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Development of biodegradable stent grafts using decellularized bovine pericardium

Research Project

Project/Area Number 19K18169
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 55030:Cardiovascular surgery-related
Research InstitutionAsahikawa Medical College

Principal Investigator

Nakanishi Sentaro  旭川医科大学, 医学部, 助教 (90596298)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2021: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Keywordsステントグラフト / Polycaprolacton / 人工血管 / 3Dプリンター / Polycaprolactone / 3Dプリンター / 脱細胞化 / ウシ心膜 / 生体吸収性ステントグラフト
Outline of Research at the Start

本研究は、材質自体の変更における有用性を検討する点が特徴である。摘出した血管を組織学的に解析した結果からは、人工血管の移植時には自己組織への炎症細胞や繊維芽細胞の浸潤のみに留まり、生体性材へは組織に元々存在していた細胞の浸潤が見込まれ、自己組織への細胞浸潤・内膜肥厚の抑制が予想される。この結果感染性動脈瘤など人工物の体内留置が憚られる症例に対する治療使用が可能になることや、豚の成長に合わせて生体材料がきちんと適合して拡張・成長していることが予想され、それにより成長著しい若年者に対しての適応拡大を考慮することができ、今後脱細胞化ウシ心膜への薬剤の塗布での治療成績向上の可能性も期待できる。

Outline of Final Research Achievements

The planned large animal experiment using pigs and other animals could not be conducted due to the unavailability of the animal experiment facility for large animals due to the Coronavirus pandemic, but numerous experiments were conducted using biodegradable materials (polycaprolactone) for rat artificial blood vessel implantation as an alternative. Good mid-term patency was confirmed, but after 8 months, polycaprolactone had not been completely absorbed yet, suggesting that further improvement of the material is necessary for the development of stent grafts using biodegradable materials, which is the main topic of this study. On the other hand, experiments using biodegradable stents with magnesium frameworks are also ongoing.

Academic Significance and Societal Importance of the Research Achievements

以下の3編の論文を発表し,生体吸収性素材を用いた血管再生の分野の研究発展に貢献した。Leal BBJ,et al. Front Cardiovasc Med. 2022, Wakabayashi N, et al. Front Cardiovasc Med. 2022, Kikuchi Y,et al. Biomater Sci. 2022

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (10 results)

All 2022 2021 2020

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (3 results)

  • [Journal Article] Insulin therapy maintains the performance of PVA-coated PCL grafts in a diabetic rat model2022

    • Author(s)
      Yuta Kikuchi, Kyohei Oyama, Takumi Yoshida, Daisuke Naruse, Masahiro Tsutsui, Shingo Kunioka, Naohiro Wakabayashi, Hiroyuki Kamiya
    • Journal Title

      Biomaterials Science

      Volume: 18 Issue: 18 Pages: 5208-5215

    • DOI

      10.1039/d2bm00531j

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polyvinyl alcohol coating prevents platelet adsorption and improves mechanical property of polycaprolactone-based small-caliber vascular graft2022

    • Author(s)
      Naohiro Wakabayashi, Takumi Yoshida, Kyohei Oyama, Daisuke Naruse, Masahiro Tsutsui, Yuta Kikuchi, Daisuke Koga, Hiroyuki Kamiya
    • Journal Title

      Front Cardiovasc Med

      Volume: 11

    • DOI

      10.3389/fsurg.2022.892309

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypothermic circulatory arrest does not induce coagulopathy in vitro2022

    • Author(s)
      Ise Hayato、Oyama Kyohei、Kunioka Shingo、Shirasaka Tomonori、Kanda Hirotsugu、Akhyari Payam、Kamiya Hiroyuki
    • Journal Title

      Journal of Artificial Organs

      Volume: - Issue: 4 Pages: 314-322

    • DOI

      10.1007/s10047-022-01324-5

    • Related Report
      2021 Research-status Report
  • [Journal Article] Five-minute test to prevent postcardiotomy reexploration2022

    • Author(s)
      Kunioka Shingo、Shirasaka Tomonori、Narita Masahiko、Shibagaki Keisuke、Kikuchi Yuta、Saijo Yasuaki、Kamiya Hiroyuki
    • Journal Title

      JTCVS Techniques

      Volume: 12 Pages: 121-129

    • DOI

      10.1016/j.xjtc.2021.08.049

    • Related Report
      2021 Research-status Report
  • [Journal Article] Vascular Tissue Engineering: Polymers and Methodologies for Small Caliber Vascular Grafts2021

    • Author(s)
      Leal BBJ, Wakabayashi N, Oyama K, Kamiya H, Braghirolli DI, Pranke P.
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 7 Pages: 1-18

    • DOI

      10.3389/fcvm.2020.592361

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proximalized Total Arch Replacement Can Be Safely Performed by Trainee2021

    • Author(s)
      Nakanishi Sentaro、Wakabayashi Naohiro、Ise Hayato、Kitahara Hiroto、Hirofuji Aina、Ishikawa Natsuya、Kamiya Hiroyuki
    • Journal Title

      The Thoracic and Cardiovascular Surgeon

      Volume: 69 Issue: 04 Pages: 336-344

    • DOI

      10.1055/s-0040-1713354

    • Related Report
      2021 Research-status Report
  • [Journal Article] Controlled autologous recellularization and inhibited degeneration of decellularized vascular implants by side-specific coating with stromal cell-derived factor 1α and fibronectin2020

    • Author(s)
      Sugimura Y, Chekhoeva A, Oyama K, Nakanishi S, Toshmatova M, Miyahara S, Barth M, Assmann AK, Lichtenberg A, Assmann A, Akhyari P.
    • Journal Title

      Biomedical Materials

      Volume: 15 Issue: 3 Pages: 1-12

    • DOI

      10.1088/1748-605x/ab54e3

    • Related Report
      2020 Research-status Report
  • [Presentation] 糖尿病病態下における生体分解性小口径人工血管の機能評価2022

    • Author(s)
      菊池悠太、小山恭平、筒井真博、紙谷寛之
    • Organizer
      第34 回代用臓器・再生医学研究会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] ポリカプロラクトン製小口径代用血管の親水化加工2021

    • Author(s)
      若林尚宏、菊池悠太、吉田巧、成瀬大輔、小山恭平、紙谷寛之
    • Organizer
      第74回 日本胸部外科学会 定期学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 糖尿病ラットを用いた生体吸収性小口径人工血管の機能評価2021

    • Author(s)
      菊池悠太、筒井真博、若林尚宏、小山恭平、紙谷寛之
    • Organizer
      第74回 日本胸部外科学会 定期学術集会
    • Related Report
      2021 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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