| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
In this study, we cultured human oral mucosa-derived fibroblasts and human skin-derived fibroblasts and investigated the factors related to the regulation of mitochondrial function (PGC-1α, TFAM, NRF-1/2). The effect of CO2 paste on wound healing was examined in a rat skin defect model. The rates of wound healing were significantly higher in the CO2 paste group than those in the control group. Inflammatory markers such as IL-1β and IL-6 were decreased in the CO2 paste group. Wound healing markers such as VEGF and TGF-β increased in the CO2 paste group. The results of the wound healing markers were similar in the immunostaining.
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