Fujimoto Hajime、D'Alessandro-Gabazza Corina、Yasuma Taro、Gabazza Esteban C
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine

      Volume: - Issue: 11 Pages: 1449-1450

    • DOI

      10.1164/rccm.202002-0271le

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein S protects against allergic bronchial asthma by modulating Th1/Th2 balance2020

    • Author(s)
      Asayama Kentaro、Kobayashi Tetsu、D'Alessandro‐Gabazza Corina N、Toda Masaaki、Yasuma Taro、Fujimoto Hajime、Okano Tomohito、Saiki Haruko、Takeshita Atsuro、Fujiwara Kentaro、Fridman D’Alessandro Valeria、Nishihama Kota、Totoki Toshiaki、Inoue Ryo、Takei Yoshiyuki、Gabazza Esteban C
    • Journal Title

      Allergy

      Volume: - Issue: 9 Pages: 2267-2278

    • DOI

      10.1111/all.14261

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Factors leading to failure to diagnose pulmonary malignant tumors using endobronchial ultrasound with guide sheath within the target lesion.2019

    • Author(s)
      Nishii Y, Yasuma T, Ito K, Suzuki Y, Watanabe F, Kobayashi T, Nishihama K, D'Alessandro-Gabazza CN, Fujimoto H, Gabazza EC, Asano F, Taguchi O, Hataji O.
    • Journal Title

      Respir Res.

      Volume: 20 Issue: 1 Pages: 207-207

    • DOI

      10.1186/s12931-019-1178-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective Role of Matrix Metalloproteinase-2 in Allergic Bronchial Asthma.2019

    • Author(s)
      Takahashi Y, Kobayashi T, D'Alessandro-Gabazza CN, Toda M, Fujiwara K, Okano T, Fujimoto H, Asayama K, Takeshita A, Yasuma T, Nishihama K, Inoue R, Qin L,Takei Y, Taguchi O, Gabazza EC.
    • Journal Title

      Front Immunol.

      Volume: 10 Pages: 1795-1795

    • DOI

      10.3389/fimmu.2019.01795

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] プロテインSのインスリン抵抗性改善効果2020

    • Author(s)
      安間 太郎、竹下 敦郎、岡野 優子、内田 明宏、西濵 康太、ガバザ コリナ、戸田 雅昭、矢野 裕、ガバザ エステバン
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒト組換えトロンボモジュリンによる慢性腎障害に対する保護作用の検討2020

    • Author(s)
      内田 明宏、井上 知紗、竹下 敦郎、岡野 優子、安間 太郎、西濱 康太、上村 明、鈴木 俊成、古田 範子、フリードマン バレリア、戸田 雅昭、ガバザ コリーナ、ガバザ エステバン、矢野 裕
    • Organizer
      第35回日本糖尿病合併症学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Protective effect of protein S in allergic bronchial asthma2019

    • Author(s)
      Taro Yasuma, Atsuro Takeshita, Yuko Okano, Kentaro Asayama, Kentaro Fujiwara,Tomohito Okano, Yoshinori Takahashi, Hajime Fujimoto,Corina N. D’Alessandro-Gabazza, Masaaki Toda, Tetsu Kobayashi, Esteban C.Gabazza
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Regulation of cytokine release from dendritic cells by protein S2019

    • Author(s)
      Masaaki Toda, Taro Yasuma, Atsuro Takeshita, Kentaro Fujiwara, Tomohito Okano,Yuko Okano, Kentaro Asayama, Ryo Inoue, Corina N. D’Alessandro-Gabazza,Esteban C.Gabazza
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] A noninvasive mouse model of renal fibrosis induced by podocyte-specific overexpression of human transforming growth factor- Β12019

    • Author(s)
      Akihiro Uchida, Atsuro Takeshita, Yuko Okano, Taro Yasuma, Chisa Inoue,Kota Nishihama, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Yutaka Yano,Esteban C.Gabazza
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Protective effect of thrombomodulin against the development of diabetic nephropathy2019

    • Author(s)
      Yuko Okano, Chisa Inoue, Akihiro Uchida, Atsuro Takeshita, Kota Nishihama,Taro Yasuma, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Yutaka Yano,Esteban C.Gabazza
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Attenuation of renal fibrosis by recombinant thrombomodulin2019

    • Author(s)
      Atsuro Takeshita, Yuko Okano, Taro Yasuma, Akihiro Uchida, Kota Nishihama, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Yutaka Yano, Esteban C.Gabazza
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] トロンボモジュリンによるポヂサイトの抗アポトーシス効果の検証2019

    • Author(s)
      内田 明宏、竹下 敦郎、岡野 優子、西濵 康太、安間 太郎、ガバザ コリナ
    • Organizer
      第34回日本糖尿病合併症学会・第25回日本糖尿病眼学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] トロンボモジュリンによるポドサイト保護効果の検証2019

    • Author(s)
      安間 太郎
    • Organizer
      第62回日本糖尿病学会年次学術集会
    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi