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The Brain Activation in the patients with Burning Mouth Syndrome -Paina Alleviating by Sweet stimulation-

Research Project

Project/Area Number 19K19211
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionTokyo Medical and Dental University (2020-2022)
Tokyo Dental College (2019)

Principal Investigator

Watanabe Motoko  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (70778620)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords舌痛症 / 口腔異常感 / 慢性疼痛 / 味覚 / 中枢神経系 / 末梢神経系 / MRI / 脳画像 / 口腔異常感症 / 歯科心身症 / Central Nervous System / 脳機能 / 脳内ネットワーク / fMRI / 疼痛緩和
Outline of Research at the Start

舌痛症は口腔内に明らかな器質的異常を伴わない慢性疼痛で、中高年の女性に多くみられる。本症ではヒリヒリ感などの灼熱感のみならず、「何となくおいしくない」「常に嫌な味がする」といった味覚の違和感、飴やガムによる疼痛軽減も散見される。また、脳血流SPECTを用いた研究から、口腔内の違和感と左右アンバランスな脳血流との関連が示唆されている。さらに、高濃度の甘味刺激による疼痛軽減が報告されており、本研究では、舌痛症患者を対象にfMRIを撮像し、味覚の違和感の有無別に、甘味刺激による疼痛の軽減と脳活動との関連を解析する。本研究の遂行は、多様な口腔内症状を呈する舌痛症の病態を解明する一助となると考える。

Outline of Final Research Achievements

Burning mouth syndrome (BMS) shows various sensations besides typical burning sensations. This study focused on gustatory related sensations revealed that pain sensations were exacerbated or ameliorated by specific taste stimuli and that taste intensity was affected by duration of illness, decrease of saliva, depression and intolerance of uncertainty. Moreover, the study focused on trigeminal nervus innervate oral sensations including pain demonstrated interaction between the presence of neurovascular compression at the root entry zone and oral sensations. The patients without NVC showed more various and severe sensations compared to the patients with NVC. These results suggest that some different mechanisms to distinguish between peripheral- and central- predominant pathology exist in the patients with BMS.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から、舌痛症の味覚と疼痛では、生理学的因子や神経学的因子だけでなく心理学的因子など多彩な因子が複合的に作用しており、舌痛症に対する心身医学的治療において、不確実さ不耐性へのアプローチも有用となる可能性を見出した。またMRIを用いた研究からは、口腔内の異常感覚について末梢から中枢にかけての病態探索を行い、その成果は病態解明の一助となり得ると考えられた。舌痛症患者の口腔内症状に関する因子を解明し、治療アプローチを考察することは、病態解明だけでなく治療法構築への貢献、ひいては患者の救済へとつながることが期待される。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (27 results)

All 2023 2022 2021 Other

All Int'l Joint Research (1 results) Journal Article (14 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 14 results,  Open Access: 11 results) Presentation (12 results)

  • [Int'l Joint Research] University of Medicine and Pharmacy(ベトナム)

    • Related Report
      2021 Research-status Report
  • [Journal Article] Case series of drug-induced open bite: Extrapyramidal symptoms related to psychotropic medications2023

    • Author(s)
      Watanabe Motoko、Tu Trang Thi Huyen、Takao Chihiro、Maeda Chizuko、Nayanar Gayatri Krishnakumar、Tominaga Risa、Kimura Yasuyuki、Takenoshita Miho、Yoshikawa Tatsuya、Sumi Koji、Sumi Satoko、Motomura Haruhiko、Nagamine Takahiko、Toyofuku Akira
    • Journal Title

      Frontiers in Psychiatry

      Volume: 14

    • DOI

      10.3389/fpsyt.2023.1137917

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dental conditions in patients with medically unexplained oral symptoms2023

    • Author(s)
      Asami M, Kimura Y, Takenoshita M, Tominaga R, Maeda C, Takao C, Watanabe M, Tu TH T, Nagamine T, Toyofuku Ain patients with medically unexplained oral symptoms
    • Journal Title

      Journal of Dental Sciences

      Volume: 1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oral cenesthopathy with pain sensation substantially improved with amitriptyline monotherapy: A case report2023

    • Author(s)
      渡邉 素子、髙尾 千紘、前田 智寿古、須賀 隆行、梅崎 陽二朗、竹之下 美穂、豊福 明
    • Journal Title

      Journal of Psychosomatic Oral Medicine

      Volume: 37 Issue: 1-2 Pages: 5-11

    • DOI

      10.11268/jjpsd.37.1-2_5

    • ISSN
      0913-6681, 2186-4128
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of an elderly patient with burning mouth syndrome who recovered with short-term inpatient treatment2023

    • Author(s)
      須賀 隆行、渡邉 素子、髙尾 千紘、前田 智寿古、豊福 明
    • Journal Title

      Journal of Psychosomatic Oral Medicine

      Volume: 37 Issue: 1-2 Pages: 12-16

    • DOI

      10.11268/jjpsd.37.1-2_12

    • ISSN
      0913-6681, 2186-4128
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of atypical odontalgia treated successfully in collaboration with family dentists2023

    • Author(s)
      髙尾 千紘、渡邉 素子、木村 康之、前田 智寿古、富永 梨沙、豊福 明
    • Journal Title

      Journal of Psychosomatic Oral Medicine

      Volume: 37 Issue: 1-2 Pages: 20-26

    • DOI

      10.11268/jjpsd.37.1-2_20

    • ISSN
      0913-6681, 2186-4128
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phantom bite syndrome2022

    • Author(s)
      Tu T. T. H.、Watanabe M.、Toyofuku A.、Yojiro U.
    • Journal Title

      British Dental Journal

      Volume: 232 Issue: 12 Pages: 839-840

    • DOI

      10.1038/s41415-022-4406-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Auditory hallucination induced by amitriptyline for treating atypical odontalgia: a case report2022

    • Author(s)
      Watanabe M, Nakabayashi T, Nayanar G, Takao C, Maeda C, Tu TTH, Motomura H, Toyofuku A.
    • Journal Title

      Frontiers in Psychiatry

      Volume: -

    • DOI

      10.3389/fpsyt.2022.863485

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Relationships Between Neurovascular Compression and Clinical Characteristics in Patients with Trigeminal Neuralgia Treated at a Psychosomatic Dental Clinic2022

    • Author(s)
      渡邉 素子、坂本 潤一郎、倉林 亨、豊福 明
    • Journal Title

      Shika Hoshasen

      Volume: 62 Issue: 1 Pages: 17-23

    • DOI

      10.11242/dentalradiology.62.17

    • ISSN
      0389-9705, 2185-6311
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 歯科心身医療科の三叉神経痛患者におけるNVCと臨床的特徴との関連2022

    • Author(s)
      渡邉素子、坂本潤一郎、倉林亨、豊福明
    • Journal Title

      歯科放射線

      Volume: 62

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Effectiveness and Adverse Events of Amitriptyline and Aripiprazole in Very Elderly Patients With BMS2022

    • Author(s)
      Watanabe Motoko、Takao Chihiro、Liu Zhenyan、Nayanar Gayatri、Suga Takayuki、Hong Chaoli、Tu Trang Thi Huyen、Yoshikawa Tatsuya、Takenoshita Miho、Motomura Haruhiko、Nagamine Takahiko、Toyofuku Akira
    • Journal Title

      Frontiers in Pain Research

      Volume: 3

    • DOI

      10.3389/fpain.2022.809207

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 歯科心身症患者の臨床実態:2017~19年度(3年間)における当科での推移2021

    • Author(s)
      渡邉素子、Hong Chaolin、Liu Zhenyan、Nayanar Gayatori、前田智寿古、Tu TH Trang、須賀隆行、竹之下美穂、豊福明
    • Journal Title

      未病と抗老化

      Volume: 30 Pages: 41-45

    • NAID

      40022765208

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 舌痛症患者における味覚と疼痛2021

    • Author(s)
      渡邉素子、髙尾千紘、前田智寿古、Tu TH Trang、須賀隆行、松岡紘史、竹之下美穂、安彦善裕、豊福明
    • Journal Title

      日本歯科心身医学会雑誌

      Volume: 36 Pages: 11-19

    • NAID

      130008154310

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Case Report: Iatrogenic Dental Progress of Phantom Bite Syndrome: Rare Cases With the Comorbidity of Psychosis2021

    • Author(s)
      Watanabe Motoko、Hong Chaoli、Liu Zhenyan、Takao Chihiro、Suga Takayuki、Tu Trang Thi Huyen、Yoshikawa Tatsuya、Takenoshita Miho、Sato Yusuke、Higashihori Norihisa、Moriyama Keiji、Motomura Haruhiko、Toyofuku Akira
    • Journal Title

      Frontiers in Psychiatry

      Volume: 12 Pages: 701232-701232

    • DOI

      10.3389/fpsyt.2021.701232

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical Characteristics of Predominantly Unilateral Oral Cenesthopathy With and Without Neurovascular Contact2021

    • Author(s)
      Watanabe Kazuya、Watanabe Motoko、Takao Chihiro、Hong Chaoli、Liu Zhenyan、Suga Takayuki、Tu Trang Thi Huyen、Sakamoto Junichiro、Umezaki Yojiro、Yoshikawa Tatsuya、Takenoshita Miho、Uezato Akihito、Motomura Haruhiko、Kurabayashi Tohru、Abiko Yoshihiro、Toyofuku Akira
    • Journal Title

      Frontiers in Neurology

      Volume: 12

    • DOI

      10.3389/fneur.2021.744561

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Amitriptyline誘発性の幻聴をきたした非定型歯痛の1例2022

    • Author(s)
      渡邉素子、髙尾千紘、Nayanar Gayatri、前田智寿古、Tu Trang、豊福明
    • Organizer
      第37回日本歯科心身医学会総会・学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 低用量のAmitriptylineによって、幻聴を認めた非定型歯痛の1例2022

    • Author(s)
      渡邉 素子, 竹之下 美穂, 豊福 明
    • Organizer
      第76回日本口腔科学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高齢の舌痛症患者におけるアミトリプチリンとアリピプラゾールの有効性2022

    • Author(s)
      渡邉 素子、 豊福 明
    • Organizer
      第63回日本心身医学会総会ならびに学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 痛みに対する破局的思考と舌痛症の労働機能障害との関連性の検討2022

    • Author(s)
      松岡 紘史, 宇津宮 雅史, 渡邉 素子, Paudel Durga, 吉田 光希, 三浦 宏子, 豊福 明, 安彦 善裕
    • Organizer
      第63回日本心身医学会総会ならびに学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 舌痛症患者の気分状態に森田神経質と痛みに対する破局的思考が及ぼす影響2022

    • Author(s)
      松岡 紘史, 宇津宮 雅史, Paudel Durga, 吉田 光希, 竹之下 美穂, 渡邉 素子, 三浦 宏子, 豊福 明, 安彦 善裕
    • Organizer
      日本口腔診断学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 紹介元から見た当科受診患者の病態分布2021

    • Author(s)
      渡邉素子、須賀隆行、竹之下美穂、豊福明
    • Organizer
      第75回日本口腔科学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 口腔領域における片側優位の不快感とTrigeminal Neurovascular Contactの関与2021

    • Author(s)
      2.渡邉素子、須賀隆行、Chaoli Hong、Zhenyan Liu、高尾千紘、Trang Tu、坂本潤一郎、竹之下美穂、倉林亨、豊福明
    • Organizer
      第61回日本歯科放射線学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 歯科心身症患者における片側優位症状とTrigeminal Neurovascular Contactとの関連2021

    • Author(s)
      渡邉素子、須賀隆行、高尾千紘、竹之下美穂、豊福明
    • Organizer
      第36回日本歯科心身医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 医原性に増悪を認めた 精神病が併存するPhantom Bite Syndromeの 3例2021

    • Author(s)
      渡邉素子、須賀隆行、高尾千紘、佐藤佑介、竹之下美穂、豊福明
    • Organizer
      第36回日本歯科心身医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 当科受診患者の受診経路と疾患分布2021

    • Author(s)
      渡邉素子、須賀隆行、竹之下美穂、豊福明
    • Organizer
      第62回日本心身医学会学術講演会
    • Related Report
      2021 Research-status Report
  • [Presentation] 片側優位な口腔内症状とTrigeminal Neurovascular Contactとの関連2021

    • Author(s)
      渡邉素子、須賀隆行、Chaoli Hong、Zhenyan Liu、 高尾千紘、Trang Tu、坂本潤一郎、竹之下美穂、倉林亨、豊福明
    • Organizer
      第61回日本歯科放射線学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 歯科心身症患者における片側優位症状とTrigeminal Neurovascular Contactとの関連2021

    • Author(s)
      渡邉素子、須賀隆行、高尾千紘、竹之下美穂、豊福明
    • Organizer
      第36回日本歯科心身医学会学術大会
    • Related Report
      2020 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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