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Development of appropriate test food and receiving coils for use in cine MRI acquisition performed for evaluating swallowing

Research Project

Project/Area Number 19K19193
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionOsaka University

Principal Investigator

TSUJIMOTO Tomomi  大阪大学, 大学院歯学研究科, 助教 (00632150)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords超高速MRI / 嚥下機能 / 放射線治療 / MRI
Outline of Research at the Start

舌癌などの口腔癌を手術で取り切った場合、食べる・話す等の口腔機能の低下が起こる。一方、放射線治療で癌を根絶できれば、手術で切った場合よりも口腔機能や形態の温存が見込まれると言われている。しかし実際は、放射線治療によって癌治療が成功したとしても、口腔機能が低下したと訴える患者もいる。
現在、口腔機能検査で実施されているのはエックス線を使用した方法が主流である。放射線被曝を伴うので頻回に検査ができない。そこで被曝のないMRIを用いて口腔機能検査を行いたいが、口腔機能評価に適した検査食材はなく、詳細に動きを捉える装置(受信コイル)が存在しないので、これらを開発することを目的とした。

Outline of Final Research Achievements

The purpose of this study was to develop of appropriate test food and receiving coils for use in cine MRI acquisition performed for evaluating swallowing. Eight volunteers underwent cine MRI using the FIESTA method.It was able to get moving image that confirmed the flow of the test food bolus from oral cavity to the pharyngeal space in the midline sagittal section.In addition, there were individual differences in the appropriate test food in healthy volunteers. Therefore, it is necessary to study the appropriate test food for patients with disease or the elderly.

Academic Significance and Societal Importance of the Research Achievements

一般的に嚥下機能評価に用いられる動態検査は、エックス線を使用した方法が主流で、放射線被曝の観点から反復して検査を行うことが躊躇される。そこで被曝のない超高速MRIを嚥下機能検査として活用できるとなれば、患者への侵襲は減少されると予想された。本研究ではMRI撮像でも被験者の頭部の正中矢状断画像にて口腔期から咽頭期までの食塊の流れが確認できたため、今後嚥下機能評価に応用できる可能性が示唆された。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (3 results)

All 2023 2021

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Outpatient High-Dose-Rate Mold Brachytherapy for Lower Gingival Squamous Cell Carcinoma: A First Report2023

    • Author(s)
      Ami Takeshita, Hiroaki Shimamoto, Yuka Uchimoto, Tomomi Tsujimoto, Tetsuo Miyamoto, Sven Kreiborg, Sanjay M. Mallya, Michio Oda, Takero Hirata, Kazuhiko Ogawa, Hiroya Shiomi,Shumei Murakami
    • Journal Title

      International Journal of Radiation Research

      Volume: -

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Carcinoma of mandibular gingiva case given brachytherapy in an out-patient treatment.2021

    • Author(s)
      Tomomi Tsujimoto, Ami Takeshita, Yuka Uchimoto, Makihito Hamamoto, Yuri Iwamoto, Ryoko Okahata, Hiroaki Shimamoto, Atsutoshi Nakatani, Yuka Uchiyama, Tetsuro Miyamoto, Shumei Murakami.
    • Organizer
      The 23rd International Congress of DentoMaxilloFacial Radiology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Carcinoma of mandibular gingiva case given brachytherapy in an out-patient treatment2021

    • Author(s)
      Tomomi Tsujimoto, Ami Takeshita, Yuka Uchimoto, Makihito Hamamoto, Yuri Iwamoto, Ryoko Okahata1, Hiroaki Shimamoto, Atsutoshi Nakatani, Yuka Uchiyama, Tetsuro Miyamoto, Shumei Murakami
    • Organizer
      The 23rd International Congress of DentoMaxilloFacial Radiology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2024-01-30  

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