• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of Reading Function, Preservation and Plasticity at the Temporoparietal Junction in Awake Brain Surgery

Research Project

Project/Area Number 19K18407
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionFujita Health University

Principal Investigator

MUTO Jun  藤田医科大学, 医学部, 講師 (30383839)

Project Period (FY) 2019-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords白質解析 / 脳機能 / 脳腫瘍 / ベイズ深層学習モデル / 機能解析 / 失語 / 白質繊維解析 / ベイツ深層学習モデル / 失読 / VBM解析 / 覚醒下手術
Outline of Research at the Start

脳腫瘍患者を対象に、読字機能を中心に評価解析を行う。覚醒下手術中に電気刺激にて、
陽性反応、陰性反応を生じた部位を、それぞれMRI上で示し、MNI152標準脳に変換を行う。そしてVoxel-Based morphometry(VBM)を用いた白質繊維解析で白質繊維の障害割合を、白質繊維障害部位を評価、解析する。MRI画像は術前、術直後、術後6ヶ月後で評価を行う。それぞれに、神経機能評価試験を行い、失語試験、非言語意味性理解、空間認知、実行機能、計算などの神経検査も行い、読字機能の変化との関連について解析を行う。

Outline of Final Research Achievements

We evaluated the existing neural basis models of language, especially the picture naming task, by combining VBM analysis using cortical and white matter fiber mapping data from craniotomies of brain tumor patients, preoperative and postoperative MRI data, and the results of neurological function tests at different time points, as well as Bayesian deep learning model was used to reproduce the results. The possibility of using deep learning models to quantitatively deal with the visual features of images and the semantic features of language was investigated, and the relationship between the semantic features of the vocabulary produced by the aphasic patients and the pictorial illustrations was examined.
It is now possible to provide quantitative information on semantic and visual illocutionary errors in aphasia.

Academic Significance and Societal Importance of the Research Achievements

現在、臨床現場で用いられている神経心理試験を用いて、その脳内機構を明らかにすることで、脳内の障害部位と神経心理試験の結果をベイズ深層学習モデルで再現し、脳内ネットワークの解明に寄与するという学術的意義がある。さらに、損傷から、リハビリを行い、回復過程を追うことで、脳内の白質繊維の変化と神経心理試験の結果を合わせて解釈し、
ベイズ深層学習モデルで再現を試みることで、リハビリテーションにも寄与するという意義があると考える。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (34 results)

All 2021 2020 2019

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (26 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Intraoperative real-time near-infrared optical imaging for the identification of metastatic brain tumors via microscope and exoscope2021

    • Author(s)
      Muto Jun、Mine Yutaka、Nakagawa Yu、Joko Masahiro、Kagami Hiroshi、Inaba Makoto、Hasegawa Mitsuhiro、Lee John Y. K.、Hirose Yuichi
    • Journal Title

      Neurosurgical Focus

      Volume: 50 Issue: 1 Pages: E11-E11

    • DOI

      10.3171/2020.10.focus20767

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diploic veins as collateral venous pathways in patients with dural venous sinus invasion by meningiomas2021

    • Author(s)
      Yamashiro Kei、Muto Jun、Wakako Akira、Murayama Kazuhiro、Kojima Daijiro、Omi Tatsuo、Adachi Kazuhide、Hasegawa Mitsuhiro、Hirose Yuichi
    • Journal Title

      Acta Neurochirurgica

      Volume: 163 Issue: 6 Pages: 1687-1696

    • DOI

      10.1007/s00701-021-04777-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temozolomide radiochemotherapy for high-grade glioma patients with hemodialysis: a case series of 7 patients.2020

    • Author(s)
      Muto J, Matsutani T, Matsuda R, Kinoshita M, Oikawa M, Pallud J, Sasaki H
    • Journal Title

      Neuro-Oncology Practice

      Volume: 7 Issue: 1 Pages: 111-117

    • DOI

      10.1093/nop/npz034

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Primary spinal intramedullary Ewing-like sarcoma harboring CIC-DUX4 translocation: a similar cytological appearance as its soft tissue counterpart but no lobulation in association with desmoplastic stroma2020

    • Author(s)
      Yamada Seiji、Muto Jun、De Leon John Clemente Aniceto、Kumai Tadashi、Ito Keisuke、Murayama Kazuhiro、Hama Natsuko、Nakano Yoshiko、Satomi Kaishi、Arai Yasuhito、Shibata Tatsuhiro、Inoue Tatsushi、Nobusawa Sumihito、Ichimura Koichi、Hirose Yuichi、Abe Masato
    • Journal Title

      Brain Tumor Pathology

      Volume: 37 Issue: 3 Pages: 111-117

    • DOI

      10.1007/s10014-020-00366-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Objective and quantitative evaluation of angiographic vascularity in meningioma: parameters of dynamic susceptibility contrast-perfusion-weighted imaging as clinical indicators of preoperative embolization2020

    • Author(s)
      Adachi Kazuhide、Murayama Kazuhiro、Hayakawa Motoharu、Hasegawa Mitsuhiro、Muto Jun、Nishiyama Yuya、Ohba Shigeo、Hirose Yuichi
    • Journal Title

      Neurosurgical Review

      Volume: 1 Issue: 5 Pages: 111-117

    • DOI

      10.1007/s10143-020-01431-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ACT-18 SHOULD THE DOSE OF TEMOZOLOMIDE BE DECREASED FOR PATIENTS WITH HIGH-GRADE GLIOMAS WHO ARE ON HEMODIALYSIS?2020

    • Author(s)
      Muto Jun、Matsutani Tomoo、Matsuda Ryosuke、Kinoshita Masashi、Oikawa Mitsuteru、Johan Pallud、Adachi Kazuhide、Hirose Yuichi、Sasaki Hikaru
    • Journal Title

      Neuro-Oncology Advances

      Volume: 1 Issue: Supplement_2 Pages: ii15-ii15

    • DOI

      10.1093/noajnl/vdz039.066

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 高齢者非機能性下垂体腺腫に対する内視鏡下経鼻手術の手術適応2021

    • Author(s)
      武藤 淳 西山悠也 山田勢至 牧野真樹 長谷川光広 廣瀬雄一
    • Organizer
      第31回日本間脳下垂体腫瘍学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 近赤外線を用いたリアルタイム術中蛍光造影による転移性脳腫瘍手術2021

    • Author(s)
      武藤 淳 峯裕  各務宏 稲葉真 長谷川光広  廣瀬雄一
    • Organizer
      第30回脳神経外科手術と機器学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Intraoperative Near-Infrated Optical Contrast Can Localize Brain Metastasic Tumors via exoscope2021

    • Author(s)
      Muto J, Mine Y, Nakagawa Y, Joko M, Kagami H, Inaba M, Hasegawa M, Hirose Y
    • Organizer
      第4回蛍光造影研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Avoidance of Thronbolysis for Spontaneous Spinal epidural hematoma mimicking the stroke multicenter study of 39 cases2021

    • Author(s)
      Muto J Inoie T, Hasegawa M, Hirose Y
    • Organizer
      第25回日本脊髄外科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Intraoperative Near-Infrated Optical Contrast Can Localize spinal schwannoma via microscope2021

    • Author(s)
      Muto J, Inoue T, Nagai S, Takeda T, Ikeda H, Saito F, Joko M, Mine Y, Kaneko S,Hasegawa M, Hirose Y
    • Organizer
      第25回日本脊髄外科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The utility of endoscopic diving technique in the pituitary surgery 28thconference of Japanese society for hypothalamic and pituitary tumors2020

    • Author(s)
      Muto J, Nishiyama Y, Hasegawa M, Hirose Y
    • Organizer
      第28回間脳下垂体腫瘍学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The development of special Scissors in Endonasal Endoscopic Surgery2020

    • Author(s)
      Muto J, Takayama T, Kamiyama Y, Hirose Y,
    • Organizer
      第29回脳神経外科手術と機器学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 近赤外線を用いたリアルタイム術中蛍光造影による転移性脳腫瘍手術2020

    • Author(s)
      武藤 淳 峯裕  各務宏 稲葉真 長谷川光広  廣瀬雄一
    • Organizer
      脳神経外科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Avoidance of Thrombolysis in Spontaneous Cervical Spinal Epidural Hematoma Mimicking Stroke: Multi-center Study of 39 Cases2020

    • Author(s)
      MUTO J, INOUE T, HASEGAWA M, HIROSE Y
    • Organizer
      Asiaspine 2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 侵襲性を加味した近赤外線を用いたリアルタイム術中蛍光造影による転移性脳腫瘍手術2020

    • Author(s)
      武藤 淳 峯裕  各務宏 稲葉真 長谷川光広  廣瀬雄一
    • Organizer
      第79回脳腫瘍外科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脳腫瘍のための白質解剖2020

    • Author(s)
      武藤 淳
    • Organizer
      東海脳腫瘍セミナー2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 頭蓋陥入症に対する環軸椎固定を伴う後方固定後の前方除圧における経鼻内視鏡手術の有用性入症に対する環軸椎固定を伴う後方固定後の前方除圧における経鼻内視鏡手術の有用性2019

    • Author(s)
      武藤 淳
    • Organizer
      第62回中部脊椎セミナー
    • Related Report
      2019 Research-status Report
  • [Presentation] 超撥水技術を利用した内視鏡撥水システムの開発2019

    • Author(s)
      武藤 淳
    • Organizer
      第28回脳神経外科手術と機器学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 超撥水加工によって焦げ付き予防効果を持つバイポーラーの開発2019

    • Author(s)
      武藤 淳
    • Organizer
      第28回脳神経外科手術と機器学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 完全奏功2年後に脳出血発症した甲状腺乳頭癌の転移性脳腫瘍の1例2019

    • Author(s)
      武藤 淳
    • Organizer
      第96回日本脳神経外科中部支部会
    • Related Report
      2019 Research-status Report
  • [Presentation] 突然片麻痺発症の特発性脊髄硬膜外血腫をいかに脳卒中と鑑別するか2019

    • Author(s)
      武藤 淳
    • Organizer
      第34回日本脊髄外科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 頭蓋底解剖から見た内視鏡時代の副咽頭間隙、側頭下窩へのアプローチ2019

    • Author(s)
      武藤 淳
    • Organizer
      第31回日本頭蓋底外科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 第3脳室内頭蓋咽頭腫への内視鏡手術2019

    • Author(s)
      武藤 淳
    • Organizer
      第6回Wetfieldの会
    • Related Report
      2019 Research-status Report
  • [Presentation] 突然片麻痺発症の特発性脊髄硬膜外血腫をいかに脳卒中と鑑別するか 39例の多施設研究2019

    • Author(s)
      武藤 淳
    • Organizer
      第23回ニューロスパインカンファレンス
    • Related Report
      2019 Research-status Report
  • [Presentation] 超撥水技術を利用した内視鏡撥水システムの開発2019

    • Author(s)
      武藤 淳
    • Organizer
      第24回日本脳腫瘍の外科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 滑膜コーティング技術を利用した内視鏡撥水システムの開発2019

    • Author(s)
      武藤 淳
    • Organizer
      第26回日本神経内視鏡学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Avoidance of Thrombolysis for Spontaneous Spinal epidural hematoma mimicking the stroke multicenter study of 39 cases2019

    • Author(s)
      Jun MUTO
    • Organizer
      World Federation of Neurosurgery 2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 後頭葉病変が示唆する視機能の局在とネットワーク解析2019

    • Author(s)
      武藤 淳
    • Organizer
      日本脳神経外科学会第78回学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 透析患者に対するテモゾロマイドを用いた悪性神経膠腫の治療-8症例の多施設reviewより-2019

    • Author(s)
      武藤 淳
    • Organizer
      第37回日本脳腫瘍外科学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Glioma手術に必要な白質解剖2019

    • Author(s)
      武藤 淳
    • Organizer
      桶狭間カンファレンス
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Endoscopic endonasal surgery for skull base tumor in boundary lesion2019

    • Author(s)
      Jun MUTO
    • Organizer
      北京第一大学
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] Atlas of 360 degree skull base surgery2020

    • Author(s)
      Muto J, De Leon, Hirose Y
    • Total Pages
      1064
    • Publisher
      Thieme Publisher
    • ISBN
      9789388257893
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 高分子膜2020

    • Inventor(s)
      美和高光 武藤 淳  白鳥世明
    • Industrial Property Rights Holder
      美和高光 武藤 淳  白鳥世明
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Acquisition Date
      2021
    • Related Report
      2020 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi