• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of pathophysiological mechanism of chronic obstructive pulmonary disease (COPD)-related osteoporosis

Research Project

Project/Area Number 19K18513
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

Tsukamoto Manabu  産業医科大学, 医学部, 助教 (70778159)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords慢性閉塞肺疾患 / COPD / 骨粗鬆症 / サルコペニア / モデル動物 / 酸化ストレス / p38 MAPK / ミトコンドリア / 慢性閉塞性肺疾患 / 骨折 / 抗酸化防御機構 / Nrf2 / 骨形態計測 / 動物モデル / 身体活動性 / 骨形成能低下 / 海綿骨量減少 / COPD急性増悪 / 転倒 / 肺気腫 / 筋萎縮 / ロコモティブシンドローム
Outline of Research at the Start

慢性閉塞性肺疾患(COPD)は、骨粗鬆症やサルコペニアの危険因子とされているが、その病態は不明な点が多い。本研究では、我々が独自に確立させたCOPDに伴う筋骨格系疾患のモデル動物を用いて、COPDが筋や骨に与える影響因子を解明していく。本研究成果により、COPDに伴う筋骨格系疾患の病態が明らかになれば、病態に応じた治療を検討することが可能となり、ヒトにおいても有益な情報となることが予想される。

Outline of Final Research Achievements

To elucidate the molecular mechanism of osteoporosis associated with chronic obstructive pulmonary disease (COPD), we conducted investigations using an animal model. In COPD mice, despite no decrease in physical activity, musculoskeletal disorders (trabecular bone loss, impaired bone formation, soleus muscle weight loss, each muscle fiber atrophy, type I muscle fiber to type II muscle fiber switching) occurred, and oxidative stress markers were elevated in vivo. Focusing on p38 MAPK signaling pathway, the oxidative stress-related muscle atrophy signaling pathway, administration of antioxidants or p38 inhibitors prevented skeletal muscle disorder observed in COPD mice. Because of the close relationship between sarcopenia and osteoporosis, the results of our study may be the key to unraveling the molecular mechanism of COPD-associated osteoporosis.

Academic Significance and Societal Importance of the Research Achievements

改正高年齢者雇用安定法により勤労者は65歳まで継続して働くことが可能となり、高年齢の勤労者における健康寿命の維持・増進は今後の重要なテーマであると言える。慢性閉塞性肺疾患(COPD)は男性骨粗鬆症の主な原因であるが、COPD骨粗鬆症の病態メカニズムは未だ明らかではない。COPD骨粗鬆症の病態機序を解明していくことで、COPDを有する勤労者の健康寿命の維持・増進に貢献できるのではないかと考え、本研究を立案した。近年、勤労者の転倒災害が問題となっており、勤労者における転倒や骨折リスクを軽減させることで、労働力の維持・向上に繋がることが期待され、本研究成果による社会への波及効果は高いと考える。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (53 results)

All 2022 2021 2020 2019 2018

All Journal Article (22 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 21 results,  Open Access: 12 results) Presentation (30 results) (of which Int'l Joint Research: 6 results,  Invited: 6 results) Book (1 results)

  • [Journal Article] Trabecular Bone Volume Is Reduced, With Deteriorated Microstructure, With Aging in a Rat Model of Duchenne Muscular Dystrophy2022

    • Author(s)
      OBARA Hinako、TAJIMA Takafumi、TSUKAMOTO Manabu、YAMANAKA Yoshiaki、SUZUKI Hitoshi、ZENKE Yukichi、KAWASAKI Makoto、KOUZAKI Karina、NAKAZATO Koichi、HIRANUMA Kenji、SAKAI Akinori
    • Journal Title

      Journal of UOEH

      Volume: 44 Issue: 4 Pages: 323-330

    • DOI

      10.7888/juoeh.44.323

    • ISSN
      0387-821X, 2187-2864
    • Year and Date
      2022-12-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accurate cup placement using a portable navigation system during total hip arthroplasty based on pelvic orientation in the lateral decubitus position2022

    • Author(s)
      Tsukamoto Manabu、Kawasaki Makoto、Suzuki Hitoshi、Fujitani Teruaki、Uchida Soshi、Sakai Akinori
    • Journal Title

      Artificial Organs

      Volume: 46 Issue: 12 Pages: 2412-2422

    • DOI

      10.1111/aor.14281

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress causes muscle structural alterations via p38 MAPK signaling in COPD mouse model2022

    • Author(s)
      Mano Y, Tsukamoto M, Wang KY, Nabeshima T, Kosugi K, Tajima T, Yamanaka Y, Suzuki H, Kawasaki M, Nakamura E, Zhou Q, Azuma K, Nakashima T, Tamura Y, Kozaki K, Nakazato K, Li YS, Kawai K, Yatera K, Sakai A
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 40 Issue: 6 Pages: 927-939

    • DOI

      10.1007/s00774-022-01371-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long Bones Exhibit Adaptive Responses to Chronic Low‐Dose‐Rate Ionizing Radiation despite its Lifespan‐Shortening and Carcinogenic Effects on <scp>C57BL</scp> /6 Mice2022

    • Author(s)
      Kohzaki Masaoki、Ootsuyama Akira、Abe Toshiaki、Tsukamoto Manabu、Umata Toshiyuki、Okazaki Ryuji
    • Journal Title

      JBMR Plus

      Volume: 6 Issue: 12 Pages: 1-13

    • DOI

      10.1002/jbm4.10688

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Daily activity relates to not only femoral bone mineral density, but also hip structural analysis parameters: A cross-sectional observational study2021

    • Author(s)
      Fujii Norifumi、Okimoto Nobukazu、Tsukamoto Manabu、Fujii Norimitsu、Asano Kei、Ikejiri Yoshiaki、Yoshioka Toru、Tajima Takafumi、Yamanaka Yoshiaki、Zenke Yukichi、Kawasaki Makoto、Ozawa Junya、Umehara Takuya、Takano Shogo、Murata Hideaki、Kito Nobuhiro
    • Journal Title

      Osteoporosis and Sarcopenia

      Volume: 7 Issue: 4 Pages: 127-133

    • DOI

      10.1016/j.afos.2021.10.001

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone microstructure changes due to once-/twice-weekly teriparatide administration: a report of five cases using high-resolution peripheral quantitative computed tomography2021

    • Author(s)
      Tsukamoto M, Okimoto N, Mori M, Yoshioka T, Asano K, Ikejiri Y, Uzawa T, Yoshimura T, Suzuki H, Yamanaka Y, Kawasaki M, Sakai A
    • Journal Title

      Modern Rheumatology Case Reports

      Volume: rxab048 Issue: 2 Pages: 1-4

    • DOI

      10.1093/mrcr/rxab048

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Longitudinal study of risk factors for decreased cross-sectional area of psoas major and paraspinal muscle in 1849 individuals2021

    • Author(s)
      Murata Yoichi、Nakamura Eiichiro、Tsukamoto Manabu、Nakagawa Toru、Takeda Masaru、Kozuma Mio、Kadomura Takayuki、Narusawa Kenichiro、Shimizu Kenji、Uchida Soshi、Hayashi Takeshi、Sakai Akinori
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 16986-16986

    • DOI

      10.1038/s41598-021-96448-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in the effects of BMI on bone microstructure between loaded and unloaded bones assessed by HR-pQCT in Japanese postmenopausal women2021

    • Author(s)
      Fujii Norifumi、Tsukamoto Manabu、Okimoto Nobukazu、Mori Miyuki、Ikejiri Yoshiaki、Yoshioka Toru、Kawasaki Makoto、Kito Nobuhiro、Ozawa Junya、Nakamura Ryoichi、Takano Shogo、Fujiwara Saeko
    • Journal Title

      Osteoporosis and Sarcopenia

      Volume: 7 Issue: 2 Pages: 54-62

    • DOI

      10.1016/j.afos.2021.05.002

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proposal of accurate cup placement procedure during total hip arthroplasty based on pelvic tilt discrepancies in the lateral position2021

    • Author(s)
      Tsukamoto Manabu, Kawasaki Makoto, Suzuki Hitoshi, Fujitani Teruaki, Sakai Akinori
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 13780-13780

    • DOI

      10.1038/s41598-021-93418-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 慢性閉塞性肺疾患に伴う骨折リスクと骨折治癒への影響2021

    • Author(s)
      塚本 学、真野洋佑、鍋島貴行、酒井昭典
    • Journal Title

      Bone Joint Nerve

      Volume: 11 Pages: 29-34

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronic obstructive pulmonary disease severity in middle-aged and older men with osteoporosis associates with decreased bone formation2020

    • Author(s)
      Manabu Tsukamoto, Toshiharu Mori, Eiichiro Nakamura, Yasuaki Okada, Hokuto Fukuda, Yoshiaki Yamanaka, Ken Sabanai, Ke-Yong Wang, Takeshi Hanagiri, Satoshi Kuboi, Kazuhiro Yatera, Akinori Sakai
    • Journal Title

      Osteoporosis and Sarcopenia

      Volume: 6 Issue: 4 Pages: 179-184

    • DOI

      10.1016/j.afos.2020.11.003

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Performance of two bone substitutes of novel cotton-like β-TCP/PDLGA and granular β-TCP on bone regeneration in the femoral bone defect of the Beagle dogs2020

    • Author(s)
      Okada Yasuaki、Yamanaka Yoshiaki、Menuki Kunitaka、Zenke Yukichi、Tsukamoto Manabu、Tajima Takafumi、Kosugi Kenji、Kawasaki Makoto、Nakamura Eiichiro、Toyota Naoka、Kawabe Yasuhiro、Sakai Akinori
    • Journal Title

      Bone Reports

      Volume: 13 Pages: 100718-100718

    • DOI

      10.1016/j.bonr.2020.100718

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Zoledronic acid sequential therapy could avoid disadvantages due to the discontinuation of less than 3-year denosumab treatment2020

    • Author(s)
      Kondo Hideomi、Okimoto Nobukazu、Yoshioka Toru、Akahoshi Shojiro、Fuse Yoshifumi、Ogawa Takayuki、Okazaki Yuichi、Katae Yuji、Tsukamoto Manabu、Yamanaka Yoshiaki、Kawasaki Makoto、Sakai Akinori
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 38 Issue: 6 Pages: 894-902

    • DOI

      10.1007/s00774-020-01126-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transient receptor potential vanilloid 1 and 4 double knockout leads to increased bone mass in mice2020

    • Author(s)
      Nishimura Haruki、Kawasaki Makoto、Tsukamoto Manabu、Menuki Kunitaka、Suzuki Hitoshi、Matsuura Takanori、Baba Kazuhiko、Motojima Yasuhito、Fujitani Teruaki、Ohnishi Hideo、Yamanaka Yoshiaki、Kosugi Kenji、Okada Yasuaki、Tokuda Kotaro、Tajima Takafumi、Yoshioka Toru、Okimoto Nobukazu、Ueta Yoichi、Sakai Akinori
    • Journal Title

      Bone Reports

      Volume: 12 Pages: 100268-100268

    • DOI

      10.1016/j.bonr.2020.100268

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disruption of the aldehyde dehydrogenase 2 gene increases the bone anabolic response to intermittent PTH treatment in an ovariectomized mouse model2020

    • Author(s)
      Kosugi Kenji、Tajima Takafumi、Menuki Kunitaka、Okuma Kayoko Furukawa、Tokuda Kotaro、Fukuda Hokuto、Okada Yasuaki、Tsukamoto Manabu、Yamanaka Yoshiaki、Zenke Yukichi、Sakai Akinori
    • Journal Title

      Bone

      Volume: 136 Pages: 115370-115370

    • DOI

      10.1016/j.bone.2020.115370

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 薬物の併用・逐次療法2020

    • Author(s)
      塚本 学、酒井 昭典
    • Journal Title

      日本臨牀

      Volume: 78 Pages: 2110-2114

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Systemic bone loss, impaired osteogenic activity and type I muscle fiber atrophy in mice with elastase-induced pulmonary emphysema: Establishment of a COPD-related osteoporosis mouse model2019

    • Author(s)
      Tsukamoto Manabu、Mori Toshiharu、Wang Ke-Yong、Okada Yasuaki、Fukuda Hokuto、Naito Keisuke、Yamanaka Yoshiaki、Sabanai Ken、Nakamura Eiichiro、Yatera Kazuhiro、Sakai Akinori
    • Journal Title

      Bone

      Volume: 120 Pages: 114-124

    • DOI

      10.1016/j.bone.2018.10.017

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Findings as a starting point to unravel the underlying mechanisms of in vivo interactions involving Wnt10a in bone, fat and muscle.2019

    • Author(s)
      Tsukamoto M, Wang KY, Tasaki T, Murata Y, Okada Y, Yamanaka Y, Nakamura E, Yamada S, Izumi H, Zhou Q, Azuma K, Sasaguri Y, Kohno K, Sakai A
    • Journal Title

      Bone

      Volume: 120 Pages: 75-84

    • DOI

      10.1016/j.bone.2018.10.009

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Attenuation of Post‐Traumatic Osteoarthritis After Anterior Cruciate Ligament Injury Via Inhibition of Hedgehog Signaling2019

    • Author(s)
      Takada Shinichiro、Nakamura Eiichiro、Sabanai Ken、Tsukamoto Manabu、Otomo Hajime、Kanoh Shinkichi、Murai Teppei、Fukuda Hokuto、Okada Yasuaki、Uchida Soshi、Sakai Akinori
    • Journal Title

      Journal of Orthopaedic Research

      Volume: 38 Issue: 3 Pages: 609-619

    • DOI

      10.1002/jor.24494

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical and Radiographic Predictors for Unsalvageable Labral Tear at the Time of Initial Hip Arthroscopic Management for Femoroacetabular Impingement2019

    • Author(s)
      Nakashima Hirotaka、Tsukamoto Manabu、Ohnishi Yasuo、Utsunomiya Hajime、Kanezaki Shiho、Sakai Akinori、Uchida Soshi
    • Journal Title

      The American Journal of Sports Medicine

      Volume: 47 Issue: 9 Pages: 2029-2037

    • DOI

      10.1177/0363546519856018

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 慢性閉塞性肺疾患に伴う骨粗鬆症の病態メカニズム解明に向けて ─新たな骨粗鬆症モデルの確立─2019

    • Author(s)
      塚本 学、酒井昭典
    • Journal Title

      The Journal of Japan Osteoporosis Society

      Volume: 5 Pages: 90-91

    • Related Report
      2019 Research-status Report
  • [Journal Article] Depletion of WNT10A Prevents Tumor Growth by Suppressing Microvessels and Collagen Expression.2018

    • Author(s)
      Kumagai M, Guo X, Wang KY, Izumi H, Tsukamoto M, Nakashima T, Tasaki T, Kurose N, Uramoto H, Sasaguri Y,Kohno K, Yamada S.
    • Journal Title

      International Journal of Medical Sciences

      Volume: 16 Issue: 3 Pages: 416-423

    • DOI

      10.7150/ijms.26997

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] DELAYED CORTICAL BONE HEALING DUE TO INACTIVATED NRF2 SIGNALING PATHWAY IN COPD MICE2022

    • Author(s)
      Takayuki Nabeshima, Manabu Tsukamoto, Yosuke Mano, Daisuke Arakawa, Ke-Yong Wang, Takafumi Tajima, Yoshiaki Yamanaka, Eiichiro Nakamura, Akinori Sakai
    • Organizer
      ANZBMS 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of astaxanthin on the structural alterations in muscles of elastase-induced emphysema mouse models2022

    • Author(s)
      Yosuke Mano, Manabu Tsukamoto, Takayuki Nabeshima, Ke-Yong Wang, Takafumi Tajima, Yoshiaki Yamanaka, Eiichiro Nakamura, Akinori Sakai
    • Organizer
      ANZBMS 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 慢性閉塞性肺疾患合併サルコペニアの病態解明2022

    • Author(s)
      塚本 学、真野洋佑、王 克鏞、鍋島貴行、田島貴文、山中芳亮、中村英一郎、東 華岳、李 云善、矢寺和博、酒井昭典
    • Organizer
      第40回産業医科大学学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] COPDマウスではNrf2シグナル伝達経路障害により皮質骨修復が遅延する2022

    • Author(s)
      塚本 学、鍋島貴行、真野洋佑、王 克鏞、田島貴文、山中芳亮、中村英一郎、酒井昭典
    • Organizer
      第40回産業医科大学学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] エラスターゼ誘導性肺気腫マウスの骨格筋萎縮に対するアスタキサンチンの効果2022

    • Author(s)
      真野洋佑、塚本 学、王 克鏞、鍋島貴行、田島貴文、山中芳亮、中村英一郎、矢寺和博、酒井昭典
    • Organizer
      第42回日本骨形態計測学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 荷重の増減による四肢骨の構造変化と整形外科医としての役割2022

    • Author(s)
      塚本 学、田島貴文、山中芳亮、藤井紀文、沖本信和、中村英一郎、酒井昭典
    • Organizer
      第42回日本骨形態計測学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 骨微細構造を再構築して骨強度を高めるための骨粗鬆症治療2022

    • Author(s)
      塚本 学、沖本信和、酒井昭典
    • Organizer
      第24回日本骨粗鬆症学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] COPDマウスではNrf2シグナル伝達経路障害により皮質骨修復が遅延する2022

    • Author(s)
      鍋島貴行、塚本 学、真野洋佑、王 克鏞、田島貴文、山中芳亮、 中村英一郎、酒井昭典
    • Organizer
      第37回日本整形外科学会基礎学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] エラスターゼ誘導性肺気腫マウスの骨格筋萎縮に対するp38阻害剤の効果2022

    • Author(s)
      真野洋佑、塚本 学、王 克鏞、鍋島貴行、田島貴文、山中芳亮、中村英一郎、酒井昭典
    • Organizer
      第40回日本骨代謝学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] エラスターゼ誘導性肺気腫マウスにおける皮質骨修復遅延にはNrf2応答不良が関与している2022

    • Author(s)
      鍋島貴行、塚本 学、真野洋佑、王 克鏞、田島貴文、山中芳亮、酒井昭典
    • Organizer
      第40回日本骨代謝学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] COPDマウスにおける内因性酸化ストレスとp38 MAPK活性化によるI型筋線維萎縮2021

    • Author(s)
      塚本 学、真野洋佑、王 克鏞、鍋島貴行、小杉健二、田島貴文、山中芳亮、鈴木仁士、川﨑展、中村英一郎、中島民治、周倩、東 華岳、李 云善、河合一明、矢寺和博、酒井昭典
    • Organizer
      第39回 産業医科大学学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 荷重による骨への機械的刺激と骨微細構造変化2021

    • Author(s)
      塚本 学、田島貴文、山中芳亮、藤井紀文、沖本信和、酒井昭典
    • Organizer
      第41回 日本骨形態計測学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 勤労者における腰痛の発生頻度と危険因子 -10年縦断調査2021

    • Author(s)
      塚本 学、中村英一郎、村田洋一、上妻美緒、中川 徹、酒井昭典
    • Organizer
      第94回 日本整形外科学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] エラスターゼ誘導性肺気腫マウスでは皮質骨の修復が遅延する2021

    • Author(s)
      鍋島貴行、塚本 学、真野洋佑、王 克鏞、田島貴文、山中芳亮、酒井昭典
    • Organizer
      第39回 日本骨代謝学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] エラスターゼ誘導性肺気腫マウスにおけるI型筋線維萎縮の病態解明2021

    • Author(s)
      真野洋佑、塚本 学、鍋島貴行、王 克鏞、山中芳亮、中村英一郎、周倩、東 華岳、李 云善、河合一明、矢寺和博、酒井昭典
    • Organizer
      第36回 日本整形外科学会基礎学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Chronic obstructive pulmonary disease severity in male osteoporosis patients associates with decreased bone formation2021

    • Author(s)
      Manabu Tsukamoto, Toshiharu Mori, Yosuke Mano, Takayuki Nabeshima, Yoshiaki Yamanaka, Eiichiro Nakamura, Ke-Yong Wang, Kazuhiro Yatera, Akinori Sakai
    • Organizer
      The American Society for Bone and Mineral Research 2021 Annual Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 荷重・非荷重と骨のシグナル伝達2020

    • Author(s)
      塚本 学、田島貴文、山中芳亮、酒井昭典
    • Organizer
      第40回 日本骨形態計測学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 慢性閉塞性肺疾患に伴う筋骨格系疾患モデル動物の確立2020

    • Author(s)
      塚本 学、森 俊陽、王 克鏞、真野洋佑、山中芳亮、中村英一郎、矢寺和博、酒井昭典
    • Organizer
      第40回 日本骨形態計測学会
    • Related Report
      2020 Research-status Report
  • [Presentation] エラスターゼ誘導性肺気腫モデルマウスにおける酸化ストレスと筋萎縮との関連2020

    • Author(s)
      真野洋佑、塚本 学、王 克鏞、小杉健二、山中芳亮、中村英一郎、李 云善、河合一明、矢寺和博、酒井昭典
    • Organizer
      第40回 日本骨形態計測学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Wnt10a遺伝子欠損マウスの骨・筋肉・脂肪における組織学的変化2020

    • Author(s)
      塚本 学、王 克鏞、山中芳亮、中村英一郎、東 華岳、酒井昭典
    • Organizer
      第38回 日本骨代謝学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] エラスターゼ誘導性肺気腫マウスにおける酸化ストレスと筋萎縮との関連2020

    • Author(s)
      真野洋佑、塚本 学、王 克鏞、小杉健二、山中芳亮、中村英一郎、酒井昭典
    • Organizer
      第38回 日本骨代謝学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 1870名のCT検診データを用いた体幹筋面積の10年間の縦断調査 - 筋面積減少のリスクファクターの検討 -2020

    • Author(s)
      村田洋一、中村英一郎、塚本 学、上妻美緒、中川 徹、酒井昭典
    • Organizer
      第93回 日本整形外科学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Findings to unravel the underlying mechanisms of in vivo interactions involving Wnt10a in bone, fat and muscle2020

    • Author(s)
      Manabu Tsukamoto, Ke-Yong Wang, Takashi Tasaki, Yoichi Murata, Yasuaki Okada, Yoshiaki Yamanaka, Eiichiro Nakamura, Sohsuke Yamada, Hiroto Izumi, Qian Zhou, Kagaku Azuma, Yasuyuki Sasaguri, Kimitoshi Kohno, Akinori Sakai
    • Organizer
      The American Society for Bone and Mineral Research 2020 Annual Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Association between endogenous oxidative stress and muscle atrophy in the elastase-induced pulmonary emphysema mouse model2020

    • Author(s)
      Yosuke Mano, Manabu Tsukamoto, Ke-Yong Wang, Kenji Kosugi, Takafumi Tajima, Yoshiaki Yamanaka, Eiichiro Nakamura, Tamiji Nakashima, Qian Zhou, Kagaku Azuma, Yun-shan Li, Kazuaki Kawai, Kazuhiro Yatera, Akinori Sakai
    • Organizer
      The American Society for Bone and Mineral Research 2020 Annual Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 廃用性骨粗鬆症とカルシトニン2019

    • Author(s)
      塚本 学、目貫邦隆、酒井昭典
    • Organizer
      第39回 日本骨形態計測学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Wnt10a遺伝子欠損マウスにおける骨形態学的調査2019

    • Author(s)
      塚本 学、王 克鏞、田崎貴嗣、山中芳亮、佐羽内研、中村英一郎、山田壮亮、和泉弘人、東 華岳、河野公俊、酒井昭典
    • Organizer
      第39回 日本骨形態計測学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 慢性閉塞性肺疾患に伴う骨粗鬆症の病態メカニズム解明に向けて -新たな骨粗鬆症モデルの確立-2019

    • Author(s)
      塚本 学
    • Organizer
      臨床研究サマーセミナー2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] エラスターゼ誘導性肺気腫マウスにおける骨形成障害を伴う全身性骨量減少と型筋線維萎縮:COPDに伴う筋骨格系疾患モデル動物の確立2019

    • Author(s)
      塚本 学、森 俊陽、王 克鏞、岡田祥明、福田北斗、内藤圭佑、山中芳亮、佐羽内研、中村英一郎、矢寺和博、酒井昭典
    • Organizer
      第37回 日本骨代謝学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Systemic Bone loss, Impaired Osteogenic Activity and Type I Muscle Fiber Atrophy in Mice with Elastase-Induced Pulmonary Emphysema: Establishment of a COPD-Related Osteoporosis/Sarcopenia Mouse Model2019

    • Author(s)
      Manabu Tsukamoto, Toshiharu Mori, Ke-Yong Wang, Yasuaki Okada, Hokuto Fukuda, Keisuke Naito, Yoshiaki Yamanaka, Ken Sabanai, Eiichiro Nakamura, Kazuhiro Yatera, Akinori Sakai
    • Organizer
      The American Society for Bone and Mineral Research 2019 Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] エラスターゼ誘導性肺気腫マウスにおける骨形成障害を伴う全身性骨量減少とI型筋線維萎縮:COPDに伴う筋骨格系疾患モデルの確立2019

    • Author(s)
      塚本 学、森 俊陽、王 克鏞、岡田祥明、福田北斗、内藤圭佑、山中芳亮、佐羽内研、中村英一郎、矢寺和博、酒井昭典
    • Organizer
      第34回 日本整形外科学会基礎学術集会
    • Related Report
      2019 Research-status Report
  • [Book] Monthly Book Orthopaedics2022

    • Author(s)
      塚本 学、沖本信和
    • Total Pages
      7
    • Publisher
      全日本病院出版会
    • Related Report
      2022 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi