Development of biodegradable stent grafts using decellularized bovine pericardium
| Project/Area Number |
19K18169
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55030:Cardiovascular surgery-related
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2021: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
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| Keywords | ステントグラフト / Polycaprolacton / 人工血管 / 3Dプリンター / Polycaprolactone / ３Dプリンター / 脱細胞化 / ウシ心膜 / 生体吸収性ステントグラフト |
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| Outline of Research at the Start |
本研究は、材質自体の変更における有用性を検討する点が特徴である。摘出した血管を組織学的に解析した結果からは、人工血管の移植時には自己組織への炎症細胞や繊維芽細胞の浸潤のみに留まり、生体性材へは組織に元々存在していた細胞の浸潤が見込まれ、自己組織への細胞浸潤・内膜肥厚の抑制が予想される。この結果感染性動脈瘤など人工物の体内留置が憚られる症例に対する治療使用が可能になることや、豚の成長に合わせて生体材料がきちんと適合して拡張・成長していることが予想され、それにより成長著しい若年者に対しての適応拡大を考慮することができ、今後脱細胞化ウシ心膜への薬剤の塗布での治療成績向上の可能性も期待できる。
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| Outline of Final Research Achievements |
The planned large animal experiment using pigs and other animals could not be conducted due to the unavailability of the animal experiment facility for large animals due to the Coronavirus pandemic, but numerous experiments were conducted using biodegradable materials (polycaprolactone) for rat artificial blood vessel implantation as an alternative. Good mid-term patency was confirmed, but after 8 months, polycaprolactone had not been completely absorbed yet, suggesting that further improvement of the material is necessary for the development of stent grafts using biodegradable materials, which is the main topic of this study. On the other hand, experiments using biodegradable stents with magnesium frameworks are also ongoing.
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| Academic Significance and Societal Importance of the Research Achievements |
以下の3編の論文を発表し,生体吸収性素材を用いた血管再生の分野の研究発展に貢献した。Leal BBJ,et al. Front Cardiovasc Med. 2022, Wakabayashi N, et al. Front Cardiovasc Med. 2022, Kikuchi Y,et al. Biomater Sci. 2022
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Report
(5 results)
Research Products
(10 results)
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[Journal Article] Controlled autologous recellularization and inhibited degeneration of decellularized vascular implants by side-specific coating with stromal cell-derived factor 1α and fibronectin2020
Author(s)
Sugimura Y, Chekhoeva A, Oyama K, Nakanishi S, Toshmatova M, Miyahara S, Barth M, Assmann AK, Lichtenberg A, Assmann A, Akhyari P.
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Journal Title
Biomedical Materials
Volume: 15
Issue: 3
Pages: 1-12
DOI
Related Report
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