| Project/Area Number |
19K18276
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MURAKAMI Chiaki 徳島大学, 大学院医歯薬学研究部(医学域), 助教 (70825877)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 術後神経・認知機能障害 / 高齢者 / マイオカイン / 骨格筋量 / 術後神経・認知機能異常 |
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| Outline of Research at the Start |
術後神経・認知機能異常と骨格筋から分泌される生理活性物質であるマイオカイン分泌量、骨格筋量の関係性について、また術後神経・認知機能異常の危険因子との関係性について臨床的見地から検討する。
下肢手術を受ける患者を対象に高齢者群と非高齢者群の2群に群分けし、術前・術後に認知機能評価、体成分分析、マイオカイン測定を行い、統計学的手法で術後神経・認知機能異常の関連因子を検討する。
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| Outline of Final Research Achievements |
Postoperative cognitive disease (POCD) is one of common complications with general anesthesia especially in elderly patients. POCD can prolong hospital stays and decrease quality of life. Neuroinflammation is considered to be one cause of POCD. It is characterized by physical responses to the released inflammatory cytokines. Myokines are one of cytokines secreted from skeletal muscle mass. We examined an association between plasma myokine levels, skeletal muscle mass and postoperative delirium, which is a kind of POCD.
Patients aged over 65 years old undergoing general anesthesia were enrolled in this study. Plasma levels of myokines, skeletal muscle mass and occurrence of postoperative delirium were measured until 14 postoperative days. There was no significant association between plasma levels of myokines, skeletal muscle mass and POCD.
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| Academic Significance and Societal Importance of the Research Achievements |
POCDは高齢者で起きやすく、高齢化が進む現代では原因解明と予防が重要な課題となっている。本研究ではPOCDの原因とされる脳内炎症を引き起こすサイトカインとして、これまでに報告のないマイオカインに注目した。新たなアプローチを検討することでPOCD研究における今後の可能性を広げることができた。
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