Endocrinological crosstalk between aldosterone-related hypertension and calcium metabolism
| Project/Area Number |
19K17974
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Tohoku University |
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Principal Investigator |
YAMAZAKI Yuto 東北大学, 医学系研究科, 講師 (70833367)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Ca チャネル / アルドステロン / 高血圧 / 副腎 / Ca チャネル拮抗薬 / カルシウム代謝 / 原発性アルドステロン症 / 病理 |
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| Outline of Research at the Start |
本研究では、PA患者より外科的切除された副腎手術検体を用いて、Ca代謝を調節する因
子（PTH, ビタミンD, Ca等）の受容体の発現動態を病理組織学的に解析する。更に、ヒト
副腎皮質癌培養細胞を用いて、PTHやビタミンD、Ca濃度等のアルドステロン合成に与える
影響を機能的に解析する。Caの代謝機構がアルドステロン合成をどのように制御しているのかを解明する事を目的とする。
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| Outline of Final Research Achievements |
In this study, the effects of Ca ions and Ca channel blocker on steroidogenesis, especially for aldosterone biosynthesis in adrenocortical cells were histopathologically investigated and further verified by in vitro study. The present study has demonstrated a possibile new therapeutic target or a potential prognostic factor for secondary complications of osteoporosis in the patients with primary aldosteronism.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、若年者に多く、治療抵抗性の高血圧症を来す原発性アルドステロン症患者における二次性のCa代謝障害や骨粗鬆症の二次予防を目的とする新規バイオマーカーの発見に貢献するのみならず、Caイオンのステロイド合成に与える直接的影響を明らかにすることでアルドステロン過剰産生に対するCa拮抗薬の治療薬としての可能性についても検討出来た。これらの知見は今後の原発性アルドステロン症の診療に影響を与える臨床的意義の大きいものである。
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection2021
Author(s)
Hirotaka Ishida, Atsuko Kasajima, Fumiyoshi Fujishima, Ryujiro Akaishi, Shunsuke Ueki, Yuto Yamazaki, Yoshiaki Onodera, Xin Gao, Hiroshi Okamoto, Yusuke Taniyama, Takashi Kamei, Hironobu Sasano
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Journal Title
Virchows Archiv
Volume: 478
Issue: 2
Pages: 219-229
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Histological characterization of aldosterone-producing adrenocortical adenomas with different somatic mutations.2020
Author(s)
Ono Y, Yamazaki Y, Omata K, Else T, Tomlins SA, Rhayem Y, Williams TA, Reincke M, Carling T, Monticone S, Mulatero P, Beuschlein F, Ito S, Satoh F, Rainey WE, Sasano H
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Journal Title
J Clin Endocrinol Metab
Volume: 105
Issue: 3
Pages: e282-e289
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Unique Sex Steroid Profiles in Estrogen-Producing Adrenocortical Adenoma Associated with Bilateral Hyperaldosteronism.2020
Author(s)
Tezuka Y, Yamazaki Y, Ono Y, Morimoto R, Omata K, Seiji K, Takase K, Kawasaki Y, Ito A, Nakamura Y, Harigae H, Sasano H, Satoh F
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Journal Title
Journal of the Endocrine Society
Volume: 4
Issue: 2
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Non-neoplastic/hyperplastic primary aldosteronism-Its Histopathology and Genotype-2019
Author(s)
Yamazaki Y, Omata K, Tezuka Y, Gao X, Ogata H, Pieroni J, Ono Y, Morimoto R, Nakamura Y, Gomez-Sanchez CE, Satoh F, Sasano H
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Journal Title
Current Opinion in Endocrine and Metabolic Research
Volume: 8
Pages: 122-131
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] A precise prevalence of genotypes and histological subtypes of consecutive Japanese PA cases undergoing surgery from 2012 to 20172019
Author(s)
Yuto Yamazaki, Kei Onodera, Hiroki Ebina, Xin Gao, Yuta Tezuka, Yuko Kitawaki, Hiroko Ogata, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Yasuhiro Nakamura, Sadayoshi Ito, Fumitoshi, Satoh, Hironobu Sasano
Organizer
ENDO 2019
Related Report
Int'l Joint Research
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[Presentation] Challenges for predicting KCNJ5 somatic mutation in aldosterone-producing adenomas using histopathological scoring system2019
Author(s)
Yuto Yamazaki, Xin Gao, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Celso Gomez-Sanchez, Yasuhiro Nakamura, Fumitoshi, Satoh, Hironobu Sasano
Organizer
Progress in Primary Aldosteronism 6
Related Report
Int'l Joint Research
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