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Establishment of sepsis management: Approach for the construction of regional sepsis network

Research Project

Project/Area Number 19K18349
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 55060:Emergency medicine-related
Research InstitutionMie University

Principal Investigator

Suzuki Kei  三重大学, 医学部附属病院, 准教授 (40585171)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords感染症 / 集中治療 / 新型コロナウイルス感染症 / 敗血症 / 地域ネットワーク / COVID-19 / 標準モデル / ネットワーク構築
Outline of Research at the Start

本研究では、1)地域における敗血症診療の実態を明らかとし、2)この結果に基づき教育ツール・診療支援モジュール開発など地域での敗血症診療支援を行い、3)最終的に地域特性を加味した敗血症診療ネットワークを樹立し、敗血症診療の質を向上させることを目的としている。本研究は、これまでに解明されていなかった地域における敗血症診療の問題点を浮き彫りにするのみならず、敗血症診療の質向上のための一手法となり、新たなエビデンス発信に至るものと考えられる。

Outline of Final Research Achievements

This project aimed to improve the management of infectious diseases to clarify the underlying problem and establish sepsis management in our region. During the study period, novel coronavirus infection (COVID-19) became main problem in intensive care unit. Hence, we analyzed the epidemiology of COVID-19 and made practical protocol for COVID-19. This protocol was provided to regional hospital.

Academic Significance and Societal Importance of the Research Achievements

近年、国際的ガイドラインの整備がすすみ、机上では標準的な敗血症治療が展開できる準備が整いつつある。 しかし現実に目を向けると、集中治療室には限りがあり、そもそも地域においては集中治療医は不足している。本研究期間中に、新型コロナウイルス感染症(COVID-19)が全世界的な公衆衛生上の問題となったが、プライマリケアや地域の救急を担っている中・小規模病院では、集中治療が十分に提供できていないことが明らかとなった。今後、感染症診療に長けた集中治療医を効率的に育成する必要性が示唆されるものであった。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (24 results)

All 2022 2021 2020 2019

All Journal Article (19 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 19 results,  Open Access: 15 results) Presentation (5 results)

  • [Journal Article] Esophageal Perforation Accompanying Mediastinitis in Blunt Trauma in a Patient with Thoracic Osteophytes2022

    • Author(s)
      Suzuki Kei、Yoshida Haruna、Esumi Ryo、Ieki Yohei、Yamamoto Akira、Ohi Masaki、Kaneko Tadashi、Imai Hiroshi
    • Journal Title

      Internal Medicine

      Volume: 61 Issue: 17 Pages: 2601-2605

    • DOI

      10.2169/internalmedicine.8930-21

    • NAID

      130008158363

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2022-09-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disruption of the glomerular basement membrane associated with nutcracker syndrome and double inferior vena cava in Noonan syndrome: a case report2022

    • Author(s)
      Omori Ayumi、Katayama Kan、Saiki Ryosuke、Masui Satoru、Suzuki Kei、Kanii Yoshinori、Tsujimoto Kayo、Nakamori Shiro、Kurita Tairo、Murata Tomohiro、Inoue Takahiro、Dohi Kaoru
    • Journal Title

      BMC Nephrology

      Volume: 23 Issue: 1 Pages: 65-65

    • DOI

      10.1186/s12882-022-02671-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proposal of Quick Diagnostic Criteria for Disseminated Intravascular Coagulation2022

    • Author(s)
      Wada Hideo、Yamamoto Akitaka、Tomida Masaki、Ichikawa Yuhuko、Ezaki Minoru、Masuda Jun、Yoshida Masamichi、Fukui Shunsuke、Moritani Isao、Inoue Hidekazu、Shiraki Katsuya、Suzuki Kei、Imai Hiroshi、Shimaoka Motomu、Shimpo Hideto
    • Journal Title

      Journal of Clinical Medicine

      Volume: 11 Issue: 4 Pages: 1028-1028

    • DOI

      10.3390/jcm11041028

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Use and effectiveness of a two‐level initiation strategy for fixed‐dose prothrombin complex concentrate according to the initial international normalized ratio in an emergency department in Japan2021

    • Author(s)
      Suzuki Kei、Ikejiri Kaoru、Ishikura Ken、Imai Hiroshi
    • Journal Title

      Acute Medicine and Surgery

      Volume: 8 Issue: 1

    • DOI

      10.1002/ams2.669

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An evaluation of the Japanese Society on Thrombosis and Hemostasis criteria for disseminated intravascular coagulation as a predictor of prognosis in patients with infection2021

    • Author(s)
      Madoiwa Seiji、Honda Goichi、Kawano Noriaki、Uchiyama Toshimasa、Kawasugi Kazuo、Takezako Naoki、Suzuki Kei、Seki Yoshinobu、Ikezoe Takayuki、Okamoto Kohji、Wada Hideo
    • Journal Title

      International Journal of Laboratory Hematology

      Volume: 43 Issue: 6 Pages: 1566-1574

    • DOI

      10.1111/ijlh.13643

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of acute bromvalerylurea intoxication that was successfully treated with direct hemoperfusion2021

    • Author(s)
      Ishikura Ken、Katayama Kan、Hara Akiko、Kotani Hirokazu、Suzuki Kei、Kaneko Tadashi、Dohi Kaoru、Imai Hiroshi
    • Journal Title

      CEN Case Reports

      Volume: in press Issue: 2 Pages: 269-272

    • DOI

      10.1007/s13730-021-00666-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Challenges in Diagnosing Comatose Patients with Ethylene Glycol Poisoning2021

    • Author(s)
      Esumi Ryo、Suzuki Kei、Ishikura Ken、Imai Hiroshi
    • Journal Title

      The American Journal of Medicine

      Volume: 134 Issue: 2 Pages: e127-e128

    • DOI

      10.1016/j.amjmed.2020.06.039

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypofibrinogenemia is associated with a high degree of risk in infectious diseases: a post-hoc analysis of post-marketing surveillance of patients with disseminated intravascular coagulation treated with thrombomodulin alfa.2021

    • Author(s)
      Kawasugi K, Wada H, Honda G, Kawano N, Uchiyama T, Madoiwa S, Takezako N, Suzuki K, Seki Y, Ikezoe T, Iba T, Okamoto K.
    • Journal Title

      Thromb J.

      Volume: 19 Issue: 1 Pages: 12-12

    • DOI

      10.1186/s12959-021-00264-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Veno-arterial extracorporeal membrane oxygenation and targeted temperature management in tricyclic antidepressant-induced cardiac arrest2021

    • Author(s)
      Ikejiri Kaoru、Akama Yuichi、Ieki Yohei、Kawamoto Eiji、Suzuki Kei、Yokoyama Kazuto、Ishikura Ken、Imai Hiroshi
    • Journal Title

      Medicine

      Volume: 100 Issue: 9 Pages: e24980-e24980

    • DOI

      10.1097/md.0000000000024980

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful treatment with cyclosporine in a patient with rituximab-refractory thrombocytopenic purpura2021

    • Author(s)
      名藤 佑真、永春 圭規、岡野 元彦、鈴木 圭、松本 剛史、俵 功
    • Journal Title

      Rinsho Ketsueki

      Volume: 62 Issue: 3 Pages: 176-179

    • DOI

      10.11406/rinketsu.62.176

    • NAID

      130008022237

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of the Association Between Resolution of Disseminated Intravascular Coagulation (DIC) and Treatment Outcomes in Post-Marketing Surveillance of Thrombomodulin Alpha for DIC With Infectious Disease and With Hematological Malignancy by Organ Failure2020

    • Author(s)
      Kawano N, Wada H, Uchiyama T, Kawasugi K, Madoiwa S, Takezako N, Suzuki K, Seki Y, Ikezoe T, Hattori T, Okamoto K.
    • Journal Title

      Thromb J.

      Volume: - Issue: 1

    • DOI

      10.1186/s12959-020-0216-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endovascular Cooling Catheter-Related Thrombosis After Targeted Temperature Management for Out-of-Hospital Cardiac Arrest: A Case Report.2020

    • Author(s)
      Ikejiri Kaoru, Suzuki Kei, Ishikura Ken, Imai Hiroshi
    • Journal Title

      Therapeutic Hypothermia and Temperature Management

      Volume: - Issue: 4 Pages: 244-247

    • DOI

      10.1089/ther.2019.0044

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Severe Antithrombin Deficiency May be Associated With a High Risk of Pathological Progression of DIC With Suppressed Fibrinolysis2020

    • Author(s)
      Wada Hideo、Honda Goichi、Kawano Noriaki、Uchiyama Toshimasa、Kawasugi Kazuo、Madoiwa Seiji、Takezako Naoki、Suzuki Kei、Seki Yoshinobu、Ikezoe Takayuki、Iba Toshiaki、Okamoto Kohji
    • Journal Title

      Clinical and Applied Thrombosis/Hemostasis

      Volume: 26

    • DOI

      10.1177/1076029620941112

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Invasive Salmonella Enteritidis infection complicated by bacterial meningitis and vertebral osteomyelitis shortly after influenza A infection in an immunocompetent young adult2020

    • Author(s)
      Ikejiri Kaoru、Suzuki Kei、Ito Asami、Yasuda Kazunari、Shindo Akihiro、Ishikura Ken、Imai Hiroshi
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 26 Issue: 2 Pages: 269-273

    • DOI

      10.1016/j.jiac.2019.08.001

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reversible splenial lesion in a patient with new-onset refractory status epilepticus (NORSE)2020

    • Author(s)
      Mizutani Akane Unno、Shindo Akihiro、Arikawa Shigeo、Shimada Takuya、Matsuura Keita、Ikejiri Kaoru、Suzuki Kei、Imai Hiroshi、Tomimoto Hidekazu
    • Journal Title

      eNeurologicalSci

      Volume: 18 Pages: 100220-100220

    • DOI

      10.1016/j.ensci.2019.100220

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiopulmonary resuscitation of a cardiac arrest patient with left ventricular assist device in an out-of-hospital setting2020

    • Author(s)
      Iwashita Yoshiaki、Ito Asami、Sasaki Ken、Suzuki Kei、Fujioka Masaki、Maruyama Kazuo、Imai Hiroshi
    • Journal Title

      Medicine

      Volume: 99 Issue: 2 Pages: e18658-e18658

    • DOI

      10.1097/md.0000000000018658

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case of toxic epidermal necrolysis in immunocompromised patient possibly due to Streptococcus pneumoniae serotype uncovered by vaccine2020

    • Author(s)
      Kondo Makoto、Suzuki Kei、Nakayama Yuichi、Matsushima Yoshiaki、Mizutani Kento、Habe Koji、Imai Hiroshi、Yamanaka Keiichi
    • Journal Title

      The Journal of Dermatology

      Volume: 47 Issue: 4

    • DOI

      10.1111/1346-8138.15268

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Elevated plasma levels of soluble C-type lectin-like receptor 2 (CLEC2) in patients with thrombotic microangiopathy2019

    • Author(s)
      Yamashita Yoshiki、Suzuki Kei、Mastumoto Takeshi、Ikejiri Makoto、Ohishi Koji、Katayama Naoyuki、Suzuki-Inoue Katsue、Wada Hideo
    • Journal Title

      Thrombosis Research

      Volume: 178 Pages: 54-58

    • DOI

      10.1016/j.thromres.2019.03.018

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk2019

    • Author(s)
      Suzuki Kei、Wada Hideo、Matsumoto Takeshi、Ikejiri Makoto、Ohishi Kohshi、Yamashita Yoshiki、Imai Hiroshi、Iba Toshiaki、Katayama Naoyuki
    • Journal Title

      Thrombosis Journal

      Volume: 17 Issue: 1 Pages: 1-8

    • DOI

      10.1186/s12959-019-0201-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 当院における新型コロナウイルス感染症(COVID-19)の治療経験:第5波での死亡者増加に関する考察2022

    • Author(s)
      鈴木圭
    • Organizer
      第49回日本集中治療医学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 当院におけるCOVID-19の治療経験:第4波での変化2021

    • Author(s)
      鈴木圭
    • Organizer
      第49回日本救急医学会総会・学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 当院救命救急領域におけるプロトロンビン複合体製剤の使用経験と有用性:26例の経験から2021

    • Author(s)
      鈴木圭
    • Organizer
      第43回日本血栓止血学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 当院におけるセフトロザン/タゾバクタムの使用経験と今後の展望2021

    • Author(s)
      鈴木圭
    • Organizer
      第95回日本感染症学会学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 当院救命救急センターにおける新型コロナウイルス感染症(COVID-19)の治療経験2021

    • Author(s)
      鈴木圭
    • Organizer
      第91回日本感染症学会中日本地方会学術集会
    • Related Report
      2021 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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